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Protein-coding gene in the species Homo sapiens
Protein family
ATP synthase subunit g, mitochondrial is an enzyme that in humans is encoded by the ATP5MG gene .[ 5] [ 6] [ 7]
Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The F1 complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the other 3. The Fo seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the g subunit of the F0 complex.[ 7]
The function of subunit G is currently unknown. There is no counterpart in chloroplast or bacterial F-ATPases identified so far.[ 8]
^ a b c GRCh38: Ensembl release 89: ENSG00000167283 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038717 – Ensembl , May 2017
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^ a b "Entrez Gene: ATP5MG ATP synthase membrane subunit g" .
^ Collinson IR, Runswick MJ, Buchanan SK, Fearnley IM, Skehel JM, van Raaij MJ, Griffiths DE, Walker JE (June 1994). "Fo membrane domain of ATP synthase from bovine heart mitochondria: purification, subunit composition, and reconstitution with F1-ATPase". Biochemistry . 33 (25): 7971–8. doi :10.1021/bi00191a026 . PMID 8011660 .
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