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Genotype and Haplotype Reconstruction from Low-Coverage Short Sequencing Reads. Conference paper. pp 52–53; Cite this conference paper. Download book PDF.
Coupled with continuously decreasing sequencing costs, HTS data provides opportunities to study genome structure, function, and evolution at an unprecedented ...
We show that our method requires only low sequencing coverage and can reconstruct haplotypes ... sequencing coverage is low or the reads are short. In this ...
8 days ago · First, Gibbs sampling is performed to generate a posterior estimate of the read labels (an estimate of what haplotype each read comes from) ...
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Reconstruction of evolving gene variants and fitness from short ...
www.ncbi.nlm.nih.gov › PMC8551035
Oct 11, 2021 · Genotype reconstruction during evolution from short-read sequencing data with incomplete physical linkage. a, Overview of the method. b ...
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Aug 14, 2019 · Reconstruction of high-resolution founder mosaic haplotypes using low-coverage sequencing data ... Haplotype estimation using sequencing reads.
Nov 23, 2023 · Reconstructing haplotypes of an organism from a set of sequencing reads is a computationally challenging (NP-hard) problem.
Improved haplotype inference by exploiting long-range linking and ...
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Sep 16, 2020 · Haplotype reconstruction of distant genetic variants remains an unsolved problem due to the short-read length of common sequencing data.
Apr 12, 2021 · DNA microarrays and short-read sequencing can determine the collection of alleles at genetic loci (that is, genotypes) but provide no ...
Nov 28, 2019 · Here we present a method, SHAPEIT4, which substantially improves upon other methods to process large genotype and high coverage sequencing ...