SCH-442,416: Difference between revisions

| verifiedrevid = 409169500464385200

| ImageSize=200px

|IUPACName PIN=2-(Furan-2-furylyl)-7-[3-(4-methoxyphenyl)propyl]-7''H''-pyrazolo[4,3-''e''][1,2,4]triazolo[1,5-''c'']pyrimidin-5-amine

| OtherNames=SCH-442,416

|Section1= {{Chembox Identifiers

| PubChem = 10668061

| SMILES = n1n3c(nc4c(c3nc1c2occc2)cnn4CCCc5ccc(OC)cc5)N

|Section2= {{Chembox Properties

| Formula=C₂₀H₁₉N₇O₂

| MolarMass=389.410

| Appearance=

| Density=

| MeltingPt=

| BoilingPt=

| Solubility=

|Section3= {{Chembox Hazards

| MainHazards=

| FlashPt=

'''SCH-442,416''' is a highly selective [[adenosine]] [[Adenosine A2a receptor|A_2a]] subtype receptor [[Antagonist (pharmacology)|antagonist]]. It is widely used in its ¹¹C [[isotopic labelling|radiolabelled]] form to map the distribution of A_2a receptors in the brain, where they are mainly found in the [[striatum]], [[nucleus accumbens]], and [[olfactory tubercle]].<ref>{{cite journal | vauthors = Moresco RM, Todde S, Belloli S, Simonelli P, Panzacchi A, Rigamonti M, Galli-Kienle M, Fazio F. | display-authors = 6 | title = In vivo imaging of adenosine A2A receptors in rat and primate brain using [11C]SCH442416. ''| journal = European Journal of Nuclear Medicine and Molecular Imaging''. 2005| volume = Apr;32( | issue = 4):405-13. PMID| pages = 405–13 | date = April 2005 | pmid = 15549298 | doi = 10.1007/s00259-004-1688-5 | s2cid = 20909406 }}</ref> Given its distribution in the brain, A_2a receptors have been investigated for the treatment of various neurological disorders, and SCH-442,416 has shown promise in treatment of [[depression (mood)|depression]],<ref>{{cite journal | vauthors = El Yacoubi M, Costentin J, Vaugeois JM. | title = Adenosine A2A receptors and depression. ''| journal = Neurology''. 2003| Decvolume = 9;61( | issue = 11 Suppl 6): | pages = S82-7. PMID| date = December 2003 | pmid = 14663017 | doi = 10.1212/01.wnl.0000095220.87550.f6 | s2cid = 36219448 }}</ref> [[Parkinson's disease]],<ref>{{cite journal | vauthors = Matsuya T, Takuma K, Sato K, Asai M, Murakami Y, Miyoshi S, Noda A, Nagai T, Mizoguchi H, Nishimura S, Yamada K. | display-authors = 6 | title = Synergistic effects of adenosine A2A antagonist and L-DOPA on rotational behaviors in 6-hydroxydopamine-induced hemi-Parkinsonian mouse model. ''| journal = Journal of Pharmacological Sciences''. 2007| volume = Mar;103( | issue = 3):329-32. PMID| pages = 329–32 | date = March 2007 | pmid = 17341841 | doi = 10.1254/jphs.scz070058 | doi-access = free }}</ref> and [[catalepsy]].<ref>{{cite journal | vauthors = Mihara T, Noda A, Arai H, Mihara K, Iwashita A, Murakami Y, Matsuya T, Miyoshi S, Nishimura S, Matsuoka N. | display-authors = 6 | title = Brain adenosine A2A receptor occupancy by a novel A1/A2A receptor antagonist, ASP5854, in rhesus monkeys: relationship to anticataleptic effect. ''| journal = Journal of Nuclear Medicine''. 2008| volume = Jul;49( | issue = 7):1183-8. PMID| pages = 1183–8 | date = July 2008 | pmid = 18552135 | doi = 10.2967/jnumed.108.051474 | doi-access = free }}</ref>

[[Category:Phenol4-Methoxyphenyl etherscompounds]]

[[Category:Furans2-Furyl compounds]]