L-AP4: Difference between revisions
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| verifiedrevid = |
| verifiedrevid = 438864433 |
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| IUPAC_name = (2S)-2-amino-4-phosphonobutanoic acid |
| IUPAC_name = (2S)-2-amino-4-phosphonobutanoic acid |
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| image = L-AP4_structure.png |
| image = L-AP4_structure.png |
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| PubChem = 179394 |
| PubChem = 179394 |
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| IUPHAR_ligand = 1412 |
| IUPHAR_ligand = 1412 |
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Revision as of 22:51, 18 September 2011
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| Identifiers | |
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| CAS Number | |
| PubChem CID | |
| IUPHAR/BPS | |
| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.164.384 |
| Chemical and physical data | |
| Formula | C4H10NO5P |
| Molar mass | 183.099 g/mol g·mol−1 |
| 3D model (JSmol) | |
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| (verify) | |
L-AP4 is a drug used in scientific research, which acts as a group-selective agonist for the group III metabotropic glutamate receptors (mGluR4/6/7/8). It was the first ligand found to act as an agonist selective for this group of mGlu receptors,[1] but does not show selectivity between the different mGluR Group III subtypes. It is widely used in the study of this receptor family and their various functions.[2][3][4][5]
References
- ^ Thomsen, C (1997). "The L-AP4 receptor". General pharmacology. 29 (2): 151–8. PMID 9251893.
{{cite journal}}: Cite has empty unknown parameter:|author-name-separator=(help); Unknown parameter|author-separator=ignored (help) - ^ Lopez, S; Turle-Lorenzo, N; Acher, F; De Leonibus, E; Mele, A; Amalric, M (2007). "Targeting group III metabotropic glutamate receptors produces complex behavioral effects in rodent models of Parkinson's disease". Journal of Neuroscience. 27 (25): 6701–11. doi:10.1523/JNEUROSCI.0299-07.2007. PMID 17581957.
{{cite journal}}: Cite has empty unknown parameter:|author-name-separator=(help); Unknown parameter|author-separator=ignored (help) - ^ MacInnes, N; Duty, S (2008). "Group III metabotropic glutamate receptors act as hetero-receptors modulating evoked GABA release in the globus pallidus in vivo". European journal of pharmacology. 580 (1–2): 95–9. doi:10.1016/j.ejphar.2007.10.030. PMID 18035348.
{{cite journal}}: Cite has empty unknown parameter:|author-name-separator=(help); Unknown parameter|author-separator=ignored (help) - ^ Zhang, HM; Chen, SR; Pan, HL (2009). "Effects of activation of group III metabotropic glutamate receptors on spinal synaptic transmission in a rat model of neuropathic pain". Neuroscience. 158 (2): 875–84. doi:10.1016/j.neuroscience.2008.10.042. PMC 2649787. PMID 19017536.
{{cite journal}}: Cite has empty unknown parameter:|author-name-separator=(help); Unknown parameter|author-separator=ignored (help) - ^ MacIejak, P; Szyndler, J; Turzyńska, D; Sobolewska, A; Taracha, E; Skórzewska, A; Lehner, M; Bidziński, A; Hamed, A (2009). "The effects of group III mGluR ligands on pentylenetetrazol-induced kindling of seizures and hippocampal amino acids concentration". Brain research. 1282: 20–7. doi:10.1016/j.brainres.2009.05.049. PMID 19481536.
{{cite journal}}: Cite has empty unknown parameter:|author-name-separator=(help); Unknown parameter|author-separator=ignored (help)
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