BD1052: Difference between revisions
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| C=17 | H=24 | N=2 | Cl=2 |
| C=17 | H=24 | N=2 | Cl=2 |
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| molecular_weight = 327. |
| molecular_weight = 327.2938 g/mol |
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Revision as of 23:26, 23 August 2012
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| Chemical and physical data | |
| Formula | C17H24Cl2N2 |
| Molar mass | 327.2938 g/mol g·mol−1 |
BD1052 or N-[2-(3,4-dichlorophenyl)ethyl]-N-2-propen-1-yl-1-pyrrolidineethanamine is a selective sigma receptor agonist, with a reported binding affinity of Ki = 2 ± 0.5 nM for the sigma-1 receptor and 30 times selectivity over the sigma-2 receptor.[1]
Consistent with other reported sigma receptor agonists, pretreating Swiss Webster mice with BD1052 significantly increases the behavioral toxicity of cocaine.[1]
See also
References
- ^ a b Matsumoto RR, McCracken KA, Pouw B, Miller J, Bowen WD, Williams W, De Costa BR (2001). "N-alkyl substituted analogs of the sigma receptor ligand BD1008 and traditional sigma receptor ligands affect cocaine-induced convulsions and lethality in mice". Eur. J. Pharmacol. 411 (3): 261–73.
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