Thioridazine hydrochlorideProduct ingredient for Thioridazine
- Name
- Thioridazine hydrochloride
- Drug Entry
- Thioridazine
A phenothiazine antipsychotic used in the management of psychoses, including schizophrenia, and in the control of severely disturbed or agitated behavior. It has little antiemetic activity. Thioridazine has a higher incidence of antimuscarinic effects, but a lower incidence of extrapyramidal symptoms, than chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p618).
Thioridazine was withdrawn worldwide in 2005 due to its association with cardiac arrythmias.
- Accession Number
- DBSALT000503
- Structure
- Synonyms
- Thioridazine HCl
- UNII
- 4WCI67NK8M
- CAS Number
- 130-61-0
- Weight
- Average: 407.035
Monoisotopic: 406.130417961 - Chemical Formula
- C21H27ClN2S2
- InChI Key
- NZFNXWQNBYZDAQ-UHFFFAOYSA-N
- InChI
- InChI=1S/C21H26N2S2.ClH/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(24-2)15-19(21)23;/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3;1H
- IUPAC Name
- 10-[2-(1-methylpiperidin-2-yl)ethyl]-2-(methylsulfanyl)-10H-phenothiazine hydrochloride
- SMILES
- Cl.CSC1=CC2=C(SC3=CC=CC=C3N2CCC2CCCCN2C)C=C1
- External Links
- PubChem Compound
- 66062
- ChemSpider
- 59452
- ChEBI
- 48566
- ChEMBL
- CHEMBL1200916
- Wikipedia
- Thioridazine
- Predicted Properties
Property Value Source Water Solubility 0.000855 mg/mL ALOGPS logP 5.93 ALOGPS logP 5.47 Chemaxon logS -5.6 ALOGPS pKa (Strongest Basic) 8.93 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 6.48 Å2 Chemaxon Rotatable Bond Count 4 Chemaxon Refractivity 113.52 m3·mol-1 Chemaxon Polarizability 43.1 Å3 Chemaxon Number of Rings 4 Chemaxon Bioavailability 1 Chemaxon Rule of Five No Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon