CARD11: Difference between revisions

CARD11
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4JUP, 4LWD
Identifiers
Aliases	CARD11, BENTA, BIMP3, CARMA1, IMD11, PPBL, caspase recruitment domain family member 11, IMD11A
External IDs	OMIM: 607210; MGI: 1916978; HomoloGene: 13024; GeneCards: CARD11; OMA:CARD11 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	3,043,867 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	140,986,337 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; lymph node; ; spleen; ; appendix; ; blood; ; superficial temporal artery; ; parotid gland; ; palpebral conjunctiva; ; amniotic fluid; ; gallbladder;
	Top expressed in
	mesenteric lymph nodes; ; spleen; ; thymus; ; blood; ; ciliary body; ; Paneth cell; ; embryo; ; subcutaneous adipose tissue; ; duodenum; ; embryo;
	More reference expression data
	n/a
Gene ontology
Molecular function	guanylate kinase activity; protein binding; CARD domain binding;
Cellular component	cytoplasm; cytosol; membrane; T cell receptor complex; immunological synapse; membrane raft; extracellular exosome; plasma membrane; CBM complex;
Biological process	regulation of apoptotic process; positive regulation of cytokine production; T cell costimulation; stimulatory C-type lectin receptor signaling pathway; Fc-epsilon receptor signaling pathway; positive regulation of T cell activation; positive regulation of B cell proliferation; positive regulation of T cell proliferation; regulation of immune response; positive regulation of I-kappaB kinase/NF-kappaB signaling; T cell receptor signaling pathway; regulation of B cell differentiation; thymic T cell selection; regulation of T cell differentiation; signal transduction; GMP metabolic process; positive regulation of NF-kappaB transcription factor activity; GDP metabolic process; immunoglobulin production; B cell differentiation; B cell proliferation; T cell activation; lymphocyte activation; homeostasis of number of cells; I-kappaB kinase/NF-kappaB signaling; TORC1 signaling;
	Sources:Amigo / QuickGO
Orthologs
	84433
	108723
	ENSG00000198286
	ENSMUSG00000036526
	Q9BXL7
	Q8CIS0
	NM_032415; NM_001324281
	NM_175362
	NP_001311210; NP_115791
	NP_780571
	Wikidata
View/Edit Human	View/Edit Mouse

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Caspase recruitment domain-containing protein 11 also known as CARD-containing MAGUK protein 1 (Carma 1) is a protein in the CARD-CC protein family that in humans is encoded by the CARD11 gene.^[5]^[6]^[7] CARD 11 is a membrane associated protein that is found in various human tissues, including the thymus, spleen, liver, and peripheral blood leukocytes. Similarly, CARD 11 is also found in abundance in various lines of cancer cells.^[5]

Function

The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). CARD11 (CARMA1) has a domain structure similar to that of CARD10 (CARMA3) and CARD14 (CARMA2) as a member of the CARD-CC family with a C terminal MAGUK domain (the so-called CARMA proteins). The CARD domain of proteins in the CARD-CC family have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of NF-κB activation by recruitment and activation of MALT1. When overexpressed in cells, this protein family activates NF-κB and induces the phosphorylation of BCL10.^[7]

CARD11 is critical for T cell and B cell function and is activated after T cell receptor or B cell receptor stimulation. After receptor stimulation, CARD11 is phosphorylated by PKC-θ (in T cells) or PKC-β (in B cells). The phosphorylation induces formation of filamentous CARD11 multimers that recruit BCL10 and MALT1, which in turn activates NF-κB. Loss of function mutations in CARD11 cause severe combined immunodeficiency (SCID) since the function of cells critical for adaptive immunity are disrupted.

Structure

The structure of CARD11 involves multiple domains that impact the protein's ability to activate BCL10 and NF-κB activity. CARD11 has a CARD domain, a serine-threonine rich region, is associated with the N-terminus, which is essential for NF-κB signaling activity. The region following the CARD domain is highly coiled. In deleting the CARD domain, all NF-κB signaling activity was prevented. The CARD domain on CARD11 interacts with the CARD domain on BCL10 to initiate the signaling pathway.^[5]

On the C-terminus of CARD11 there is the MAGUK domain that is associated with the cell membrane. This domain is often referred to as the inhibitory domain. Protein kinase C activates CARD11 by phosphorylating serine residues within the inhibitory domain.^[5]^[8]

Interactions

CARD11 has been shown to interact with BCL10.^[9] This interaction occurs between the CARD domain on BCL10 and the CARD domain on CARD11, and results in signal propagation and NF-κB activation.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000198286 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000036526 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b ^c ^d Bertin J, Wang L, Guo Y, Jacobson MD, Poyet JL, Srinivasula SM, Merriam S, DiStefano PS, Alnemri ES (Apr 2001). "CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B". J. Biol. Chem. 276 (15): 11877–82. doi:10.1074/jbc.M010512200. PMID 11278692. S2CID 35815019.
^ Gaide O, Martinon F, Micheau O, Bonnet D, Thome M, Tschopp J (May 2001). "Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation". FEBS Lett. 496 (2–3): 121–7. doi:10.1016/S0014-5793(01)02414-0. PMID 11356195. S2CID 22024213.
^ ^a ^b "Entrez Gene: CARD11 caspase recruitment domain family, member 11".
^ ^a ^b Holliday MJ, Witt A, Rodriguez Gama A, Walters B, Arthur C, Halfman R, Rohou A, Dueber E, Fairbrother W (2019). "Structures of autoinhibited and polymerized forms of CARD9 reveal mechanisms of CARD9 and CARD11 activation". Nat Commun. 10 (3070): 3070. Bibcode:2019NatCo..10.3070H. doi:10.1038/s41467-019-10953-z. PMC 6624267. PMID 31296852.
^ Bertin J, Wang L, Guo Y, Jacobson MD, Poyet JL, Srinivasula SM, Merriam S, DiStefano PS, Alnemri ES (April 2001). "CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B". J. Biol. Chem. 276 (15): 11877–82. doi:10.1074/jbc.M010512200. PMID 11278692. S2CID 35815019.

External links

Human CARD11 genome location and CARD11 gene details page in the UCSC Genome Browser.

Hillier LD, Lennon G, Becker M, Bonaldo MF, Chiapelli B, Chissoe S, Dietrich N, DuBuque T, Favello A, Gish W, Hawkins M, Hultman M, Kucaba T, Lacy M, Le M, Le N, Mardis E, Moore B, Morris M, Parsons J, Prange C, Rifkin L, Rohlfing T, Schellenberg K, Bento Soares M, Tan F, Thierry-Meg J, Trevaskis E, Underwood K, Wohldman P, Waterston R, Wilson R, Marra M (1996). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
Sanger Centre T, Washington University Genome Sequencing Cente T (1998). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
Wang L, Guo Y, Huang WJ, Ke X, Poyet JL, Manji GA, Merriam S, Glucksmann MA, DiStefano PS, Alnemri ES, Bertin J (2001). "Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B". J. Biol. Chem. 276 (24): 21405–9. doi:10.1074/jbc.M102488200. PMID 11259443.
Wang D, You Y, Case SM, McAllister-Lucas LM, Wang L, DiStefano PS, Nuñez G, Bertin J, Lin X (2002). "A requirement for CARMA1 in TCR-induced NF-kappa B activation". Nat. Immunol. 3 (9): 830–5. doi:10.1038/ni824. PMID 12154356. S2CID 19250072.
Gaide O, Favier B, Legler DF, Bonnet D, Brissoni B, Valitutti S, Bron C, Tschopp J, Thome M (2002). "CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-kappa B activation". Nat. Immunol. 3 (9): 836–43. doi:10.1038/ni830. PMID 12154360. S2CID 42949809.
Pomerantz JL, Denny EM, Baltimore D (2002). "CARD11 mediates factor-specific activation of NF-kappaB by the T cell receptor complex". EMBO J. 21 (19): 5184–94. doi:10.1093/emboj/cdf505. PMC 129028. PMID 12356734.
Wang D, Matsumoto R, You Y, Che T, Lin XY, Gaffen SL, Lin X (2004). "CD3/CD28 costimulation-induced NF-kappaB activation is mediated by recruitment of protein kinase C-theta, Bcl10, and IkappaB kinase beta to the immunological synapse through CARMA1". Mol. Cell. Biol. 24 (1): 164–71. doi:10.1128/MCB.24.1.164-171.2003. PMC 303359. PMID 14673152.
Stilo R, Liguoro D, Di Jeso B, Formisano S, Consiglio E, Leonardi A, Vito P (2004). "Physical and functional interaction of CARMA1 and CARMA3 with Ikappa kinase gamma-NFkappaB essential modulator". J. Biol. Chem. 279 (33): 34323–31. doi:10.1074/jbc.M402244200. PMID 15184390.
Lee KY, D'Acquisto F, Hayden MS, Shim JH, Ghosh S (2005). "PDK1 nucleates T cell receptor-induced signaling complex for NF-kappaB activation". Science. 308 (5718): 114–8. Bibcode:2005Sci...308..114L. doi:10.1126/science.1107107. PMID 15802604. S2CID 84389997.
Shinohara H, Yasuda T, Aiba Y, Sanjo H, Hamadate M, Watarai H, Sakurai H, Kurosaki T (2005). "PKC beta regulates BCR-mediated IKK activation by facilitating the interaction between TAK1 and CARMA1". J. Exp. Med. 202 (10): 1423–31. doi:10.1084/jem.20051591. PMC 2212994. PMID 16301747.
Sommer K, Guo B, Pomerantz JL, Bandaranayake AD, Moreno-García ME, Ovechkina YL, Rawlings DJ (2005). "Phosphorylation of the CARMA1 linker controls NF-kappaB activation". Immunity. 23 (6): 561–74. doi:10.1016/j.immuni.2005.09.014. PMID 16356855.
Matsumoto R, Wang D, Blonska M, Li H, Kobayashi M, Pappu B, Chen Y, Wang D, Lin X (2005). "Phosphorylation of CARMA1 plays a critical role in T Cell receptor-mediated NF-kappaB activation". Immunity. 23 (6): 575–85. doi:10.1016/j.immuni.2005.10.007. PMID 16356856.
Narayan P, Holt B, Tosti R, Kane LP (2006). "CARMA1 is required for Akt-mediated NF-kappaB activation in T cells". Mol. Cell. Biol. 26 (6): 2327–36. doi:10.1128/MCB.26.6.2327-2336.2006. PMC 1430296. PMID 16508008.
Ishiguro K, Avruch J, Landry A, Qin S, Ando T, Goto H, Xavier R (2006). "Nore1B regulates TCR signaling via Ras and Carma1". Cell. Signal. 18 (10): 1647–54. doi:10.1016/j.cellsig.2006.01.015. PMC 3204664. PMID 16520020.
Ishiguro K, Green T, Rapley J, Wachtel H, Giallourakis C, Landry A, Cao Z, Lu N, Takafumi A, Goto H, Daly MJ, Xavier RJ (2006). "Ca2+/calmodulin-dependent protein kinase II is a modulator of CARMA1-mediated NF-kappaB activation". Mol. Cell. Biol. 26 (14): 5497–508. doi:10.1128/MCB.02469-05. PMC 1592706. PMID 16809782.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000198286 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000036526 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11278692-5] Bertin J, Wang L, Guo Y, Jacobson MD, Poyet JL, Srinivasula SM, Merriam S, DiStefano PS, Alnemri ES (Apr 2001). "CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B". J. Biol. Chem. 276 (15): 11877–82. doi:10.1074/jbc.M010512200. PMID 11278692. S2CID 35815019.

[pmid11356195-6] Gaide O, Martinon F, Micheau O, Bonnet D, Thome M, Tschopp J (May 2001). "Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation". FEBS Lett. 496 (2–3): 121–7. doi:10.1016/S0014-5793(01)02414-0. PMID 11356195. S2CID 22024213.

[entrez-7] "Entrez Gene: CARD11 caspase recruitment domain family, member 11".

[Holliday_2019-8] Holliday MJ, Witt A, Rodriguez Gama A, Walters B, Arthur C, Halfman R, Rohou A, Dueber E, Fairbrother W (2019). "Structures of autoinhibited and polymerized forms of CARD9 reveal mechanisms of CARD9 and CARD11 activation". Nat Commun. 10 (3070): 3070. Bibcode:2019NatCo..10.3070H. doi:10.1038/s41467-019-10953-z. PMC 6624267. PMID 31296852.

[autogenerated1-9] Bertin J, Wang L, Guo Y, Jacobson MD, Poyet JL, Srinivasula SM, Merriam S, DiStefano PS, Alnemri ES (April 2001). "CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B". J. Biol. Chem. 276 (15): 11877–82. doi:10.1074/jbc.M010512200. PMID 11278692. S2CID 35815019.

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@@ Line 1: / Line 1: @@
+{{cs1 config|name-list-style=vanc}}
+{{Short description|Protein-coding gene in the species Homo sapiens}}
 {{Infobox_gene}}
-'''Caspase recruitment domain-containing protein 11''' also known as '''CARD-containing MAGUK protein 1''' (Carma 1) is a [[protein]] that in humans is encoded by the ''CARD11'' [[gene]].<ref name="pmid11278692">{{cite journal | vauthors = Bertin J, Wang L, Guo Y, Jacobson MD, Poyet JL, Srinivasula SM, Merriam S, DiStefano PS, Alnemri ES | title = CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B | journal = J. Biol. Chem. | volume = 276 | issue = 15 | pages = 11877–82  | date = Apr 2001 | pmid = 11278692 | pmc =  | doi = 10.1074/jbc.M010512200 }}</ref><ref name="pmid11356195">{{cite journal | vauthors = Gaide O, Martinon F, Micheau O, Bonnet D, Thome M, Tschopp J | title = Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation | journal = FEBS Lett. | volume = 496 | issue = 2-3 | pages = 121–7  | date = May 2001 | pmid = 11356195 | pmc =  | doi = 10.1016/S0014-5793(01)02414-0 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CARD11 caspase recruitment domain family, member 11| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84433| accessdate = }}</ref>
+'''Caspase recruitment domain-containing protein 11''' also known as '''CARD-containing MAGUK protein 1''' (Carma 1) is a [[protein]] in the [[CARD-CC_family|CARD-CC protein family]] that in humans is encoded by the ''CARD11'' [[gene]].<ref name="pmid11278692">{{cite journal | vauthors = Bertin J, Wang L, Guo Y, Jacobson MD, Poyet JL, Srinivasula SM, Merriam S, DiStefano PS, Alnemri ES | title = CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B | journal = J. Biol. Chem. | volume = 276 | issue = 15 | pages = 11877–82  | date = Apr 2001 | pmid = 11278692 | doi = 10.1074/jbc.M010512200 | s2cid = 35815019 | doi-access = free }}</ref><ref name="pmid11356195">{{cite journal | vauthors = Gaide O, Martinon F, Micheau O, Bonnet D, Thome M, Tschopp J | title = Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation | journal = FEBS Lett. | volume = 496 | issue = 2–3 | pages = 121–7  | date = May 2001 | pmid = 11356195 | doi = 10.1016/S0014-5793(01)02414-0 | s2cid = 22024213 | doi-access = free }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CARD11 caspase recruitment domain family, member 11| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84433}}</ref> CARD 11 is a membrane associated protein that is found in various human tissues, including the thymus, spleen, liver, and peripheral blood leukocytes. Similarly, CARD 11 is also found in abundance in various lines of cancer cells.<ref name="pmid11278692">{{cite journal | vauthors = Bertin J, Wang L, Guo Y, Jacobson MD, Poyet JL, Srinivasula SM, Merriam S, DiStefano PS, Alnemri ES | title = CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B | journal = J. Biol. Chem. | volume = 276 | issue = 15 | pages = 11877–82  | date = Apr 2001 | pmid = 11278692 | doi = 10.1074/jbc.M010512200 | s2cid = 35815019 | doi-access = free }}</ref>
 == Function ==
-The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain ([[CARD domain|CARD]]). This protein has a domain structure similar to that of [[CARD14]] protein. The CARD domains of both proteins have been shown to specifically interact with [[BCL10]], a protein known to function as a positive regulator of cell apoptosis and [[NF-κB]] activation. When expressed in cells, this protein activates NF-kappaB and induces the [[phosphorylation]] of BCL10.<ref name="entrez"/>
+The protein encoded by this gene belongs to the [[membrane-associated guanylate kinase]] (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain ([[CARD domain|CARD]]). CARD11 (CARMA1) has a domain structure similar to that of [[CARD10]] (CARMA3) and [[CARD14]] (CARMA2) as a member of the [[CARD-CC family]] with a C terminal MAGUK domain (the so-called CARMA proteins). The CARD domain of proteins in the [[CARD-CC family]] have been shown to specifically interact with [[BCL10]], a protein known to function as a positive regulator of [[NF-κB]] activation by recruitment and activation of [[MALT1]]. When overexpressed in cells, this protein family activates NF-κB and induces the [[phosphorylation]] of BCL10.<ref name="entrez"/>
+CARD11 is critical for [[T cell]] and [[B cell]] function and is activated after [[T cell receptor]] or [[B cell receptor]] stimulation. After receptor stimulation, CARD11 is phosphorylated by [[PKC-θ]] (in T cells) or [[PRKCB1|PKC-β]] (in B cells). The phosphorylation induces formation of filamentous CARD11 multimers that recruit [[BCL10]] and [[MALT1]], which in turn activates [[NF-κB]]. Loss of function mutations in CARD11 cause [[severe combined immunodeficiency]] (SCID) since the function of cells critical for [[adaptive immunity]] are disrupted.
+== Structure ==
+[[File:CARD11.png|thumb|
+This is the predicted structure of CARD11 produced by AlphaFold. The different colored regions reflect the confidence that a particular residue is in that location, with dark blue being the most confident and orange indicating the least confidence.]]
+The structure of CARD11 involves multiple domains that impact the protein's ability to activate [[BCL10]] and [[NF-κB]] activity. CARD11 has a CARD domain, a serine-threonine rich region, is associated with the N-terminus, which is essential for [[NF-κB]] signaling activity. The region following the CARD domain is highly coiled. In deleting the CARD domain, all [[NF-κB]] signaling activity was prevented. The CARD domain on CARD11 interacts with the CARD domain on [[BCL10]] to initiate the signaling pathway.<ref name="pmid11278692">{{cite journal | vauthors = Bertin J, Wang L, Guo Y, Jacobson MD, Poyet JL, Srinivasula SM, Merriam S, DiStefano PS, Alnemri ES | title = CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B | journal = J. Biol. Chem. | volume = 276 | issue = 15 | pages = 11877–82  | date = Apr 2001 | pmid = 11278692 | doi = 10.1074/jbc.M010512200 | s2cid = 35815019 | doi-access = free }}</ref>
+On the C-terminus of CARD11 there is the MAGUK domain that is associated with the cell membrane. This domain is often referred to as the inhibitory domain. [[Protein kinase C]] activates CARD11 by phosphorylating serine residues within the inhibitory domain.<ref name="pmid11278692">{{cite journal | vauthors = Bertin J, Wang L, Guo Y, Jacobson MD, Poyet JL, Srinivasula SM, Merriam S, DiStefano PS, Alnemri ES | title = CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B | journal = J. Biol. Chem. | volume = 276 | issue = 15 | pages = 11877–82  | date = Apr 2001 | pmid = 11278692 | doi = 10.1074/jbc.M010512200 | s2cid = 35815019 | doi-access = free }}</ref><ref name="Holliday_2019">{{cite journal | vauthors = Holliday MJ, Witt A, Rodriguez Gama A, Walters B, Arthur C, Halfman R, Rohou A, Dueber E, Fairbrother W| title = Structures of autoinhibited and polymerized forms of CARD9 reveal mechanisms of CARD9 and CARD11 activation | journal = Nat Commun | volume = 10 | issue = 3070 | year = 2019 | page = 3070 | pmid = 31296852 | pmc = 6624267 | doi = 10.1038/s41467-019-10953-z| bibcode = 2019NatCo..10.3070H }}</ref>
+{{clear|left}}
 == Interactions ==
-CARD11 has been shown to [[Protein-protein interaction|interact]] with [[BCL10]].<ref name=autogenerated1>{{cite journal | vauthors = Bertin J, Wang L, Guo Y, Jacobson MD, Poyet JL, Srinivasula SM, Merriam S, DiStefano PS, Alnemri ES | title = CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B | journal = J. Biol. Chem. | volume = 276 | issue = 15 | pages = 11877–82  | date = April 2001 | pmid = 11278692 | doi = 10.1074/jbc.M010512200 }}</ref>
+CARD11 has been shown to [[Protein-protein interaction|interact]] with [[BCL10]].<ref name=autogenerated1>{{cite journal | vauthors = Bertin J, Wang L, Guo Y, Jacobson MD, Poyet JL, Srinivasula SM, Merriam S, DiStefano PS, Alnemri ES | title = CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B | journal = J. Biol. Chem. | volume = 276 | issue = 15 | pages = 11877–82  | date = April 2001 | pmid = 11278692 | doi = 10.1074/jbc.M010512200 | s2cid = 35815019 | doi-access = free }}</ref> This interaction occurs between the CARD domain on [[BCL10]] and the CARD domain on CARD11, and results in signal propagation and NF-κB activation.<ref name="Holliday_2019" />
 == References ==
 {{reflist}}
+==External links==
+* {{UCSC gene info|CARD11}}
 == Further reading ==
 {{refbegin | 2}}
-* {{cite journal | vauthors = Hillier LD, Lennon G, Becker M, Bonaldo MF, Chiapelli B, Chissoe S, Dietrich N, DuBuque T, Favello A, Gish W, Hawkins M, Hultman M, Kucaba T, Lacy M, Le M, Le N, Mardis E, Moore B, Morris M, Parsons J, Prange C, Rifkin L, Rohlfing T, Schellenberg K, Bento Soares M, Tan F, Thierry-Meg J, Trevaskis E, Underwood K, Wohldman P, Waterston R, Wilson R, Marra M | title = Generation and analysis of 280,000 human expressed sequence tags | journal = Genome Res. | volume = 6 | issue = 9 | pages = 807–28 | year = 1996 | pmid = 8889549 | doi = 10.1101/gr.6.9.807 }}
+* {{cite journal | vauthors = Hillier LD, Lennon G, Becker M, Bonaldo MF, Chiapelli B, Chissoe S, Dietrich N, DuBuque T, Favello A, Gish W, Hawkins M, Hultman M, Kucaba T, Lacy M, Le M, Le N, Mardis E, Moore B, Morris M, Parsons J, Prange C, Rifkin L, Rohlfing T, Schellenberg K, Bento Soares M, Tan F, Thierry-Meg J, Trevaskis E, Underwood K, Wohldman P, Waterston R, Wilson R, Marra M | title = Generation and analysis of 280,000 human expressed sequence tags | journal = Genome Res. | volume = 6 | issue = 9 | pages = 807–28 | year = 1996 | pmid = 8889549 | doi = 10.1101/gr.6.9.807 | doi-access = free }}
-* {{cite journal | vauthors =  | title = Toward a complete human genome sequence | journal = Genome Res. | volume = 8 | issue = 11 | pages = 1097–108 | year = 1998 | pmid = 9847074 | doi = 10.1101/gr.8.11.1097 }}
+* {{cite journal | title = Toward a complete human genome sequence | journal = Genome Res. | volume = 8 | issue = 11 | pages = 1097–108 | year = 1998 | pmid = 9847074 | doi = 10.1101/gr.8.11.1097 | doi-access = free | last1 = Sanger Centre | first1 = The | last2 = Washington University Genome Sequencing Cente | first2 = The }}
-* {{cite journal | vauthors = Wang L, Guo Y, Huang WJ, Ke X, Poyet JL, Manji GA, Merriam S, Glucksmann MA, DiStefano PS, Alnemri ES, Bertin J | title = Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B | journal = J. Biol. Chem. | volume = 276 | issue = 24 | pages = 21405–9 | year = 2001 | pmid = 11259443 | doi = 10.1074/jbc.M102488200 }}
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-* {{cite journal | vauthors = Stilo R, Liguoro D, Di Jeso B, Formisano S, Consiglio E, Leonardi A, Vito P | title = Physical and functional interaction of CARMA1 and CARMA3 with Ikappa kinase gamma-NFkappaB essential modulator | journal = J. Biol. Chem. | volume = 279 | issue = 33 | pages = 34323–31 | year = 2004 | pmid = 15184390 | doi = 10.1074/jbc.M402244200 }}
+* {{cite journal | vauthors = Stilo R, Liguoro D, Di Jeso B, Formisano S, Consiglio E, Leonardi A, Vito P | title = Physical and functional interaction of CARMA1 and CARMA3 with Ikappa kinase gamma-NFkappaB essential modulator | journal = J. Biol. Chem. | volume = 279 | issue = 33 | pages = 34323–31 | year = 2004 | pmid = 15184390 | doi = 10.1074/jbc.M402244200 | doi-access = free }}
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+* {{cite journal | vauthors = Lee KY, D'Acquisto F, Hayden MS, Shim JH, Ghosh S | title = PDK1 nucleates T cell receptor-induced signaling complex for NF-kappaB activation | journal = Science | volume = 308 | issue = 5718 | pages = 114–8 | year = 2005 | pmid = 15802604 | doi = 10.1126/science.1107107 | bibcode = 2005Sci...308..114L | s2cid = 84389997 }}
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-* {{cite journal | vauthors = Sommer K, Guo B, Pomerantz JL, Bandaranayake AD, Moreno-García ME, Ovechkina YL, Rawlings DJ | title = Phosphorylation of the CARMA1 linker controls NF-kappaB activation | journal = Immunity | volume = 23 | issue = 6 | pages = 561–74 | year = 2005 | pmid = 16356855 | doi = 10.1016/j.immuni.2005.09.014 }}
+* {{cite journal | vauthors = Sommer K, Guo B, Pomerantz JL, Bandaranayake AD, Moreno-García ME, Ovechkina YL, Rawlings DJ | title = Phosphorylation of the CARMA1 linker controls NF-kappaB activation | journal = Immunity | volume = 23 | issue = 6 | pages = 561–74 | year = 2005 | pmid = 16356855 | doi = 10.1016/j.immuni.2005.09.014 | doi-access = free }}
-* {{cite journal | vauthors = Matsumoto R, Wang D, Blonska M, Li H, Kobayashi M, Pappu B, Chen Y, Wang D, Lin X | title = Phosphorylation of CARMA1 plays a critical role in T Cell receptor-mediated NF-kappaB activation | journal = Immunity | volume = 23 | issue = 6 | pages = 575–85 | year = 2005 | pmid = 16356856 | doi = 10.1016/j.immuni.2005.10.007 }}
+* {{cite journal | vauthors = Matsumoto R, Wang D, Blonska M, Li H, Kobayashi M, Pappu B, Chen Y, Wang D, Lin X | title = Phosphorylation of CARMA1 plays a critical role in T Cell receptor-mediated NF-kappaB activation | journal = Immunity | volume = 23 | issue = 6 | pages = 575–85 | year = 2005 | pmid = 16356856 | doi = 10.1016/j.immuni.2005.10.007 | doi-access = free }}
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 {{refend}}
 [[Category:Proteins]]