Sulfur
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Identification
- Summary
Sulfur is an ingredient of various cosmetic preparations for its keratolytic, antifungal, and antibacterial properties.
- Brand Names
- Acnomel, Avar, Plexion, Rezamid, Sumadan Wash, Sumaxin
- Generic Name
- Octasulfur
Commonly known or available as Sulfur - DrugBank Accession Number
- DB09353
- Background
Sulfur is a chemical element that is present in all living tissues. The most commonly used form of pharmaceutical sulfur is Octasulfur (S8). After calcium and phosphorus, it is the third most abundant mineral in the human body. Sulfur is also found in garlic, onions and broccoli.
People take sulfur by mouth for shortness of breath, allergies, swelling in the back of the throat (pharyngitis), high cholesterol, clogged arteries, menopause, and upper respiratory tract infections like the common cold. Sulfur seems to have an antibacterial activity. It has been also used for acne.
- Type
- Small Molecule
- Groups
- Approved
- Structure
- Weight
- Average: 256.52
Monoisotopic: 255.77656552 - Chemical Formula
- S8
- Synonyms
- Cyclooctasulfur
Pharmacology
- Indication
Topically it is indicated for dandruff, acne, Hayfever, common cold, scaly and red skin patches (seborrheic dermatitis). Poison ivy, and sumac infections.
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Associated Conditions
Indication Type Indication Combined Product Details Approval Level Age Group Patient Characteristics Dose Form Used in combination to treat Acne Combination Product in combination with: Salicylic acid (DB00936) ••• ••• ••••• Treatment of Acne ••• ••• Used in combination to prevent Blemishes caused by acne Combination Product in combination with: Salicylic acid (DB00936) ••• ••• ••••• Used in combination to treat Blemishes caused by acne Combination Product in combination with: Salicylic acid (DB00936) ••• ••• ••••• - Contraindications & Blackbox Warnings
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- Pharmacodynamics
Sulfur is converted to hydrogen sulfide (H2S) through reduction, partly by bacteria. H2S has a lethal action on bacteria (possibly including Propionibacterium acnes) which plays a role in acne, fungi, and parasites such as scabies mites.
- Mechanism of action
Sulfur acts as a keratolytic agent and also it has antibacterial activity. It also kills fungi, scabies mites and other parasites. Precipitated sulfur and colloidal sulfur are used, in form of lotions, creams, powders, soaps, and bath additives, for the treatment of acne vulgaris, acne rosacea, and seborrhoeic dermatitis.
- Absorption
Intended for local use only, no systemic absorption.
- Volume of distribution
Intended for local use only, no systemic absorption.
- Protein binding
Intended for local use only, no systemic absorption.
- Metabolism
Intended for local use only, no systemic absorption.
- Route of elimination
Intended for local use only, no systemic absorption.
- Half-life
Intended for local use only, no systemic absorption.
- Clearance
Intended for local use only, no systemic absorption.
- Adverse Effects
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- Toxicity
rat oral LD50 of greater than 5,000 mg/kg (3, 10); and greater than 8,437 mg/kg.
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- No interactions found.
Products
- Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.
- Brand Name Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Sodium Sulfacetamide and Sulfur Kit 1250 mg/25g Topical Perrigo New York Inc. 2008-10-08 2012-02-01 US - Over the Counter Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image 111MedCo 6% Sulfur Skin Cleansing Bar Soap 60 mg/1g Topical 111MedCo LLC 2023-09-06 Not applicable US 5s Blemish Treatment Cream 3 % Topical Shiseido Company Ltd. 2000-09-15 2003-07-01 Canada Acne All-Star 3-in-1 Acne Cleanser, Mask and Spot Treatment Liquid 0.03 g/1g Topical Tula Life Llc 2022-07-25 Not applicable US Acne and Blemish Control Mask Cream 5 g/100mL Topical USRX LLC 2020-04-28 Not applicable US Acne Blemish Cream(sulfur Cream) Cream 4 % Topical Bonne Bell Llc 1987-12-31 1999-07-07 Canada - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Acne Aid Gel Octasulfur (2.5 %) + Chloroxylenol (.375 %) + Resorcinol (1.25 %) Gel Topical Stiefel Laboratories, Inc. 1966-12-31 1998-07-09 Canada Acne Clearning Treatment Face Octasulfur (.012 mg/.024mg) + Benzoyl peroxide (.006 mg/.024mg) + Salicylic acid (.0048 mg/.024mg) Liquid Topical Care Pluss Pharma S.A. De C.V. 2012-08-06 Not applicable US Acne Drying Topical Octasulfur (8 g/100mL) + Resorcinol (2 g/100mL) Lotion Topical Only Yourx, Inc. 2014-08-26 Not applicable US Acne Treatment maximum strength CVS Octasulfur (8 g/100g) + Resorcinol (2 g/100g) Cream Topical CVS Health 2014-12-26 Not applicable US Acne Vanishing Gel- 10% with Sulfur Octasulfur (3 g/100mL) + Benzoyl peroxide (10 g/100mL) Gel Topical Only Yourx, Inc. 2014-03-28 Not applicable US - Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Avar Octasulfur (50 mg/1g) + Sulfacetamide sodium (100 mg/1g) Emulsion Topical Mission Pharmacal Company 2011-09-15 Not applicable US Avar Octasulfur (50 mg/1g) + Sulfacetamide sodium (95 mg/1g) Aerosol, foam Topical Mission Pharmacal Company 2010-07-15 2019-05-31 US Avar Cleansing Pads Octasulfur (50 mg/1g) + Sulfacetamide sodium (95 mg/1g) Cloth Topical Mission Pharmacal Company 2011-09-15 2019-11-30 US Avar LS Octasulfur (20 mg/1g) + Sulfacetamide sodium (100 mg/1g) Aerosol, foam Topical Mission Pharmacal Company 2010-07-15 2019-09-30 US Avar Ls Octasulfur (20 mg/1g) + Sulfacetamide sodium (100 mg/1g) Emulsion Topical Mission Pharmacal Company 2011-09-15 Not applicable US
Categories
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of inorganic compounds known as other non-metal sulfides. These are inorganic compounds containing a sulfur atom of an oxidation state of -2, in which the heaviest atom bonded to the oxygen belongs to the class of other non-metals.
- Kingdom
- Inorganic compounds
- Super Class
- Homogeneous non-metal compounds
- Class
- Other non-metal organides
- Sub Class
- Other non-metal sulfides
- Direct Parent
- Other non-metal sulfides
- Alternative Parents
- Inorganic sulfides
- Substituents
- Inorganic sulfide / Other non-metal sulfide
- Molecular Framework
- Not Available
- External Descriptors
- homomonocyclic compound, elemental sulfur (CHEBI:29385)
- Affected organisms
- Humans and other mammals
Chemical Identifiers
- UNII
- 70FD1KFU70
- CAS number
- 10544-50-0
- InChI Key
- JLQNHALFVCURHW-UHFFFAOYSA-N
- InChI
- InChI=1S/S8/c1-2-4-6-8-7-5-3-1
- IUPAC Name
- octathiocane
- SMILES
- S1SSSSSSS1
References
Clinical Trials
- Clinical Trials
Clinical Trial & Rare Diseases Add-on Data Package
Explore 4,000+ rare diseases, orphan drugs & condition pairs, clinical trial why stopped data, & more. Preview package Phase Status Purpose Conditions Count Start Date Why Stopped 100+ additional columns Unlock 175K+ rows when you subscribe.View sample dataNot Available Completed Diagnostic Pancreatic Adenocarcinoma 1 somestatus stop reason just information to hide 4 Unknown Status Treatment Treatment of Acne Vulgaris Grade II in a Short Period of Time 1 somestatus stop reason just information to hide 3 Completed Treatment Gastritis Associated With Helicobacter Pylori 1 somestatus stop reason just information to hide 3 Completed Treatment Scabies 1 somestatus stop reason just information to hide 1 Completed Treatment Scabies 1 somestatus stop reason just information to hide
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Soap Topical 60 mg/1g Cream Topical 4 % Cream Topical 35 mg/1g Cream Topical 4 g/100mL Lotion Topical 30 mg/1mL Liquid Topical 3 g/100mL Ointment Topical 5 g/100g Cream Topical 35 mg/1mL Cream Topical 35 g/1g Powder, for solution Topical Cream Topical 10 g/100mL Cream Topical 5 % Cream Topical 5 g/100mL Soap Topical 1 g/100g Liquid Vaginal 0.12 mg/3mL Powder Topical 30 mg/1g Cream Topical 30 mg/1mL Cream Topical 5 mL/100mL Cream Topical 10 mg/100mL Tablet Oral Cream Topical 3 g/100mL Aerosol, foam Topical Cream Topical 50 mg/1g Paste Topical Solution Topical 10 g/100mL Emulsion Topical Lotion Topical 10 % Cream Topical 0.28 g/2.8g Suspension Topical 2.8 g/28g Lotion Topical 100 mg/1mL Ointment Topical 1.4 g/14g Cream Topical 40 mg/1mL Cream Topical 0.56 g/14g Ointment Topical 2 % w/w Lotion Topical 50 mg/1mL Paste Topical 100 mg/1g Cream Topical 0.10 g/1g Gel Topical 5 mg/100mL Soap Topical 5 g/85g Cream Topical 6 mg/0.2g Cream Topical 0.48750 g/15mL Lotion Topical 1.5 g/50mL Soap Topical 3 g/100g Cream Topical 5 g/100g Powder Topical 3 g/100g Lotion, augmented Topical .05 g/1g Lotion, augmented Topical .05 g/1mL Gel Topical 0.033 g/1g Liquid Topical 10 g/100mL Gel Topical 3 g/100mL Lotion Topical 5 g/100mL Lotion Topical 100 mg/1g Soap Topical 2 g/100g Cream Topical 100 mg/1mL Cream Topical 3.3 g/100mL Suspension Topical 25 mg/1mL Cream Topical 64 mg/1g Soap Topical 3.0 g/100g Ointment Topical 1.5 g/15mL Gel Topical 0.5 g/100g Shampoo Topical Lotion Topical 6.3 1/95mL Lotion Topical 6.6 mg/100mL Soap Topical 9 g/100g Lotion Topical 1.4 g/14mL Cream Topical 1.12 g/28g Paste Topical 3 g Soap Topical 3 % Cream Topical 3 mg/100mL Powder Topical 3 1/100g Patch Transdermal 9 mg/9mg Lotion Topical 100 mg/ml Lotion Topical 0.9 g/30mL Cream Paste Topical 120 mg/1mL Suspension Topical 6.6 g/100g Liquid Topical 100 mg/1mL Cream Topical 3 % Lotion Topical 2 % Soap Topical 30 mg/1mL Soap Topical Suspension Topical Gel Topical 6 mg/100mL Lotion Topical 8 mg/100mL Cream Topical 0.06 g/1g Lotion Topical 6 g/100g Cream Topical 6 g/100g Lotion Topical 10 g/100mL Emulsion Topical 5 g/100mL Suspension Topical 1.4 g/14g Liquid Topical 1.4 g/14g Cream Topical 3 mL/100mL Ointment Topical Lotion Topical Liquid; shampoo Topical Gel Topical 50 mg/1mL Cream Topical 3 g/100g Swab Topical Rinse Topical Kit Topical 1250 mg/25g Gel Topical Kit Topical Solution Topical Liquid Topical 10 g/100g Powder Topical Powder Oral; Topical Shampoo Topical 0.4 mL/100mL Cream Topical 0.1 g/100g Soap Topical 5 % Liquid Topical Soap Topical 0.33 g/1 Cloth Topical Cream Topical Soap Topical 30 mg/1g Liquid Topical 8 g/100g Ointment Topical 10 g/100g Soap Cutaneous Soap Topical 10 g/100g Soap Topical 5 g/100g Ointment Topical 2 % Cream Topical 0.001 g/1g Cream Topical 10 g/100g Liquid Topical 0.03 g/1g Paste Topical 3.5 mg/1mL Gel Topical 60 mg/1mL Powder Oral Soap Topical 5.0 g/100g Ointment Topical 10 % Ointment Topical 20 mg/1g Cloth; kit Topical Paste Topical 100 mg/1mL Cream Topical 35 g/1000g Liquid Topical .003 mg/.06mg Rinse Topical 30 mg/1mL Paste Topical 30 mg/1mL Cream Topical 0.1 g/1mL Ointment Topical 10 g Cream Topical 8 % Ointment Topical 6 % w/w Lotion Topical 6 g/100mL Capsule Oral Powder Oral; Topical Cream; kit Topical 100 mg/1g Cream Topical 100 mg/1g Ointment Topical 10 %w/w Ointment Powder Topical - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source logP 4.76 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 0 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 0 Å2 Chemaxon Rotatable Bond Count 0 Chemaxon Refractivity 46.05 m3·mol-1 Chemaxon Polarizability 20.4 Å3 Chemaxon Number of Rings 1 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 133.0338 predictedDeepCCS 1.0 (2019) [M+H]+ 135.08188 predictedDeepCCS 1.0 (2019) [M+Na]+ 143.22038 predictedDeepCCS 1.0 (2019)
Drug created at November 30, 2015 19:10 / Updated at October 20, 2024 02:07