Aug 22, 2022 · The large-scale conformational transition of the HVR from the intrinsically disordered to the ordered conformation remains poorly understood.
Aug 22, 2022 · The large-scale conformational transition of the HVR from the intrinsically disordered to the ordered conformation remains poorly understood.
Our findings reveal a stepwise pathway for the HVR transition and uncover several key conformational substates along the transition pathway. Importantly, key ...
Markov State Models and Molecular Dynamics Simulations Reveal the Conformational Transition of the Intrinsically Disordered Hypervariable Region of K-Ras4B ...
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A new two-states Markov-State Model is constructed, according to the qualities of the K-Ras4B dynamics processes; the new analysis of the transition to the ...
Dec 27, 2023 · Markov State Models and Molecular Dynamics Simulations Reveal the. Conformational Transition of the Intrinsically Disordered Hypervariable.
... Dynamics Simulations Reveal the Conformational Transition of the Intrinsically Disordered Hypervariable Region of K-Ras4B to the Ordered Conformation
4 days ago · The kinetically metastable states refer to the potential pathways of MRTX1133 binding to KRAS G12D were revealed by Markov state models (MSM) ...
Markov State Models and Molecular Dynamics Simulations Reveal the Conformational Transition of the Intrinsically Disordered Hypervariable Region of K-Ras4B ...
In the inactive guanosine diphosphate-bound state, the intrinsically disordered HVR interacts with the catalytic domain at the effector-binding region, ...