α-Neoendorphin

α-Neoendorphin
Names
	Other names Alpha-Neoendorphin
Identifiers
CAS Number	69671-17-6;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:80261;
ChEMBL	ChEMBL2409222;
ChemSpider	4470544;
IUPHAR/BPS	1600;
KEGG	C16039;
PubChem CID	5311003;
CompTox Dashboard (EPA)	DTXSID701029640 ;
	InChI InChI=1S/C60H89N15O13/c1-36(2)30-46(73-56(84)47(32-37-12-4-3-5-13-37)69-51(79)35-67-50(78)34-68-52(80)42(63)31-38-18-22-40(76)23-19-38)55(83)71-44(16-10-28-66-60(64)65)53(81)70-43(14-6-8-26-61)54(82)74-48(33-39-20-24-41(77)25-21-39)58(86)75-29-11-17-49(75)57(85)72-45(59(87)88)15-7-9-27-62/h3-5,12-13,18-25,36,42-49,76-77H,6-11,14-17,26-35,61-63H2,1-2H3,(H,67,78)(H,68,80)(H,69,79)(H,70,81)(H,71,83)(H,72,85)(H,73,84)(H,74,82)(H,87,88)(H4,64,65,66)/t42-,43-,44-,45-,46-,47-,48-,49-/m0/s1 Key: KZTDMJBCZSGHOG-XJIZABAQSA-N;
	SMILES N[C@@H](CC1=CC=C(O)C=C1)C(NCC(NCC(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CC3=CC=C(O)C=C3)C(N4CCC[C@H]4C(N[C@H](C(O)=O)CCCCN)=O)=O)=O)=O)=O)=O)=O)=O)=O;
Properties
Chemical formula	C60H89N15O13
Molar mass	1228.464 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

α-Neoendorphin is an endogenous opioid peptide with a decapeptide structure and the amino acid sequence Tyr-Gly-Gly-Phe-Leu-Arg-Lys-Tyr-Pro-Lys.^[1]

α-Neoendorphin is a neuropeptide. Prodynorphin or Proenkephalin B is its precursor. Researchers and anatomists have not yet studied the distribution of α-neoendorphin in the human in detail. However, some studies have been done which supports the presence of α-neoendorphin immunoreactive fibers throughout the human brainstem. According to a study done by Duque, Ewing, Arturo Mangas, Pablo Salinas, Zaida Díaz-cabiale, José Narváez, and Rafael Coveñas; α-neoendorphin immunoreactive fibers can be found in the caudal part of the solitary nucleus, in the caudal and the gelatinosa parts of the spinal trigeminal nucleus, and only low density was found in the central grey matter of medulla.^[2]

References

^ Kangawa K.; Minamino N.; Chino N (1981). "The complete amino acid sequence of α-neo-endorphin". Biochemical and Biophysical Research Communications. 99 (3): 871–878. doi:10.1016/0006-291X(81)91244-4. PMID 7247946.
^ Duque, Ewing; Mangas, Arturo; Salinas, Pablo; Díaz-Cabiale, Zaida; Narváez, José Angel; Coveñas, Rafael (2012-02-09). "Mapping of alpha-neo-endorphin- and neurokinin B-immunoreactivity in the human brainstem". Brain Structure and Function. 218 (1): 131–149. doi:10.1007/s00429-012-0388-3. ISSN 1863-2653. PMID 22318412. S2CID 253974523.

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[1] Kangawa K.; Minamino N.; Chino N (1981). "The complete amino acid sequence of α-neo-endorphin". Biochemical and Biophysical Research Communications. 99 (3): 871–878. doi:10.1016/0006-291X(81)91244-4. PMID 7247946.

[2] Duque, Ewing; Mangas, Arturo; Salinas, Pablo; Díaz-Cabiale, Zaida; Narváez, José Angel; Coveñas, Rafael (2012-02-09). "Mapping of alpha-neo-endorphin- and neurokinin B-immunoreactivity in the human brainstem". Brain Structure and Function. 218 (1): 131–149. doi:10.1007/s00429-012-0388-3. ISSN 1863-2653. PMID 22318412. S2CID 253974523.

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[2]

See also

References