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Apolipoprotein E (ApoE) is a major cholesterol carrier and plays an important role in maintaining lipid homeostasis. APOE-ε4 constitutes the most important known genetic risk factor for late-onset AD. It has been proposed that the BCHE-K allele (Ala539Thr) acts in synergy with the APOE-ε4 allele to promote risk for AD.
Mar 26, 2019
So far, at least three genes, APP, PS1, and PS2, have been identified as causative genes. Mutations in these genes have been found to cause mainly early-onset ...
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May 17, 2016 · Mainly four strategies have governed the field of AD genetics: genetic linkage analysis, study of candidate genes, GWASs, and NGS technology.
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Nowadays, Alzheimer's disease (AD) is the most common form of dementia af- fecting more than 25 million individuals worldwide. AD is a complex progressive.
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Mutations in three different genes are known to cause EOAD: amyloid beta (A4) precursor protein (APP) [28], presenilin 1 (PSEN1) [29], and presenilin 2 (PSEN2) ...
Apr 30, 2024 · Model-based stratification of progression along the Alzheimer disease continuum highlights the centrality of biomarker synergies. Alzheimers Res ...
Apr 22, 2024 · This strategy employs biomimetic nanovesicles for the delivery of dual nucleic acids, achieving synergistic gene therapy for AD, thus offering ...
Missing: Synergies | Show results with:Synergies
Oct 4, 2023 · In this review, we focus on the synergistic relationship between LATE-NC and tau in AD, highlighting the aggravating role of TDP-43 aggregates ...
All four genes definitively linked to inherited forms of the disease to date have been shown to increase the production and/or deposition of amyloid β-protein ...
Missing: Synergies | Show results with:Synergies
May 1, 2024 · We review genetic, epigenomic, and gene expression findings related to AD pathogenesis and explore how their integration enables a better ...
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