Purpose: Many patients with metastatic bone disease have t o use radiopharmaceuticals associated ... more Purpose: Many patients with metastatic bone disease have t o use radiopharmaceuticals associated with chemotherapy to relieve bone pain. The aim of this study was to assess the influence of docetaxel on the biodistribution of sa marium-153-EDTMP in bones and other organs of rats. Methods: Wistar male rats were randomly allocated into 2 g roups of 6 rats each. The DS (docetaxel/samarium) group received docetaxe l (15 mg/kg) intraperitoneally in two cycles 11 days apart. The S (samarium/control) grou p ats were not treated with docetaxel. Nine days after chemotherapy, all the rats were injected with 0.1ml of samarium-153-EDTMP via orbital plexus (25 μCi). After 2 hours, the animals were killed and sam ples of the brain, thyroid, lung, heart, stomach, colon, liver, kidney and both femurs were removed. The percentage radioactivity of each sample (% ATI/g) was determin ed in an automatic gamma-counter (Wizard-1470, Perkin-Elmer, Finland). Results: On the 9 day after the administration of...
In this work, an experimental and modeling study is described, focusing on the performance of a P... more In this work, an experimental and modeling study is described, focusing on the performance of a Pd–Ag membrane reactor recently proposed and suitable for the production of ultra-pure hydrogen. A packed-bed membrane reactor (MR) with a “finger-like” membrane configuration has been used for carrying out the water-gas shift reaction (WGS) in the region of low temperature operation using a simulated
Purpose: Many patients with metastatic bone disease have t o use radiopharmaceuticals associated ... more Purpose: Many patients with metastatic bone disease have t o use radiopharmaceuticals associated with chemotherapy to relieve bone pain. The aim of this study was to assess the influence of docetaxel on the biodistribution of sa marium-153-EDTMP in bones and other organs of rats. Methods: Wistar male rats were randomly allocated into 2 g roups of 6 rats each. The DS (docetaxel/samarium) group received docetaxe l (15 mg/kg) intraperitoneally in two cycles 11 days apart. The S (samarium/control) grou p ats were not treated with docetaxel. Nine days after chemotherapy, all the rats were injected with 0.1ml of samarium-153-EDTMP via orbital plexus (25 μCi). After 2 hours, the animals were killed and sam ples of the brain, thyroid, lung, heart, stomach, colon, liver, kidney and both femurs were removed. The percentage radioactivity of each sample (% ATI/g) was determin ed in an automatic gamma-counter (Wizard-1470, Perkin-Elmer, Finland). Results: On the 9 day after the administration of...
In this work, an experimental and modeling study is described, focusing on the performance of a P... more In this work, an experimental and modeling study is described, focusing on the performance of a Pd–Ag membrane reactor recently proposed and suitable for the production of ultra-pure hydrogen. A packed-bed membrane reactor (MR) with a “finger-like” membrane configuration has been used for carrying out the water-gas shift reaction (WGS) in the region of low temperature operation using a simulated
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