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==Education==
==Education==
Patapoutian was born to an Armenian family in [[Beirut]], [[Lebanon]].{{Citation needed|date=October 2021}} He attended the [[American University of Beirut]] before emigrating to the United States in 1986.{{Citation needed|date=October 2021}} He received a bachelor's degree in cell and developmental biology from the [[University of California, Los Angeles]] in 1990 and a Ph.D. in biology from the [[California Institute of Technology]] in 1996.{{Citation needed|date=October 2021}}
Patapoutian was born to an Armenian family in [[Beirut]], [[Lebanon]].{{Citation needed|date=October 2021}} He attended the [[American University of Beirut]] before emigrating to the United States in 1986.<ref name="Scripps Research 2020">{{cite web | title=Scripps Research neurobiologist Ardem Patapoutian elected to American Academy of Arts and Sciences | website=Scripps Research | date=30 April 2020 | url=https://www.scripps.edu/news-and-events/press-room/2020/20200430-patapoutian-academy.html | access-date=5 October 2021}}</ref> He received a bachelor's degree in cell and developmental biology from the [[University of California, Los Angeles]] in 1990 and a Ph.D. in biology from the [[California Institute of Technology]] in 1996.{{Citation needed|date=October 2021}}


As a postdoctoral fellow, Patapoutian worked with Louis F. Reichardt at the [[University of California, San Francisco]]. In 2000, he became an assistant professor at the Scripps Research Institute. Between 2000 and 2014, he had an additional research position for the Novartis Research Foundation. Since 2014, Patapoutian has been an investigator for the [[Howard Hughes Medical Institute]] (HHMI).<ref>{{Cite web|url=https://kavliprize.org/prizes-and-laureates/laureates/ardem-patapoutian|title=Ardem Patapoutian|date=March 12, 2021|website=www.kavliprize.org|access-date=June 23, 2021|archive-date=June 24, 2021|archive-url=https://web.archive.org/web/20210624204431/https://kavliprize.org/prizes-and-laureates/laureates/ardem-patapoutian|url-status=live}}</ref>
As a postdoctoral fellow, Patapoutian worked with Louis F. Reichardt at the [[University of California, San Francisco]]. In 2000, he became an assistant professor at the Scripps Research Institute. Between 2000 and 2014, he had an additional research position for the Novartis Research Foundation. Since 2014, Patapoutian has been an investigator for the [[Howard Hughes Medical Institute]] (HHMI).<ref>{{Cite web|url=https://kavliprize.org/prizes-and-laureates/laureates/ardem-patapoutian|title=Ardem Patapoutian|date=March 12, 2021|website=www.kavliprize.org|access-date=June 23, 2021|archive-date=June 24, 2021|archive-url=https://web.archive.org/web/20210624204431/https://kavliprize.org/prizes-and-laureates/laureates/ardem-patapoutian|url-status=live}}</ref>

Revision as of 18:32, 5 October 2021

Ardem Patapoutian
Occupations
  • Molecular biologist
  • neuroscientist
AwardsNobel Prize in Medicine (2021)
Academic background
Education
Academic work
InstitutionsScripps Research

Ardem Patapoutian (Armenian: Արտեմ Փաթափութեան, romanized: Ardem P'at'ap'ut'ean; born 1967) is an American molecular biologist, neuroscientist, and Nobel Prize laureate. He is known for his work in characterizing the PIEZO1, PIEZO2, and TRPM8 receptors that detect pressure, menthol, and temperature. Patapoutian is a neuroscience professor and Howard Hughes Medical Institute investigator at Scripps Research in La Jolla, California. He won the Nobel Prize in Physiology or Medicine in 2021 jointly with David Julius.[1]

Education

Patapoutian was born to an Armenian family in Beirut, Lebanon.[citation needed] He attended the American University of Beirut before emigrating to the United States in 1986.[2] He received a bachelor's degree in cell and developmental biology from the University of California, Los Angeles in 1990 and a Ph.D. in biology from the California Institute of Technology in 1996.[citation needed]

As a postdoctoral fellow, Patapoutian worked with Louis F. Reichardt at the University of California, San Francisco. In 2000, he became an assistant professor at the Scripps Research Institute. Between 2000 and 2014, he had an additional research position for the Novartis Research Foundation. Since 2014, Patapoutian has been an investigator for the Howard Hughes Medical Institute (HHMI).[3]

Research

Patapoutian's research is into the biological receptors for temperature and touch (nociception).[1] The knowledge is used to develop treatments for a range of diseases, including chronic pain.[4] The discoveries made it possible to understand how heat, cold and mechanical forces trigger nerve impulses.[4]

Patapoutian researches the signal transduction of sensors. To find the molecular basis for touch, Patapoutian and his collaborators inactivated genes until they identified the single one that, when disabled, made the cells insensitive.[5] The channel integral to the sense of touch became known as PIEZO1, after the Greek word for pressure.[5] Through its similarity to PIEZO1, a second gene was discovered and named PIEZO2.[6] This ion channel, the more important of the two mechanoreceptors, is essential for the sense of touch.[6][7] PIEZO1 and PIEZO2 channels have been shown to regulate additional important physiological processes including blood pressure, respiration and urinary bladder control.[6]

Patapoutian also made significant contributions to the identification of novel ion channels and receptors that are activated by temperature, mechanical forces or increased cell volume.[8][9] Patapoutian and co-workers were able to show that these ion channels play an outstanding role in the sensation of temperature, in the sensation of touch, in proprioception,[10] in the sensation of pain and in the regulation of vascular tone. More recent work uses functional genomics techniques to identify and characterize mechanosensitive ion channels (mechanotransduction).[11][12][13][14]

Awards and honors

Nobel Prize in Physiology or Medicine 2021: Discovery of TRPV1 and PIEZO2

Patapoutian has an h-index of 68 according to Google Scholar,[15] and of 63 according to Scopus[16] as of May 2020. He has been a Fellow of the American Association for the Advancement of Science since 2016, a member of the National Academy of Sciences since 2017 [17] and of the American Academy of Arts and Sciences since 2020.[18] In 2017, Patapoutian received the W. Alden Spencer Award,[19] in 2019 the Rosenstiel Award,[20] in 2020 the Kavli Prize for Neuroscience,[21] and the BBVA Foundation Frontiers of Knowledge Award in Biology / Biomedicine.[22]

In 2021, he was awarded the Nobel Prize in Physiology or Medicine jointly with David Julius for their discoveries of receptors for temperature and touch.[1][23]

Selected publications

PIEZO1 + PIEZO2

  • Coste, B.; Mathur, J.; Schmidt, M.; Earley, T. J.; Ranade, S.; Petrus, M. J.; Dubin, A. E.; Patapoutian, A. (September 2, 2010). "Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels". Science. 330 (6000). American Association for the Advancement of Science (AAAS): 55–60. Bibcode:2010Sci...330...55C. doi:10.1126/science.1193270. ISSN 0036-8075. PMC 3062430. PMID 20813920.[5]
  • Coste, Bertrand; Xiao, Bailong; Santos, Jose S.; Syeda, Ruhma; Grandl, Jörg; Spencer, Kathryn S.; Kim, Sung Eun; Schmidt, Manuela; Mathur, Jayanti; Dubin, Adrienne E.; Montal, Mauricio; Patapoutian, Ardem (February 19, 2012). "Piezo proteins are pore-forming subunits of mechanically activated channels". Nature. 483 (7388). Springer Science and Business Media LLC: 176–181. Bibcode:2012Natur.483..176C. doi:10.1038/nature10812. ISSN 0028-0836. PMC 3297710. PMID 22343900.

PIEZO2

References

  1. ^ a b c "The Nobel Prize in Physiology or Medicine 2021". NobelPrize.org. Archived from the original on October 4, 2021. Retrieved October 4, 2021.
  2. ^ "Scripps Research neurobiologist Ardem Patapoutian elected to American Academy of Arts and Sciences". Scripps Research. April 30, 2020. Retrieved October 5, 2021.
  3. ^ "Ardem Patapoutian". www.kavliprize.org. March 12, 2021. Archived from the original on June 24, 2021. Retrieved June 23, 2021.
  4. ^ a b "Medizin-Nobelpreis – US-Forscher David Julius und Ardem Patapoutian ausgezeichnet". Deutschlandfunk (in German). April 15, 2019. Archived from the original on October 4, 2021. Retrieved October 4, 2021.
  5. ^ a b c "Nobel Prize in Medicine Awarded to David Julius and Ardem Patapoutian". The New York Times. October 4, 2021. Retrieved October 4, 2021.
  6. ^ a b c "The Nobel Prize in Physiology or Medicine 2021". NobelPrize.org. October 4, 2021. Retrieved October 4, 2021.
  7. ^ a b "Medizin-Nobelpreis: Wie Nervenzellen Temperaturen und Berührungen erkennen". Deutsches Ärzteblatt (in German). October 4, 2021. Retrieved October 5, 2021.
  8. ^ Syeda, Ruhma; Qiu, Zhaozhu; Dubin, Adrienne E.; Murthy, Swetha E.; Florendo, Maria N.; Mason, Daniel E.; Mathur, Jayanti; Cahalan, Stuart M.; Peters, Eric C.; Montal, Mauricio; Patapoutian, Ardem (January 28, 2016). "LRRC8 Proteins Form Volume-Regulated Anion Channels that Sense Ionic Strength". Cell. 164 (3): 499–511. doi:10.1016/j.cell.2015.12.031. ISSN 1097-4172. PMC 4733249. PMID 26824658.
  9. ^ Qiu, Zhaozhu; Dubin, Adrienne E.; Mathur, Jayanti; Tu, Buu; Reddy, Kritika; Miraglia, Loren J.; Reinhardt, Jürgen; Orth, Anthony P.; Patapoutian, Ardem (2014). "SWELL1, a Plasma Membrane Protein, Is an Essential Component of Volume-Regulated Anion Channel". Cell. 157 (2). Elsevier BV: 447–458. doi:10.1016/j.cell.2014.03.024. ISSN 0092-8674. PMC 4023864. PMID 24725410.
  10. ^ Woo, Seung-Hyun; Lukacs, Viktor; de Nooij, Joriene C; Zaytseva, Dasha; Criddle, Connor R; Francisco, Allain; Jessell, Thomas M; Wilkinson, Katherine A; Patapoutian, Ardem (November 9, 2015). "Piezo2 is the principal mechanotransduction channel for proprioception". Nature Neuroscience. 18 (12). Springer Science and Business Media LLC: 1756–1762. doi:10.1038/nn.4162. ISSN 1097-6256. PMC 4661126. PMID 26551544.
  11. ^ "Ardem Patapoutian". Scripps Research. Archived from the original on February 2, 2021. Retrieved October 4, 2021.
  12. ^ "Piezo channels in mechanotransduction: Sensory biology to disease – Ardem Patapoutian". Wu Tsai Neurosciences Institute. December 17, 2019. Archived from the original on October 4, 2021. Retrieved October 4, 2021.
  13. ^ Syeda, Ruhma; Xu, Jie; Dubin, Adrienne E; Coste, Bertrand; Mathur, Jayanti; Huynh, Truc; Matzen, Jason; Lao, Jianmin; Tully, David C; Engels, Ingo H; Petrassi, H Michael; Schumacher, Andrew M; Montal, Mauricio; Bandell, Michael; Patapoutian, Ardem (May 22, 2015). "Chemical activation of the mechanotransduction channel Piezo1". eLife. 4. eLife Sciences Publications, Ltd. doi:10.7554/elife.07369. ISSN 2050-084X. PMC 4456433. PMID 26001275.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  14. ^ Murthy, Swetha E.; Dubin, Adrienne E.; Patapoutian, Ardem (October 4, 2017). "Piezos thrive under pressure: mechanically activated ion channels in health and disease". Nature Reviews Molecular Cell Biology. 18 (12). Springer Science and Business Media LLC: 771–783. doi:10.1038/nrm.2017.92. ISSN 1471-0072. PMID 28974772. S2CID 20977908.
  15. ^ Ardem Patapoutian publications indexed by Google Scholar Edit this at Wikidata
  16. ^ "Patapoutian, Ardem". scopus.com. Scopus. Archived from the original on October 4, 2021.
  17. ^ "Ardem Patapoutian". www.nasonline.org. Archived from the original on June 3, 2020. Retrieved January 30, 2021.
  18. ^ "Members Elected in 2020". American Academy of Arts & Sciences. Archived from the original on January 22, 2021. Retrieved January 30, 2021.
  19. ^ "The Thirty-Ninth Annual W. Alden Spencer Award and Lecture". Kavli Institute for Brain Science. June 4, 2020. Archived from the original on December 27, 2020. Retrieved January 30, 2021.
  20. ^ "Lewis S. Rosenstiel Award for Distinguished Work in Basic Medical Research". www.brandeis.edu. Archived from the original on June 15, 2021. Retrieved January 30, 2021.
  21. ^ "2020 Kavli Prize in Neuroscience". www.kavliprize.org. March 12, 2021. Archived from the original on June 24, 2021. Retrieved June 23, 2021.
  22. ^ "Fundación BBVA". FBBVA. Archived from the original on January 30, 2021. Retrieved January 30, 2021.
  23. ^ "Armenian President congratulates Ardem Patapoutian on winning the Nobel Prize in Medicine". Public Radio of Armenia. October 4, 2021. Retrieved October 5, 2021.

External links

Scholia has an author profile for Ardem Patapoutian.
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