Megakaryocyte–erythroid progenitor cell: Difference between revisions

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Megakaryocyte–erythroid progenitor cells (MEPs), among other blood cells, are generated as a result of hematopoiesis, which occurs in the bone marrow. Hematopoietic stem cells (HSC) can differentiate into one of two progenitor cells: the common lymphoid progenitor and the common myeloid progenitor. MEPs derive from the common myeloid progenitor lineage.^[1] Megakaryocyte–erythroid progenitor cells must commit to becoming either platelet-producing megakaryocytes via megakaryopoiesis or erythrocyte-producing erythroblasts via erythropoiesis.^[2]^[3] Most of the blood cells produced in the bone marrow during hematopoiesis come from megakaryocyte–erythroid progenitor progenitor cells.^[4]

References

^ Xavier-Ferrucio, Juliana; Krause, Diane S. (2018-08-01). "Concise Review: Bipotent Megakaryocytic-Erythroid Progenitors: Concepts and Controversies". Stem Cells. 36 (8): 1138–1145. doi:10.1002/stem.2834. ISSN 1066-5099. PMC 6105498. PMID 29658164.
^ Shin, Eunju; Jeong, Jong-Gwan; Chung, Hyunmin; Jung, Haiyoung; Park, Charny; Yoon, Suk Ran; Kim, Tae-Don; Lee, Seung Jin; Choi, Inpyo; Noh, Ji-Yoon (2020-07-12). "The Gata1low murine megakaryocyte–erythroid progenitor cells expand robustly and alter differentiation potential". Biochemical and Biophysical Research Communications. 528 (1): 46–53. doi:10.1016/j.bbrc.2020.04.143. ISSN 0006-291X. PMID 32456797. S2CID 218911834.
^ Soares-da-Silva, Francisca; Freyer, Laina; Elsaid, Ramy; Burlen-Defranoux, Odile; Iturri, Lorea; Sismeiro, Odile; Pinto-do-Ó, Perpétua; Gomez-Perdiguero, Elisa; Cumano, Ana (2021-04-05). "Yolk sac, but not hematopoietic stem cell–derived progenitors, sustain erythropoiesis throughout murine embryonic life". Journal of Experimental Medicine. 218 (4): e20201729. doi:10.1084/jem.20201729. ISSN 0022-1007. PMC 7879581. PMID 33566111.
^ Psaila, Bethan; Mead, Adam J. (2019-03-28). "Single-cell approaches reveal novel cellular pathways for megakaryocyte and erythroid differentiation". Blood. 133 (13): 1427–1435. doi:10.1182/blood-2018-11-835371. ISSN 0006-4971. PMC 6443046. PMID 30728145.

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[1] Xavier-Ferrucio, Juliana; Krause, Diane S. (2018-08-01). "Concise Review: Bipotent Megakaryocytic-Erythroid Progenitors: Concepts and Controversies". Stem Cells. 36 (8): 1138–1145. doi:10.1002/stem.2834. ISSN 1066-5099. PMC 6105498. PMID 29658164.

[2] Shin, Eunju; Jeong, Jong-Gwan; Chung, Hyunmin; Jung, Haiyoung; Park, Charny; Yoon, Suk Ran; Kim, Tae-Don; Lee, Seung Jin; Choi, Inpyo; Noh, Ji-Yoon (2020-07-12). "The Gata1low murine megakaryocyte–erythroid progenitor cells expand robustly and alter differentiation potential". Biochemical and Biophysical Research Communications. 528 (1): 46–53. doi:10.1016/j.bbrc.2020.04.143. ISSN 0006-291X. PMID 32456797. S2CID 218911834.

[3] Soares-da-Silva, Francisca; Freyer, Laina; Elsaid, Ramy; Burlen-Defranoux, Odile; Iturri, Lorea; Sismeiro, Odile; Pinto-do-Ó, Perpétua; Gomez-Perdiguero, Elisa; Cumano, Ana (2021-04-05). "Yolk sac, but not hematopoietic stem cell–derived progenitors, sustain erythropoiesis throughout murine embryonic life". Journal of Experimental Medicine. 218 (4): e20201729. doi:10.1084/jem.20201729. ISSN 0022-1007. PMC 7879581. PMID 33566111.

[4] Psaila, Bethan; Mead, Adam J. (2019-03-28). "Single-cell approaches reveal novel cellular pathways for megakaryocyte and erythroid differentiation". Blood. 133 (13): 1427–1435. doi:10.1182/blood-2018-11-835371. ISSN 0006-4971. PMC 6443046. PMID 30728145.

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 [[Image:Drzewko rozwojowe komórek macierzystych krwi.JPG|thumb|Hematopoiesis: MEP differentiates into megakaryocytes and erythrocytes.]]
-'''Megakaryocyte–erythroid progenitor cells''' ('''MEPs'''), among other [[blood cells]], are generated as a result of [[hematopoiesis]], which occurs in the [[bone marrow]]. [[Hematopoietic stem cells]] (HSC) can differentiate into one of two progenitor cells: the common lymphoid progenitor and the common myeloid progenitor. MEPs derive from the common myeloid progenitor lineage.<ref>{{Cite journal |last1=Xavier-Ferrucio |first1=Juliana |last2=Krause |first2=Diane S. |date=2018-08-01 |title=Concise Review: Bipotent Megakaryocytic-Erythroid Progenitors: Concepts and Controversies |journal=Stem Cells |language=en |volume=36 |issue=8 |pages=1138–1145 |doi=10.1002/stem.2834 |issn=1066-5099 |pmc=6105498 |pmid=29658164}}</ref> Megakaryocyte–erythroid progenitor cells must commit to becoming either platelet-producing megakaryocytes via megakaryopoiesis or erythrocyte-producing erythroblasts via erythropoiesis.<ref>{{Cite journal |last1=Shin |first1=Eunju |last2=Jeong |first2=Jong-Gwan |last3=Chung |first3=Hyunmin |last4=Jung |first4=Haiyoung |last5=Park |first5=Charny |last6=Yoon |first6=Suk Ran |last7=Kim |first7=Tae-Don |last8=Lee |first8=Seung Jin |last9=Choi |first9=Inpyo |last10=Noh |first10=Ji-Yoon |date=2020-07-12 |title=The Gata1low murine megakaryocyte–erythroid progenitor cells expand robustly and alter differentiation potential |url=https://www.sciencedirect.com/science/article/pii/S0006291X20308834 |journal=Biochemical and Biophysical Research Communications |language=en |volume=528 |issue=1 |pages=46–53 |doi=10.1016/j.bbrc.2020.04.143 |pmid=32456797 |s2cid=218911834 |issn=0006-291X}}</ref><ref>{{Cite journal |last1=Soares-da-Silva |first1=Francisca |last2=Freyer |first2=Laina |last3=Elsaid |first3=Ramy |last4=Burlen-Defranoux |first4=Odile |last5=Iturri |first5=Lorea |last6=Sismeiro |first6=Odile |last7=Pinto-do-Ó |first7=Perpétua |last8=Gomez-Perdiguero |first8=Elisa |last9=Cumano |first9=Ana |date=2021-04-05 |title=Yolk sac, but not hematopoietic stem cell–derived progenitors, sustain erythropoiesis throughout murine embryonic life |journal=Journal of Experimental Medicine |language=en |volume=218 |issue=4 |pages=e20201729 |doi=10.1084/jem.20201729 |pmid=33566111 |pmc=7879581 |issn=0022-1007}}</ref> Most of the blood cells produced in the bone marrow during hematopoiesis come from megakaryocyte–erythroid progenitor progenitor cells.<ref>{{Cite journal |last1=Psaila |first1=Bethan |last2=Mead |first2=Adam J. |date=2019-03-28 |title=Single-cell approaches reveal novel cellular pathways for megakaryocyte and erythroid differentiation |url=https://ashpublications.org/blood/article/133/13/1427/261456/Singlecell-approaches-reveal-novel-cellular |journal=Blood |language=en |volume=133 |issue=13 |pages=1427–1435 |doi=10.1182/blood-2018-11-835371 |issn=0006-4971 |pmc=6443046 |pmid=30728145}}</ref>
+'''Megakaryocyte–erythroid progenitor cells''' ('''MEPs'''), among other [[blood cells]], are generated as a result of [[hematopoiesis]], which occurs in the [[bone marrow]]. [[Hematopoietic stem cells]] (HSC) can differentiate into one of two progenitor cells: the common lymphoid progenitor and the common myeloid progenitor. MEPs derive from the common myeloid progenitor lineage.<ref>{{Cite journal |last1=Xavier-Ferrucio |first1=Juliana |last2=Krause |first2=Diane S. |date=2018-08-01 |title=Concise Review: Bipotent Megakaryocytic-Erythroid Progenitors: Concepts and Controversies |journal=Stem Cells |language=en |volume=36 |issue=8 |pages=1138–1145 |doi=10.1002/stem.2834 |issn=1066-5099 |pmc=6105498 |pmid=29658164}}</ref> Megakaryocyte–erythroid progenitor cells must commit to becoming either platelet-producing megakaryocytes via megakaryopoiesis or erythrocyte-producing [[erythroblasts]] via [[erythropoiesis]].<ref>{{Cite journal |last1=Shin |first1=Eunju |last2=Jeong |first2=Jong-Gwan |last3=Chung |first3=Hyunmin |last4=Jung |first4=Haiyoung |last5=Park |first5=Charny |last6=Yoon |first6=Suk Ran |last7=Kim |first7=Tae-Don |last8=Lee |first8=Seung Jin |last9=Choi |first9=Inpyo |last10=Noh |first10=Ji-Yoon |date=2020-07-12 |title=The Gata1low murine megakaryocyte–erythroid progenitor cells expand robustly and alter differentiation potential |url=https://www.sciencedirect.com/science/article/pii/S0006291X20308834 |journal=Biochemical and Biophysical Research Communications |language=en |volume=528 |issue=1 |pages=46–53 |doi=10.1016/j.bbrc.2020.04.143 |pmid=32456797 |s2cid=218911834 |issn=0006-291X}}</ref><ref>{{Cite journal |last1=Soares-da-Silva |first1=Francisca |last2=Freyer |first2=Laina |last3=Elsaid |first3=Ramy |last4=Burlen-Defranoux |first4=Odile |last5=Iturri |first5=Lorea |last6=Sismeiro |first6=Odile |last7=Pinto-do-Ó |first7=Perpétua |last8=Gomez-Perdiguero |first8=Elisa |last9=Cumano |first9=Ana |date=2021-04-05 |title=Yolk sac, but not hematopoietic stem cell–derived progenitors, sustain erythropoiesis throughout murine embryonic life |journal=Journal of Experimental Medicine |language=en |volume=218 |issue=4 |pages=e20201729 |doi=10.1084/jem.20201729 |pmid=33566111 |pmc=7879581 |issn=0022-1007}}</ref> Most of the blood cells produced in the bone marrow during hematopoiesis come from megakaryocyte–erythroid progenitor progenitor cells.<ref>{{Cite journal |last1=Psaila |first1=Bethan |last2=Mead |first2=Adam J. |date=2019-03-28 |title=Single-cell approaches reveal novel cellular pathways for megakaryocyte and erythroid differentiation |url=https://ashpublications.org/blood/article/133/13/1427/261456/Singlecell-approaches-reveal-novel-cellular |journal=Blood |language=en |volume=133 |issue=13 |pages=1427–1435 |doi=10.1182/blood-2018-11-835371 |issn=0006-4971 |pmc=6443046 |pmid=30728145}}</ref>
 [[File:Platelets release in mature megakaryocytes .gif|thumb|Megakaryopoiesis: Megakaryocyte actively forming platelets.]]