Aquaporin-5

Aquaporin-5 (AQP-5) is a protein that in humans is encoded by the AQP5 gene.

AQP5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3D9S, 5C5X, 5DYE
Identifiers
Aliases	AQP5, AQP-5, PPKB, aquaporin 5
External IDs	OMIM: 600442; MGI: 106215; HomoloGene: 20398; GeneCards: AQP5; OMA:AQP5 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) Band 12q13.12 Start 49,961,872 bp End 49,965,682 bp
Gene location (Mouse) Chr. Chromosome 15 (mouse) Band 15 F1|15 56.13 cM Start 99,488,663 bp End 99,492,710 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in olfactory zone of nasal mucosa palpebral conjunctiva left testis right testis parotid gland skin of leg nasal epithelium minor salivary glands trachea skin of abdomen Top expressed in submandibular gland parotid gland lacrimal gland right lung right lung lobe respiratory epithelium olfactory epithelium trachea epithelium of lens left lung More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transporter activity protein binding water channel activity identical protein binding channel activity Cellular component integral component of membrane membrane plasma membrane integral component of plasma membrane microvillus basal plasma membrane apical plasma membrane endoplasmic reticulum extracellular exosome cytoplasmic vesicle membrane cytoplasmic vesicle Biological process excretion water transport pancreatic juice secretion saliva secretion odontogenesis ion transmembrane transport camera-type eye morphogenesis carbon dioxide transport transport transmembrane transport protein homotetramerization cellular hypotonic response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 362 11830 Ensembl ENSG00000161798 ENSMUSG00000044217 UniProt P55064 Q9WTY4 RefSeq (mRNA) NM_001651 NM_009701 RefSeq (protein) NP_001642 NP_033831 Location (UCSC) Chr 12: 49.96 – 49.97 Mb Chr 15: 99.49 – 99.49 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Aquaporin-5 (AQP-5) is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin-5 plays a role in the generation of saliva, tears and pulmonary secretions. AQP0, AQP2, AQP5, and AQP6 are closely related and all map to 12q13.

Further reading

• Verkman AS (2003). "Role of aquaporin water channels in eye function". Exp. Eye Res. 76 (2): 137–43. doi:10.1016/S0014-4835(02)00303-2. PMID 12565800.
• Ma T, Yang B, Umenishi F, Verkman AS (1997). "Closely spaced tandem arrangement of AQP2, AQP5, and AQP6 genes in a 27-kilobase segment at chromosome locus 12q13". Genomics. 43 (3): 387–9. doi:10.1006/geno.1997.4836. PMID 9268644.
• Smith JK, Siddiqui AA, Modica LA, et al. (1999). "Interferon-alpha upregulates gene expression of aquaporin-5 in human parotid glands". J. Interferon Cytokine Res. 19 (8): 929–35. doi:10.1089/107999099313479. PMID 10476940.
• Kreda SM, Gynn MC, Fenstermacher DA, et al. (2001). "Expression and localization of epithelial aquaporins in the adult human lung". Am. J. Respir. Cell Mol. Biol. 24 (3): 224–34. doi:10.1165/ajrcmb.24.3.4367. PMID 11245621. S2CID 12825671.
• Gresz V, Kwon TH, Hurley PT, et al. (2001). "Identification and localization of aquaporin water channels in human salivary glands". Am. J. Physiol. Gastrointest. Liver Physiol. 281 (1): G247–54. doi:10.1152/ajpgi.2001.281.1.G247. PMID 11408278.
• Nejsum LN, Kwon TH, Jensen UB, et al. (2002). "Functional requirement of aquaporin-5 in plasma membranes of sweat glands". Proc. Natl. Acad. Sci. U.S.A. 99 (1): 511–6. Bibcode:2002PNAS...99..511N. doi:10.1073/pnas.012588099. PMC 117591. PMID 11773623.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Burghardt B, Elkaer ML, Kwon TH, et al. (2003). "Distribution of aquaporin water channels AQP1 and AQP5 in the ductal system of the human pancreas". Gut. 52 (7): 1008–16. doi:10.1136/gut.52.7.1008. PMC 1773699. PMID 12801959.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Chen Z, Wang X, Gao L, et al. (2006). "Regulation of MUC5AC mucin secretion by depletion of AQP5 in SPC-A1 cells". Biochem. Biophys. Res. Commun. 342 (3): 775–81. doi:10.1016/j.bbrc.2006.01.103. PMID 16500622.
• Sidhaye VK, Güler AD, Schweitzer KS, et al. (2006). "Transient receptor potential vanilloid 4 regulates aquaporin-5 abundance under hypotonic conditions". Proc. Natl. Acad. Sci. U.S.A. 103 (12): 4747–52. Bibcode:2006PNAS..103.4747S. doi:10.1073/pnas.0511211103. PMC 1450241. PMID 16537379.
• Pedersen PS, Braunstein TH, Jørgensen A, et al. (2007). "Stimulation of aquaporin-5 and transepithelial water permeability in human airway epithelium by hyperosmotic stress". Pflügers Arch. 453 (6): 777–85. doi:10.1007/s00424-006-0157-3. PMID 17043812. S2CID 6205954.
• Skowron-zwarg M, Boland S, Caruso N, et al. (2007). "Interleukin-13 interferes with CFTR and AQP5 expression and localization during human airway epithelial cell differentiation". Exp. Cell Res. 313 (12): 2695–702. doi:10.1016/j.yexcr.2007.02.035. PMID 17553491.

External links

• AQP5+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Human AQP5 genome location and AQP5 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.