Talk:Crohn's disease

Crohn's disease

Ought Crohn's disease of the vulva be added to this page? --Iztwoz (talk) 18:36, 17 February 2018 (UTC)

A bit late, but I think it should be mentioned as extra-intenstinal manifestations. It's probably an infection. AXONOV (talk) ⚑ 14:33, 21 January 2024 (UTC)

Deaths

This "47,400 with ulcerative colitis (2015)"

Represents the number of deaths together with UC.

The ref https://www.ncbi.nlm.nih.gov/pubmed/27733281 does not give them individually.Doc James (talk · contribs · email) 03:46, 4 April 2018 (UTC)

In my opinion, it is very confusing. Also keep in mind that it is intended for the general public, of all intellectual levels. What does the reader have to understand? That these are deaths of people who have both Crohn's disease and ulcerative colitis? Or that are people who only have ulcerative colitis? And where...?

I would leave these figures only on the IBD page. Here it is not informative, just the opposite. If we do not have specific figures, we do not have specific figures.

As I have said more times, attempts to simplify sometimes confuse rather than help. And that is worrisome. --BallenaBlanca 🐳 ♂ (Talk) 09:58, 4 April 2018 (UTC)

Okay. Will look for specific figures with respect to CD. Doc James (talk · contribs · email) 19:21, 4 April 2018 (UTC)

New sections pertaining to oral health

There are two new sections on oral health that have been added to the bottom of the article by @Eileeneelie:. These sections are in need of references and also need to be placed in the correct place in the article. Eileeneelie please see WP:MEDMOS for the medical manual of style to determine where this info would best fit into the present article and also WP:MEDRS for what sources are acceptable for Wikipedia. I have moved these sections to the talk page so they can be improved and then added back in.

Moved sections:

Oral manifestations

A wide range of oral lesions has been clinically reported in Crohn disease; however, many of the abnormalities described are relatively nonspecific and may be associated with other conditions that cause orofacial granulomatosis. The more prominent findings such as diffuse or nodular swelling of the oral and perioral tissues, a cobblestone appearance of the mucosa, granulomatous appearing ulcers and pyostomatitis vegetans represent granulomatous changes that constitute the hallmark of Crohn’s disease. Patchy erythematous macules and plaques at the gingiva are termed mucogingivitis and may be one of the common lesions.

(Redacted)

References

JenOttawa (talk) 03:21, 24 January 2020 (UTC)

I have removed some of the above material, which is copyright material copied from the source book. Visible here — Diannaa (talk) 15:29, 24 January 2020 (UTC)

Thank you for noticing this @Diannaa: JenOttawa (talk) 15:33, 24 January 2020 (UTC)

It was found by the bot— Diannaa (talk) 15:34, 24 January 2020 (UTC)

Thanks @Diannaa: for sharing the link to the list and for cleaning up both the talk page and the article. Have a great day! JenOttawa (talk) 15:46, 24 January 2020 (UTC)

Is the Pyoderma Gangrenosum Image Relevant?

From what I've managed to gather it appears that PD prevalence is associated in general with autoimmune diseases and IBDs not specifically with Crohn's, and even then isn't exactly a typical symptom, the article itself mentions a prevelence of around 1.2% for people with Crohn's.

PG is also mentioned in just 2 sentences throughout the article (the second of which by the way, appears strangely out of place in the paragraph it is written in). Giving it an images appears to be a somewhat out-sized representation, when other physical presentations mentioned in the article (uveitis, gallstones, Primary sclerosing cholangitis, ankylosing spondylitis, deep venous thrombosis, Clubbing, Erythema nodosum) are not pictured.

It is also notable how prominent the image is when compared to the images of symptoms actually used in the diagnosis of the CD.

Finally, I'm not certain it represents a typical presentation of PG, and not a rather severe case, while I managed to find some other images of PG online (some appeared more and some appeared less severe), I wasn't able to find much to point me either way.

TJmichael (talk) 15:17, 23 July 2020 (UTC)

Let's put it this way, for the above reasons, I really don't think the image belongs in this article, however, it has been here for a really long time, and I that means multiple editors have seen it and didn't see a reason for it to go. I'm increasingly leaning towards just remove this image. Does anyone have any justification for not doing so? TJmichael (talk) 07:41, 3 August 2020 (UTC)

Agree. Less relevant here than erythema nodosum. Changed figure and added a large (free) epidemiological study with prevalences.Jrfw51 (talk)

While you're at it I might take a look at Ulcerative colitis too, there's a large image of PG there that feels equally out of place. Not only is PG less prevalent in UC paitents (according to the chart posted on this very article), but the image also shows large PG ulcers on a person's back, which it is my understanding isn't even the typical presentation of PG (https://www.mayoclinic.org/diseases-conditions/pyoderma-gangrenosum/symptoms-causes/syc-20350386). Though I admit I have fat less knowledge of UC than I do Crohn's. TJmichael (talk) 14:51, 4 August 2020 (UTC)

The data in these Tables for complications are wrong and not supported by the cited article. We need to revisit these for both Crohns and UC.Jrfw51 (talk) 08:53, 6 August 2020 (UTC)

Onset?

Tends to start in the teens and twenties. Usual onset 20 to 30. Which one is true? jtg (talk) 19:01, 27 August 2021 (UTC)

From my own experience, first symptoms in my late teens, with it getting very much worse in my early 20s. Lugnuts ^{Fire Walk with Me} 19:34, 27 August 2021 (UTC)

Titanium dioxide increases the inflammations in patients with inflammatory bowel diseases

Hello, about my edit @Zefr: I have found many sources about it, someone professional please keep it back on this article.

1. https://europepmc.org/article/med/36191962
2. https://pubs.acs.org/doi/abs/10.1021/acs.jafc.9b02391
3. https://www.zora.uzh.ch/id/eprint/222379/
4. https://www.researchgate.net/publication/293168967_Titanium_dioxide_nanoparticles_exacerbate_DSS-induced_colitis_Role_of_the_NLRP3_inflammasome
5. https://www.mdpi.com/1422-0067/22/2/772
6. https://hal.inrae.fr/hal-03321952/document
7. https://particleandfibretoxicology.biomedcentral.com/articles/10.1186/s12989-021-00421-2
8. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8275967/
9. https://gut.bmj.com/content/66/7/1216
10. https://eomifne.gr/images/pdf/ioibd/IOIBD%20-%20IBD%20&%20dietary%20GLs%202020.pdf
11. https://www.viridian-nutrition.com/blog/nutrition-news-and-views/breakthrough-study-common-colouring-titanium-dioxide-aggravates-bowel-disease
12. https://ibdnewstoday.com/2017/07/20/study-suggests-food-additive-titanium-dioxide-can-exacerbate-bowel-disease/
13. https://www.crohnscolitisfoundation.org/diet-and-nutrition/what-should-i-eat
14. https://www.youtube.com/watch?v=pBCiBx5YLtU
15. https://www.medicalnewstoday.com/articles/ibd-common-red-food-coloring-may-cause-intestinal-inflammation-colitis
16. https://www.nature.com/articles/srep40373
17. https://www.bcchr.ca/news/food-additives-inflammatory-bowel-disease
18. https://www.gastroscience.ch/research/inflammation/the-impact-of-nano-and-microparticles/

plus Voice of America Persian News Network made a report about it: https://ir.voanews.com/a/food-/3956976.html

Thank you. NameGame (talk) 06:14, 12 March 2023 (UTC)

We are writing for a medical topic in an encyclopedia, requiring high-quality review sources on human studies, as described in WP:MEDRS. Not one of the sources above meets the definition of "high-quality review" - see WP:MEDASSESS, left pyramid. Zefr (talk) 15:05, 12 March 2023 (UTC)

@Zefr: Thank you for your answer. my goal is to make an awareness to the inflammatory bowel disease patients.

Now, do you believe that I might be allowed to replace this significant research about the Titanium dioxide in its own article? NameGame (talk) 18:20, 12 March 2023 (UTC)

There is no review literature to indicate it is involved specifically as a factor in IBD. There are no systematic reviews of randomized controlled trials on this topic. I did add this section to the titanium dioxide article. Zefr (talk) 20:44, 12 March 2023 (UTC)

I appreciate it. NameGame (talk) 21:18, 12 March 2023 (UTC)

The "Etiology" and "Causes" sections should be combined.

"Etiology" is essentially just a fancy word for "cause", so having both sections is a bit nonsensical. — Guillaume Pelletier ~ 01:05, 4 April 2023 (UTC)

@Epgui I do agree with you about the wordage issue, however both sections seem to discuss slightly different topics. The causes section seems to discuss risk factors more than true etiology, so it might be more pertinent to rename the section to risk factors rather than keep it as causes.

As far as combining them, that would work too. All just depends on how you want to go about it. Justin99887 (talk) 14:35, 8 April 2023 (UTC)

Treatment: clarithromycin + rifabutin

There are various studies related to treatment of CD by clarithromycin + rifabutin (both basically anti-mycobacterial / tuberculosis drugs (i.e. mycobacterium avium complex): [1][2][3]

May be worth checking. AXONOV (talk) ⚑ 14:41, 21 January 2024 (UTC)

Any WP:MEDRS ? Bon courage (talk) 14:48, 21 January 2024 (UTC)

Enough to mention in given WP:RSCONTEXT. These aren't reviews of course. So far nobody can state that therapy is efficient. AXONOV (talk) ⚑ 19:53, 21 January 2024 (UTC)

There is a review [4] with uncertain reliability. AXONOV (talk) ⚑ 08:11, 23 January 2024 (UTC)

Not a great source, but possibly okay for a mild claim like "no good evidence of benefit". Bon courage (talk) 09:02, 23 January 2024 (UTC)

ALSO: there is a limited evidence of high IgG concentrations (read antibodies) to mycobacteria in Chron's patients. AXONOV (talk) ⚑ 19:03, 12 February 2024 (UTC)

Elevated levels of IgG to Micobacterium in CD patients

There is a limited evidence that CD patients have high IgG to Mycobacterium: [5][6][7] AXONOV (talk) ⚑ 19:40, 12 February 2024 (UTC)