ADH1C

ADH1C
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1HT0, 1U3W
Identifiers
Aliases	ADH1C, ADH3, alcohol dehydrogenase 1C (class I), gamma polypeptide
External IDs	OMIM: 103730; MGI: 87921; HomoloGene: 73888; GeneCards: ADH1C; OMA:ADH1C - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	99,352,746 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	137,996,459 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; jejunal mucosa; ; nasal epithelium; ; right lobe of liver; ; olfactory zone of nasal mucosa; ; duodenum; ; mucosa of sigmoid colon; ; rectum; ; palpebral conjunctiva; ; bronchial epithelial cell;
	Top expressed in
	conjunctival fornix; ; left lung lobe; ; transitional epithelium of urinary bladder; ; left colon; ; adrenal gland; ; left lobe of liver; ; gallbladder; ; seminal vesicula; ; efferent ductule; ; right kidney;
	More reference expression data
	n/a
Gene ontology
Molecular function	oxidoreductase activity; zinc ion binding; alcohol dehydrogenase (NAD+) activity; metal ion binding; NAD-retinol dehydrogenase activity; alcohol dehydrogenase activity, zinc-dependent;
Cellular component	cytoplasm; nucleoplasm; cytosol; plasma membrane;
Biological process	ethanol oxidation; retinol metabolic process; retinoic acid metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	126
	11522
	ENSG00000248144
	ENSMUSG00000074207
	P00326
	P00329
	NM_000669
	NM_007409
	NP_000660
	NP_031435
	Wikidata
View/Edit Human	View/Edit Mouse

Alcohol dehydrogenase 1C is an enzyme that in humans is encoded by the ADH1C gene.^[5]

Function

This gene encodes class I alcohol dehydrogenase, gamma subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol (beverage alcohol), retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class I alcohol dehydrogenase, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibit high activity for ethanol oxidation and play a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000248144 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000074207 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Smith M (Mar 1986). "Genetics of Human Alcohol and Aldehyde Dehydrogenases". Advances in Human Genetics 15. Vol. 15. pp. 249–90. doi:10.1007/978-1-4615-8356-1_5. ISBN 978-1-4615-8358-5. PMID 3006456.
^ "Entrez Gene: ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide".

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Hurley TD, Bosron WF, Stone CL, Amzel LM (Jun 1994). "Structures of three human beta alcohol dehydrogenase variants. Correlations with their functional differences". Journal of Molecular Biology. 239 (3): 415–29. doi:10.1006/jmbi.1994.1382. PMID 8201622.
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