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Catharanthus roseus

(Redirected from Madagascar periwinkle)

Catharanthus roseus, commonly known as bright eyes, Cape periwinkle, graveyard plant, Madagascar periwinkle, old maid, pink periwinkle, rose periwinkle,[2] is a perennial species of flowering plant in the family Apocynaceae. It is native and endemic to Madagascar, but is grown elsewhere as an ornamental and medicinal plant, and now has a pantropical distribution. It is a source of the drugs vincristine and vinblastine, used to treat cancer.[3] It was formerly included in the genus Vinca as Vinca rosea.

Catharanthus roseus
Scientific classification Edit this classification
Kingdom: Plantae
Clade: Tracheophytes
Clade: Angiosperms
Clade: Eudicots
Clade: Asterids
Order: Gentianales
Family: Apocynaceae
Genus: Catharanthus
Species:
C. roseus
Binomial name
Catharanthus roseus
Synonyms
  • Vinca rosea L.
  • Pervinca rosea (L.) Gaterau
  • Lochnera rosea (L.) Rchb. ex Spach
  • Ammocallis rosea (L.) Small

(See also Synonyms section)

White flower with yellow center

It has many vernacular names among which are arivotaombelona or rivotambelona, tonga, tongatse or trongatse, tsimatiririnina, and vonenina.[4]

Taxonomy

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Two varieties are recognized

  • Catharanthus roseus var. roseus
Synonymy for this variety
Catharanthus roseus var. angustus Steenis ex Bakhuizen f.[5]
Catharanthus roseus var. albus G.Don[6]
Catharanthus roseus var. occellatus G.Don[6]
Catharanthus roseus var. nanus Markgr.[7]
Lochnera rosea f. alba (G.Don) Woodson[8]
Lochnera rosea var. ocellata (G.Don) Woodson
  • Catharanthus roseus var. angustus (Steenis) Bakh. f.[9]
Synonymy for this variety
Catharanthus roseus var. nanus Markgr.[10]
Lochnera rosea var. angusta Steenis[11]

Description

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In morning

Catharanthus roseus is an evergreen subshrub or herbaceous plant growing 1 m (39 in) tall. The leaves are oval to oblong, 2.5–9 cm (1.0–3.5 in) long and 1–3.5 cm (0.4–1.4 in) wide, glossy green, hairless, with a pale midrib and a short petiole 1–1.8 cm (0.4–0.7 in) long; they are arranged in opposite pairs. The flowers range from white with a yellow or red center to dark pink with a darker red center, with a basal tube 2.5–3 cm (1.0–1.2 in) long and a corolla 2–5 cm (0.8–2.0 in) diameter with five petal-like lobes. The fruit is a pair of follicles 2–4 cm (0.8–1.6 in) long and 3 mm (0.1 in) wide.[12][13][14][15] [1][</ref>

Ecology

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In its natural range along the dry coasts of southern Madagascar, Catharanthus roseus is considered weedy and invasive, often self-seeding prolifically in disturbed areas along roadsides and in fallow fields. [16][17] It is also, however, widely cultivated and is naturalized in subtropical and tropical areas of the world such as Australia, Bangladesh, India, Malaysia, Pakistan, and the United States.[12] It is so well adapted to growth in Australia that it is listed as a noxious weed in Western Australia and the Australian Capital Territory,[18] and also in parts of eastern Queensland.[19]

 
Pale Pink with Red Centre Cultivar

Cultivation

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As an ornamental plant, it is appreciated for its hardiness in dry and nutritionally deficient conditions, popular in subtropical gardens where temperatures never fall below 5–7 °C (41–45 °F), and as a warm-season bedding plant in temperate gardens. It is noted for its long flowering period, throughout the year in tropical conditions, and from spring to late autumn, in warm temperate climates. Full sun and well-drained soil are preferred. Numerous cultivars have been selected, for variation in flower colour (white, mauve, peach, scarlet, and reddish-orange), and also for tolerance of cooler growing conditions in temperate regions.

Notable cultivars include 'Albus' (white flowers), 'Grape Cooler' (rose-pink; cool-tolerant), the Ocellatus Group (various colours), and 'Peppermint Cooler' (white with a red centre; cool-tolerant).[12]

In the U.S. it often remains identified as "Vinca" although botanists have shifted its identification and it often can be seen growing along roadsides in the south.

In the United Kingdom it has gained the Royal Horticultural Society's Award of Garden Merit[20] (confirmed 2017).[21]

Uses

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Traditional

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In Ayurveda (Indian traditional medicine) the extracts of its roots and shoots, although poisonous, are used against several diseases. In traditional Chinese medicine, extracts from it have been used against numerous diseases, including diabetes, malaria, and Hodgkin's lymphoma.[22][13] In the 1950s, vinca alkaloids, including vinblastine and vincristine, were isolated from Catharanthus roseus while screening for anti-diabetic drugs.[23] This chance discovery led to increased research into the chemotherapeutic effects of vinblastine and vincristine. Conflict between historical indigenous use, and a patent from 2001 on C. roseus-derived drugs by western pharmaceutical companies, without compensation, has led to accusations of biopiracy.[24]

Medicinal

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Vinblastine and vincristine, chemotherapy medications used to treat several types of cancers, are found in the plant[25][26][27][28] and are biosynthesised from the coupling of the alkaloids catharanthine and vindoline.[29] The newer semi-synthetic chemotherapeutic agent vinorelbine, used in the treatment of non-small-cell lung cancer,[27][30] can be prepared either from vindoline and catharanthine[27][31] or from the vinca alkaloid leurosine,[32] in both cases via anhydrovinblastine.[31] The insulin-stimulating vincoline has been isolated from the plant.[33][34]

 
A periwinkle shrub
 

Research

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Despite the medical importance and wide use, the desired alkaloids (vinblastine and vincristine) are naturally produced at very low yields. Additionally, it is complex and costly to synthesize the desired products in a lab, resulting in difficulty satisfying the demand and a need for overproduction.[35] Treatment of the plant with phytohormones, such as salicylic acid[36] and methyl jasmonate,[37][38] have been shown to trigger defense mechanisms and overproduce downstream alkaloids. Studies using this technique vary in growth conditions, choice of phytohormone, and location of treatment. Concurrently, there are various efforts to map the biosynthetic pathway producing the alkaloids to find a direct path to overproduction via genetic engineering.[39][40]

C. roseus is used in plant pathology as an experimental host for phytoplasmas.[41] This is because it is easy to infect with a large majority of phytoplasmas, and also often has very distinctive symptoms such as phyllody and significantly reduced leaf size.[42]

In 1995 and 2006 Malagasy agronomists and American political ecologists studied the production of Catharanthus roseus around Fort Dauphin and Ambovombe and its export as a natural source of the alkaloids used to make vincristine, vinblastine and other vinca alkaloid cancer drugs. Their research focused on the wild collection of periwinkle roots and leaves from roadsides and fields and its industrial cultivation on large farms.[43][44][45]

Biology

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Rosinidin is the pink anthocyanidin pigment found in the flowers of C. roseus.[46] Lochnericine is a major alkaloid in roots.[47]

Toxicity

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C. roseus can be extremely toxic if consumed orally by humans, and is cited (under its synonym Vinca rosea) in the Louisiana State Act 159. All parts of the plant are poisonous. On consumption, symptoms consist of mild stomach cramps, cardiac complications, hypotension, systematic paralysis eventually leading to death.[48]

According to French botanist Pierre Boiteau, its poisonous properties are made known along generations of Malagasy people as a poison consumed in ordeal trials, even before the tangena fruit was used. This lent the flower one of its names vonenina, from Malagasy: vony enina meaning "flower of remorse".[49]

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  •  
    Deep-red Catharanthus roseus
  •  
    This one was grown in Bangladesh as a ornamental plant in a flower tub in the balcony of a house
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    Off-white Catharanthus roseus
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    White with red-centered Catharanthus roseus
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    Red Catharanthus roseus
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    White periwinkle with thin petals
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    Catharanthus roseus in Kerala
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    Purple Catharanthus roseus
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    Periwinkle From a garden at Cox's Bazar, Bangladesh
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    Catharanthus roseus in Ishwardi, Bangladesh
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    Flower bud in West Bengal, India
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    Periwinkle Plant in India
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    Common periwinkle plant in India
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    Catharanthus roseus in Pakistan
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    Grown in Malaysia
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    Flower plant raised in India temples
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    Seed pod and seeds
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    Matured fruits of Madagascar Periwinkle
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    Immature fruits of Madagascar periwinkle
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    Pacifica Burgundy Halo – Madagascar Periwinkle
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    Red cultivar of Madagascar Periwinkle
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    Potted Plant in New Delhi
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    Seeds
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    A fully bloomed white plant
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  •  
    A rare mutation of Periwinkle flower which causes an additional petal(6), found in Chandannagar

References

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  1. ^ "Catharanthus roseus". World Checklist of Selected Plant Families (WCSP). Royal Botanic Gardens, Kew. Retrieved 4 August 2019.
  2. ^ "Catharanthus roseus". Germplasm Resources Information Network. Agricultural Research Service, United States Department of Agriculture. Retrieved 4 August 2019.
  3. ^ Moudi, Maryam; Go, Rusea; Yien, Christina Yong Seok; Nazre, Mohd. (2013-11-04). "Vinca Alkaloids". International Journal of Preventive Medicine. 4 (11): 1231–1235. ISSN 2008-7802. PMC 3883245. PMID 24404355.
  4. ^ de La Beaujardière, Jean-Marie, ed. (2001). "Botanical scientific bames". Malagasy Dictionary and Malagasy Encyclopedia. Archived from the original on 2022-11-01. Retrieved 2022-11-01.
  5. ^ Steenis ex Bakhuizen f., Blumea 6: 384. 1950.
  6. ^ a b G.Don, Gen. Hist. 4(1): 95. 1837.
  7. ^ Markgr., Adansonia, ser. 2. 12: 222. 1972.
  8. ^ Woodson, N. Amer. Fl. 29: 124. 1938.
  9. ^ Bakh. f.Blumea 6 (2): 384. 1950.
  10. ^ Markgr. Adansonia, ser. 2. 12: 222. 1972.
  11. ^ Steenis Trop. Nat. 25: 18. 1936.
  12. ^ a b c Huxley, A., ed. (1992). New RHS Dictionary of Gardening. Macmillan ISBN 0-333-47494-5.
  13. ^ a b Flora of China: Catharanthus roseus
  14. ^ College of Micronesia: Catharanthus roseus
  15. ^ Jepson Flora: Catharanthus roseus
  16. ^ Andriamanalintsoa, Jean Joseph (1995). Contribution a l'etude de la producition de la pervenche de Madagascar ou Catharanthus roseus, Cas d' Ambovombe, d'Amboasary-sud, de Beloha et Tsihombe (PhD Dissertation) (in French). Antananarivo, Madagascar: Universityersité d'Antananarivo, Ecole Superieur des Sciences Agronomiques.
  17. ^ Neimark, Ben (2012). "Green grabbing at the 'pharm' gate: rosy periwinkle production in southern Madagascar". The Journal of Peasant Studies. 39 (2): 423-445. doi:10.1080/03066150.2012.666975. S2CID 153584071. Retrieved 14 July 2023.
  18. ^ "Catharanthus roseus". Orpheus Island Research Station – James Cook University. Retrieved 2 November 2015.[permanent dead link‍]
  19. ^ "Factsheet – Catharanthus roseus". Queensland Government. Archived from the original on 12 March 2016. Retrieved 2 November 2015.
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  23. ^ Heijden, Robert; Jacobs, Denise; Snoeijer, Wim; Hallard, Didier; Verpoorte, Robert (2004-03-01). "The Catharanthus Alkaloids:Pharmacognosy and Biotechnology". Current Medicinal Chemistry. 11 (5): 607–628. doi:10.2174/0929867043455846. ISSN 0929-8673. PMID 15032608.
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  25. ^ Gansäuer, Andreas; Justicia, José; Fan, Chun-An; Worgull, Dennis; Piestert, Frederik (2007). "Reductive C—C bond formation after epoxide opening via electron transfer". In Krische, Michael J. (ed.). Metal Catalyzed Reductive C—C Bond Formation: A Departure from Preformed Organometallic Reagents. Topics in Current Chemistry. Vol. 279. Springer Science & Business Media. pp. 25–52. doi:10.1007/128_2007_130. ISBN 978-3-540-72879-5.
  26. ^ Cooper, Raymond; Deakin, Jeffrey John (2016). "Africa's gift to the world". Botanical Miracles: Chemistry of Plants That Changed the World. CRC Press. pp. 46–51. ISBN 978-1-4987-0430-4.
  27. ^ a b c Keglevich, Péter; Hazai, Laszlo; Kalaus, György; Szántay, Csaba (2012). "Modifications on the basic skeletons of vinblastine and vincristine". Molecules. 17 (5): 5893–5914. doi:10.3390/molecules17055893. PMC 6268133. PMID 22609781.
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  29. ^ Hirata, K.; Miyamoto, K.; Miura, Y. (1994). "Catharanthus roseus L. (Periwinkle): Production of Vindoline and Catharanthine in Multiple Shoot Cultures". In Bajaj, Y. P. S. (ed.). Biotechnology in Agriculture and Forestry 26. Medicinal and Aromatic Plants. Vol. VI. Springer-Verlag. pp. 46–55. ISBN 978-3-540-56391-4.
  30. ^ Faller, Bryan A.; Pandi, Trailokya N. (2011). "Safety and efficacy of vinorelbine in the treatment of non-small cell lung cancer". Clinical Medicine Insights: Oncology. 5: 131–144. doi:10.4137/CMO.S5074. PMC 3117629. PMID 21695100.
  31. ^ a b Ngo, Quoc Anh; Roussi, Fanny; Cormier, Anthony; Thoret, Sylviane; Knossow, Marcel; Guénard, Daniel; Guéritte, Françoise (2009). "Synthesis and biological evaluation of Vinca alkaloids and phomopsin hybrids". Journal of Medicinal Chemistry. 52 (1): 134–142. doi:10.1021/jm801064y. PMID 19072542.
  32. ^ Hardouin, Christophe; Doris, Eric; Rousseau, Bernard; Mioskowski, Charles (2002). "Concise synthesis of anhydrovinblastine from leurosine". Organic Letters. 4 (7): 1151–1153. doi:10.1021/ol025560c. PMID 11922805.
  33. ^ Aynilian, GH; Weiss, SG; Cordell, GA; Abraham, DJ; Crane, FA; Farnsworth, NR (1974). "Catharanthus alkaloids. XXIX. Isolation and structure elucidation of vincoline". Journal of Pharmaceutical Sciences. 63 (4): 536–8. doi:10.1002/jps.2600630409. PMID 4828700.
  34. ^ Yao, XG; Chen, F; Li, P; Quan, L; Chen, J; Yu, L; Ding, H; Li, C; Chen, L; Gao, Z; Wan, P; Hu, L; Jiang, H; Shen, X (2013). "Natural product vindoline stimulates insulin secretion and efficiently ameliorates glucose homeostasis in diabetic murine models". Journal of Ethnopharmacology. 150 (1): 285–97. doi:10.1016/j.jep.2013.08.043. PMID 24012527.
  35. ^ Pan, Qifang; Wang, Chenyi; Xiong, Zhiwei; Wang, Hang; Fu, Xueqing; Shen, Qian; Peng, Bowen; Ma, Yanan; Sun, Xiaofen; Tang, Kexuan (2019-07-18). "CrERF5, an AP2/ERF Transcription Factor, Positively Regulates the Biosynthesis of Bisindole Alkaloids and Their Precursors in Catharanthus roseus". Frontiers in Plant Science. 10: 931. doi:10.3389/fpls.2019.00931. ISSN 1664-462X. PMC 6657538. PMID 31379908.
  36. ^ ABABAF, M; OMIDI, H; BAKHSHANDEH, A M (2019). "Germination Indices and Antioxidant Activity Enzyme Responses of Madagascar Periwinkle (Catharanthus Roseus (L.) G. Don) Under Pretreatment by Salicylic Acid". Applied Ecology and Environmental Research. 17 (2): 3989–4005. doi:10.15666/aeer/1702_39894005. ISSN 1589-1623.
  37. ^ Khataee, Elham; Karimi, Farah; Razavi, Khadijeh (2021). "Different carbon sources and their concentrations change alkaloid production and gene expression in Catharanthus roseus shoots in vitro". Functional Plant Biology. 48 (1): 40–53. doi:10.1071/FP19254. ISSN 1445-4408. PMID 32690131. S2CID 220670971.
  38. ^ Fraser, Valerie N.; Philmus, Benjamin; Megraw, Molly (September 2020). "Metabolomics analysis reveals both plant variety and choice of hormone treatment modulate vinca alkaloid production in Catharanthus roseus". Plant Direct. 4 (9): e00267. doi:10.1002/pld3.267. ISSN 2475-4455. PMC 7520646. PMID 33005857.
  39. ^ Singh, Sanjay Kumar; Patra, Barunava; Paul, Priyanka; Liu, Yongliang; Pattanaik, Sitakanta; Yuan, Ling (April 2020). "Revisiting the ORCA gene cluster that regulates terpenoid indole alkaloid biosynthesis in Catharanthus roseus". Plant Science. 293: 110408. Bibcode:2020PlnSc.29310408S. doi:10.1016/j.plantsci.2020.110408. ISSN 0168-9452. PMID 32081258. S2CID 211231123.
  40. ^ Mortensen, Samuel; Weaver, Jessica D.; Sathitloetsakun, Suphinya; Cole, Lauren F.; Rizvi, Noreen F.; Cram, Erin J.; Lee-Parsons, Carolyn W. T. (December 2019). "The regulation of ZCT1, a transcriptional repressor of monoterpenoid indole alkaloid biosynthetic genes in Catharanthus roseus". Plant Direct. 3 (12): e00193. doi:10.1002/pld3.193. ISSN 2475-4455. PMC 6937483. PMID 31909362.
  41. ^ Marcone, C.; Ragozzino, A.; Seemuller, E. (1997). "Dodder transmission of alder yellows phytoplasma to the experimental host Catharanthus roseus (periwinkle)". Forest Pathology. 27 (6): 347–350. doi:10.1111/j.1439-0329.1997.tb01449.x.
  42. ^ Chang, Chung-Jan (1998). "Pathogenicity of Aster Yellows Phytoplasma and Spiroplasma citri on Periwinkle". Phytopathology. 88 (12): 1347–1350. doi:10.1094/PHYTO.1998.88.12.1347. PMID 18944838.
  43. ^ Andriamanalintsoa, Jean Joseph (1995). Contribution a l'etude de la producition de la pervenche de Madagascar ou Catharanthus roseus, Cas d' Ambovombe, d'Amboasary-sud, de Beloha et Tsihombe (PhD Dissertation) (in French). Antananarivo, Madagascar: Universityersité d'Antananarivo, Ecole Superieur des Sciences Agronomiques.
  44. ^ Neimark, Benjamin (2009). "At the "Pharm" gate: The case study of the rosy periwinkle (Catharanthus roseus)". Industrial Heartlands of Nature: The Political Economy of Biological Prospecting in Madagascar (PhD Dissertation). New Brunswick: Rutgers, The State University of New Jersey. p. 70-112. doi:10.7282/T3WD40Q7.
  45. ^ Neimark, Ben (2012). "Green grabbing at the 'pharm' gate: rosy periwinkle production in southern Madagascar". The Journal of Peasant Studies. 39 (2): 423-445. doi:10.1080/03066150.2012.666975. S2CID 153584071. Retrieved 14 July 2023.
  46. ^ Toki, Kenjiro; Saito, Norio; Irie, Yuki; Tatsuzawa, Fumi; Shigihara, Atsushi; Honda, Toshio (2008). "7-O-Methylated anthocyanidin glycosides from Catharanthus roseus". Phytochemistry. 69 (5): 1215–1219. Bibcode:2008PChem..69.1215T. doi:10.1016/j.phytochem.2007.11.005. PMID 18164044.
  47. ^ "American Society of Plant Biologists". August 2018.
  48. ^ "Is Periwinkle Plant Poisonous or Toxic?". 9 June 2020.
  49. ^ Boiteau, Pierre (1999). "vonenina". Dictionnaire des noms malgaches de végétaux (in French). Vol. IV. Editions Alzieu. Archived from the original on 2022-11-01. Retrieved 2022-11-01 – via Malagasy Dictionary and Malagasy Encyclopedia.

https://link.springer.com/chapter/10.1007/978-3-319-51620-2_7

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