Solute carrier organic anion transporter family member 1B3

Solute carrier organic anion transporter family member 1B3 (SLCO1B3) also known as organic anion-transporting polypeptide 1B3 (OATP1B3) is a protein that in humans is encoded by the SLCO1B3 gene.

SLCO1B3
Identifiers
Aliases	SLCO1B3, HBLRR, LST-2, LST-3TM13, LST3, OATP-8, OATP1B3, OATP8, SLC21A8, solute carrier organic anion transporter family member 1B3
External IDs	OMIM: 605495; MGI: 1351899; HomoloGene: 75119; GeneCards: SLCO1B3; OMA:SLCO1B3 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) Band 12p12.2 Start 20,810,702 bp End 20,916,911 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6 G2|6 72.57 cM Start 141,575,244 bp End 141,632,372 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver testicle olfactory zone of nasal mucosa Epithelium of choroid plexus gonad nasal epithelium buccal mucosa cell tibial nerve canal of the cervix gallbladder Top expressed in left lobe of liver embryo sexually immature organism medial head of gastrocnemius muscle primary visual cortex proximal tubule jejunum thoracic diaphragm pancreas right kidney More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transporter activity organic anion transmembrane transporter activity bile acid transmembrane transporter activity sodium-independent organic anion transmembrane transporter activity Cellular component integral component of membrane basolateral plasma membrane integral component of plasma membrane membrane plasma membrane Biological process ion transport bile acid and bile salt transport organic anion transport sodium-independent organic anion transport transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 28234 28253 Ensembl ENSG00000111700 ENSMUSG00000030236 UniProt Q9NPD5 Q9JJL3 RefSeq (mRNA) NM_019844 NM_001349920 NM_020495 NM_178235 RefSeq (protein) NP_062818 NP_001336849 NP_065241 Location (UCSC) Chr 12: 20.81 – 20.92 Mb Chr 6: 141.58 – 141.63 Mb PubMed search
Wikidata
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OATP1B3 is a 12-transmembrane domain influx transporter. Normally expressed in the liver, the transporter functions to uptake large, non-polar drugs and hormones from the portal vein.

Clinical significance

OATP1B3 has also been identified as a transporter aberrantly expressed in prostate cancer and implicated in prostate cancer progression. Increasing mRNA expression of OATP1B3 was also correlated to prostate cancer Gleason score.

In addition, lower expression of OATP1B3 mRNA was also detected in testicular cancer.

Substrates

Small molecules that are transported by SLCO1B3 include:

• Amanitin
• Atrasentan
• Bilirubin
• Bosentan
• BQ-123
• Bromsulphthalein (BSP)
• CDCA-NBD
• Cholate (CA)
• Cholecystokinin octapeptide (CCK-8)
• Dehydroepiandroserone-3-sulfate (DHEAS)
• Deltorphin II
• Demethylphalloin
• Digoxin
• Docetaxel
• [D-penicillamine2,5]enkephalin (DPDPE)
• Enalapril
• Estradiol-17β-glucuronide 5–25
• Estrone-3-sulfate
• Fexofenadine
• Fluvastatin
• Fluo-3
• Glutathione (GSH)
• Glycocholate (GCA)
• Glycoursodeoxycholate (GUDCA)
• Irinotecan
• Leukotriene C4 (LTC4)
• Methotrexate
• Microcystin
• Monoglyucuronosyl
• Olmesartan
• Ouabain
• Paclitaxel
• Phalloidin
• Pitavastatin
• Rifampicin
• Ro 48-5033 (Bosentan metabolite)
• Rosuvastatin
• SN-38
• Taurocholate (TCA)
• Taurochenodeoxycholate (TCDCA)
• Taurodeoxycholate (TDCA)
• Tauroursodeoxycholate (TUDCA)
• Telmisartan
• Thyroxine (T4)
• TR-14035
• Triiodothyronine (T3)
• Valsartan

See also

• Solute carrier family

Further reading

• König J, Cui Y, Nies AT, Keppler D (2000). "Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide". J. Biol. Chem. 275 (30): 23161–8. doi:10.1074/jbc.M001448200. PMID 10779507.
• Abe T, Unno M, Onogawa T, et al. (2001). "LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers". Gastroenterology. 120 (7): 1689–99. doi:10.1053/gast.2001.24804. PMID 11375950.
• Ismair MG, Stieger B, Cattori V, et al. (2001). "Hepatic uptake of cholecystokinin octapeptide by organic anion-transporting polypeptides OATP4 and OATP8 of rat and human liver" (PDF). Gastroenterology. 121 (5): 1185–90. doi:10.1053/gast.2001.28704. PMID 11677211.
• Jung D, Podvinec M, Meyer UA, et al. (2002). "Human organic anion transporting polypeptide 8 promoter is transactivated by the farnesoid X receptor/bile acid receptor". Gastroenterology. 122 (7): 1954–66. doi:10.1053/gast.2002.33583. PMID 12055601.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Cui Y, König J, Nies AT, et al. (2003). "Detection of the human organic anion transporters SLC21A6 (OATP2) and SLC21A8 (OATP8) in liver and hepatocellular carcinoma". Lab. Invest. 83 (4): 527–38. doi:10.1097/01.lab.0000065015.02412.48. PMID 12695556.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Vavricka SR, Jung D, Fried M, et al. (2004). "The human organic anion transporting polypeptide 8 (SLCO1B3) gene is transcriptionally repressed by hepatocyte nuclear factor 3beta in hepatocellular carcinoma". J. Hepatol. 40 (2): 212–8. doi:10.1016/j.jhep.2003.10.008. PMID 14739090.
• Hirano M, Maeda K, Shitara Y, Sugiyama Y (2004). "Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the hepatic uptake of pitavastatin in humans". J. Pharmacol. Exp. Ther. 311 (1): 139–46. doi:10.1124/jpet.104.068056. PMID 15159445. S2CID 9691203.
• Letschert K, Keppler D, König J (2005). "Mutations in the SLCO1B3 gene affecting the substrate specificity of the hepatocellular uptake transporter OATP1B3 (OATP8)". Pharmacogenetics. 14 (7): 441–52. doi:10.1097/01.fpc.0000114744.08559.92. PMID 15226676.
• Yamaguchi H, Okada M, Akitaya S, et al. (2006). "Transport of fluorescent chenodeoxycholic acid via the human organic anion transporters OATP1B1 and OATP1B3" (PDF). J. Lipid Res. 47 (6): 1196–202. doi:10.1194/jlr.M500532-JLR200. PMID 16534140. S2CID 14682342.
• Ohtsuka H, Abe T, Onogawa T, et al. (2006). "Farnesoid X receptor, hepatocyte nuclear factors 1alpha and 3beta are essential for transcriptional activation of the liver-specific organic anion transporter-2 gene". J. Gastroenterol. 41 (4): 369–77. doi:10.1007/s00535-006-1784-3. PMID 16741617. S2CID 7626543.
• Briz O, Romero MR, Martinez-Becerra P, et al. (2006). "OATP8/1B3-mediated cotransport of bile acids and glutathione: an export pathway for organic anions from hepatocytes?". J. Biol. Chem. 281 (41): 30326–35. doi:10.1074/jbc.M602048200. PMID 16877380.
• Mahagita C, Grassl SM, Piyachaturawat P, Ballatori N (2007). "Human organic anion transporter 1B1 and 1B3 function as bidirectional carriers and do not mediate GSH-bile acid cotransport". Am. J. Physiol. Gastrointest. Liver Physiol. 293 (1): G271–8. doi:10.1152/ajpgi.00075.2007. PMID 17412826.
• Treiber A, Schneiter R, Häusler S, Stieger B (2007). "Bosentan is a substrate of human OATP1B1 and OATP1B3: inhibition of hepatic uptake as the common mechanism of its interactions with cyclosporin A, rifampicin, and sildenafil". Drug Metab. Dispos. 35 (8): 1400–7. doi:10.1124/dmd.106.013615. PMID 17496208. S2CID 2625368.
• Muto M, Onogawa T, Suzuki T, et al. (2007). "Human liver-specific organic anion transporter-2 is a potent prognostic factor for human breast carcinoma". Cancer Sci. 98 (10): 1570–6. doi:10.1111/j.1349-7006.2007.00570.x. PMC 11159603. PMID 17760952. S2CID 35010274.