Propylpyrazoletriol: Difference between revisions

'''Propylpyrazoletriol''' ('''PPT''') is a [[Organicsynthetic compound#Synthetic compounds|synthetic]], [[non-steroidalnonsteroidal]] [[agonist]] of [[Estrogen receptor alpha|ERα]] with 400-fold selectivity over [[ERβ]]<ref name="OttowWeinmann2008">{{cite book |author1 vauthors =Eckhard OttowWeatherman RV |author2 chapter =Hilmar Untangling the Estrogen Receptor Web: Tools to Selectively Study Estrogen‐Binding Receptors | veditors = Ottow E, Weinmann H |title=Nuclear Receptors as Drug Targets |url series =http Methods and Principles in Medicinal Chemistry | pages = 47–64 ([https://books.google.com/books?id=iATfLbPgRugC&pg=PA50 50]) |date=8 September 2008|publisher=John Wiley & Sons|isbn=978-3-527-62330-3 |pages doi =50– 10.1002/9783527623297.ch3 }}</ref> that is used widely in [[scientific research]] to study the function of [[Estrogen receptor alpha|ERα]].<ref name="PlantZeleznik2014">{{cite book|author1 vauthors =Tony M.Pfaus JG, Jones SL, Flanagan-Cato LM, Blaustein JD Plant|author2 chapter =Anthony J.Female sexual behavior: Hormonal Priming and Control | veditors = Plant TM, Zeleznik AJ |title=Knobil and Neill's Physiology of Reproduction: Two-Volume Set | volume = 2 | chapter-url=httphttps://bookswww.googleresearchgate.comnet/books?id=I1ACBAAAQBAJ&pg=PA2311publication/282594468 |date=15 November 2014|publisher=Academic Press|isbn=978-0-12-397769-4|pages=2311–2287-2370 (2311) }}</ref><ref name="pmid20977477">{{cite bookjournal | vauthors = Aguirre C, Jayaraman A, Pike C, Baudry M | title =Cytoplasmic andProgesterone Nuclearinhibits Receptors—Advancesestrogen-mediated inneuroprotection Researchagainst andexcitotoxicity Application:by 2012down-regulating estrogen receptor-β Edition|url journal =http://books.google.com/books?id Journal of Neurochemistry | volume =AH0i2PG-MjsC&pg 115 | issue =PT220 5 | pages = 1277–87 | date =26 December 20122010 |publisher pmid =ScholarlyEditions 20977477 |isbn pmc =978-1-4649-9741-9 3010223 |pages doi =220– 10.1111/j.1471-4159.2010.07038.x }}</ref><ref>{{cite bookthesis | vauthors = Mann MK | degree = Ph.D. | publisher = University of Illinois at Urbana-Champaign |title=Synthesis of Non-steroidal Estrogen Receptor Proteolysis Targeting Chimeric Molecules (PROTACS).|url=httphttps://bookswww.googleproquest.com/booksopenview/4482238ffd6011e4d9945c0a5e196298/1?idpq-origsite=A8QIy4avIS0Cgscholar&pgcbl=PA1118750 |year=2008|publisher=ProQuest|isbn=978-0-549-90990-3 |pages=11–}}</ref> Though originally thought to be highly selective for ERα, PPT has subsequently been found to also act as an [[agonist]] of the [[GPER]] (GPR30).<ref name="ProssnitzBarton2014">{{cite journal |last1 vauthors = Prossnitz|first1=Eric R.|last2=ER, Barton M |first2=Matthias| title = Estrogen biology: Newnew insights into GPER function and clinical opportunities | journal = Molecular and Cellular Endocrinology | volume = 389 | issue =1-2 1–2 |year pages = 71–83 | date = May 2014 |pages pmid =71–83 24530924 |issn pmc =0303-7207 4040308 | doi = 10.1016/j.mce.2014.02.002 }}</ref>

== See also ==

== References ==

{{Reflist|2}}

[[Category:Phenols4-Hydroxyphenyl compounds]]