MK-4721
Explore a selection of our essential drug information below, or:
Identification
- Generic Name
- MK-4721
- DrugBank Accession Number
- DB05933
- Background
MK-4721 is a fully human monoclonal antibody directed to Agensys’ proprietary target Prostate Stem Cell Antigen (PSCA), an antigen expressed at significant levels on tumor cells from the majority of patients with all stages of prostate, pancreatic and bladder cancers.
- Type
- Biotech
- Groups
- Investigational
- Biologic Classification
- Protein Based Therapies
Monoclonal antibody (mAb) - Protein Chemical Formula
- Not Available
- Protein Average Weight
- Not Available
- Sequences
- Not Available
- Synonyms
- ANTI-PSCA MONOCLONAL ANTIBODY AGS-1C4D4
- External IDs
- AGS 1C4D4
- AGS-1C4D4
- AGS-PSCA
Pharmacology
- Indication
Investigated for use/treatment in prostate cancer.
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- Pharmacodynamics
Not Available
- Mechanism of action
AGS-PSCA is a high affinity, fully human IgG1k MAb directed to PSCA, generated using XenoMouse technology. PSCA is expressed at significant levels on tumor cells from a majority of patients with all stages of prostate, pancreatic and bladder cancers. Pre-clinical studies utilizing human specimens of these tumors in xenograft mouse models have consistently demonstrated that AGS-PSCA significantly inhibits both tumor growth and metastases. Pre-clinical animal toxicology and pharmacokinetic studies have indicated that all administered doses of AGS-PSCA is well tolerated and demonstrated a long serum half-life.
Target Actions Organism UProstate stem cell antigen Not Available Humans - Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
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- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- Not Available
- Kingdom
- Organic Compounds
- Super Class
- Organic Acids
- Class
- Carboxylic Acids and Derivatives
- Sub Class
- Amino Acids, Peptides, and Analogues
- Direct Parent
- Peptides
- Alternative Parents
- Not Available
- Substituents
- Not Available
- Molecular Framework
- Not Available
- External Descriptors
- Not Available
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- L0505LPC7O
- CAS number
- Not Available
References
- General References
- Not Available
- External Links
- Not Available
Clinical Trials
- Clinical Trials
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Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
- Not Available
Targets
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- May be involved in the regulation of cell proliferation. Has a cell-proliferation inhibition activity in vitro.
- Specific Function
- acetylcholine receptor binding
- Gene Name
- PSCA
- Uniprot ID
- O43653
- Uniprot Name
- Prostate stem cell antigen
- Molecular Weight
- 11958.705 Da
Drug created at November 18, 2007 18:28 / Updated at October 03, 2023 22:09