NKX6-1

Homeobox protein Nkx-6.1 is a protein that in humans is encoded by the NKX6-1 gene.

NKX6-1
Identifiers
Aliases	NKX6-1, NKX6.1, NKX6A, NK6 homeobox 1
External IDs	OMIM: 602563; MGI: 1206039; HomoloGene: 4495; GeneCards: NKX6-1; OMA:NKX6-1 - orthologs
Gene location (Human) Chr. Chromosome 4 (human) Band 4q21.23 Start 84,491,985 bp End 84,499,292 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5|5 E4- E5 Start 101,806,005 bp End 101,812,862 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastric mucosa islet of Langerhans testicle body of pancreas stromal cell of endometrium left lobe of thyroid gland substantia nigra left testis Hypothalamus right testis Top expressed in islet of Langerhans primordial pancreas stria vascularis embryo facial motor nucleus esophagus spinal cord anterior horn of spinal cord vestibular membrane of cochlear duct cochlea More reference expression data BioGPS n/a
Gene ontology Molecular function DNA-binding transcription repressor activity, RNA polymerase II-specific sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding chromatin binding DNA-binding transcription factor activity DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus extracellular exosome Biological process smoothened signaling pathway detection of glucose pancreas development transcription, DNA-templated regulation of axon extension multicellular organism development cellular response to peptide hormone stimulus central nervous system neuron differentiation response to nicotine negative regulation of glial cell differentiation type B pancreatic cell proliferation cellular response to cytokine stimulus positive regulation of DNA-binding transcription factor activity neurogenesis regulation of transcription by RNA polymerase II type B pancreatic cell development positive regulation of neuron differentiation negative regulation of transcription by RNA polymerase II positive regulation of type B pancreatic cell development type B pancreatic cell maturation oligodendrocyte differentiation regulation of transcription, DNA-templated cell population proliferation positive regulation of transcription by RNA polymerase II transcription by RNA polymerase II positive regulation of glial cell differentiation cell differentiation positive regulation of insulin secretion animal organ morphogenesis regulation of neuron migration neuron migration regulation of insulin secretion endocrine pancreas development type B pancreatic cell differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4825 18096 Ensembl ENSG00000163623 ENSMUSG00000035187 UniProt P78426 Q99MA9 RefSeq (mRNA) NM_006168 NM_144955 RefSeq (protein) NP_006159 NP_659204 Location (UCSC) Chr 4: 84.49 – 84.5 Mb Chr 5: 101.81 – 101.81 Mb PubMed search
Wikidata
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Function

In the pancreas, NKX6.1 is required for the development of beta cells and is a potent bifunctional transcription regulator that binds to AT-rich sequences within the promoter region of target genes.

Further reading

• Schisler JC, Fueger PT, Babu DA, et al. (2008). "Stimulation of human and rat islet beta-cell proliferation with retention of function by the homeodomain transcription factor Nkx6.1". Mol. Cell. Biol. 28 (10): 3465–76. doi:10.1128/MCB.01791-07. PMC 2423154. PMID 18347054.
• Hori Y, Gu X, Xie X, Kim SK (2005). "Differentiation of insulin-producing cells from human neural progenitor cells". PLOS Med. 2 (4): e103. doi:10.1371/journal.pmed.0020103. PMC 1087208. PMID 15839736.
• Jørgensen MC, Vestergírd Petersen H, Ericson J, et al. (1999). "Cloning and DNA-binding properties of the rat pancreatic beta-cell-specific factor Nkx6.1". FEBS Lett. 461 (3): 287–94. doi:10.1016/S0014-5793(99)01436-2. PMID 10567713. S2CID 1735843.
• Iype T, Taylor DG, Ziesmann SM, et al. (2004). "The transcriptional repressor Nkx6.1 also functions as a deoxyribonucleic acid context-dependent transcriptional activator during pancreatic beta-cell differentiation: evidence for feedback activation of the nkx6.1 gene by Nkx6.1". Mol. Endocrinol. 18 (6): 1363–75. doi:10.1210/me.2004-0006. PMID 15056733.
• Yokoi N, Kanamori M, Horikawa Y, et al. (2006). "Association studies of variants in the genes involved in pancreatic beta-cell function in type 2 diabetes in Japanese subjects". Diabetes. 55 (8): 2379–86. doi:10.2337/db05-1203. PMID 16873704.
• Zhu S, Xia HH, Yang Y, et al. (2009). "Alterations of gastric homeoprotein expression in Helicobacter pylori infection, incisural antralisation, and intestinal metaplasia". Dig. Dis. Sci. 54 (5): 996–1002. doi:10.1007/s10620-008-0459-8. PMID 18754095. S2CID 25173708.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.