In this paper, we show how a cross-inhibitory positive feedback or toggle switch mechanism driven by two extracellular morphogens – BMP and FGF - produces ...
Feb 13, 2014 · A BMP-FGF morphogen toggle switch drives the ultrasensitive expression of multiple genes in the developing forebrain. PLoS Comput Biol. 2014 ...
A BMP-FGF Morphogen Toggle Switch Drives the Ultrasensitive Expression of Multiple Genes in the Developing Forebrain.
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Feb 13, 2014 · A variety of mechanisms have been proposed to explain how shallow morphogen gradients are converted into sharp borders of gene expression and ...
As the toggle switch explicitly links extracellular morphogens to cellular ultrasensitivity, it provides a mechanism for making multiple sharp borders that can ...
Cells on the right experience higher BMP signaling. The CIPF toggle switch turns on BMP target genes where BMP>FGF signaling and turns them off where BMP<FGF ...
A cross-inhibitory positive feedback (CIPF) mechanism, or “toggle switch”, which acts upstream of transcriptional targets in dorsal telencephalic cells is ...
A BMP-FGF Morphogen Toggle Switch Drives the Ultrasensitive Expression of Multiple Genes in the Developing Forebrain. Overview of attention for article ...
Apr 25, 2024 · A BMP-FGF Morphogen Toggle Switch Drives the Ultrasensitive Expression of Multiple Genes in the Developing Forebrain. PLoS Comput. Biol ...
(2014) A BMP-FGF morphogen toggle switch drives the ultrasensitive expression of multiple genes in the developing forebrain. PLoS Comp Biol 10(2):e1003463 ...