Jalal ISAAD is born in Mohammedia - Morocco on October 27th, 1979. In 2004, he obtained his master’s degree y in Fine Organic Chemistry from Claude Bernard Lyon 1 University – France. In September 2005, he joined the group of Pr. Roberto Bianchini as PhD student at Florence University – Italy, where he obtained his PhD in chemical sciences on February 2009. From 2009 to 2014, he was associate research professor of chemistry and then researcher at École nationale supérieure des arts et industries textile – France, and since April 2015 he is an assistant professor of organic chemistry at Faculty of Science and Technology Al Hoceima- Morocco and member of the research team “Engineering Environment, Food and Valuation of Bio-molecules” in the same Faculty. His research interests revolve around the design and synthesis of new bio-derived materials (polymers, nanoparticles, and macromolecules) and their application in removal and chemo-sensing of toxic anions, heavy metals and VOCs for wastewater treatments. Jalal Isaad has participated in the realization of an Italian industrial project and 2 research & development projects funded by the European Union, and he is editorial board member in 8 international journals of chemistry and has more than 41 articles, 1 European patent, and more than 29 conference presentations in international conferences.
Novel water soluble triazene dyes based on glyco-conjugated pyrazolone amines were synthetized by... more Novel water soluble triazene dyes based on glyco-conjugated pyrazolone amines were synthetized by using N-propyl-2-pyrrolidonium hydrogen sulfate supported on silica-coated magnetite nanoparticle as acid catalyst. This organic–inorganic hybrid composite showed an excellent catalytic activity toward diazotization reaction of pyrazolone amines performing triazene dyes under solvent-free conditions in high yields. The spectroscopic properties confirmed the tendency of these dyes to exist in their hydrazo-keto tautomer forms. The study of the solubility of these dyes in water showed that their water solubility requires a minimum percentage weight of 50% of the carbohydrate part.
Abstract Novel family of azoic dyes pyrazolone based were prepared by an efficient and rapid meth... more Abstract Novel family of azoic dyes pyrazolone based were prepared by an efficient and rapid methodology through diazotization reaction of different pyrazolone amine derivatives, in the presence of acidic ionic liquid supported on silica-coated magnetite nanoparticles as acidic catalyst at room temperature and under solvent-free conditions. The attractive advantages of the present process include short reaction times, milder and cleaner conditions, higher purity and yields, easy isolation of products, easier work-up procedure and lower generation of waste or pollution. This catalyst was easily separated by an external magnet and the recovered catalyst was reused several times without any significant loss of activity. Therefore, this method provides improved protocol over the existing methods.
Pomegranate peel (PP), a by-product of agro-food consumption, has a low adsorption capacity for n... more Pomegranate peel (PP), a by-product of agro-food consumption, has a low adsorption capacity for nitrate and phosphate ions in aqueous media, but its surface is very rich in alcohol functional groups. In this work, the surface of pomegranate peels was functionalized by chemo-grafting 3-(2-Aminoethylamino) propyl] trimethoxy silane (AEAPTES) using the availability of alcohol groups to increase the adsorption capacity of the resulting adsorbent (PP/AEAPTES) towards nitrate and phosphate ions. The prepared PP/AEAPTES adsorbent was analyzed by Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), Zeta potential, and X-ray photoelectron spectrometry (XPS). Under experimental conditions, the adsorption capacity of PP/AEAPTES has been found to be 124.57 mg/g and 94.65 mg/g for NO3− and PO43−, respectively, at pH 6 over a wide temperature range, and adsorption is exothermic for NO3− and endothermic for PO43−, as well as spontaneous and physical in nature. The adsorptions ...
In recent years, several studies have focused on environmental pollutants. Bisphenol A (BPA) is o... more In recent years, several studies have focused on environmental pollutants. Bisphenol A (BPA) is one prominent industrial raw material, and its extensive utilization and release into the environment constitute an environmental hazard. BPA is considered as to be an endocrine disruptor which mimics hormones, and has a direct relationship to the development and growth of animal and human reproductive systems. Moreover, intensive exposure to the compound is related to prostate and breast cancer, infertility, obesity, and diabetes. Hence, accurate and reliable determination techniques are crucial for preventing human exposure to BPA. Experts in the field have published general electrochemical procedures for detecting BPA. The present timely review critically evaluates diverse chemically modified electrodes using various substances that have been reported in numerous studies in the recent decade for use in electrochemical sensors and biosensors to detect BPA. Additionally, the essential co...
ABSTRACT The potential use of vanillin for the chemical substitution of toxic carriers used in lo... more ABSTRACT The potential use of vanillin for the chemical substitution of toxic carriers used in low temperature dyeing of polyester fabrics, was assessed. Both para and ortho-vanillin were used to compare the dyeing of a woven polyester fabric with two different blue disperse dyes: a high molecular weight anthraqui-none dye D-79 and a low molecular weight azoic dye D-56. When 1 g of vanillin was used for dyeing with 3% of disperse dye, the dye uptakes increased for both vanillins, but were higher with ortho-vanillin especially in the case of the low molecular weight dye. The impact of different dyeing parameters such as pH, o-vanillin concentration and use of ethanol co-solvent, on the dye uptake was also studied. Highest dye uptake was reached with 2 g of ortho-vanillin at pH 7, without use of the co-solvent. Dye uptakes were compared to those of traditional carriers such as phenylphenol, dichlorobenzene, benzoic acid, and a commercial Levegal DTE carrier. With 2 g of vanillin, K/S of dyed fabric reached 16, which is equivalent to that obtained with 1 g of the commercial carrier. The study confirms that vanillin can be used as a chemical substitute to traditional carriers and leads to good wash and rub fastness properties. At present, few literature data are available to compare toxicity of all carriers and apply the principle of substitution. A toxicity analysis carried out using USEtox (TM) model showed that both para and ortho vanillins used in agro-food industries are not recognized as toxic for human health, unlike most traditional carriers. Ortho-vanillin has however high ecotoxicity.
A new selective chemodosimeter probe of cyanide anions in aqueous media was developed by the intr... more A new selective chemodosimeter probe of cyanide anions in aqueous media was developed by the introduction of a simple glyco-conjugated o-(carboxamido) aldehyde hydrazone into an azo dye as chemodosimeter that recognizes cyanide anions among other competing anions such as acetate, dihydrogen phosphate, fluoride through reversible covalent bonding. The sensing properties of the new materials were investigated in pure water and have demonstrated a very high selectivity toward the cyanide anions. The detection limit of the new chromogenic probe was measured to be 1.29 μM which is much lower than most recently reported chromogenic probes for cyanide determination.
The elaboration of some N‐alkylated pyrazole‐tetrazole derivatives is reported. The structures of... more The elaboration of some N‐alkylated pyrazole‐tetrazole derivatives is reported. The structures of the newly ones are verified using NMR and FTIR spectroscopies, mass spectrometry as well as elemental analysis. Their potencies to inhibit the α‐amylase enzyme were evaluated using spectrophotometric method and the obtained results showed that some of them were extremely potent with respect to the used positive control. The structure activity relationship showed that the α‐amylase inhibition activity depends on the alkylation position as well as the nature of the alkyl moiety and the alkylation at the N1 position with a donor group improves the α‐amylase inhibition activity. Docking study was also performed and the obtained results support the experimental results in the case of the alkylation position effect. These findings suggest that the molecules reported in this study may be used as good drug candidate to treat Type 2 diabetes.
Novel water soluble triazene dyes based on glyco-conjugated pyrazolone amines were synthetized by... more Novel water soluble triazene dyes based on glyco-conjugated pyrazolone amines were synthetized by using N-propyl-2-pyrrolidonium hydrogen sulfate supported on silica-coated magnetite nanoparticle as acid catalyst. This organic–inorganic hybrid composite showed an excellent catalytic activity toward diazotization reaction of pyrazolone amines performing triazene dyes under solvent-free conditions in high yields. The spectroscopic properties confirmed the tendency of these dyes to exist in their hydrazo-keto tautomer forms. The study of the solubility of these dyes in water showed that their water solubility requires a minimum percentage weight of 50% of the carbohydrate part.
Abstract Novel family of azoic dyes pyrazolone based were prepared by an efficient and rapid meth... more Abstract Novel family of azoic dyes pyrazolone based were prepared by an efficient and rapid methodology through diazotization reaction of different pyrazolone amine derivatives, in the presence of acidic ionic liquid supported on silica-coated magnetite nanoparticles as acidic catalyst at room temperature and under solvent-free conditions. The attractive advantages of the present process include short reaction times, milder and cleaner conditions, higher purity and yields, easy isolation of products, easier work-up procedure and lower generation of waste or pollution. This catalyst was easily separated by an external magnet and the recovered catalyst was reused several times without any significant loss of activity. Therefore, this method provides improved protocol over the existing methods.
Pomegranate peel (PP), a by-product of agro-food consumption, has a low adsorption capacity for n... more Pomegranate peel (PP), a by-product of agro-food consumption, has a low adsorption capacity for nitrate and phosphate ions in aqueous media, but its surface is very rich in alcohol functional groups. In this work, the surface of pomegranate peels was functionalized by chemo-grafting 3-(2-Aminoethylamino) propyl] trimethoxy silane (AEAPTES) using the availability of alcohol groups to increase the adsorption capacity of the resulting adsorbent (PP/AEAPTES) towards nitrate and phosphate ions. The prepared PP/AEAPTES adsorbent was analyzed by Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), Zeta potential, and X-ray photoelectron spectrometry (XPS). Under experimental conditions, the adsorption capacity of PP/AEAPTES has been found to be 124.57 mg/g and 94.65 mg/g for NO3− and PO43−, respectively, at pH 6 over a wide temperature range, and adsorption is exothermic for NO3− and endothermic for PO43−, as well as spontaneous and physical in nature. The adsorptions ...
In recent years, several studies have focused on environmental pollutants. Bisphenol A (BPA) is o... more In recent years, several studies have focused on environmental pollutants. Bisphenol A (BPA) is one prominent industrial raw material, and its extensive utilization and release into the environment constitute an environmental hazard. BPA is considered as to be an endocrine disruptor which mimics hormones, and has a direct relationship to the development and growth of animal and human reproductive systems. Moreover, intensive exposure to the compound is related to prostate and breast cancer, infertility, obesity, and diabetes. Hence, accurate and reliable determination techniques are crucial for preventing human exposure to BPA. Experts in the field have published general electrochemical procedures for detecting BPA. The present timely review critically evaluates diverse chemically modified electrodes using various substances that have been reported in numerous studies in the recent decade for use in electrochemical sensors and biosensors to detect BPA. Additionally, the essential co...
ABSTRACT The potential use of vanillin for the chemical substitution of toxic carriers used in lo... more ABSTRACT The potential use of vanillin for the chemical substitution of toxic carriers used in low temperature dyeing of polyester fabrics, was assessed. Both para and ortho-vanillin were used to compare the dyeing of a woven polyester fabric with two different blue disperse dyes: a high molecular weight anthraqui-none dye D-79 and a low molecular weight azoic dye D-56. When 1 g of vanillin was used for dyeing with 3% of disperse dye, the dye uptakes increased for both vanillins, but were higher with ortho-vanillin especially in the case of the low molecular weight dye. The impact of different dyeing parameters such as pH, o-vanillin concentration and use of ethanol co-solvent, on the dye uptake was also studied. Highest dye uptake was reached with 2 g of ortho-vanillin at pH 7, without use of the co-solvent. Dye uptakes were compared to those of traditional carriers such as phenylphenol, dichlorobenzene, benzoic acid, and a commercial Levegal DTE carrier. With 2 g of vanillin, K/S of dyed fabric reached 16, which is equivalent to that obtained with 1 g of the commercial carrier. The study confirms that vanillin can be used as a chemical substitute to traditional carriers and leads to good wash and rub fastness properties. At present, few literature data are available to compare toxicity of all carriers and apply the principle of substitution. A toxicity analysis carried out using USEtox (TM) model showed that both para and ortho vanillins used in agro-food industries are not recognized as toxic for human health, unlike most traditional carriers. Ortho-vanillin has however high ecotoxicity.
A new selective chemodosimeter probe of cyanide anions in aqueous media was developed by the intr... more A new selective chemodosimeter probe of cyanide anions in aqueous media was developed by the introduction of a simple glyco-conjugated o-(carboxamido) aldehyde hydrazone into an azo dye as chemodosimeter that recognizes cyanide anions among other competing anions such as acetate, dihydrogen phosphate, fluoride through reversible covalent bonding. The sensing properties of the new materials were investigated in pure water and have demonstrated a very high selectivity toward the cyanide anions. The detection limit of the new chromogenic probe was measured to be 1.29 μM which is much lower than most recently reported chromogenic probes for cyanide determination.
The elaboration of some N‐alkylated pyrazole‐tetrazole derivatives is reported. The structures of... more The elaboration of some N‐alkylated pyrazole‐tetrazole derivatives is reported. The structures of the newly ones are verified using NMR and FTIR spectroscopies, mass spectrometry as well as elemental analysis. Their potencies to inhibit the α‐amylase enzyme were evaluated using spectrophotometric method and the obtained results showed that some of them were extremely potent with respect to the used positive control. The structure activity relationship showed that the α‐amylase inhibition activity depends on the alkylation position as well as the nature of the alkyl moiety and the alkylation at the N1 position with a donor group improves the α‐amylase inhibition activity. Docking study was also performed and the obtained results support the experimental results in the case of the alkylation position effect. These findings suggest that the molecules reported in this study may be used as good drug candidate to treat Type 2 diabetes.
Uploads
Papers by JALAL ISAAD