Frontiers in Bioengineering and Biotechnology, Feb 13, 2023
Cartilage lesions are common conditions, affecting elderly and non-athletic populations. Despite ... more Cartilage lesions are common conditions, affecting elderly and non-athletic populations. Despite recent advances, cartilage regeneration remains a major challenge today. The absence of an inflammatory response following damage and the inability of stem cells to penetrate into the healing site due to the absence of blood and lymph vessels are assumed to hinder joint repair. Stem cell-based regeneration and tissue engineering have opened new horizons for treatment. With advances in biological sciences, especially stem cell research, the function of various growth factors in the regulation of cell proliferation and differentiation has been established. Mesenchymal stem cells (MSCs) isolated from different tissues have been shown to increase into therapeutically relevant cell numbers and differentiate into mature chondrocytes. As MSCs can differentiate and become engrafted inside the host, they are considered suitable candidates for cartilage regeneration. Stem cells from human exfoliated deciduous teeth (SHED) provide a novel and non-invasive source of MSCs. Due to their simple isolation, chondrogenic differentiation potential, and minimal immunogenicity, they can be an interesting option for cartilage regeneration. Recent studies have reported that SHED-derived secretome contains biomolecules and compounds that efficiently promote regeneration in damaged tissues, including cartilage. Overall, this review highlighted the advances and challenges of cartilage regeneration using stem cell-based therapies by focusing on SHED.
Bone tissue engineering has been a fast growing area recently. It suggests a novel and talented m... more Bone tissue engineering has been a fast growing area recently. It suggests a novel and talented method for bone regeneration. The aim of the current work is to produce nanofiber scaffolds based on starch/ collagen/ polycaprolactone (PCL) biomaterials by means of an electrospinning methodology for bone tissue engineering purposes. The results showed that the developed structures have good physicochemical and interconnected properties that could be considered for bone tissues engineering. The results from the characterization specified that the nanofibers were successfully prepared with monodispersed nanosized diameter (60 nm), uniform network shaped morphology and negative surface charge (-13.5 mV). Besides, the applied method can be set up to prepare fiber-based structures using other polymeric materials. We believe that by incorporating different materials to reduce the degradation rate of the fibers, it can be matched with the speed of tissue regeneration. In this case, the prepared nanofibers can be used as the membrane biomaterials, for example, guided bone regeneration (GBR) membrane.
A systematic review and meta-analysis were conducted to evaluate the effect of endodontic irrigat... more A systematic review and meta-analysis were conducted to evaluate the effect of endodontic irrigation on the mineral content of root canal dentine. A systematic search was performed in the following databases: PubMed, Web of Science, Scopus, Cochrane, ProQuest, and Wiley. The quality assessment of the articles was performed. The meta-analysis was carried out using the random effects model in the Stata 16 software (p<0.05). The results showed that Er:YAG Laser had a significant effect on the removal of the phosphorus content of dentine (Hedges' g=-0.49; 95% CI:-0.85,-0.13; I2=0.0%). In addition, the EDTA 5Min had a lower removal effect compared to the control group on the magnesium content of dentine (Hedges' g=0.58; 95% CI: 0.00, 1.16; I2=0.0%). Other irrigations had no significant effect on other on the mineral content of root canal dentine. Evidence was found to support that most root canal irrigation protocols did not have a significantly affected in terms of the mineral content of root dentine.
Journal of dental research, dental clinics, dental prospects, Nov 15, 2022
Background. This study assessed the antimicrobial effects of different concentrations of simvasta... more Background. This study assessed the antimicrobial effects of different concentrations of simvastatin versus triple antibiotic paste (TAP) on Enterococcus faecalis biofilms at different stages of development. Methods. In this in vitro study, 70 human single-rooted mature premolars were decoronated, instrumented, and autoclave-sterilized. Next, an E. faecalis suspension was prepared and inoculated into the canals to obtain 4-and 6-week biofilms. After ensuring biofilm formation, the samples in each group were randomly assigned to 5 subgroups (n = 12): 1 mg/mL TAP, 10 mg/ mL TAP, 1 mg/mL simvastatin, 10 mg/mL simvastatin, and positive control (phosphate-buffered saline solution). The medicaments were applied in the canals, and the teeth were incubated for one week. Dentin samples were collected by a rotary file, cultured, and the number of E. faecalis colonies was counted. The Kruskal-Wallis, Mann-Whitney U, and Wilcoxon tests were used for data analysis (α = 0.05). Results. There were significant differences in colony counts between the two concentrations of TAP and the control group against both 4-and 6-week biofilms (P < 0.05). The antibacterial effect of 10 mg/mL TAP and simvastatin was stronger than that of 1 mg/mL concentration against the 4-and 6-week E. faecalis biofilms (P < 0.05). Furthermore, 10 mg/mL TAP and simvastatin were more effective against the 4-week biofilms than the 6-week biofilms (P < 0.05). Conclusion. According to the present results and since biofilms may remain viable in the root canal system for weeks to months, applying 10 mg/mL TAP and simvastatin might be more effective.
Background and Aim: Bacterial disinfection is considered as the primary etiology of pulpal and pe... more Background and Aim: Bacterial disinfection is considered as the primary etiology of pulpal and periapical lesions and as the result, adequate elimination of such infections is one of the purposes of root canal treatment; But since this purpose is impossible to achieve, reducing the bacterial load seems to be as a rational goal. Diode lasers have made their way into endodontics for better disinfection and penetration into the root canal dentine. This study reports 3 cases of Diode laser assisted endodontic treatments in periapical lesions repair. Case Report: 3 patients referred to an endodontist for root canal treatment and 2 patients were treated with diode laser (wavelength of 940 nm and power output of 1W) and one patient was treated with diode laser (wavelength of 810 nm and power output of 1 W). The follow-up outcomes for all three patients showed the treatment success. Conclusion: Diode laser can be used in root canal treatment of teeth with periapical lesions.
This study compared the effect(s) of smear layer removal on push-out bond strength of Biodentine ... more This study compared the effect(s) of smear layer removal on push-out bond strength of Biodentine between laser-assisted endodontic preparation and conventional method of preparation in which the smear layer was removed using sodium hypochlorite (NaOCl) and ethylenediaminetetraacetic (EDTA). Sixty single-rooted teeth were used which were decoronated and endodontically prepared. The teeth were then randomly assigned to three groups (20 per group). In the experimental group, the smear layer was removed by Er,Cr:YSGG laser with 1.25 watts radiated power, pulse repetition rate of 50 Hz, 60 µs pulse duration, 80% water, and 30% air distribution, H-mode, and followed by diode laser 940 nm, which was operated at 1 W, as a continuous wave irradiation. In the conventional group, the smear layer was removed using EDTA 17%. In the control group, the smear layer was not removed. Two teeth from each group were randomly selected for scanning electron microscopy examination, and from each of the other samples, three slices with 1.0 ± 0.1 mm of thickness were cut and each hole was filled with Biodentine. Then, the specimens were immersed in the simulated body fluid (SBF) for 27 days. Using a universal testing machine, the bonding force for dislodgment of filling materials during the push-out test was calculated. Then, a stereomicroscope was used to assess the bond failure mode of Biodentine filling material at × 40. The debonding force in the control, conventional, and experimental groups was 5.3 ± 2.7, 5.4 ± 3.1, and 5.4 ± 2.5 MPs, respectively (p = 0.9). Also, laser and chemicals removed the smear layer effectively. The results of this study showed that, despite the smear layer removal, the push-out bond strength between Biodentine and root canal dentinal wall was not influenced by 17% EDTA + 5% NaOCl and Er,Cr:YSGG + diode lasers irradiation.
Journal of lasers in medical sciences, Dec 9, 2022
The effect of beam direction on absorption and transmission of ultraviolet to infrared wavelength... more The effect of beam direction on absorption and transmission of ultraviolet to infrared wavelength regions in three different dentin thicknesses.
Objective: Root canal anatomy significantly impacts the working length determination. This study ... more Objective: Root canal anatomy significantly impacts the working length determination. This study aimed to investigate the effect of the preflaring technique on the accuracy of four electronic apex locators. Methods: Forty-five single-canal central maxillary teeth were selected. The working length was measured before and after the coronal preparation by four types of electronic apex locators in the range of ±0.5 and ±1 mm matched for the apical constriction. The actual working length was calculated under a microscope. Data were analyzed using ICC and paired t-tests in SPSS16. A p < 0.05 was considered significant. Results: The accuracies of Root ZX, DTE, Denjoy, and Coxo apex locators in the range of ± 0.05 mm were 71.1, 93.3, 84.4, and 75.6% before preflaring, and 82.2, 93.3, 97.8, and 100% after that. The corresponding values in the range of ±1 mm were 86.7, 97.8, 93.3, and 100% before and 97.8, 100, 100, and 100% after preflaring. Significant differences were found between the ...
Background: Oral cancer is one of the most prevailing neoplasms globally, and human papillomaviru... more Background: Oral cancer is one of the most prevailing neoplasms globally, and human papillomavirus (HPV) is one of the risk factors for this condition. Knowledge and awareness about HPV-related oral cancer can lead to a better diagnosis and prognosis of this disease. This systematic review aimed to evaluate knowledge and awareness about HPV-related oral cancer among dentists and dental students. Methods: We searched Web of Science, Scopus, PubMed, and ProQuest databases with Medical Subject Headings (MeSH) and non-MeSH keywords to find related articles. Our eligibility criteria were: 1) cross-sectional studies including knowledge and awareness about HPV-related oral cancers, 2) publication date up to August 18, 2021, 3) studies containing dentists or dental students as the main participants, or as part of the participants. The Joanne Briggs Institute (JBI) checklist was used for quality assessment. Results: A total of 10 studies were included in this systematic review. Five studies ...
Journal of dental research, dental clinics, dental prospects, Nov 15, 2022
Background. This study assessed the antimicrobial effects of different concentrations of simvasta... more Background. This study assessed the antimicrobial effects of different concentrations of simvastatin versus triple antibiotic paste (TAP) on Enterococcus faecalis biofilms at different stages of development. Methods. In this in vitro study, 70 human single-rooted mature premolars were decoronated, instrumented, and autoclave-sterilized. Next, an E. faecalis suspension was prepared and inoculated into the canals to obtain 4-and 6-week biofilms. After ensuring biofilm formation, the samples in each group were randomly assigned to 5 subgroups (n = 12): 1 mg/mL TAP, 10 mg/ mL TAP, 1 mg/mL simvastatin, 10 mg/mL simvastatin, and positive control (phosphate-buffered saline solution). The medicaments were applied in the canals, and the teeth were incubated for one week. Dentin samples were collected by a rotary file, cultured, and the number of E. faecalis colonies was counted. The Kruskal-Wallis, Mann-Whitney U, and Wilcoxon tests were used for data analysis (α = 0.05). Results. There were significant differences in colony counts between the two concentrations of TAP and the control group against both 4-and 6-week biofilms (P < 0.05). The antibacterial effect of 10 mg/mL TAP and simvastatin was stronger than that of 1 mg/mL concentration against the 4-and 6-week E. faecalis biofilms (P < 0.05). Furthermore, 10 mg/mL TAP and simvastatin were more effective against the 4-week biofilms than the 6-week biofilms (P < 0.05). Conclusion. According to the present results and since biofilms may remain viable in the root canal system for weeks to months, applying 10 mg/mL TAP and simvastatin might be more effective.
Introduction: Lasers and optics have been used extensively in dental procedures in recent years, ... more Introduction: Lasers and optics have been used extensively in dental procedures in recent years, and realizing the optical properties of the tooth is also an essential in its successful applications. The aim of this study was to compare the absorption and transmission of applied wavelengths in the range of 190–1100 nm at different dentin thicknesses and the effect of changing the direction of radiation emission on the dentin tubules. Methods: There were fifteen dentin specimens with thicknesses of 300, 600, and 1000 mm, five specimens for each thickness, prepared through a transverse section of the coronal dentin over the pulpal roof area of human molars. Considering the coronal-apical and apical-coronal directions, we measured the absorption and transmission of parallel light rays perpendicular to the dentin samples in different thicknesses and two directions with a Cecil CE 7400 UV/Vis spectrometer. Data analysis was performed using SPSS software version 19. P value<0.05 was co...
Background and Aim: Bacterial disinfection is considered as the primary etiology of pulpal and pe... more Background and Aim: Bacterial disinfection is considered as the primary etiology of pulpal and periapical lesions and as the result, adequate elimination of such infections is one of the purposes of root canal treatment; But since this purpose is impossible to achieve, reducing the bacterial load seems to be as a rational goal. Diode lasers have made their way into endodontics for better disinfection and penetration into the root canal dentine. This study reports 3 cases of Diode laser assisted endodontic treatments in periapical lesions repair. Case Report: 3 patients referred to an endodontist for root canal treatment and 2 patients were treated with diode laser (wavelength of 940 nm and power output of 1W) and one patient was treated with diode laser (wavelength of 810 nm and power output of 1 W). The follow-up outcomes for all three patients showed the treatment success. Conclusion: Diode laser can be used in root canal treatment of teeth with periapical lesions.
The COVID-19 outbreak has led to increasing global concerns about infection control. Amid this pa... more The COVID-19 outbreak has led to increasing global concerns about infection control. Amid this pandemic, dentistry could be considered as one of the most high-risk medical sectors for health workers due to the high exposure to patients infected with this deadly virus. After the decline of the steep prevalence of COVID-19 cases, the dental associations have allowed dental offices to reopen under special circumstances by taking the necessary precautions and following the prescribed guidelines to keep both the dentists and their patients safe and healthy during the treatment. The aim of this review is to present a policy to manage and facilitate the dental procedures in the dental practice routine amid coronavirus by focusing on the patients' risk level in order to keep the possibility of COVID-19 transmission to a minimum.
Bone tissue engineering has been a fast growing area recently. It suggests a novel and talented m... more Bone tissue engineering has been a fast growing area recently. It suggests a novel and talented method for bone regeneration. The aim of the current work is to produce nanofiber scaffolds based on starch/ collagen/ polycaprolactone (PCL) biomaterials by means of an electrospinning methodology for bone tissue engineering purposes. The results showed that the developed structures have good physicochemical and interconnected properties that could be considered for bone tissues engineering. The results from the characterization specified that the nanofibers were successfully prepared with monodispersed nanosized diameter (60 nm), uniform network shaped morphology and negative surface charge (-13.5 mV). Besides, the applied method can be set up to prepare fiber-based structures using other polymeric materials. We believe that by incorporating different materials to reduce the degradation rate of the fibers, it can be matched with the speed of tissue regeneration. In this case, the prepared nanofibers can be used as the membrane biomaterials, for example, guided bone regeneration (GBR) membrane.
This study compared the effect(s) of smear layer removal on push-out bond strength of Biodentine ... more This study compared the effect(s) of smear layer removal on push-out bond strength of Biodentine between laser-assisted endodontic preparation and conventional method of preparation in which the smear layer was removed using sodium hypochlorite (NaOCl) and ethylenediaminetetraacetic (EDTA). Sixty single-rooted teeth were used which were decoronated and endodontically prepared. The teeth were then randomly assigned to three groups (20 per group). In the experimental group, the smear layer was removed by Er,Cr:YSGG laser with 1.25 watts radiated power, pulse repetition rate of 50 Hz, 60 µs pulse duration, 80% water, and 30% air distribution, H-mode, and followed by diode laser 940 nm, which was operated at 1 W, as a continuous wave irradiation. In the conventional group, the smear layer was removed using EDTA 17%. In the control group, the smear layer was not removed. Two teeth from each group were randomly selected for scanning electron microscopy examination, and from each of the ot...
The COVID-19 outbreak has led to increasing global concerns about infection control. Amid this pa... more The COVID-19 outbreak has led to increasing global concerns about infection control. Amid this pandemic, dentistry could be considered as one of the most high-risk medical sectors for health workers due to the high exposure to patients infected with this deadly virus.After the decline of the steep prevalence of COVID -19 cases, the dental associations have allowed dental offices to reopen under special circumstances by taking the necessary precautions and following the prescribed guidelines to keep both the dentists and their patients safe and healthy during the treatment. The aim of this review is to present a policy to manage and facilitate the dental procedures in the dental practice routine amid coronavirus by focusing on the patients’ risk level in order to keep the possibility of COVID -19 transmission to a minimum.
Frontiers in Bioengineering and Biotechnology, Feb 13, 2023
Cartilage lesions are common conditions, affecting elderly and non-athletic populations. Despite ... more Cartilage lesions are common conditions, affecting elderly and non-athletic populations. Despite recent advances, cartilage regeneration remains a major challenge today. The absence of an inflammatory response following damage and the inability of stem cells to penetrate into the healing site due to the absence of blood and lymph vessels are assumed to hinder joint repair. Stem cell-based regeneration and tissue engineering have opened new horizons for treatment. With advances in biological sciences, especially stem cell research, the function of various growth factors in the regulation of cell proliferation and differentiation has been established. Mesenchymal stem cells (MSCs) isolated from different tissues have been shown to increase into therapeutically relevant cell numbers and differentiate into mature chondrocytes. As MSCs can differentiate and become engrafted inside the host, they are considered suitable candidates for cartilage regeneration. Stem cells from human exfoliated deciduous teeth (SHED) provide a novel and non-invasive source of MSCs. Due to their simple isolation, chondrogenic differentiation potential, and minimal immunogenicity, they can be an interesting option for cartilage regeneration. Recent studies have reported that SHED-derived secretome contains biomolecules and compounds that efficiently promote regeneration in damaged tissues, including cartilage. Overall, this review highlighted the advances and challenges of cartilage regeneration using stem cell-based therapies by focusing on SHED.
Bone tissue engineering has been a fast growing area recently. It suggests a novel and talented m... more Bone tissue engineering has been a fast growing area recently. It suggests a novel and talented method for bone regeneration. The aim of the current work is to produce nanofiber scaffolds based on starch/ collagen/ polycaprolactone (PCL) biomaterials by means of an electrospinning methodology for bone tissue engineering purposes. The results showed that the developed structures have good physicochemical and interconnected properties that could be considered for bone tissues engineering. The results from the characterization specified that the nanofibers were successfully prepared with monodispersed nanosized diameter (60 nm), uniform network shaped morphology and negative surface charge (-13.5 mV). Besides, the applied method can be set up to prepare fiber-based structures using other polymeric materials. We believe that by incorporating different materials to reduce the degradation rate of the fibers, it can be matched with the speed of tissue regeneration. In this case, the prepared nanofibers can be used as the membrane biomaterials, for example, guided bone regeneration (GBR) membrane.
A systematic review and meta-analysis were conducted to evaluate the effect of endodontic irrigat... more A systematic review and meta-analysis were conducted to evaluate the effect of endodontic irrigation on the mineral content of root canal dentine. A systematic search was performed in the following databases: PubMed, Web of Science, Scopus, Cochrane, ProQuest, and Wiley. The quality assessment of the articles was performed. The meta-analysis was carried out using the random effects model in the Stata 16 software (p<0.05). The results showed that Er:YAG Laser had a significant effect on the removal of the phosphorus content of dentine (Hedges' g=-0.49; 95% CI:-0.85,-0.13; I2=0.0%). In addition, the EDTA 5Min had a lower removal effect compared to the control group on the magnesium content of dentine (Hedges' g=0.58; 95% CI: 0.00, 1.16; I2=0.0%). Other irrigations had no significant effect on other on the mineral content of root canal dentine. Evidence was found to support that most root canal irrigation protocols did not have a significantly affected in terms of the mineral content of root dentine.
Journal of dental research, dental clinics, dental prospects, Nov 15, 2022
Background. This study assessed the antimicrobial effects of different concentrations of simvasta... more Background. This study assessed the antimicrobial effects of different concentrations of simvastatin versus triple antibiotic paste (TAP) on Enterococcus faecalis biofilms at different stages of development. Methods. In this in vitro study, 70 human single-rooted mature premolars were decoronated, instrumented, and autoclave-sterilized. Next, an E. faecalis suspension was prepared and inoculated into the canals to obtain 4-and 6-week biofilms. After ensuring biofilm formation, the samples in each group were randomly assigned to 5 subgroups (n = 12): 1 mg/mL TAP, 10 mg/ mL TAP, 1 mg/mL simvastatin, 10 mg/mL simvastatin, and positive control (phosphate-buffered saline solution). The medicaments were applied in the canals, and the teeth were incubated for one week. Dentin samples were collected by a rotary file, cultured, and the number of E. faecalis colonies was counted. The Kruskal-Wallis, Mann-Whitney U, and Wilcoxon tests were used for data analysis (α = 0.05). Results. There were significant differences in colony counts between the two concentrations of TAP and the control group against both 4-and 6-week biofilms (P < 0.05). The antibacterial effect of 10 mg/mL TAP and simvastatin was stronger than that of 1 mg/mL concentration against the 4-and 6-week E. faecalis biofilms (P < 0.05). Furthermore, 10 mg/mL TAP and simvastatin were more effective against the 4-week biofilms than the 6-week biofilms (P < 0.05). Conclusion. According to the present results and since biofilms may remain viable in the root canal system for weeks to months, applying 10 mg/mL TAP and simvastatin might be more effective.
Background and Aim: Bacterial disinfection is considered as the primary etiology of pulpal and pe... more Background and Aim: Bacterial disinfection is considered as the primary etiology of pulpal and periapical lesions and as the result, adequate elimination of such infections is one of the purposes of root canal treatment; But since this purpose is impossible to achieve, reducing the bacterial load seems to be as a rational goal. Diode lasers have made their way into endodontics for better disinfection and penetration into the root canal dentine. This study reports 3 cases of Diode laser assisted endodontic treatments in periapical lesions repair. Case Report: 3 patients referred to an endodontist for root canal treatment and 2 patients were treated with diode laser (wavelength of 940 nm and power output of 1W) and one patient was treated with diode laser (wavelength of 810 nm and power output of 1 W). The follow-up outcomes for all three patients showed the treatment success. Conclusion: Diode laser can be used in root canal treatment of teeth with periapical lesions.
This study compared the effect(s) of smear layer removal on push-out bond strength of Biodentine ... more This study compared the effect(s) of smear layer removal on push-out bond strength of Biodentine between laser-assisted endodontic preparation and conventional method of preparation in which the smear layer was removed using sodium hypochlorite (NaOCl) and ethylenediaminetetraacetic (EDTA). Sixty single-rooted teeth were used which were decoronated and endodontically prepared. The teeth were then randomly assigned to three groups (20 per group). In the experimental group, the smear layer was removed by Er,Cr:YSGG laser with 1.25 watts radiated power, pulse repetition rate of 50 Hz, 60 µs pulse duration, 80% water, and 30% air distribution, H-mode, and followed by diode laser 940 nm, which was operated at 1 W, as a continuous wave irradiation. In the conventional group, the smear layer was removed using EDTA 17%. In the control group, the smear layer was not removed. Two teeth from each group were randomly selected for scanning electron microscopy examination, and from each of the other samples, three slices with 1.0 ± 0.1 mm of thickness were cut and each hole was filled with Biodentine. Then, the specimens were immersed in the simulated body fluid (SBF) for 27 days. Using a universal testing machine, the bonding force for dislodgment of filling materials during the push-out test was calculated. Then, a stereomicroscope was used to assess the bond failure mode of Biodentine filling material at × 40. The debonding force in the control, conventional, and experimental groups was 5.3 ± 2.7, 5.4 ± 3.1, and 5.4 ± 2.5 MPs, respectively (p = 0.9). Also, laser and chemicals removed the smear layer effectively. The results of this study showed that, despite the smear layer removal, the push-out bond strength between Biodentine and root canal dentinal wall was not influenced by 17% EDTA + 5% NaOCl and Er,Cr:YSGG + diode lasers irradiation.
Journal of lasers in medical sciences, Dec 9, 2022
The effect of beam direction on absorption and transmission of ultraviolet to infrared wavelength... more The effect of beam direction on absorption and transmission of ultraviolet to infrared wavelength regions in three different dentin thicknesses.
Objective: Root canal anatomy significantly impacts the working length determination. This study ... more Objective: Root canal anatomy significantly impacts the working length determination. This study aimed to investigate the effect of the preflaring technique on the accuracy of four electronic apex locators. Methods: Forty-five single-canal central maxillary teeth were selected. The working length was measured before and after the coronal preparation by four types of electronic apex locators in the range of ±0.5 and ±1 mm matched for the apical constriction. The actual working length was calculated under a microscope. Data were analyzed using ICC and paired t-tests in SPSS16. A p < 0.05 was considered significant. Results: The accuracies of Root ZX, DTE, Denjoy, and Coxo apex locators in the range of ± 0.05 mm were 71.1, 93.3, 84.4, and 75.6% before preflaring, and 82.2, 93.3, 97.8, and 100% after that. The corresponding values in the range of ±1 mm were 86.7, 97.8, 93.3, and 100% before and 97.8, 100, 100, and 100% after preflaring. Significant differences were found between the ...
Background: Oral cancer is one of the most prevailing neoplasms globally, and human papillomaviru... more Background: Oral cancer is one of the most prevailing neoplasms globally, and human papillomavirus (HPV) is one of the risk factors for this condition. Knowledge and awareness about HPV-related oral cancer can lead to a better diagnosis and prognosis of this disease. This systematic review aimed to evaluate knowledge and awareness about HPV-related oral cancer among dentists and dental students. Methods: We searched Web of Science, Scopus, PubMed, and ProQuest databases with Medical Subject Headings (MeSH) and non-MeSH keywords to find related articles. Our eligibility criteria were: 1) cross-sectional studies including knowledge and awareness about HPV-related oral cancers, 2) publication date up to August 18, 2021, 3) studies containing dentists or dental students as the main participants, or as part of the participants. The Joanne Briggs Institute (JBI) checklist was used for quality assessment. Results: A total of 10 studies were included in this systematic review. Five studies ...
Journal of dental research, dental clinics, dental prospects, Nov 15, 2022
Background. This study assessed the antimicrobial effects of different concentrations of simvasta... more Background. This study assessed the antimicrobial effects of different concentrations of simvastatin versus triple antibiotic paste (TAP) on Enterococcus faecalis biofilms at different stages of development. Methods. In this in vitro study, 70 human single-rooted mature premolars were decoronated, instrumented, and autoclave-sterilized. Next, an E. faecalis suspension was prepared and inoculated into the canals to obtain 4-and 6-week biofilms. After ensuring biofilm formation, the samples in each group were randomly assigned to 5 subgroups (n = 12): 1 mg/mL TAP, 10 mg/ mL TAP, 1 mg/mL simvastatin, 10 mg/mL simvastatin, and positive control (phosphate-buffered saline solution). The medicaments were applied in the canals, and the teeth were incubated for one week. Dentin samples were collected by a rotary file, cultured, and the number of E. faecalis colonies was counted. The Kruskal-Wallis, Mann-Whitney U, and Wilcoxon tests were used for data analysis (α = 0.05). Results. There were significant differences in colony counts between the two concentrations of TAP and the control group against both 4-and 6-week biofilms (P < 0.05). The antibacterial effect of 10 mg/mL TAP and simvastatin was stronger than that of 1 mg/mL concentration against the 4-and 6-week E. faecalis biofilms (P < 0.05). Furthermore, 10 mg/mL TAP and simvastatin were more effective against the 4-week biofilms than the 6-week biofilms (P < 0.05). Conclusion. According to the present results and since biofilms may remain viable in the root canal system for weeks to months, applying 10 mg/mL TAP and simvastatin might be more effective.
Introduction: Lasers and optics have been used extensively in dental procedures in recent years, ... more Introduction: Lasers and optics have been used extensively in dental procedures in recent years, and realizing the optical properties of the tooth is also an essential in its successful applications. The aim of this study was to compare the absorption and transmission of applied wavelengths in the range of 190–1100 nm at different dentin thicknesses and the effect of changing the direction of radiation emission on the dentin tubules. Methods: There were fifteen dentin specimens with thicknesses of 300, 600, and 1000 mm, five specimens for each thickness, prepared through a transverse section of the coronal dentin over the pulpal roof area of human molars. Considering the coronal-apical and apical-coronal directions, we measured the absorption and transmission of parallel light rays perpendicular to the dentin samples in different thicknesses and two directions with a Cecil CE 7400 UV/Vis spectrometer. Data analysis was performed using SPSS software version 19. P value<0.05 was co...
Background and Aim: Bacterial disinfection is considered as the primary etiology of pulpal and pe... more Background and Aim: Bacterial disinfection is considered as the primary etiology of pulpal and periapical lesions and as the result, adequate elimination of such infections is one of the purposes of root canal treatment; But since this purpose is impossible to achieve, reducing the bacterial load seems to be as a rational goal. Diode lasers have made their way into endodontics for better disinfection and penetration into the root canal dentine. This study reports 3 cases of Diode laser assisted endodontic treatments in periapical lesions repair. Case Report: 3 patients referred to an endodontist for root canal treatment and 2 patients were treated with diode laser (wavelength of 940 nm and power output of 1W) and one patient was treated with diode laser (wavelength of 810 nm and power output of 1 W). The follow-up outcomes for all three patients showed the treatment success. Conclusion: Diode laser can be used in root canal treatment of teeth with periapical lesions.
The COVID-19 outbreak has led to increasing global concerns about infection control. Amid this pa... more The COVID-19 outbreak has led to increasing global concerns about infection control. Amid this pandemic, dentistry could be considered as one of the most high-risk medical sectors for health workers due to the high exposure to patients infected with this deadly virus. After the decline of the steep prevalence of COVID-19 cases, the dental associations have allowed dental offices to reopen under special circumstances by taking the necessary precautions and following the prescribed guidelines to keep both the dentists and their patients safe and healthy during the treatment. The aim of this review is to present a policy to manage and facilitate the dental procedures in the dental practice routine amid coronavirus by focusing on the patients' risk level in order to keep the possibility of COVID-19 transmission to a minimum.
Bone tissue engineering has been a fast growing area recently. It suggests a novel and talented m... more Bone tissue engineering has been a fast growing area recently. It suggests a novel and talented method for bone regeneration. The aim of the current work is to produce nanofiber scaffolds based on starch/ collagen/ polycaprolactone (PCL) biomaterials by means of an electrospinning methodology for bone tissue engineering purposes. The results showed that the developed structures have good physicochemical and interconnected properties that could be considered for bone tissues engineering. The results from the characterization specified that the nanofibers were successfully prepared with monodispersed nanosized diameter (60 nm), uniform network shaped morphology and negative surface charge (-13.5 mV). Besides, the applied method can be set up to prepare fiber-based structures using other polymeric materials. We believe that by incorporating different materials to reduce the degradation rate of the fibers, it can be matched with the speed of tissue regeneration. In this case, the prepared nanofibers can be used as the membrane biomaterials, for example, guided bone regeneration (GBR) membrane.
This study compared the effect(s) of smear layer removal on push-out bond strength of Biodentine ... more This study compared the effect(s) of smear layer removal on push-out bond strength of Biodentine between laser-assisted endodontic preparation and conventional method of preparation in which the smear layer was removed using sodium hypochlorite (NaOCl) and ethylenediaminetetraacetic (EDTA). Sixty single-rooted teeth were used which were decoronated and endodontically prepared. The teeth were then randomly assigned to three groups (20 per group). In the experimental group, the smear layer was removed by Er,Cr:YSGG laser with 1.25 watts radiated power, pulse repetition rate of 50 Hz, 60 µs pulse duration, 80% water, and 30% air distribution, H-mode, and followed by diode laser 940 nm, which was operated at 1 W, as a continuous wave irradiation. In the conventional group, the smear layer was removed using EDTA 17%. In the control group, the smear layer was not removed. Two teeth from each group were randomly selected for scanning electron microscopy examination, and from each of the ot...
The COVID-19 outbreak has led to increasing global concerns about infection control. Amid this pa... more The COVID-19 outbreak has led to increasing global concerns about infection control. Amid this pandemic, dentistry could be considered as one of the most high-risk medical sectors for health workers due to the high exposure to patients infected with this deadly virus.After the decline of the steep prevalence of COVID -19 cases, the dental associations have allowed dental offices to reopen under special circumstances by taking the necessary precautions and following the prescribed guidelines to keep both the dentists and their patients safe and healthy during the treatment. The aim of this review is to present a policy to manage and facilitate the dental procedures in the dental practice routine amid coronavirus by focusing on the patients’ risk level in order to keep the possibility of COVID -19 transmission to a minimum.
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Papers by Ezatolah Kazeminejad