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{{Infobox medical condition
| name =
| synonym = Van Wyk-Grumbach syndrome (VWGS)
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| specialty = endocrine
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'''Van Wyk and Grumbach syndrome''' is a medical condition defined by a combination of [[hypothyroidism]], [[precocious puberty]] (with delayed bone age and lack of pubic hair), and [[ovarian cyst]]s in pre- and post-pubertal girls or macroorchidism (unusually large testes) in boys.<ref name=":0">{{Cite journal |last1=Rastogi |first1=Ashu |last2=Bhadada |first2=Sanjay Kumar |last3=Bhansali |first3=Anil |date=July 2011 |title=An unusual presentation of a usual disorder: Van Wyk-Grumbach syndrome |journal=Indian Journal of Endocrinology and Metabolism |volume=15 |issue=Suppl 2 |pages=S141–143 |doi=10.4103/2230-8210.83356 |issn=2230-9500 |pmc=3169870 |pmid=21966653 |doi-access=free }}</ref>
==
The presumed pathogenesis is that primary hypothyroidism causes enlargement and hyperstimulation of the [[pituitary gland]] which in turn cause ovarian hyperstimulation, ovarian cysts and precocious puberty.▼
== Mechanism ==
▲Further symptoms are [[ascites]], pleural and pericardial effusions, elevated ovarian tumour markers, enlarged pituitary gland and elevated [[prolactin]] and [[alpha-fetoprotein]] levels.
▲The presumed pathogenesis is that primary hypothyroidism causes enlargement and hyperstimulation of the [[pituitary gland]] which in turn cause ovarian hyperstimulation, ovarian cysts and precocious puberty.{{citation needed|date=August 2020}}
== Diagnosis ==
Diagnosis is made by imaging/sonography and thyroid hormone tests.{{citation needed|date=August 2020}}
== Treatment ==
The syndrome usually responds well to thyroid hormone replacement with complete resolution of symptoms.<ref name=":0" />
== History ==
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| pmid = 18283448
| year = 2008
|
| first1 = L. P.
| title = Van Wyk and Grumbach syndrome revisited: Imaging and clinical findings in pre- and postpubertal girls
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| first6 = R. P.
| doi = 10.1007/s00247-008-0777-1
| s2cid = 10001906
}}</ref><ref>{{Cite journal
| pmid = 23155707
| year = 2012
|
| first1 = N
| title = Elevated alpha-fetoprotein levels in Van Wyk-Grumbach syndrome: A case report and review of literature
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| first3 = A
| doi = 10.1515/jpem-2012-0112
| s2cid = 70369330
}}</ref><ref>{{Cite journal
| pmid = 19127572
| year = 2009
|
| first1 = A
| title = Ovarian tumor in a 12-year
| journal = Pediatric Blood & Cancer
| volume = 52
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| first7 = H. J.
| doi = 10.1002/pbc.21920
| s2cid = 21495694
}}</ref>
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[[Category:Noninflammatory disorders of female genital tract]]
[[Category:Syndromes]]
▲{{endocrine-disease-stub}}
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