Qrr RNA
| Quorum regulatory RNA | |
|---|---|
 | |
| Identifiers | |
| Symbol | Qrr |
| Alt. Symbols | Qrr1-5 |
| Rfam | RF00378 |
| Other data | |
| RNA type | sRNA |
| Domain(s) | Vibrio |
| PDB structures | PDBe |
Qrr (Quorum regulatory RNA)[1] is a non-coding RNA that is thought to be involved in the regulation of quorum sensing in Vibrio species. It is believed that these RNAs, guided by a protein, Hfq, can mediate the destabilisation of the quorum-sensing master regulators LuxR/HapR/VanT mRNAs.[2][3]
Qrr operates as part of a negative feedback loop which regulates the shift in cell state from that of low density populations to that in high density populations.[4] In Vibrio harveyi, Qrr binds and represses expression of the luxR mRNA transcript, a master regulator of quorum-sensing genes.[5] At higher population densities, increased autoinducer concentration leads to termination of qrr transcription hence derepression of luxR.[4]
There are 5 different qrr genes (Qrr1-5) in V. harveyi; of these, qrr2, 3 and 4 are activated by LuxR.[6]
References
- ^ Lenz, DH (2004). "The Small RNA Chaperone Hfq and Multiple Small RNAs Control Quorum Sensing in Vibrio harveyi and Vibrio cholerae". Cell. 118 (1): 69–82. doi:10.1016/j.cell.2004.06.009. PMID 15242645.
{{cite journal}}: Unknown parameter|coauthors=ignored (|author=suggested) (help) - ^ Svenningsen SL, Tu KC, Bassler BL (2009). "Gene dosage compensation calibrates four regulatory RNAs to control Vibrio cholerae quorum sensing". EMBO J. 28 (4): 429–39. doi:10.1038/emboj.2008.300. PMC 2632942. PMID 19165149.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 18808382, please use {{cite journal}} with
|pmid=18808382instead. - ^ a b Tu KC, Long T, Svenningsen SL, Wingreen NS, Bassler BL (2010). "Negative Feedback Loops Involving Small Regulatory RNAs Precisely Control the Vibrio harveyi Quorum-Sensing Response". Mol Cell. 37 (4): 567–79. doi:10.1016/j.molcel.2010.01.022. PMC 2844700. PMID 20188674.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Miyamoto, CM (October 1994). "Proximal and distal sites bind LuxR independently and activate expression of the Vibrio harveyi lux operon". Molecular microbiology. 14 (2): 255–62. doi:10.1111/j.1365-2958.1994.tb01286.x. PMID 7830570.
{{cite journal}}: Unknown parameter|coauthors=ignored (|author=suggested) (help) - ^ Tu, KC (November 2008). "A small-RNA-mediated negative feedback loop controls quorum-sensing dynamics in Vibrio harveyi". Molecular microbiology. 70 (4): 896–907. doi:10.1111/j.1365-2958.2008.06452.x. PMC 2680268. PMID 18808382.
{{cite journal}}: Unknown parameter|coauthors=ignored (|author=suggested) (help)
Further Reading
- Shao, Y (2014 Apr 3). "Quorum regulatory small RNAs repress type VI secretion in Vibrio cholerae". Molecular microbiology. PMID 24698180.
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External links
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