DCLK1: Difference between revisions

DCLK1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1MFW, 1MG4, 1UF0
Identifiers
Aliases	DCLK1, CL1, CLICK1, DCAMKL1, DCDC3A, DCLK, doublecortin like kinase 1
External IDs	OMIM: 604742; MGI: 1330861; HomoloGene: 130530; GeneCards: DCLK1; OMA:DCLK1 - orthologs
Gene location (Human)
Chr.	Chromosome 13 (human)
End	36,131,382 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	55,446,489 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; frontal pole; ; Brodmann area 10; ; Brodmann area 23; ; pars reticulata; ; pars compacta; ; occipital lobe; ; middle temporal gyrus; ; superior vestibular nucleus; ; primary visual cortex;
	Top expressed in
	stria vascularis; ; Rostral migratory stream; ; piriform cortex; ; vestibular sensory epithelium; ; habenula; ; visual cortex; ; superior frontal gyrus; ; primary visual cortex; ; primary motor cortex; ; prefrontal cortex;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein kinase activity; nucleotide binding; kinase activity; ATP binding; protein serine/threonine kinase activity;
Cellular component	integral component of plasma membrane; intracellular anatomical structure; postsynaptic density;
Biological process	cell differentiation; axonogenesis; dendrite morphogenesis; phosphorylation; response to virus; neuron migration; nervous system development; multicellular organism development; endosomal transport; protein phosphorylation; central nervous system development; brain development; axon extension; forebrain development; central nervous system projection neuron axonogenesis; negative regulation of protein localization to nucleus; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; intracellular signal transduction; neuron projection morphogenesis;
	Sources:Amigo / QuickGO
Orthologs
	9201
	13175
	ENSG00000133083
	ENSMUSG00000027797
	O15075
	Q9JLM8
NM_001195415; NM_001195416; NM_001195430; NM_004734; NM_001330071;
	NM_001330072
NM_001111051; NM_001111052; NM_001111053; NM_001195538; NM_001195539;
	NM_001195540; NM_019978; NM_001357466; NM_001357468; NM_001357469; NM_001357475; NM_001357476
NP_001182344; NP_001182345; NP_001182359; NP_001317000; NP_001317001;
	NP_004725
NP_001104521; NP_001104522; NP_001104523; NP_001182467; NP_001182468;
	NP_001182469; NP_064362; NP_001344395; NP_001344397; NP_001344398; NP_001344404; NP_001344405
	Wikidata
View/Edit Human	View/Edit Mouse

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Latest revision as of 22:48, 30 May 2024

Doublecortin-like kinase protein 1 (DCLK1)^[5]^[6]^[7]^[8] is an enzyme that in humans is encoded by the DCLK1 gene.^[5]^[6]^[8] Its C-terminal domain in rats is expressed independently from an alternative transcript, cpg16, and can function alone as a serine/threonine protein kinase that is cyclic AMP dependent.^[9]^[10]

DCLK1 expression is a marker for tuft cells, a type of chemosensory cell of the intestinal epithelium.^[7]^[11]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000133083 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027797 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Omori Y, Suzuki M, Ozaki K, Harada Y, Nakamura Y, Takahashi E, Fujiwara T (Oct 1998). "Expression and chromosomal localization of KIAA0369, a putative kinase structurally related to Doublecortin". J Hum Genet. 43 (3): 169–77. doi:10.1007/s100380050063. PMID 9747029.
^ ^a ^b Sossey-Alaoui K, Srivastava AK (May 1999). "DCAMKL1, a brain-specific transmembrane protein on 13q12.3 that is similar to doublecortin (DCX)". Genomics. 56 (1): 121–6. doi:10.1006/geno.1998.5718. PMID 10036192.
^ ^a ^b Ding L, Weygant N, Ding C, Lai Y, Li H (2023). "DCLK1 and tuft cells: Immune-related functions and implications for cancer immunotherapy". Critical Reviews in Oncology and Hematology. 191. doi:10.1016/j.critrevonc.2023.104118. PMID 37660932. Art. No. 104118.
^ ^a ^b "Entrez Gene: DCAMKL1 doublecortin and CaM kinase-like 1". Gene. National Library of Medicine. 7 April 2024. Retrieved 30 May 2024.
^ Silverman MA, Benard O, Jaaro H, Rattner A, Citri Y, Seger R (1999). "CPG16, a novel protein serine/threonine kinase downstream of cAMP-dependent protein kinase". Journal of Biological Chemistry. 274 (5): 2631–2636. doi:10.1074/jbc.274.5.2631. PMID 9915791.
^ Lin PT, Gleeson JG, Corbo JC, et al. (2001). "DCAMKL1 encodes a protein kinase with homology to doublecortin that regulates microtubule polymerization". J. Neurosci. 20 (24): 9152–61. doi:10.1523/JNEUROSCI.20-24-09152.2000. PMC 6773030. PMID 11124993.
^ Gerbe F, Legraverend C, Jay P (2012). "The intestinal epithelium tuft cells: specification and function". Cellular and Molecular Life Sciences. 69 (17): 2907–2917. doi:10.1007/s00018-012-0984-7. PMC 3417095. PMID 22527717.

External links

Overview of all the structural information available in the PDB for UniProt: O15075 (Serine/threonine-protein kinase DCLK1) at the PDBe-KB.

This article on a gene on human chromosome 13 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000133083 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027797 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9747029-5] Omori Y, Suzuki M, Ozaki K, Harada Y, Nakamura Y, Takahashi E, Fujiwara T (Oct 1998). "Expression and chromosomal localization of KIAA0369, a putative kinase structurally related to Doublecortin". J Hum Genet. 43 (3): 169–77. doi:10.1007/s100380050063. PMID 9747029.

[pmid10036192-6] Sossey-Alaoui K, Srivastava AK (May 1999). "DCAMKL1, a brain-specific transmembrane protein on 13q12.3 that is similar to doublecortin (DCX)". Genomics. 56 (1): 121–6. doi:10.1006/geno.1998.5718. PMID 10036192.

[ding2023-7] Ding L, Weygant N, Ding C, Lai Y, Li H (2023). "DCLK1 and tuft cells: Immune-related functions and implications for cancer immunotherapy". Critical Reviews in Oncology and Hematology. 191. doi:10.1016/j.critrevonc.2023.104118. PMID 37660932. Art. No. 104118.

[entrez-8] "Entrez Gene: DCAMKL1 doublecortin and CaM kinase-like 1". Gene. National Library of Medicine. 7 April 2024. Retrieved 30 May 2024.

[9] Silverman MA, Benard O, Jaaro H, Rattner A, Citri Y, Seger R (1999). "CPG16, a novel protein serine/threonine kinase downstream of cAMP-dependent protein kinase". Journal of Biological Chemistry. 274 (5): 2631–2636. doi:10.1074/jbc.274.5.2631. PMID 9915791.

[10] Lin PT, Gleeson JG, Corbo JC, et al. (2001). "DCAMKL1 encodes a protein kinase with homology to doublecortin that regulates microtubule polymerization". J. Neurosci. 20 (24): 9152–61. doi:10.1523/JNEUROSCI.20-24-09152.2000. PMC 6773030. PMID 11124993.

[11] Gerbe F, Legraverend C, Jay P (2012). "The intestinal epithelium tuft cells: specification and function". Cellular and Molecular Life Sciences. 69 (17): 2907–2917. doi:10.1007/s00018-012-0984-7. PMC 3417095. PMID 22527717.

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@@ Line 1: / Line 1: @@
+{{Short description|Protein-coding gene in the species Homo sapiens}}
-{{Underlinked|date=May 2016}}
+{{cs1 config|name-list-style=vanc}}
 {{Infobox_gene}}
-'''Serine/threonine-protein kinase DCLK1''' is an [[enzyme]] that in humans is encoded by the ''DCLK1'' [[gene]].<ref name="pmid9747029">{{cite journal | vauthors = Omori Y, Suzuki M, Ozaki K, Harada Y, Nakamura Y, Takahashi E, Fujiwara T | title = Expression and chromosomal localization of KIAA0369, a putative kinase structurally related to Doublecortin | journal = J Hum Genet | volume = 43 | issue = 3 | pages = 169–77 |date=Oct 1998 | pmid = 9747029 | pmc =  | doi = 10.1007/s100380050063 }}</ref><ref name="pmid10036192">{{cite journal | vauthors = Sossey-Alaoui K, Srivastava AK | title = DCAMKL1, a brain-specific transmembrane protein on 13q12.3 that is similar to doublecortin (DCX) | journal = Genomics | volume = 56 | issue = 1 | pages = 121–6 |date=May 1999 | pmid = 10036192 | pmc =  | doi = 10.1006/geno.1998.5718 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: DCAMKL1 doublecortin and CaM kinase-like 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9201| accessdate = }}</ref>
+'''Doublecortin-like kinase protein 1''' ('''DCLK1''')<ref name="pmid9747029">{{cite journal | vauthors = Omori Y, Suzuki M, Ozaki K, Harada Y, Nakamura Y, Takahashi E, Fujiwara T | title = Expression and chromosomal localization of KIAA0369, a putative kinase structurally related to Doublecortin | journal = J Hum Genet | volume = 43 | issue = 3 | pages = 169–77 |date=Oct 1998 | pmid = 9747029 | doi = 10.1007/s100380050063 | doi-access = free }}</ref><ref name="pmid10036192">{{cite journal | vauthors = Sossey-Alaoui K, Srivastava AK | title = DCAMKL1, a brain-specific transmembrane protein on 13q12.3 that is similar to doublecortin (DCX) | journal = Genomics | volume = 56 | issue = 1 | pages = 121–6 |date=May 1999 | pmid = 10036192 | doi = 10.1006/geno.1998.5718 }}</ref><ref name=ding2023>{{cite journal|vauthors=Ding L, Weygant N, Ding C, Lai Y, Li H|title=DCLK1 and tuft cells: Immune-related functions and implications for cancer immunotherapy|journal=Critical Reviews in Oncology and Hematology|volume=191|id=Art. No. 104118|year=2023|doi=10.1016/j.critrevonc.2023.104118|pmid=37660932}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: DCAMKL1 doublecortin and CaM kinase-like 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9201|access-date=30 May 2024|date=7 April 2024|website=Gene|publisher=National Library of Medicine}}</ref> is an [[enzyme]] that in humans is encoded by the ''DCLK1'' [[gene]].<ref name="pmid9747029"/><ref name="pmid10036192"/><ref name="entrez"/>  Its C-terminal domain in rats is expressed independently from an alternative transcript, ''cpg16'', and can function alone as a [[serine/threonine protein kinase]] that is [[cyclic AMP]] dependent.<ref>{{cite journal|vauthors=Silverman MA, Benard O, Jaaro H, Rattner A, Citri Y, Seger R|title=CPG16, a novel protein serine/threonine kinase downstream of cAMP-dependent protein kinase|journal=Journal of Biological Chemistry|year=1999|volume=274|issue=5|pages=2631-2636|doi-access=free|pmid=9915791|doi=10.1074/jbc.274.5.2631}}</ref><ref>{{cite journal  | vauthors=Lin PT, Gleeson JG, Corbo JC |title=DCAMKL1 encodes a protein kinase with homology to doublecortin that regulates microtubule polymerization. |journal=J. Neurosci. |volume=20 |issue= 24 |pages= 9152–61 |year= 2001 |pmid= 11124993 |doi=  10.1523/JNEUROSCI.20-24-09152.2000|pmc=6773030 |display-authors=etal|doi-access=free }}</ref>
+DCLK1 expression is a marker for [[tuft cells]], a type of chemosensory cell of the intestinal epithelium.<ref name=ding2023/><ref>{{cite journal|vauthors=Gerbe F, Legraverend C, Jay P|title=The intestinal epithelium tuft cells: specification and function|journal=Cellular and Molecular Life Sciences|volume=69|pages=2907-2917|year=2012|issue=17|pmid=22527717|pmc=3417095|doi=10.1007/s00018-012-0984-7|doi-access=free}}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
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-}}
 ==References==
@@ Line 14: / Line 11: @@
 ==Further reading==
 {{refbegin | 2}}
+*{{cite journal  | vauthors=Nagase T, Ishikawa K, Nakajima D |title=Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. |journal=DNA Res. |volume=4 |issue= 2 |pages= 141–50 |year= 1997 |pmid= 9205841 |doi=10.1093/dnares/4.2.141  |display-authors=etal|doi-access=free }}
-{{PBB_Further_reading
-| citations =
-*{{cite journal  | vauthors=Nagase T, Ishikawa K, Nakajima D |title=Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. |journal=DNA Res. |volume=4 |issue= 2 |pages= 141–50 |year= 1997 |pmid= 9205841 |doi=10.1093/dnares/4.2.141  |display-authors=etal}}
 *{{cite journal  | vauthors=Matsumoto N, Pilz DT, Ledbetter DH |title=Genomic structure, chromosomal mapping, and expression pattern of human DCAMKL1 (KIAA0369), a homologue of DCX (XLIS). |journal=Genomics |volume=56 |issue= 2 |pages= 179–83 |year= 1999 |pmid= 10051403 |doi= 10.1006/geno.1998.5673 }}
-*{{cite journal  | vauthors=Lin PT, Gleeson JG, Corbo JC |title=DCAMKL1 encodes a protein kinase with homology to doublecortin that regulates microtubule polymerization. |journal=J. Neurosci. |volume=20 |issue= 24 |pages= 9152–61 |year= 2001 |pmid= 11124993 |doi=  |display-authors=etal}}
+*{{cite journal  | vauthors=Burgess HA, Reiner O |title=Alternative splice variants of doublecortin-like kinase are differentially expressed and have different kinase activities. |journal=J. Biol. Chem. |volume=277 |issue= 20 |pages= 17696–705 |year= 2002 |pmid= 11884394 |doi= 10.1074/jbc.M111981200 |doi-access= free }}
-*{{cite journal  | vauthors=Burgess HA, Reiner O |title=Alternative splice variants of doublecortin-like kinase are differentially expressed and have different kinase activities. |journal=J. Biol. Chem. |volume=277 |issue= 20 |pages= 17696–705 |year= 2002 |pmid= 11884394 |doi= 10.1074/jbc.M111981200 }}
+*{{cite journal  | vauthors=Kim MH, Derewenda U, Devedjiev Y |title=Purification and crystallization of the N-terminal domain from the human doublecortin-like kinase. |journal=Acta Crystallogr. D |volume=59 |issue= Pt 3 |pages= 502–5 |year= 2003 |pmid= 12595708 |doi=10.1107/S0907444903000027  |bibcode=2003AcCrD..59..502K |display-authors=etal}}
-*{{cite journal  | vauthors=Kim MH, Derewenda U, Devedjiev Y |title=Purification and crystallization of the N-terminal domain from the human doublecortin-like kinase. |journal=Acta Crystallogr. D Biol. Crystallogr. |volume=59 |issue= Pt 3 |pages= 502–5 |year= 2003 |pmid= 12595708 |doi=10.1107/S0907444903000027  |display-authors=etal}}
+*{{cite journal  | vauthors=Kim MH, Cierpicki T, Derewenda U |title=The DCX-domain tandems of doublecortin and doublecortin-like kinase. |journal=Nat. Struct. Biol. |volume=10 |issue= 5 |pages= 324–33 |year= 2003 |pmid= 12692530 |doi= 10.1038/nsb918 |s2cid=10173864 |display-authors=etal}}
-*{{cite journal  | vauthors=Kim MH, Cierpicki T, Derewenda U |title=The DCX-domain tandems of doublecortin and doublecortin-like kinase. |journal=Nat. Struct. Biol. |volume=10 |issue= 5 |pages= 324–33 |year= 2003 |pmid= 12692530 |doi= 10.1038/nsb918 |display-authors=etal}}
+*{{cite journal  | vauthors=Seet LF, Liu N, Hanson BJ, Hong W |title=Endofin recruits TOM1 to endosomes. |journal=J. Biol. Chem. |volume=279 |issue= 6 |pages= 4670–9 |year= 2004 |pmid= 14613930 |doi= 10.1074/jbc.M311228200 |doi-access= free }}
-*{{cite journal  | vauthors=Seet LF, Liu N, Hanson BJ, Hong W |title=Endofin recruits TOM1 to endosomes. |journal=J. Biol. Chem. |volume=279 |issue= 6 |pages= 4670–9 |year= 2004 |pmid= 14613930 |doi= 10.1074/jbc.M311228200 }}
+*{{cite journal  | vauthors=Ballif BA, Villén J, Beausoleil SA |title=Phosphoproteomic analysis of the developing mouse brain. |journal=Mol. Cell. Proteomics |volume=3 |issue= 11 |pages= 1093–101 |year= 2005 |pmid= 15345747 |doi= 10.1074/mcp.M400085-MCP200 |display-authors=etal|doi-access=free }}
-*{{cite journal  | vauthors=Ballif BA, Villén J, Beausoleil SA |title=Phosphoproteomic analysis of the developing mouse brain. |journal=Mol. Cell Proteomics |volume=3 |issue= 11 |pages= 1093–101 |year= 2005 |pmid= 15345747 |doi= 10.1074/mcp.M400085-MCP200 |display-authors=etal}}
-}}
 {{refend}}
+== External links ==
+* {{PDBe-KB2|O15075|Serine/threonine-protein kinase DCLK1}}
 {{PDB Gallery|geneid=9201}}
 {{Serine/threonine-specific protein kinases}}
 {{Enzymes}}
-{{Portal bar|Molecular and Cellular Biology|border=no}}
+{{Portal bar|Biology|border=no}}
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 [[Category:EC 2.7.11]]

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)