GP2 (gene)

GP2
Identifiers
Aliases	GP2, ZAP75, glycoprotein 2
External IDs	OMIM: 602977; MGI: 1914383; HomoloGene: 133790; GeneCards: GP2; OMA:GP2 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	20,327,808 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	119,058,508 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; islet of Langerhans; ; pancreatic ductal cell; ; gallbladder; ; olfactory zone of nasal mucosa; ; sperm; ; duodenum; ; renal medulla; ; pylorus; ; prostate;
	Top expressed in
	pyloric antrum; ; trachea; ; islet of Langerhans; ; duodenum; ; conjunctival fornix; ; olfactory epithelium; ; lumbar spinal ganglion; ; right kidney; ; thymus; ; cervix;
	More reference expression data
	; ; ; ;
	More reference expression data
Orthologs
	2813
	67133
	ENSG00000169347
	ENSMUSG00000030954
	P55259
	Q9D733
	NM_001007240; NM_001007241; NM_001007242; NM_001502
	NM_025989
	NP_001007241; NP_001007242; NP_001007243; NP_001493
	NP_080265
	Wikidata
View/Edit Human	View/Edit Mouse

Pancreatic secretory granule membrane major glycoprotein GP2 is a protein that in humans is encoded by the GP2 gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000169347 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030954 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Fukuoka SI, Suzuki M, Okabayashi K, Takahashi E (Jun 1998). "Assignment of pancreatic zymogen granule membrane protein GP2 (GP2) to human chromosome band 9q21.11 to q21.2 by in situ hybridization". Cytogenet Cell Genet. 79 (3–4): 231–2. doi:10.1159/000134730. PMID 9605860.
^ "Entrez Gene: GP2 glycoprotein 2 (zymogen granule membrane)".

Jacob M, Lainé J, LeBel D (1993). "Specific interactions of pancreatic amylase at acidic pH. Amylase and the major protein of the zymogen granule membrane (GP-2) bind to immobilized or polymerized amylase". Biochem. Cell Biol. 70 (10–11): 1105–14. doi:10.1139/o92-156. PMID 1284286.
Fukuoka S, Freedman SD, Yu H, et al. (1992). "GP-2/THP gene family encodes self-binding glycosylphosphatidylinositol-anchored proteins in apical secretory compartments of pancreas and kidney". Proc. Natl. Acad. Sci. U.S.A. 89 (4): 1189–93. Bibcode:1992PNAS...89.1189F. doi:10.1073/pnas.89.4.1189. PMC 48414. PMID 1531535.
Paul E, Leblond FA, LeBel D (1991). "In resting conditions, the pancreatic granule membrane protein GP-2 is secreted by cleavage of its glycosylphosphatidylinositol anchor". Biochem. J. 277 (3): 879–81. doi:10.1042/bj2770879. PMC 1151326. PMID 1651706.
Fukuoka S, Freedman SD, Scheele GA (1991). "A single gene encodes membrane-bound and free forms of GP-2, the major glycoprotein in pancreatic secretory (zymogen) granule membranes". Proc. Natl. Acad. Sci. U.S.A. 88 (7): 2898–902. Bibcode:1991PNAS...88.2898F. doi:10.1073/pnas.88.7.2898. PMC 51347. PMID 2011597.
Rindler MJ, Hoops TC (1991). "The pancreatic membrane protein GP-2 localizes specifically to secretory granules and is shed into the pancreatic juice as a protein aggregate". Eur. J. Cell Biol. 53 (1): 154–63. PMID 2076702.
Hoops TC, Ivanov I, Cui Z, et al. (1994). "Incorporation of the pancreatic membrane protein GP-2 into secretory granules in exocrine but not endocrine cells". J. Biol. Chem. 268 (34): 25694–705. doi:10.1016/S0021-9258(19)74445-7. PMID 7503984.
Freedman SD, Sakamoto K, Scheele GA (1994). "Nonparallel secretion of GP-2 from exocrine pancreas implies luminal coupling between acinar and duct cells". Am. J. Physiol. 267 (1 Pt 1): G40–51. doi:10.1152/ajpgi.1994.267.1.G40. PMID 7519402.
Wong SM, Lowe AW (1996). "Sequence of the cDNA encoding human GP-2, the major membrane protein in the secretory granule of the exocrine pancreas". Gene. 171 (2): 311–2. doi:10.1016/0378-1119(96)00065-0. PMID 8666297.
Fukuoka S (2000). "Molecular cloning and sequences of cDNAs encoding alpha (large) and beta (small) isoforms of human pancreatic zymogen granule membrane-associated protein GP2". Biochim. Biophys. Acta. 1491 (1–3): 376–80. doi:10.1016/S0167-4781(00)00057-9. PMID 10760606.
Parker EM, Zaman MM, Freedman SD (2001). "GP2, a GPI-anchored protein in the apical plasma membrane of the pancreatic acinar cell, co-immunoprecipitates with src kinases and caveolin". Pancreas. 21 (3): 219–25. doi:10.1097/00006676-200010000-00001. PMID 11039464. S2CID 21316326.
Kalus I, Hodel A, Koch A, et al. (2002). "Interaction of syncollin with GP-2, the major membrane protein of pancreatic zymogen granules, and association with lipid microdomains". Biochem. J. 362 (Pt 2): 433–42. doi:10.1042/0264-6021:3620433. PMC 1222404. PMID 11853552.
Tsujii-Hayashi Y, Kitahara M, Yamagaki T, et al. (2003). "A potential endogenous ligand of annexin IV in the exocrine pancreas. Carbohydrate structure of GP-2, a glycosylphosphatidylinositol-anchored glycoprotein of zymogen granule membranes". J. Biol. Chem. 277 (49): 47493–9. doi:10.1074/jbc.M206572200. PMID 12324456.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Tamiya G, Shinya M, Imanishi T, et al. (2005). "Whole genome association study of rheumatoid arthritis using 27 039 microsatellites". Hum. Mol. Genet. 14 (16): 2305–21. doi:10.1093/hmg/ddi234. PMID 16000323.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Stsiapanava A, Xu C, Nishio S, Han L, Yamakawa N, Carroni M, Tunyasuvunakool K, Jumper J, de Sanctis D, Wu B, Jovine L (2022). "Structure of the decoy module of human glycoprotein 2 and uromodulin and its interaction with bacterial adhesin FimH". Nat. Struct. Mol. Biol. 29 (3): 190–193. doi:10.1038/s41594-022-00729-3. PMC 8930769. PMID 35273390. PDB: 7P6R, 7P6S, 7P6T

This article on a gene on human chromosome 16 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000169347 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030954 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9605860-5] Fukuoka SI, Suzuki M, Okabayashi K, Takahashi E (Jun 1998). "Assignment of pancreatic zymogen granule membrane protein GP2 (GP2) to human chromosome band 9q21.11 to q21.2 by in situ hybridization". Cytogenet Cell Genet. 79 (3–4): 231–2. doi:10.1159/000134730. PMID 9605860.

[entrez-6] "Entrez Gene: GP2 glycoprotein 2 (zymogen granule membrane)".

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References

Further reading