Aug 8, 2007 · Here, we present a quantitative study of sequence and function divergence, based on the Gene Ontology classification of function.
Aug 8, 2007 · Our results show that, among homologous proteins, the proportion of divergent functions decreases dramatically above a threshold of sequence ...
The results show that the proportion of divergent functions decreases dramatically above a threshold of sequence similarity at about 50% residue identity, ...
The relationship between divergence of amino-acid sequence and divergence of function among homologous proteins is complex. The assumption that homologs ...
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Here, we present a quantitative study of sequence and function divergence, based on the Gene Ontology classification of function. We determined the relationship ...
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Quantitative sequence-function relationships in proteins based on gene ontology · List of references · Publications that cite this publication.
We present an analysis of the relationship between sequence similarity and function similarity for the proteins in four model organisms.
Our statistical model is based on sets of proteins with experimentally validated functions and numeric measures of function specificity and function similarity ...
In this study, we developed a method named GoFDR for predicting Gene Ontology (GO)-based protein functions. The input for GoFDR is simply a query ...