APBB2: Difference between revisions

APBB2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WGU, 2ROZ, 2YSZ, 2YT0, 2YT1
Identifiers
Aliases	APBB2, FE65L, FE65L1, amyloid beta precursor protein binding family B member 2
External IDs	OMIM: 602710; MGI: 108405; HomoloGene: 32079; GeneCards: APBB2; OMA:APBB2 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	41,216,714 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	66,776,127 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; Achilles tendon; ; sural nerve; ; dorsal motor nucleus of vagus nerve; ; inferior olivary nucleus; ; tendon of biceps brachii; ; internal globus pallidus; ; ventricular zone; ; corpus callosum; ; tibia;
	Top expressed in
	genital tubercle; ; lateral geniculate nucleus; ; renal corpuscle; ; medial dorsal nucleus; ; pontine nuclei; ; ankle; ; triceps brachii muscle; ; deep cerebellar nuclei; ; lateral septal nucleus; ; medial geniculate nucleus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; transcription factor binding; amyloid-beta binding;
Cellular component	growth cone; membrane; cytoplasm; lamellipodium; synapse; nucleus;
Biological process	positive regulation of apoptotic process; intracellular signal transduction; negative regulation of cell growth; negative regulation of apoptotic process; extracellular matrix organization; axon guidance; neuron migration; regulation of transcription, DNA-templated;
	Sources:Amigo / QuickGO
Orthologs
	323
	11787
	ENSG00000163697
	ENSMUSG00000029207
	Q92870
	Q9DBR4
NM_001166050; NM_001166051; NM_001166052; NM_001166053; NM_001166054;
	NM_004307; NM_173075; NM_001330656; NM_001330658
NM_001201413; NM_001201414; NM_001201415; NM_001201416; NM_009686;
	NM_001310626
NP_001159522; NP_001159523; NP_001159524; NP_001159525; NP_001159526;
	NP_001317585; NP_001317587; NP_004298; NP_775098
NP_001188342; NP_001188343; NP_001188344; NP_001188345; NP_001297555;
	NP_033816
	Wikidata
View/Edit Human	View/Edit Mouse

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Latest revision as of 03:07, 1 December 2023

Amyloid beta A4 precursor protein-binding family B member 2 is a protein that in humans is encoded by the APBB2 gene.^[5]^[6]^[7]

The protein encoded by this gene interacts with the cytoplasmic domains of amyloid beta (A4) precursor protein and amyloid beta (A4) precursor-like protein 2. This protein contains two phosphotyrosine binding (PTB) domains, which are thought to function in signal transduction.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000163697 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029207 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ McLoughlin DM, Miller CC (Jan 1997). "The intracellular cytoplasmic domain of the Alzheimer's disease amyloid precursor protein interacts with phosphotyrosine-binding domain proteins in the yeast two-hybrid system". FEBS Lett. 397 (2–3): 197–200. doi:10.1016/S0014-5793(96)01128-3. PMID 8955346.
^ Blanco G, Irving NG, Brown SD, Miller CC, McLoughlin DM (Jun 1998). "Mapping of the human and murine X11-like genes (APBA2 and apba2), the murine Fe65 gene (Apbb1), and the human Fe65-like gene (APBB2): genes encoding phosphotyrosine-binding domain proteins that interact with the Alzheimer's disease amyloid precursor protein". Mamm Genome. 9 (6): 473–5. doi:10.1007/s003359900800. PMID 9585438. S2CID 31066473.
^ ^a ^b "Entrez Gene: APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 (Fe65-like)".

External links

Human APBB2 genome location and APBB2 gene details page in the UCSC Genome Browser.

Guénette SY, Chen J, Jondro PD, Tanzi RE (1996). "Association of a novel human FE65-like protein with the cytoplasmic domain of the beta-amyloid precursor protein". Proc. Natl. Acad. Sci. U.S.A. 93 (20): 10832–7. Bibcode:1996PNAS...9310832G. doi:10.1073/pnas.93.20.10832. PMC 38241. PMID 8855266.
Bruni P, Minopoli G, Brancaccio T, et al. (2002). "Fe65, a ligand of the Alzheimer's beta-amyloid precursor protein, blocks cell cycle progression by down-regulating thymidylate synthase expression". J. Biol. Chem. 277 (38): 35481–8. doi:10.1074/jbc.M205227200. PMID 12089154.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Chang Y, Tesco G, Jeong WJ, et al. (2004). "Generation of the beta-amyloid peptide and the amyloid precursor protein C-terminal fragment gamma are potentiated by FE65L1". J. Biol. Chem. 278 (51): 51100–7. doi:10.1074/jbc.M309561200. PMID 14527950.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Li Y, Hollingworth P, Moore P, et al. (2006). "Genetic association of the APP binding protein 2 gene (APBB2) with late onset Alzheimer disease". Hum. Mutat. 25 (3): 270–7. doi:10.1002/humu.20138. PMID 15714520. S2CID 28343972.
Lange A, Thon L, Mathieu S, Adam D (2005). "The apoptosis inhibitory domain of FE65-like protein 1 regulates both apoptotic and caspase-independent programmed cell death mediated by tumor necrosis factor". Biochem. Biophys. Res. Commun. 335 (2): 575–83. doi:10.1016/j.bbrc.2005.07.125. PMID 16083851.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Hong Q, Hsu LJ, Schultz L, et al. (2007). "Zfra affects TNF-mediated cell death by interacting with death domain protein TRADD and negatively regulates the activation of NF-κB, JNK1, p53 and WOX1 during stress response". BMC Mol. Biol. 8: 50. doi:10.1186/1471-2199-8-50. PMC 1904229. PMID 17567906.

This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000163697 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029207 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8955346-5] McLoughlin DM, Miller CC (Jan 1997). "The intracellular cytoplasmic domain of the Alzheimer's disease amyloid precursor protein interacts with phosphotyrosine-binding domain proteins in the yeast two-hybrid system". FEBS Lett. 397 (2–3): 197–200. doi:10.1016/S0014-5793(96)01128-3. PMID 8955346.

[pmid9585438-6] Blanco G, Irving NG, Brown SD, Miller CC, McLoughlin DM (Jun 1998). "Mapping of the human and murine X11-like genes (APBA2 and apba2), the murine Fe65 gene (Apbb1), and the human Fe65-like gene (APBB2): genes encoding phosphotyrosine-binding domain proteins that interact with the Alzheimer's disease amyloid precursor protein". Mamm Genome. 9 (6): 473–5. doi:10.1007/s003359900800. PMID 9585438. S2CID 31066473.

[entrez-7] "Entrez Gene: APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 (Fe65-like)".

[1]

[2]

[3]

[4]

[5]

[6]

[7]

@@ Line 1: / Line 1: @@
+{{Short description|Protein-coding gene in the species Homo sapiens}}
 {{Infobox_gene}}
-'''Amyloid beta A4 precursor protein-binding family B member 2''' is a [[protein]] that in humans is encoded by the ''APBB2'' [[gene]].<ref name="pmid8955346">{{cite journal |vauthors=McLoughlin DM, Miller CC | title = The intracellular cytoplasmic domain of the Alzheimer's disease amyloid precursor protein interacts with phosphotyrosine-binding domain proteins in the yeast two-hybrid system | journal = FEBS Lett | volume = 397 | issue = 2–3 | pages = 197–200 |date=Jan 1997 | pmid = 8955346 | pmc =  | doi =10.1016/S0014-5793(96)01128-3  }}</ref><ref name="pmid9585438">{{cite journal |vauthors=Blanco G, Irving NG, Brown SD, Miller CC, McLoughlin DM | title = Mapping of the human and murine X11-like genes (APBA2 and apba2), the murine Fe65 gene (Apbb1), and the human Fe65-like gene (APBB2): genes encoding phosphotyrosine-binding domain proteins that interact with the Alzheimer's disease amyloid precursor protein | journal = Mamm Genome | volume = 9 | issue = 6 | pages = 473–5 |date=Jun 1998 | pmid = 9585438 | pmc =  | doi =  10.1007/s003359900800}}</ref><ref name="entrez"/>
+'''Amyloid beta A4 precursor protein-binding family B member 2''' is a [[protein]] that in humans is encoded by the ''APBB2'' [[gene]].<ref name="pmid8955346">{{cite journal |vauthors=McLoughlin DM, Miller CC | title = The intracellular cytoplasmic domain of the Alzheimer's disease amyloid precursor protein interacts with phosphotyrosine-binding domain proteins in the yeast two-hybrid system | journal = FEBS Lett | volume = 397 | issue = 2–3 | pages = 197–200 |date=Jan 1997 | pmid = 8955346 | doi =10.1016/S0014-5793(96)01128-3  | doi-access = free }}</ref><ref name="pmid9585438">{{cite journal |vauthors=Blanco G, Irving NG, Brown SD, Miller CC, McLoughlin DM | title = Mapping of the human and murine X11-like genes (APBA2 and apba2), the murine Fe65 gene (Apbb1), and the human Fe65-like gene (APBB2): genes encoding phosphotyrosine-binding domain proteins that interact with the Alzheimer's disease amyloid precursor protein | journal = Mamm Genome | volume = 9 | issue = 6 | pages = 473–5 |date=Jun 1998 | pmid = 9585438 | doi =  10.1007/s003359900800| s2cid = 31066473 }}</ref><ref name="entrez"/>
+The protein encoded by this gene interacts with the [[cytoplasm]]ic domains of [[amyloid beta]] (A4) precursor protein and amyloid beta (A4) precursor-like protein 2. This protein contains two [[phosphotyrosine]] binding (PTB) domains, which are thought to function in [[signal transduction]].<ref name="entrez">{{cite web | title = Entrez Gene: APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 (Fe65-like)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=323}}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{PBB_Summary
-| section_title =
-| summary_text = The protein encoded by this gene interacts with the [[cytoplasm]]ic domains of [[amyloid beta]] (A4) precursor protein and amyloid beta (A4) precursor-like protein 2. This protein contains two [[phosphotyrosine]] binding (PTB) domains, which are thought to function in [[signal transduction]].<ref name="entrez">{{cite web | title = Entrez Gene: APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 (Fe65-like)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=323| accessdate = }}</ref>
-}}
 ==References==
@@ Line 16: / Line 13: @@
 ==Further reading==
 {{refbegin | 2}}
+*{{cite journal  |vauthors=Guénette SY, Chen J, Jondro PD, Tanzi RE |title=Association of a novel human FE65-like protein with the cytoplasmic domain of the beta-amyloid precursor protein |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 20 |pages= 10832–7 |year= 1996 |pmid= 8855266 |doi=10.1073/pnas.93.20.10832  | pmc=38241  |bibcode=1996PNAS...9310832G |doi-access=free }}
-{{PBB_Further_reading
+*{{cite journal  |vauthors=Bruni P, Minopoli G, Brancaccio T |title=Fe65, a ligand of the Alzheimer's beta-amyloid precursor protein, blocks cell cycle progression by down-regulating thymidylate synthase expression |journal=J. Biol. Chem. |volume=277 |issue= 38 |pages= 35481–8 |year= 2002 |pmid= 12089154 |doi= 10.1074/jbc.M205227200 |display-authors=etal|doi-access=free }}
-| citations =
-*{{cite journal  |vauthors=Guénette SY, Chen J, Jondro PD, Tanzi RE |title=Association of a novel human FE65-like protein with the cytoplasmic domain of the beta-amyloid precursor protein |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 20 |pages= 10832–7 |year= 1996 |pmid= 8855266 |doi=10.1073/pnas.93.20.10832  | pmc=38241  }}
+*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
-*{{cite journal  |vauthors=Bruni P, Minopoli G, Brancaccio T |title=Fe65, a ligand of the Alzheimer's beta-amyloid precursor protein, blocks cell cycle progression by down-regulating thymidylate synthase expression |journal=J. Biol. Chem. |volume=277 |issue= 38 |pages= 35481–8 |year= 2002 |pmid= 12089154 |doi= 10.1074/jbc.M205227200 |display-authors=etal}}
+*{{cite journal  |vauthors=Chang Y, Tesco G, Jeong WJ |title=Generation of the beta-amyloid peptide and the amyloid precursor protein C-terminal fragment gamma are potentiated by FE65L1 |journal=J. Biol. Chem. |volume=278 |issue= 51 |pages= 51100–7 |year= 2004 |pmid= 14527950 |doi= 10.1074/jbc.M309561200 |display-authors=etal|doi-access=free }}
-*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
-*{{cite journal  |vauthors=Chang Y, Tesco G, Jeong WJ |title=Generation of the beta-amyloid peptide and the amyloid precursor protein C-terminal fragment gamma are potentiated by FE65L1 |journal=J. Biol. Chem. |volume=278 |issue= 51 |pages= 51100–7 |year= 2004 |pmid= 14527950 |doi= 10.1074/jbc.M309561200 |display-authors=etal}}
 *{{cite journal  |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 |display-authors=etal}}
-*{{cite journal  |vauthors=Li Y, Hollingworth P, Moore P |title=Genetic association of the APP binding protein 2 gene (APBB2) with late onset Alzheimer disease |journal=Hum. Mutat. |volume=25 |issue= 3 |pages= 270–7 |year= 2006 |pmid= 15714520 |doi= 10.1002/humu.20138 |display-authors=etal}}
+*{{cite journal  |vauthors=Li Y, Hollingworth P, Moore P |title=Genetic association of the APP binding protein 2 gene (APBB2) with late onset Alzheimer disease |journal=Hum. Mutat. |volume=25 |issue= 3 |pages= 270–7 |year= 2006 |pmid= 15714520 |doi= 10.1002/humu.20138 |s2cid=28343972 |display-authors=etal|doi-access=free }}
 *{{cite journal  |vauthors=Lange A, Thon L, Mathieu S, Adam D |title=The apoptosis inhibitory domain of FE65-like protein 1 regulates both apoptotic and caspase-independent programmed cell death mediated by tumor necrosis factor |journal=Biochem. Biophys. Res. Commun. |volume=335 |issue= 2 |pages= 575–83 |year= 2005 |pmid= 16083851 |doi= 10.1016/j.bbrc.2005.07.125 }}
-*{{cite journal  |vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal}}
+*{{cite journal  |vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R |s2cid=4427026 |display-authors=etal}}
-*{{cite journal  |vauthors=Hong Q, Hsu LJ, Schultz L |title=Zfra affects TNF-mediated cell death by interacting with death domain protein TRADD and negatively regulates the activation of NF-κB, JNK1, p53 and WOX1 during stress response |journal=BMC Mol. Biol. |volume=8|pages= 50 |year= 2007 |pmid= 17567906 |doi= 10.1186/1471-2199-8-50  | pmc=1904229 |display-authors=etal}}
+*{{cite journal  |vauthors=Hong Q, Hsu LJ, Schultz L |title=Zfra affects TNF-mediated cell death by interacting with death domain protein TRADD and negatively regulates the activation of NF-κB, JNK1, p53 and WOX1 during stress response |journal=BMC Mol. Biol. |volume=8|pages= 50 |year= 2007 |pmid= 17567906 |doi= 10.1186/1471-2199-8-50  | pmc=1904229 |display-authors=etal |doi-access=free }}
-}}
 {{refend}}
 {{PDB Gallery|geneid=323}}
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