Epithelial cell adhesion molecule
Details
- Name
- Epithelial cell adhesion molecule
- Kind
- protein
- Synonyms
- Adenocarcinoma-associated antigen
- Cell surface glycoprotein Trop-1
- EGP
- EGP314
- Ep-CAM
- Epithelial cell surface antigen
- Epithelial glycoprotein
- Epithelial glycoprotein 314
- GA733-2
- hEGP314
- KS 1/4 antigen
- KSA
- M1S2
- M4S1
- Major gastrointestinal tumor-associated protein GA733-2
- MIC18
- TACSTD1
- TROP1
- Tumor-associated calcium signal transducer 1
- Gene Name
- EPCAM
- UniProtKB Entry
- P16422Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0016791|Epithelial cell adhesion molecule MAPPQVLAFGLLLAAATATFAAAQEECVCENYKLAVNCFVNNNRQCQCTSVGAQNTVICS KLAAKCLVMKAEMNGSKLGRRAKPEGALQNNDGLYDPDCDESGLFKAKQCNGTSMCWCVN TAGVRRTDKDTEITCSERVRTYWIIIELKHKAREKPYDSKSLRTALQKEITTRYQLDPKF ITSILYENNVITIDLVQNSSQKTQNDVDIADVAYYFEKDVKGESLFHSKKMDLTVNGEQL DLDPGQTLIYYVDEKAPEFSMQGLKAGVIAVIVVVVIAVVAGIVVLVISRKKRMAKYEKA EIKEMGEMHRELNA
- Number of residues
- 314
- Molecular Weight
- 34932.005
- Theoretical pI
- 7.53
- GO Classification
- Processesnegative regulation of cell-cell adhesion mediated by cadherin / positive regulation of stem cell proliferation / signal transduction involved in regulation of gene expression / stem cell differentiation / ureteric bud developmentComponentsapical plasma membrane / basolateral plasma membrane / bicellular tight junction / cell surface / extracellular exosome / lateral plasma membrane / plasma membrane
- General Function
- May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E
- Specific Function
- cadherin binding involved in cell-cell adhesion
- Pfam Domain Function
- Signal Regions
- 1-23
- Transmembrane Regions
- 266-288
- Cellular Location
- Lateral cell membrane
- Gene sequence
>lcl|BSEQ0016792|Epithelial cell adhesion molecule (EPCAM) ATGGCGCCCCCGCAGGTCCTCGCGTTCGGGCTTCTGCTTGCCGCGGCGACGGCGACTTTT GCCGCAGCTCAGGAAGAATGTGTCTGTGAAAACTACAAGCTGGCCGTAAACTGCTTTGTG AATAATAATCGTCAATGCCAGTGTACTTCAGTTGGTGCACAAAATACTGTCATTTGCTCA AAGCTGGCTGCCAAATGTTTGGTGATGAAGGCAGAAATGAATGGCTCAAAACTTGGGAGA AGAGCAAAACCTGAAGGGGCCCTCCAGAACAATGATGGGCTTTATGATCCTGACTGCGAT GAGAGCGGGCTCTTTAAGGCCAAGCAGTGCAACGGCACCTCCATGTGCTGGTGTGTGAAC ACTGCTGGGGTCAGAAGAACAGACAAGGACACTGAAATAACCTGCTCTGAGCGAGTGAGA ACCTACTGGATCATCATTGAACTAAAACACAAAGCAAGAGAAAAACCTTATGATAGTAAA AGTTTGCGGACTGCACTTCAGAAGGAGATCACAACGCGTTATCAACTGGATCCAAAATTT ATCACGAGTATTTTGTATGAGAATAATGTTATCACTATTGATCTGGTTCAAAATTCTTCT CAAAAAACTCAGAATGATGTGGACATAGCTGATGTGGCTTATTATTTTGAAAAAGATGTT AAAGGTGAATCCTTGTTTCATTCTAAGAAAATGGACCTGACAGTAAATGGGGAACAACTG GATCTGGATCCTGGTCAAACTTTAATTTATTATGTTGATGAAAAAGCACCTGAATTCTCA ATGCAGGGTCTAAAAGCTGGTGTTATTGCTGTTATTGTGGTTGTGGTGATAGCAGTTGTT GCTGGAATTGTTGTGCTGGTTATTTCCAGAAAGAAGAGAATGGCAAAGTATGAGAAGGCT GAGATAAAGGAGATGGGTGAGATGCATAGGGAACTCAATGCATAA
- Chromosome Location
- 2
- Locus
- 2p21
- External Identifiers
Resource Link UniProtKB ID P16422 UniProtKB Entry Name EPCAM_HUMAN GenBank Gene ID M32325 GeneCard ID EPCAM GenAtlas ID TACSTD1 HGNC ID HGNC:11529 PDB ID(s) 4MZV, 6I07 KEGG ID hsa:4072 NCBI Gene ID 4072 - General References
- Strnad J, Hamilton AE, Beavers LS, Gamboa GC, Apelgren LD, Taber LD, Sportsman JR, Bumol TF, Sharp JD, Gadski RA: Molecular cloning and characterization of a human adenocarcinoma/epithelial cell surface antigen complementary DNA. Cancer Res. 1989 Jan 15;49(2):314-7. [Article]
- Perez MS, Walker LE: Isolation and characterization of a cDNA encoding the KS1/4 epithelial carcinoma marker. J Immunol. 1989 May 15;142(10):3662-7. [Article]
- Simon B, Podolsky DK, Moldenhauer G, Isselbacher KJ, Gattoni-Celli S, Brand SJ: Epithelial glycoprotein is a member of a family of epithelial cell surface antigens homologous to nidogen, a matrix adhesion protein. Proc Natl Acad Sci U S A. 1990 Apr;87(7):2755-9. [Article]
- Szala S, Froehlich M, Scollon M, Kasai Y, Steplewski Z, Koprowski H, Linnenbach AJ: Molecular cloning of cDNA for the carcinoma-associated antigen GA733-2. Proc Natl Acad Sci U S A. 1990 May;87(9):3542-6. [Article]
- Linnenbach AJ, Seng BA, Wu S, Robbins S, Scollon M, Pyrc JJ, Druck T, Huebner K: Retroposition in a family of carcinoma-associated antigen genes. Mol Cell Biol. 1993 Mar;13(3):1507-15. [Article]
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- Linnenbach AJ, Wojcierowski J, Wu SA, Pyrc JJ, Ross AH, Dietzschold B, Speicher D, Koprowski H: Sequence investigation of the major gastrointestinal tumor-associated antigen gene family, GA733. Proc Natl Acad Sci U S A. 1989 Jan;86(1):27-31. [Article]
- Bjork P, Jonsson U, Svedberg H, Larsson K, Lind P, Dillner J, Hedlund G, Dohlsten M, Kalland T: Isolation, partial characterization, and molecular cloning of a human colon adenocarcinoma cell-surface glycoprotein recognized by the C215 mouse monoclonal antibody. J Biol Chem. 1993 Nov 15;268(32):24232-41. [Article]
- Chong JM, Speicher DW: Determination of disulfide bond assignments and N-glycosylation sites of the human gastrointestinal carcinoma antigen GA733-2 (CO17-1A, EGP, KS1-4, KSA, and Ep-CAM). J Biol Chem. 2001 Feb 23;276(8):5804-13. Epub 2000 Nov 15. [Article]
- Munz M, Kieu C, Mack B, Schmitt B, Zeidler R, Gires O: The carcinoma-associated antigen EpCAM upregulates c-myc and induces cell proliferation. Oncogene. 2004 Jul 29;23(34):5748-58. [Article]
- Munz M, Zeidler R, Gires O: The tumour-associated antigen EpCAM upregulates the fatty acid binding protein E-FABP. Cancer Lett. 2005 Jul 8;225(1):151-7. Epub 2004 Dec 28. [Article]
- Ladwein M, Pape UF, Schmidt DS, Schnolzer M, Fiedler S, Langbein L, Franke WW, Moldenhauer G, Zoller M: The cell-cell adhesion molecule EpCAM interacts directly with the tight junction protein claudin-7. Exp Cell Res. 2005 Oct 1;309(2):345-57. [Article]
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- Chen R, Jiang X, Sun D, Han G, Wang F, Ye M, Wang L, Zou H: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. J Proteome Res. 2009 Feb;8(2):651-61. doi: 10.1021/pr8008012. [Article]
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- Lu TY, Lu RM, Liao MY, Yu J, Chung CH, Kao CF, Wu HC: Epithelial cell adhesion molecule regulation is associated with the maintenance of the undifferentiated phenotype of human embryonic stem cells. J Biol Chem. 2010 Mar 19;285(12):8719-32. doi: 10.1074/jbc.M109.077081. Epub 2010 Jan 11. [Article]
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Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Oportuzumab monatox investigational unknown target Details ING-1 investigational unknown target Details Citatuzumab Bogatox investigational unknown target Details Catumaxomab approved, investigational, withdrawn no target ligand Details Technetium Tc-99m nofetumomab merpentan approved, withdrawn yes target binder Details Hypromellose approved unknown target Details