Malabsorption

Malabsorption
Whipple's disease: Alcian blue with apparently eosin counterstain enlarged villus with many macrophages
Specialty	Gastroenterology
Complications	Malnutrition; anaemia; steatorrhoea; diarrhoea
Causes	Coeliac disease; short bowel syndrome; lactase deficiency; exocrine pancreatic insufficiency; small intestinal bacterial overgrowth; Whipple's disease; genetic diseases; certain medications
Treatment	Depends on cause

Malabsorption is a state arising from abnormality in absorption of food nutrients across the gastrointestinal (GI) tract. Impairment can be of single or multiple nutrients depending on the abnormality. This may lead to malnutrition and a variety of anaemias.

Normally the human gastrointestinal tract digests and absorbs dietary nutrients with remarkable efficiency. A typical Western diet ingested by an adult in one day includes approximately 100 g of fat, 400 g of carbohydrate, 100 g of protein, 2 L of fluid, and the required sodium, potassium, chloride, calcium, vitamins, and other elements. Salivary, gastric, intestinal, hepatic, and pancreatic secretions add an additional 7–8 L of protein-, lipid-, and electrolyte-containing fluid to intestinal contents. This massive load is reduced by the small and large intestines to less than 200 g of stool that contains less than 8 g of fat, 1–2 g of nitrogen, and less than 20 mmol each of Na⁺, K⁺, Cl⁻, HCO−3, Ca²⁺, or Mg²⁺.

If there is impairment of any of the many steps involved in the complex process of nutrient digestion and absorption, intestinal malabsorption may ensue. If the abnormality involves a single step in the absorptive process, as in primary lactase deficiency, or if the disease process is limited to the very proximal small intestine, then selective malabsorption of only a single nutrient may occur. However, generalized malabsorption of multiple dietary nutrients develops when the disease process is extensive, thus disturbing several digestive and absorptive processes, as occurs in coeliac disease with extensive involvement of the small intestine.

Signs and symptoms

Gastrointestinal manifestations

Depending on the nature of the disease process causing malabsorption and its extent, gastrointestinal symptoms may range from severe to subtle or may even be totally absent. Diarrhea, weight loss, flatulence, abdominal bloating, abdominal cramps, and pain may be present. Although diarrhea is a common complaint, the character and frequency of stools may vary considerably ranging from over 10 watery stools per day to less than one voluminous putty-like stool, the latter causing some patients to complain of constipation. On the other hand, stool mass is invariably increased in patients with steatorrhea and generalized malabsorption above the normal with 150–200 g/day. Not only do unabsorbed nutrients contribute to stool mass but mucosal fluid and electrolyte secretion is also increased in diseases associated with mucosal inflammation such as coeliac disease. In addition, unabsorbed fatty acids, converted to hydroxy-fatty acids by colonic flora, as well as unabsorbed bile acids both impair absorption and induce secretion of water and electrolytes by the colon adding to stool mass. Weight loss is common among patients with significant intestinal malabsorption but must be evaluated in the context of caloric intake. Some patients compensate for fecal wastage of unabsorbed nutrients by significantly increasing their oral intake. Eliciting a careful dietary history from patients with suspected malabsorption is therefore crucial. Excessive flatus and abdominal bloating may reflect excessive gas production due to fermentation of unabsorbed carbohydrate, especially among patients with a primary or secondary disaccharidase deficiency, such as lactose intolerance or sucrose intolerance. Malabsorption of dietary nutrients and excessive fluid secretion by inflamed small intestine also contribute to abdominal distention and bloating. Prevalence, severity, and character of abdominal pain vary considerably among the various disease processes associated with intestinal malabsorption. For example, pain is common in patients with chronic pancreatitis or pancreatic cancer and Crohn's disease, but it is absent in many patients with coeliac disease or postgastrectomy malabsorption.

Extraintestinal manifestations

Substantial numbers of patients with intestinal malabsorption present initially with symptoms or laboratory abnormalities that point to other organ systems in the absence of or overshadowing symptoms referable to the gastrointestinal tract. For example, there is increasing epidemiologic evidence that more patients with coeliac disease present with anemia and osteopenia in the absence of significant classic gastrointestinal symptoms. Microcytic, macrocytic, or dimorphic anemia may reflect impaired iron, folate, or vitamin B12 absorption. Purpura, subconjunctival hemorrhage, or even frank bleeding may reflect hypoprothrombinemia secondary to vitamin K malabsorption. Osteopenia is common, especially in the presence of steatorrhea. Impaired calcium and vitamin D absorption and chelation of calcium by unabsorbed fatty acids resulting in fecal loss of calcium may all contribute. If calcium deficiency is prolonged, secondary hyperparathyroidism may develop. Prolonged malnutrition may induce amenorrhea, infertility, and impotence. Edema and even ascites may reflect hypoproteinemia associated with protein losing enteropathy caused by lymphatic obstruction or extensive mucosal inflammation. Dermatitis and peripheral neuropathy may be caused by malabsorption of specific vitamins or micronutrients and essential fatty acids.

Presentation

Small intestine : major site of absorption

Symptoms can manifest in a variety of ways and features might give a clue to the underlying condition. Symptoms can be intestinal or extra-intestinal - the former predominates in severe malabsorption.

• Diarrhoea, often steatorrhoea, is the most common feature. Watery, diurnal and nocturnal, bulky, frequent stools are the clinical hallmark of overt malabsorption. It is due to impaired water, carbohydrate and electrolyte absorption or irritation from unabsorbed fatty acid. The latter also results in bloating, flatulence and abdominal discomfort. Cramping pain usually suggests obstructive intestinal segment e.g. in Crohn's disease, especially if it persists after defecation.
• Weight loss can be significant despite increased oral intake of nutrients.
• Growth retardation, failure to thrive, delayed puberty in children
• Swelling or oedema from loss of protein
• Anaemias, commonly from vitamin B₁₂, folic acid and iron deficiency presenting as fatigue and weakness, and the first of which can give rise to neuropsychiatric symptoms such as abnormal sensations, difficulty walking, and decreased mental abilities.
• Muscle cramp from decreased vitamin D, calcium absorption. Also lead to osteomalacia and osteoporosis
• Bleeding tendencies from vitamin K and other coagulation factor deficiencies.

Causes

Due to infective agents HIV related malabsorption Intestinal tuberculosis Parasites e.g., diphyllobothrium (fish tape worm) (B12 malabsorption), giardiasis (Giardia lamblia), hookworm (Ancylostoma duodenale roundworm, and Necator americanus) Traveler's diarrhea Tropical sprue Whipple's disease

Due to structural defects Blind loops Fistulae, diverticula and strictures Infiltrative conditions such as amyloidosis, lymphoma, eosinophilic gastroenteritis Inflammatory bowel diseases, as in Crohn's disease Radiation enteritis Short bowel syndrome Systemic sclerosis and collagen vascular diseases

Due to surgical structural changes Bariatric surgery (Weight loss surgery) Gastrectomy; Vagotomy

Due to mucosal abnormality Coeliac disease Cows' milk intolerance Fructose malabsorption Soya milk intolerance

Due to enzyme deficiencies Lactase deficiency inducing lactose intolerance (constitutional, secondary or rarely congenital) Intestinal disaccharidase deficiency Intestinal enteropeptidase deficiency Sucrose intolerance

Due to digestive failure Bile acid/Bile salt malabsorption Bacterial overgrowth Obstructive jaundice Primary bile acid diarrhea Terminal ileal disease such as Crohn's disease Pancreatic insufficiencies: Carcinoma of pancreas Chronic pancreatitis Cystic fibrosis Zollinger-Ellison syndrome

Due to other systemic diseases affecting GI tract Abetalipoproteinaemia Addison's disease Carcinoid syndrome Coeliac disease Common variable immunodeficiency (CVID) Fiber Deficiency Pernicious anemia (lack of intrinsic factor, B12 malabsorption) Hypothyroidism and hyperthyroidism Diabetes mellitus Hyperparathyroidism and Hypoparathyroidism Malnutrition

Other Possible Causes Chronic Proton Pump Inhibitor Use

Pathophysiology

The main purpose of the gastrointestinal tract is to digest and absorb nutrients (fat, carbohydrate, protein, micronutrients (vitamins and trace minerals), water, and electrolytes. Digestion involves both mechanical and enzymatic breakdown of food. Mechanical processes include chewing, gastric churning, and the to-and-fro mixing in the small intestine. Enzymatic hydrolysis is initiated by intraluminal processes requiring gastric, pancreatic, and biliary secretions. The final products of digestion are absorbed through the intestinal epithelial cells.

Malabsorption constitutes the pathological interference with the normal physiological sequence of digestion (intraluminal process), absorption (mucosal process) and transport (postmucosal events) of nutrients.

Intestinal malabsorption can be due to:

• Congenital or acquired reduction in absorptive surface
• Defects of ion transport
• Defects of specific hydrolysis
• Impaired enterohepatic circulation
• Mucosal damage (enteropathy)
• Pancreatic insufficiency

Diagnosis

There is no single, specific test for malabsorption. As for most medical conditions, investigation is guided by symptoms and signs. A range of different conditions can produce malabsorption and it is necessary to look for each of these specifically. Many tests have been advocated, and some, such as tests for pancreatic function are complex, vary between centers and have not been widely adopted. However, better tests have become available with greater ease of use, better sensitivity and specificity for the causative conditions. Tests are also needed to detect the systemic effects of deficiency of the malabsorbed nutrients (such as anaemia with vitamin B12 malabsorption).

Classification

Some prefer to classify malabsorption clinically into three basic categories:

1. selective, as seen in lactose malabsorption.
2. partial, as observed in abetalipoproteinaemia.
3. total, as in exceptional cases of coeliac disease.

Blood tests

• Routine blood tests may reveal anaemia, high CRP or low albumin; which shows a high correlation for the presence of an organic disease. In this setting, microcytic anaemia usually implies iron deficiency and macrocytosis can be caused by impaired folic acid or B12 absorption or both. Low cholesterol or triglyceride may give a clue toward fat malabsorption. Low calcium and phosphate may give a clue toward osteomalacia from low vitamin D.
• Specific vitamins like vitamin D or micronutrient like zinc levels can be checked. Fat soluble vitamins (A, D, E and K) are affected in fat malabsorption. Prolonged prothrombin time can be caused by vitamin K deficiency.
• Serological studies. Specific tests are carried out to determine the underlying cause.IgA Anti-transglutaminase antibodies or IgA Anti-endomysial antibodies for Coeliac disease (gluten sensitive enteropathy).

Stool studies

• Microscopy is particularly useful in diarrhoea, may show protozoa like Giardia, ova, cyst and other infective agents.
• Fecal fat study to diagnose steatorrhoea is rarely performed nowadays.
• Low fecal pancreatic elastase is indicative of pancreatic insufficiency. Chymotrypsin and pancreolauryl can be assessed as well

Radiological studies

• Barium follow through is useful in delineating small intestinal anatomy. Barium enema may be undertaken to see colonic or ileal lesions.
• CT abdomen is useful in ruling out structural abnormality, done in pancreatic protocol when visualising pancreas.
• Magnetic resonance cholangiopancreatography (MRCP) to complement or as an alternative to ERCP.

Interventional studies

Biopsy of small bowel showing coeliac disease manifested by blunting of villi, crypt hyperplasia, and lymphocyte infiltration of crypts.

• OGD to detect duodenal pathology and obtain D2 biopsy (for coeliac disease, tropical sprue, Whipple's disease, abetalipoproteinaemia etc.)
• Enteroscopy for enteropathy and jejunal aspirate and culture for bacterial overgrowth
• Capsule Endoscopy is able to visualise the whole small intestine and is occasionally useful.
• Colonoscopy is necessary in colonic and ileal disease.
• ERCP will show pancreatic and biliary structural abnormalities.

Other investigations

• ⁷⁵SeHCAT test to diagnose bile acid malabsorption in ileal disease or primary bile acid diarrhea.
• Glucose hydrogen breath test for bacterial overgrowth
• Lactose hydrogen breath test for lactose intolerance
• Sugar probes or ⁵¹Cr-EDTA to determine intestinal permeability.

Obsolete tests no longer used clinically

• D-xylose absorption test for mucosal disease or bacterial overgrowth. Normal in pancreatic insufficiency.
• Bile salt breath test (¹⁴C-glycocholate) to determine bile salt malabsorption.
• Schilling test to establish cause of B₁₂ deficiency.

Management

Treatment is directed largely towards management of underlying cause:

• Replacement of nutrients, electrolytes and fluid may be necessary. In severe deficiency, hospital admission may be required for nutritional support and detailed advice from dietitians. Use of enteral nutrition by naso-gastric or other feeding tubes may be able to provide sufficient nutritional supplementation. Tube placement may also be done by percutaneous endoscopic gastrostomy, or surgical jejunostomy. In patients whose intestinal absorptive surface is severely limited from disease or surgery, long term total parenteral nutrition may be needed.
• Pancreatic enzymes are supplemented orally in pancreatic insufficiency.
• Dietary modification is important in some conditions:
  • Gluten-free diet in coeliac disease.
  • Lactose avoidance in lactose intolerance.
• Antibiotic therapy to treat Small Bowel Bacterial overgrowth.
• Cholestyramine or other bile acid sequestrants will help with reducing diarrhoea in bile acid malabsorption.

See also

• Fructose malabsorption
• Protein losing enteropathy