Tumor-associated calcium signal transducer 2
Details
- Name
- Tumor-associated calcium signal transducer 2
- Kind
- protein
- Synonyms
- Cell surface glycoprotein Trop-2
- GA733-1
- M1S1
- Membrane component chromosome 1 surface marker 1
- Pancreatic carcinoma marker protein GA733-1
- TROP2
- Gene Name
- TACSTD2
- UniProtKB Entry
- P09758Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0052393|Tumor-associated calcium signal transducer 2 MARGPGLAPPPLRLPLLLLVLAAVTGHTAAQDNCTCPTNKMTVCSPDGPGGRCQCRALGS GMAVDCSTLTSKCLLLKARMSAPKNARTLVRPSEHALVDNDGLYDPDCDPEGRFKARQCN QTSVCWCVNSVGVRRTDKGDLSLRCDELVRTHHILIDLRHRPTAGAFNHSDLDAELRRLF RERYRLHPKFVAAVHYEQPTIQIELRQNTSQKAAGDVDIGDAAYYFERDIKGESLFQGRG GLDLRVRGEPLQVERTLIYYLDEIPPKFSMKRLTAGLIAVIVVVVVALVAGMAVLVITNR RKSGKYKKVEIKELGELRKEPSL
- Number of residues
- 323
- Molecular Weight
- 35709.02
- Theoretical pI
- Not Available
- GO Classification
- Processesnegative regulation of branching involved in ureteric bud morphogenesis / negative regulation of cell motility / negative regulation of epithelial cell migration / negative regulation of ruffle assembly / negative regulation of stress fiber assembly / negative regulation of substrate adhesion-dependent cell spreading / positive regulation of stem cell differentiation / regulation of epithelial cell proliferation / ureteric bud morphogenesis / visual perceptionComponentsbasal plasma membrane / cytosol / extracellular exosome / extracellular space / lateral plasma membrane / membrane / nucleus
- General Function
- May function as a growth factor receptor
- Specific Function
- Not Available
- Pfam Domain Function
- Signal Regions
- 1-26
- Transmembrane Regions
- 275-297
- Cellular Location
- Membrane
- Gene sequence
>lcl|BSEQ0052394|Tumor-associated calcium signal transducer 2 (TACSTD2) ATGGCTCGGGGCCCCGGCCTCGCGCCGCCACCGCTGCGGCTGCCGCTGCTGCTGCTGGTG CTGGCGGCGGTGACCGGCCACACGGCCGCGCAGGACAACTGCACGTGTCCCACCAACAAG ATGACCGTGTGCAGCCCCGACGGCCCCGGCGGCCGCTGCCAGTGCCGCGCGCTGGGCTCG GGCATGGCGGTCGACTGCTCCACGCTGACCTCCAAGTGTCTGCTGCTCAAGGCGCGCATG AGCGCCCCCAAGAACGCCCGCACGCTGGTGCGGCCGAGTGAGCACGCGCTCGTGGACAAC GATGGCCTCTACGACCCCGACTGCGACCCCGAGGGCCGCTTCAAGGCGCGCCAGTGCAAC CAGACGTCGGTGTGCTGGTGCGTGAACTCGGTGGGCGTGCGCCGCACGGACAAGGGCGAC CTGAGCCTACGCTGCGATGAGCTGGTGCGCACCCACCACATCCTCATTGACCTGCGCCAC CGCCCCACCGCCGGCGCCTTCAACCACTCAGACCTGGACGCCGAGCTGAGGCGGCTCTTC CGCGAGCGCTATCGGCTGCACCCCAAGTTCGTGGCGGCCGTGCACTACGAGCAGCCCACC ATCCAGATCGAGCTGCGGCAGAACACGTCTCAGAAGGCCGCCGGTGACGTGGATATCGGC GATGCCGCCTACTACTTCGAGAGGGACATCAAGGGCGAGTCTCTATTCCAGGGCCGCGGC GGCCTGGACTTGCGCGTGCGCGGAGAACCCCTGCAGGTGGAGCGCACGCTCATCTATTAC CTGGACGAGATTCCCCCGAAGTTCTCCATGAAGCGCCTCACCGCCGGCCTCATCGCCGTC ATCGTGGTGGTCGTGGTGGCCCTCGTCGCCGGCATGGCCGTCCTGGTGATCACCAACCGG AGAAAGTCGGGGAAGTACAAGAAGGTGGAGATCAAGGAACTGGGGGAGTTGAGAAAGGAA CCGAGCTTGTAG
- Chromosome Location
- 1
- Locus
- 1p32.1
- External Identifiers
Resource Link UniProtKB ID P09758 UniProtKB Entry Name TACD2_HUMAN GeneCard ID TACSTD2 HGNC ID HGNC:11530 PDB ID(s) 2MAE, 2MVK, 2MVL, 7E5M, 7E5N, 7PEE KEGG ID hsa:4070 IUPHAR/Guide To Pharmacology ID 2837 NCBI Gene ID 4070 - General References
- Linnenbach AJ, Wojcierowski J, Wu SA, Pyrc JJ, Ross AH, Dietzschold B, Speicher D, Koprowski H: Sequence investigation of the major gastrointestinal tumor-associated antigen gene family, GA733. Proc Natl Acad Sci U S A. 1989 Jan;86(1):27-31. [Article]
- Linnenbach AJ, Seng BA, Wu S, Robbins S, Scollon M, Pyrc JJ, Druck T, Huebner K: Retroposition in a family of carcinoma-associated antigen genes. Mol Cell Biol. 1993 Mar;13(3):1507-15. [Article]
- Fornaro M, Dell'Arciprete R, Stella M, Bucci C, Nutini M, Capri MG, Alberti S: Cloning of the gene encoding Trop-2, a cell-surface glycoprotein expressed by human carcinomas. Int J Cancer. 1995 Sep 4;62(5):610-8. doi: 10.1002/ijc.2910620520. [Article]
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- Tsujikawa M, Kurahashi H, Tanaka T, Nishida K, Shimomura Y, Tano Y, Nakamura Y: Identification of the gene responsible for gelatinous drop-like corneal dystrophy. Nat Genet. 1999 Apr;21(4):420-3. doi: 10.1038/7759. [Article]
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Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Sacituzumab govitecan approved, investigational yes target antibody Details