Dec 21, 2011 · We identified with high confidence 497 HIV–human protein–protein interactions involving 435 individual human proteins, with ∼40% of the interactions being ...
Dec 21, 2011 · We found that the host proteins hijacked by HIV, especially those found interacting in both cell types, are highly conserved across primates. We ...
, Global landscape of HIV-human protein complexes. ; Jager, Stefanie ;. , ISSN: 0028-0836 , 1476-4687 ,. , Nature. , 2012, Vol.481(7381), p.365-370 ,.
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We uncovered a number of host complexes targeted by viral proteins, including the finding that HIV protease cleaves eIF3d, a subunit of eukaryotic translation ...
In total, 497 HIV–human interactions (blue) are represented between 16 HIV proteins and 435 human factors. Each node representing a human protein is split into ...
Abstract: Human immunodeficiency virus (HIV) has a small genome and therefore relies heavily on the host cellular machinery to replicate.
Downloadable (with restrictions)! Affinity tagging, mass spectroscopy and a tailor-made scoring system are used to identify 497 high-confidence interactions ...
Dec 21, 2011 · The survey reveals a pathogenic landscape in which HIV's handful of proteins makes hundreds of physical connections with human proteins and other components ...
Based on our approach we identified a global map of 40 HIV-human protein complexes with putative roles in HIV infection, some of which are involved in DNA ...
Dec 21, 2011 · In this paper, the complete interactome between all HIV proteins and the proteins from two cell lines is presented. These interactions can be ...