May 12, 2020 · The SHP2 structure includes two Src homology 2 domains (N-SH2 and C-SH2) followed by a catalytic protein tyrosine phosphatase (PTP) domain.
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May 12, 2020 · SHP2 structure includes two Src homology 2 domains (N-SH2 and C-SH2) followed by a catalytic protein tyrosine phosphatase (PTP) domain.
SHP2 structure includes two Src homology 2 domains (N-SH2 and C-SH2) followed by a catalytic protein tyrosine phosphatase (PTP) domain. Under basal conditions, ...
The structure of SHP2 consists of two Src homology 2 (SH2) domains arranged in tandem (N-SH2 and C-SH2), followed by the catalytic protein tyrosine phosphatase ...
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Structural Determinants of Phosphopeptide Binding to the N-Terminal Src Homology 2 Domain of the SHP2 Phosphatase ... Authors: Massimiliano Anselmi; Paolo ...
[PDF] SUPPORTING INFORMATION FOR Structural Determinants of ...
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Structural Determinants of Phosphopeptide Binding to the N-Terminal Src Homology 2 Domain of the SHP2. Phosphatase. Massimiliano Anselmi,1,‡,† Paolo Calligari ...
Phosphopeptides bind to SH2 domains in an extended conformation, with the phosphotyrosine in a pocket on one side of the central sheet and C-terminal residues ...
SUPPORTING INFORMATION FOR Structural Determinants of ... - bioRxiv
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Mar 29, 2020 · Structural Determinants of Phosphopeptide Binding to the N-Terminal Src Homology 2 Domain of the SHP2. Phosphatase. M. Anselmi,1,‡,† P ...
Structural Determinants of Phosphopeptide Binding to the N-Terminal Src Homology 2 Domain of the SHP2 Phosphatase ...
The crystal structure of the protein tyrosine phosphatase SHP-2 reveals the mechanism of auto-inhibition of phosphatase activity by its SH2 domains.