ASCC3

ASCC3
Identifiers
Aliases	ASCC3, ASC1p200, HELIC1, RNAH, activating signal cointegrator 1 complex subunit 3
External IDs	OMIM: 614217; MGI: 1925237; HomoloGene: 4973; GeneCards: ASCC3; OMA:ASCC3 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	100,881,372 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	50,727,581 bp
RNA expression pattern
	Top expressed in
	decidua; ; secondary oocyte; ; Achilles tendon; ; gonad; ; stromal cell of endometrium; ; ventricular zone; ; testicle; ; islet of Langerhans; ; bone marrow cells; ; right coronary artery;
	Top expressed in
	spermatid; ; tail of embryo; ; gastrula; ; spermatocyte; ; genital tubercle; ; epithelium of small intestine; ; supraoptic nucleus; ; hand; ; ascending aorta; ; submandibular gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; 3'-5' DNA helicase activity; protein binding; hydrolase activity; ATP binding; helicase activity; nucleic acid binding; RNA binding;
Cellular component	intracellular anatomical structure; membrane; nucleoplasm; nucleus; cytosol; activating signal cointegrator 1 complex; nuclear speck; cytoplasm; Golgi apparatus;
Biological process	DNA dealkylation involved in DNA repair; DNA duplex unwinding; cell population proliferation; regulation of transcription, DNA-templated; transcription, DNA-templated; cellular response to DNA damage stimulus; DNA repair;
	Sources:Amigo / QuickGO
Orthologs
	10973
	77987
	ENSG00000112249
	ENSMUSG00000038774
	Q8N3C0
	E9PZJ8
	NM_001284271; NM_006828; NM_022091
	NM_198007
	NP_001271200; NP_006819; NP_071374
	NP_932124
	Wikidata
View/Edit Human	View/Edit Mouse

Activating signal cointegrator 1 complex subunit 3 is a protein that in humans is encoded by the ASCC3 gene.^[5]^[6]

Interactions

ASCC3 has been shown to interact with RELA,^[7] C-jun^[7] and Serum response factor.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000112249 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038774 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Coulie PG, Ikeda H, Baurain JF, Chiari R (Jun 1999). "Antitumor immunity at work in a melanoma patient". Advances in Cancer Research. 76: 213–42. doi:10.1016/S0065-230X(08)60778-2. ISBN 978-0-12-006676-6. PMID 10218103.
^ "Entrez Gene: ASCC3 activating signal cointegrator 1 complex subunit 3".
^ ^a ^b ^c Jung DJ, Sung HS, Goo YW, Lee HM, Park OK, Jung SY, Lim J, Kim HJ, Lee SK, Kim TS, Lee JW, Lee YC (Jul 2002). "Novel transcription coactivator complex containing activating signal cointegrator 1". Molecular and Cellular Biology. 22 (14): 5203–11. doi:10.1128/MCB.22.14.5203-5211.2002. PMC 139772. PMID 12077347.

External links

Human ASCC3 genome location and ASCC3 gene details page in the UCSC Genome Browser.

Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (Sep 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Jung DJ, Sung HS, Goo YW, Lee HM, Park OK, Jung SY, Lim J, Kim HJ, Lee SK, Kim TS, Lee JW, Lee YC (Jul 2002). "Novel transcription coactivator complex containing activating signal cointegrator 1". Molecular and Cellular Biology. 22 (14): 5203–11. doi:10.1128/MCB.22.14.5203-5211.2002. PMC 139772. PMID 12077347.
Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (Jun 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (Oct 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (Jan 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000112249 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000038774 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10218103-5] Coulie PG, Ikeda H, Baurain JF, Chiari R (Jun 1999). "Antitumor immunity at work in a melanoma patient". Advances in Cancer Research. 76: 213–42. doi:10.1016/S0065-230X(08)60778-2. ISBN 978-0-12-006676-6. PMID 10218103.

[entrez-6] "Entrez Gene: ASCC3 activating signal cointegrator 1 complex subunit 3".

[pmid12077347-7] Jung DJ, Sung HS, Goo YW, Lee HM, Park OK, Jung SY, Lim J, Kim HJ, Lee SK, Kim TS, Lee JW, Lee YC (Jul 2002). "Novel transcription coactivator complex containing activating signal cointegrator 1". Molecular and Cellular Biology. 22 (14): 5203–11. doi:10.1128/MCB.22.14.5203-5211.2002. PMC 139772. PMID 12077347.

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Interactions

References

External links

Further reading