Interleukin 13 receptor, alpha 1 , also known as IL13RA1 and CD213A1 (cluster of differentiation 213A1), is a human gene .[ 5]
The protein encoded by this gene is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This subunit serves as a primary IL13 -binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4.[ 5]
IL13RA1 expression has been linked to higher survival rates for lung cancer patients.[ 6]
Kornau HC, Schenker LT, Kennedy MB, Seeburg PH (1995). "Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95". Science . 269 (5231): 1737–40. Bibcode :1995Sci...269.1737K . doi :10.1126/science.7569905 . PMID 7569905 . Aman MJ, Tayebi N, Obiri NI, et al. (1997). "cDNA cloning and characterization of the human interleukin 13 receptor alpha chain" . J. Biol. Chem . 271 (46): 29265–70. doi :10.1074/jbc.271.46.29265 PMID 8910586 . Miloux B, Laurent P, Bonnin O, et al. (1997). "Cloning of the human IL-13R alpha1 chain and reconstitution with the IL4R alpha of a functional IL-4/IL-13 receptor complex". FEBS Lett . 401 (2–3): 163–6. doi :10.1016/S0014-5793(96)01462-7 . PMID 9013879 . S2CID 85249806 . Zhang JG, Hilton DJ, Willson TA, et al. (1997). "Identification, purification, and characterization of a soluble interleukin (IL)-13-binding protein. Evidence that it is distinct from the cloned Il-13 receptor and Il-4 receptor alpha-chains" . J. Biol. Chem . 272 (14): 9474–80. doi :10.1074/jbc.272.14.9474 PMID 9083087 . Orchansky PL, Kwan R, Lee F, Schrader JW (1999). "Characterization of the cytoplasmic domain of interleukin-13 receptor-alpha" . J. Biol. Chem . 274 (30): 20818–25. doi :10.1074/jbc.274.30.20818 PMID 10409622 . Osawa M, Miyoshi S, Copeland NG, et al. (2000). "Characterization of the mouse interleukin-13 receptor alpha1 gene". Immunogenetics . 51 (11): 974–81. doi :10.1007/s002510000225 . PMID 11003391 . S2CID 9030454 . Umeshita-Suyama R, Sugimoto R, Akaiwa M, et al. (2000). "Characterization of IL-4 and IL-13 signals dependent on the human IL-13 receptor alpha chain 1: redundancy of requirement of tyrosine residue for STAT3 activation" . Int. Immunol . 12 (11): 1499–509. doi :10.1093/intimm/12.11.1499 PMID 11058569 . Oshima Y, Puri RK (2001). "Characterization of a powerful high affinity antagonist that inhibits biological activities of human interleukin-13" . J. Biol. Chem . 276 (18): 15185–91. doi :10.1074/jbc.M010159200 PMID 11278629 . Kawakami M, Leland P, Kawakami K, Puri RK (2002). "Mutation and functional analysis of IL-13 receptors in human malignant glioma cells" . Oncol. Res . 12 (11–12): 459–67. doi :10.3727/096504001108747468 PMID 11939409 . Roy B, Bhattacharjee A, Xu B, et al. (2002). "IL-13 signal transduction in human monocytes: phosphorylation of receptor components, association with Jaks, and phosphorylation/activation of Stats" . J. Leukoc. Biol . 72 (3): 580–9. doi :10.1189/jlb.72.3.580 PMID 12223527 . S2CID 9279523 . Andrews AL, Holloway JW, Puddicombe SM, et al. (2003). "Kinetic analysis of the interleukin-13 receptor complex" . J. Biol. Chem . 277 (48): 46073–8. doi :10.1074/jbc.M209560200 PMID 12354755 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Nagarkatti R, Ghosh B (2003). "Identification of single-nucleotide and repeat polymorphisms in two candidate genes, interleukin 4 receptor (IL4RA) and signal transducer and activator of transcription protein 6 (STAT6), for Th2-mediated diseases" . J. Hum. Genet . 47 (12): 684–7. doi :10.1007/s100380200105 PMID 12522691 . He JQ, Connett JE, Anthonisen NR, Sandford AJ (2003). "Polymorphisms in the IL13, IL13RA1, and IL4RA genes and rate of decline in lung function in smokers". Am. J. Respir. Cell Mol. Biol . 28 (3): 379–85. doi :10.1165/rcmb.4885 . PMID 12594065 . Niu Y, Murata T, Watanabe K, et al. (2003). "MIP-T3 associates with IL-13Ralpha1 and suppresses STAT6 activation in response to IL-13 stimulation" . FEBS Lett . 550 (1–3): 139–43. doi :10.1016/S0014-5793(03)00860-3 PMID 12935900 . S2CID 2517010 . Wongpiyabovorn J, Suto H, Ushio H, et al. (2004). "Up-regulation of interleukin-13 receptor alpha1 on human keratinocytes in the skin of psoriasis and atopic dermatitis". J. Dermatol. Sci . 33 (1): 31–40. doi :10.1016/S0923-1811(03)00148-8 . PMID 14527737 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Arima K, Sato K, Tanaka G, et al. (2005). "Characterization of the interaction between interleukin-13 and interleukin-13 receptors" . J. Biol. Chem . 280 (26): 24915–22. doi :10.1074/jbc.M502571200 PMID 15870068 . Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8. Bibcode :2005Natur.437.1173R . doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 . Kaur D, Hollins F, Woodman L, et al. (2007). "Mast cells express IL-13R alpha 1: IL-13 promotes human lung mast cell proliferation and Fc epsilon RI expression". Allergy . 61 (9): 1047–53. doi :10.1111/j.1398-9995.2006.01139.x . PMID 16918506 . S2CID 11962277 .
