The next generation of phosphodiesterase inhibitors: structural clues to ligand and substrate selectivity of phosphodiesterases.
Article Details
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Manallack DT, Hughes RA, Thompson PE
The next generation of phosphodiesterase inhibitors: structural clues to ligand and substrate selectivity of phosphodiesterases.
J Med Chem. 2005 May 19;48(10):3449-62.
- PubMed ID
- 15887951 [ View in PubMed]
- Abstract
Not Available
DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) Dipyridamole cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Ki (nM) 1000 N/A N/A Details Tadalafil Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A IC 50 (nM) 60000 N/A N/A Details