Gamma-glutamyl hydrolase: Difference between revisions
Content deleted Content added
m →Further reading: removed stray bracket |
m Journal cites, added 2 DOIs using AWB (9513) |
||
| Line 11: | Line 11: | ||
{{PBB|geneid=8836}} |
{{PBB|geneid=8836}} |
||
'''Gamma-glutamyl hydrolase''' is an [[enzyme]]<ref name="pmid8343522">{{cite journal | author = Wang Y, Nimec Z, Ryan TJ, Dias JA, Galivan J | title = The properties of the secreted gamma-glutamyl hydrolases from H35 hepatoma cells | journal = Biochim. Biophys. Acta | volume = 1164 | issue = 3 | pages = 227–35 | year = 1993 | month = August | pmid = 8343522 | doi = }}</ref><ref name="pmid7565632">{{cite journal | author = Yao R, Rhee MS, Galivan J | title = Effects of gamma-glutamyl hydrolase on folyl and antifolylpolyglutamates in cultured H35 hepatoma cells | journal = Mol. Pharmacol. | volume = 48 | issue = 3 | pages = 505–11 | year = 1995 | month = September | pmid = 7565632 | doi = }}</ref><ref name="pmid8816764">{{cite journal | author = Yao R, Schneider E, Ryan TJ, Galivan J | title = Human gamma-glutamyl hydrolase: cloning and characterization of the enzyme expressed in vitro | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 93 | issue = 19 | pages = 10134–8 | year = 1996 | month = September | pmid = 8816764 | pmc = 38349 | doi = }}</ref><ref name="pmid8621474">{{cite journal | author = Yao R, Nimec Z, Ryan TJ, Galivan J | title = Identification, cloning, and sequencing of a cDNA coding for rat gamma-glutamyl hydrolase | journal = J. Biol. Chem. | volume = 271 | issue = 15 | pages = 8525–8 | year = 1996 | month = April | pmid = 8621474 | doi = }}</ref> that [[catalysis|catalyses]] the following [[chemical reaction]]: |
'''Gamma-glutamyl hydrolase''' is an [[enzyme]]<ref name="pmid8343522">{{cite journal | author = Wang Y, Nimec Z, Ryan TJ, Dias JA, Galivan J | title = The properties of the secreted gamma-glutamyl hydrolases from H35 hepatoma cells | journal = Biochim. Biophys. Acta | volume = 1164 | issue = 3 | pages = 227–35 | year = 1993 | month = August | pmid = 8343522 | doi = }}</ref><ref name="pmid7565632">{{cite journal | author = Yao R, Rhee MS, Galivan J | title = Effects of gamma-glutamyl hydrolase on folyl and antifolylpolyglutamates in cultured H35 hepatoma cells | journal = Mol. Pharmacol. | volume = 48 | issue = 3 | pages = 505–11 | year = 1995 | month = September | pmid = 7565632 | doi = }}</ref><ref name="pmid8816764">{{cite journal | author = Yao R, Schneider E, Ryan TJ, Galivan J | title = Human gamma-glutamyl hydrolase: cloning and characterization of the enzyme expressed in vitro | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 93 | issue = 19 | pages = 10134–8 | year = 1996 | month = September | pmid = 8816764 | pmc = 38349 | doi = 10.1073/pnas.93.19.10134}}</ref><ref name="pmid8621474">{{cite journal | author = Yao R, Nimec Z, Ryan TJ, Galivan J | title = Identification, cloning, and sequencing of a cDNA coding for rat gamma-glutamyl hydrolase | journal = J. Biol. Chem. | volume = 271 | issue = 15 | pages = 8525–8 | year = 1996 | month = April | pmid = 8621474 | doi = 10.1074/jbc.271.15.8525}}</ref> that [[catalysis|catalyses]] the following [[chemical reaction]]: |
||
: [[Hydrolysis]] of a gamma-glutamyl bond |
: [[Hydrolysis]] of a gamma-glutamyl bond |
||
Revision as of 15:17, 10 October 2013
| Gamma-glutamyl hydrolase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.4.19.9 | ||||||||
| CAS no. | 9074-87-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Gamma-glutamyl hydrolase is an enzyme[1][2][3][4] that catalyses the following chemical reaction:
- Hydrolysis of a gamma-glutamyl bond
This lysosomal or secreted, thiol-dependent peptidase, most active at acidic pH.
In humans, gamma-glutamyl hydrolase is encoded by the GGH gene.[3][5][6] This gene catalyzes the hydrolysis of folylpoly-gamma-glutamates and antifolylpoly-gamma-glutamates by the removal of gamma-linked polyglutamates and glutamate.[6]
Nomenclature
Gamma-glutamyl hydrolase is also known as conjugase, folate conjugase, lysosomal gamma-glutamyl carboxypeptidase, gamma-Glu-X carboxypeptidase, pteroyl-poly-gamma-glutamate hydrolase, carboxypeptidase G, folic acid conjugase, poly(gamma-glutamic acid) endohydrolase, polyglutamate hydrolase, poly(glutamic acid) hydrolase II, pteroylpoly-gamma-glutamyl hydrolase.
Interactive pathway map
Click on genes, proteins and metabolites below to link to respective articles.[§ 1]
Fluorouracil (5-FU) Activity edit
- ^ The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601".
References
- ^ Wang Y, Nimec Z, Ryan TJ, Dias JA, Galivan J (1993). "The properties of the secreted gamma-glutamyl hydrolases from H35 hepatoma cells". Biochim. Biophys. Acta. 1164 (3): 227–35. PMID 8343522.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ Yao R, Rhee MS, Galivan J (1995). "Effects of gamma-glutamyl hydrolase on folyl and antifolylpolyglutamates in cultured H35 hepatoma cells". Mol. Pharmacol. 48 (3): 505–11. PMID 7565632.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ a b Yao R, Schneider E, Ryan TJ, Galivan J (1996). "Human gamma-glutamyl hydrolase: cloning and characterization of the enzyme expressed in vitro". Proc. Natl. Acad. Sci. U.S.A. 93 (19): 10134–8. doi:10.1073/pnas.93.19.10134. PMC 38349. PMID 8816764.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) Cite error: The named reference "pmid8816764" was defined multiple times with different content (see the help page). - ^ Yao R, Nimec Z, Ryan TJ, Galivan J (1996). "Identification, cloning, and sequencing of a cDNA coding for rat gamma-glutamyl hydrolase". J. Biol. Chem. 271 (15): 8525–8. doi:10.1074/jbc.271.15.8525. PMID 8621474.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link) - ^ Yin D, Chave KJ, Macaluso CR, Galivan J, Yao R (1999). "Structural organization of the human gamma-glutamyl hydrolase gene". Gene. 238 (2): 463–70. doi:10.1016/S0378-1119(99)00362-5. PMID 10570974.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ a b "Entrez Gene: GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)".
Further reading
- Galivan J, Ryan T, Rhee M; et al. (1999). "Glutamyl hydrolase: properties and pharmacologic impact". Semin. Oncol. 26 (2 Suppl 6): 33–7. PMID 10598552.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - O'Connor BM, Rotundo RF, Nimec Z; et al. (1991). "Secretion of gamma-glutamyl hydrolase in vitro". Cancer Res. 51 (15): 3874–81. PMID 1713122.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Chandler CJ, Wang TT, Halsted CH (1986). "Pteroylpolyglutamate hydrolase from human jejunal brush borders. Purification and characterization". J. Biol. Chem. 261 (2): 928–33. PMID 2867095.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - Wang TT, Chandler CJ, Halsted CH (1986). "Intracellular pteroylpolyglutamate hydrolase from human jejunal mucosa. Isolation and characterization". J. Biol. Chem. 261 (29): 13551–5. PMID 3759978.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - Yao R, Nimec Z, Ryan TJ, Galivan J (1996). "Identification, cloning, and sequencing of a cDNA coding for rat gamma-glutamyl hydrolase". J. Biol. Chem. 271 (15): 8525–8. doi:10.1074/jbc.271.15.8525. PMID 8621474.
{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link) - Rhee MS, Lindau-Shepard B, Chave KJ; et al. (1998). "Characterization of human cellular gamma-glutamyl hydrolase". Mol. Pharmacol. 53 (6): 1040–6. PMID 9614206.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Li H, Ryan TJ, Chave KJ, Van Roey P (2002). "Three-dimensional structure of human gamma -glutamyl hydrolase. A class I glatamine amidotransferase adapted for a complex substate". J. Biol. Chem. 277 (27): 24522–9. doi:10.1074/jbc.M202020200. PMID 11953431.
{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link) - Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Basrur V, Yang F, Kushimoto T; et al. (2003). "Proteomic analysis of early melanosomes: identification of novel melanosomal proteins". J. Proteome Res. 2 (1): 69–79. doi:10.1021/pr025562r. PMID 12643545.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - He P, Varticovski L, Bowman ED; et al. (2004). "Identification of carboxypeptidase E and gamma-glutamyl hydrolase as biomarkers for pulmonary neuroendocrine tumors by cDNA microarray". Hum. Pathol. 35 (10): 1196–209. doi:10.1016/j.humpath.2004.06.014. PMID 15492986.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Eisele LE, Chave KJ, Lehning AC, Ryan TJ (2006). "Characterization of Human gamma-glutamyl hydrolase in solution demonstrates that the enzyme is a non-dissociating homodimer". Biochim. Biophys. Acta. 1764 (9): 1479–86. doi:10.1016/j.bbapap.2006.06.008. PMID 16945597.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - Chi A, Valencia JC, Hu ZZ; et al. (2007). "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes". J. Proteome Res. 5 (11): 3135–44. doi:10.1021/pr060363j. PMID 17081065.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Hayashi H, Fujimaki C, Inoue K; et al. (2007). "Genetic polymorphism of C452T (T127I) in human gamma-glutamyl hydrolase in a Japanese population". Biol. Pharm. Bull. 30 (4): 839–41. doi:10.1248/bpb.30.839. PMID 17409534.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link)
External links
- Gamma-glutamyl+hydrolase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
PDB gallery | |
|---|---|
|
