We expect that overlapping paired-end read information is effective for this purpose, but no mutation caller has modeled overlapping information statistically ...

May 27, 2016 · Here, we develop a Bayesian hierarchical method, OVarCall, where overlapping paired-end read information improves the accuracy of low allele ...

Mar 1, 2017 · Abstract—Detection of somatic mutations from tumor and matched normal sequencing data has become a stan- dard approach in cancer research.

We expect that overlapping paired-end read information is effective for this purpose, but no mutation caller has modeled overlapping information statistically ...

OVarCall: Bayesian Mutation Calling Method Utilizing Overlapping Paired-End Reads. T. Moriyama, Y. Shiraishi, K. Chiba, R. Yamaguchi, S. Imoto, and S ...

Mar 29, 2019 · A paired-end read in this category (tn = 2) is overlapping between the forward read and reverse read at the mutation candidate position and ...

OVarCall: Bayesian mutation calling method utilizing overlapping paired-end reads, Proc. the 12th International Symposium on Bioinformatics Research and ...

Mar 29, 2019 · SNPs and overlapped paired-end reads, in their mutation calling process. However, no existing methods utilize multiple types of such.

Empirical Bayesian mutation Calling enables accurate calling of mutations with low allele frequencies harboured within a minor tumour subpopulation, ...

We demonstrated that our method can utilize both heterozygous SNP information and overlapping paired-end read information effectively in simulation datasets and ...