L-AP4: Difference between revisions

| verifiedrevid = 438864433

| IUPAC_name = (2S)-2-amino-4-phosphonobutanoic acid

| image = L-AP4_structure.png

| routes_of_administration =

| excretion =

| IUPHAR_ligand = 1412

| molecular_weight = 183.099 g/mol

| smiles = OC(=O)C(N)CCP(O)(O)=O

'''L-AP4''' is a drug used in scientific research, which acts as a group-selective [[agonist]] for the group III [[metabotropic glutamate receptor]]s ([[Metabotropic glutamate receptor 4|mGluR₄]]_/[[Metabotropic glutamate receptor 6|₆]]_/[[Metabotropic glutamate receptor 7|₇]]_/[[Metabotropic glutamate receptor 8|₈]]). It was the first ligand found to act as an agonist selective for this group of mGlu receptors,<ref>{{cite journal | last1 = Thomsen | first1 = C | title = The L-AP4 receptor | journal = General pharmacology | volume = 29 | issue = 2 | pages = 151–8 | year = 1997 | pmid = 9251893 | author-separator =, | author-name-separator= }}</ref> but does not show selectivity between the different mGluR Group III subtypes. It is widely used in the study of this receptor family and their various functions.<ref>{{cite journal | last1 = Lopez | first1 = S | last2 = Turle-Lorenzo | first2 = N | last3 = Acher | first3 = F | last4 = De Leonibus | first4 = E | last5 = Mele | first5 = A | last6 = Amalric | first6 = M | title = Targeting group III metabotropic glutamate receptors produces complex behavioral effects in rodent models of Parkinson's disease | journal = Journal of Neuroscience | volume = 27 | issue = 25 | pages = 6701–11 | year = 2007 | pmid = 17581957 | author-separator =, | author-name-separator= | doi = 10.1523/JNEUROSCI.0299-07.2007 }}</ref><ref>{{cite journal | last1 = MacInnes | first1 = N | last2 = Duty | first2 = S | title = Group III metabotropic glutamate receptors act as hetero-receptors modulating evoked GABA release in the globus pallidus in vivo | journal = European journal of pharmacology | volume = 580 | issue = 1-2 | pages = 95–9 | year = 2008 | pmid = 18035348 | author-separator =, | author-name-separator= | doi = 10.1016/j.ejphar.2007.10.030 }}</ref><ref>{{cite journal | last1 = Zhang | first1 = HM | last2 = Chen | first2 = SR | last3 = Pan | first3 = HL | title = Effects of activation of group III metabotropic glutamate receptors on spinal synaptic transmission in a rat model of neuropathic pain | journal = Neuroscience | volume = 158 | issue = 2 | pages = 875–84 | year = 2009 | pmid = 19017536 | author-separator =, | author-name-separator= | pmc = 2649787 | doi = 10.1016/j.neuroscience.2008.10.042 }}</ref><ref>{{cite journal | last1 = MacIejak | first1 = P | last2 = Szyndler | first2 = J | last3 = Turzyńska | first3 = D | last4 = Sobolewska | first4 = A | last5 = Taracha | first5 = E | last6 = Skórzewska | first6 = A | last7 = Lehner | first7 = M | last8 = Bidziński | first8 = A | last9 = Hamed | first9 = A | title = The effects of group III mGluR ligands on pentylenetetrazol-induced kindling of seizures and hippocampal amino acids concentration | journal = Brain research | volume = 1282 | pages = 20–7 | year = 2009 | pmid = 19481536 | author-separator =, | author-name-separator= | doi = 10.1016/j.brainres.2009.05.049 }}</ref>

{{reflist}}

{{Glutamate_receptor_ligands}}

[[Category:Amino acids]]

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