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Jill A . Padawer

Harvard Medical School, Psychiatry, Faculty Member

University of Massachusetts Amherst, Psychology, Alumnus

University of California, Davis, Psychology, Alumnus

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former Faculty, Harvard Medical School, Instructor in Psychology, Department of Psychiatry

former Faculty and Assoc Attending Psychologist, McLean Hospital

PhD Clinical Psychologist
Founder, rosewood consulting
Supervisors: Ronnie Janoff-Bulman, PhD, Bonnie R. Strickland, PhD, Howard Tennen, PhD, Judith V. Jordan, PhD, Irene P. Stiver, PhD, William Pollack, PhD, Hisham Hafez, MD, Gary Moak, MD, and Stephanie Shields, PhD

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Papers by Jill A . Padawer

WHITE-TAILED DEER IN GREENBURGH, WESTCHESTER COUNTY, N.Y. A Comprehensive Review of Deer Overpopulation Problems and Control

Effect of podophyllin lignans on mast cell morphology in rat peritoneal fluid

American Journal of Physiology-Legacy Content, 1961

The morphology of mast cells is affected by podophyllotoxin and related substances. Other nondivi... more The morphology of mast cells is affected by podophyllotoxin and related substances. Other nondividing cells respond similarly. The changes observed are cytoplasmic and identical to those demonstrated following treatment with colchicine. Biological activity of podophyllin lignans is referable to specific molecular configuration and, in the mast cell system, parallels their activity in other assays such as tumor damage and mitotic inhibition of regenerating liver. These findings extend those demonstrated for a series of colchicine derivatives and, in this respect, emphasize the similarities in biological activity of the two compounds. They also underline further the unlikelihood that well-differentiated mast cells normally undergo mitosis. Because mast cells respond rapidly and sensitively to these specific drugs, it is suggested they afford a useful index of probable carcinostatic activity. Thus, colchicine or podophyllotoxin congeners could be prescreened readily, using few animals ...

Structural Alterations in Fibroblast Monolayers Caused by Mast Cell Degranulation

Journal of Leukocyte Biology, 1989

Studies on Peritoneal Fluid in the Pregnant Rat**Supported, in part, by a grant in aid from the American Cancer Society upon recommendation of the Committee on Growth of the National Research Council

American Journal of Obstetrics and Gynecology, 1956

Antipyretic and Antiviral Action of Vitamin A in Moloney Sarcoma Virus- and Poxvirus-Inoculated Mice 2

JNCI: Journal of the National Cancer Institute, 1976

Six week-old male CBA/J mice fed a commercial powdered laboratory chow or the same chow supplemen... more Six week-old male CBA/J mice fed a commercial powdered laboratory chow or the same chow supplemented with vitamin A palmitate (150,000 U/kg) were inoculated with either the Moloney strain of murine sarcoma virus (M-MuSV) or poxvirus. Central body temperature was measured daily. Both viruses elicited fevers, but the fevers were less pronounced and of shorter duration in the mice ingesting the vitamin A-supplemented diet. Palpable M-MuSV-induced tumors appeared later, were less frequent, grew more slowly, and were resorbed sooner in the mice fed the vitamin A supplement. Similarly, in these mice the appearance of pox lesions was delayed, their numbers reduced, and their disappearance hastened.

Tumor inhibition by 3h-estrogen-lucanthone treatment. Abstr

The ins and outs of mast cell function

American Journal of Anatomy, 1974

Vitamin A and Beta-Carotene as Adjunctive Therapy to Tumor Excision, Radiation Therapy, and Chemotherapy

International Symposium on Vitamins, Nutrition, and Cancer, Denver, Colo., June 1983

Endocrine influences on the mast cells of the rat

The Anatomical Record, 1956

... JACQUES PADAWER'J AND ALBERT 5. GORDON Department of Biology, Graduate School of Arts an... more

Cellular elements in the peritoneal fluid of some mammals

The Anatomical Record, 1956

... found that injections of horse serum (Panzenhagen and Speirs, '52, '53) or asbestos... more

States of Awareness During General Anesthesia

Perspectives in Biology and Medicine, 1975

Uptake of Colloidal Thorium Dioxide by Mast Cells

The Journal of Cell Biology, 1969

Mast cells from the peritoneal cavity of the rat were obtained at various times following in situ... more Mast cells from the peritoneal cavity of the rat were obtained at various times following in situ injection of a colloidal thorium dioxide preparation (Thorotrast). They were prepared for electron microscopy by aldehyde fixation, osmium tetroxide postfixation, and embedding in Epon. Thorotrast was rapidly taken up by mast cells through enhanced or newly elicited surface specializations. It was confined at first to large vesicles which moved to the Golgi area. Subsequently, in a matter of a few hours only, it became associated with progressively more mature granules, including "fully" mature ones. In addition to demonstrating a further phagocytic or pinocytotic activity of mast cells, the findings suggest that mast cell granules share a common membranous investment, and that substances from the tissue environment may theoretically percolate over and interact with the granules. Mast cell function could thus be served primarily by absorptive rather than secretory processes.

Induction of Cellular Movements in Mast Cells by Colchicine Treatment

The Journal of Cell Biology, 1966

Zone II flexor tendon repair: Effects of vitamins A, E, β-carotene

Journal of Surgical Research, 1990

Combined treatment with radioestradiol-lucanthone in mouse C3HBA mammary adenocarcinoma and with estradiol-lucanthone in an estrogen bioassay

International Journal of Radiation Oncology*Biology*Physics, 1981

... Jacques Padawer Ph.D. Corresponding Author Contact Information , ∗ , Giuseppe Rettura Ph.D. ... more

Scanning electron microscopy: Identification of mast cells by indirect cathodoluminescence

Histochemistry, 1974

Mast cells of rat peritoneal fluid deposited on glass and stained selectively with Acridine Orang... more Mast cells of rat peritoneal fluid deposited on glass and stained selectively with Acridine Orange can be detected in the SEM by cathodoluminescence. Model experiments with dyes suggest that the stained cells block the radiation emitted by the substrate (glass slide support). This approach may be useful for SEM identification of other cell types or for histo- and cytochemical purposes.

Isolation of Mast Cells from Other Cellular Elements of Rat Peritoneal Fluid

Experimental Biology and Medicine, 1955

... (21483) JACQUES PADAWER* AND ALBERT S. GORDON.~ From Department of Biology, Graduate School o... more

Mast cells: Extended lifespan and lack of granule turnover under normal in vivo conditions

Experimental and Molecular Pathology, 1974

... Under these conditions thorium dioxide deposits stood out in high contrast, and detection of ... more

A Mechanism for the Eosinopenia Induced by Cortisone and by EPINEPHRINE1

Endocrinology, 1952

Interest has become restimulated in the subject of the eosinophilic leukocyte largely as a result... more Interest has become restimulated in the subject of the eosinophilic leukocyte largely as a result of recent findings (Forsham, Thorn, Prunty and Hills, 1948; Speirs and Meyer, 1949; McDermott, Fry, Bro-beck and Long, 1950) that the numbers of these elements in the peripheral blood are affected sensitively by hormonal factors, particularly those of the adrenal, and by a variety of stressful states. Explanations have been proposed for the drop in peripheral blood eosinophiles following cortisone or epinephrine administration primarily on the basis of redistribution and destruction of these cells; the evidence favoring these views has been inferential for the most part and the question must still be considered as open.Peripheral blood of normal animals contains relatively low concentrations of eosinophiles. Ringoen (1938) reported that eosinophiles in values as great as 25% of the total cellular count could be found in peritoneal fluid.

Some studies on the fluorescence of mast cells after paraformaldehyde treatment

Zeitschrift f�r Zellforschung und Mikroskopische Anatomie, 1966

WHITE-TAILED DEER IN GREENBURGH, WESTCHESTER COUNTY, N.Y. A Comprehensive Review of Deer Overpopulation Problems and Control

Effect of podophyllin lignans on mast cell morphology in rat peritoneal fluid

American Journal of Physiology-Legacy Content, 1961

The morphology of mast cells is affected by podophyllotoxin and related substances. Other nondivi... more The morphology of mast cells is affected by podophyllotoxin and related substances. Other nondividing cells respond similarly. The changes observed are cytoplasmic and identical to those demonstrated following treatment with colchicine. Biological activity of podophyllin lignans is referable to specific molecular configuration and, in the mast cell system, parallels their activity in other assays such as tumor damage and mitotic inhibition of regenerating liver. These findings extend those demonstrated for a series of colchicine derivatives and, in this respect, emphasize the similarities in biological activity of the two compounds. They also underline further the unlikelihood that well-differentiated mast cells normally undergo mitosis. Because mast cells respond rapidly and sensitively to these specific drugs, it is suggested they afford a useful index of probable carcinostatic activity. Thus, colchicine or podophyllotoxin congeners could be prescreened readily, using few animals ...

Structural Alterations in Fibroblast Monolayers Caused by Mast Cell Degranulation

Journal of Leukocyte Biology, 1989

Studies on Peritoneal Fluid in the Pregnant Rat**Supported, in part, by a grant in aid from the American Cancer Society upon recommendation of the Committee on Growth of the National Research Council

American Journal of Obstetrics and Gynecology, 1956

Antipyretic and Antiviral Action of Vitamin A in Moloney Sarcoma Virus- and Poxvirus-Inoculated Mice 2

JNCI: Journal of the National Cancer Institute, 1976

Six week-old male CBA/J mice fed a commercial powdered laboratory chow or the same chow supplemen... more Six week-old male CBA/J mice fed a commercial powdered laboratory chow or the same chow supplemented with vitamin A palmitate (150,000 U/kg) were inoculated with either the Moloney strain of murine sarcoma virus (M-MuSV) or poxvirus. Central body temperature was measured daily. Both viruses elicited fevers, but the fevers were less pronounced and of shorter duration in the mice ingesting the vitamin A-supplemented diet. Palpable M-MuSV-induced tumors appeared later, were less frequent, grew more slowly, and were resorbed sooner in the mice fed the vitamin A supplement. Similarly, in these mice the appearance of pox lesions was delayed, their numbers reduced, and their disappearance hastened.

Tumor inhibition by 3h-estrogen-lucanthone treatment. Abstr

The ins and outs of mast cell function

American Journal of Anatomy, 1974

Vitamin A and Beta-Carotene as Adjunctive Therapy to Tumor Excision, Radiation Therapy, and Chemotherapy

International Symposium on Vitamins, Nutrition, and Cancer, Denver, Colo., June 1983

Endocrine influences on the mast cells of the rat

The Anatomical Record, 1956

... JACQUES PADAWER'J AND ALBERT 5. GORDON Department of Biology, Graduate School of Arts an... more

Cellular elements in the peritoneal fluid of some mammals

The Anatomical Record, 1956

... found that injections of horse serum (Panzenhagen and Speirs, '52, '53) or asbestos... more

States of Awareness During General Anesthesia

Perspectives in Biology and Medicine, 1975

Uptake of Colloidal Thorium Dioxide by Mast Cells

The Journal of Cell Biology, 1969

Mast cells from the peritoneal cavity of the rat were obtained at various times following in situ... more Mast cells from the peritoneal cavity of the rat were obtained at various times following in situ injection of a colloidal thorium dioxide preparation (Thorotrast). They were prepared for electron microscopy by aldehyde fixation, osmium tetroxide postfixation, and embedding in Epon. Thorotrast was rapidly taken up by mast cells through enhanced or newly elicited surface specializations. It was confined at first to large vesicles which moved to the Golgi area. Subsequently, in a matter of a few hours only, it became associated with progressively more mature granules, including "fully" mature ones. In addition to demonstrating a further phagocytic or pinocytotic activity of mast cells, the findings suggest that mast cell granules share a common membranous investment, and that substances from the tissue environment may theoretically percolate over and interact with the granules. Mast cell function could thus be served primarily by absorptive rather than secretory processes.

Induction of Cellular Movements in Mast Cells by Colchicine Treatment

The Journal of Cell Biology, 1966

Zone II flexor tendon repair: Effects of vitamins A, E, β-carotene

Journal of Surgical Research, 1990

Combined treatment with radioestradiol-lucanthone in mouse C3HBA mammary adenocarcinoma and with estradiol-lucanthone in an estrogen bioassay

International Journal of Radiation Oncology*Biology*Physics, 1981

... Jacques Padawer Ph.D. Corresponding Author Contact Information , ∗ , Giuseppe Rettura Ph.D. ... more

Scanning electron microscopy: Identification of mast cells by indirect cathodoluminescence

Histochemistry, 1974

Mast cells of rat peritoneal fluid deposited on glass and stained selectively with Acridine Orang... more Mast cells of rat peritoneal fluid deposited on glass and stained selectively with Acridine Orange can be detected in the SEM by cathodoluminescence. Model experiments with dyes suggest that the stained cells block the radiation emitted by the substrate (glass slide support). This approach may be useful for SEM identification of other cell types or for histo- and cytochemical purposes.

Isolation of Mast Cells from Other Cellular Elements of Rat Peritoneal Fluid

Experimental Biology and Medicine, 1955

... (21483) JACQUES PADAWER* AND ALBERT S. GORDON.~ From Department of Biology, Graduate School o... more

Mast cells: Extended lifespan and lack of granule turnover under normal in vivo conditions

Experimental and Molecular Pathology, 1974

... Under these conditions thorium dioxide deposits stood out in high contrast, and detection of ... more

A Mechanism for the Eosinopenia Induced by Cortisone and by EPINEPHRINE1

Endocrinology, 1952

Interest has become restimulated in the subject of the eosinophilic leukocyte largely as a result... more Interest has become restimulated in the subject of the eosinophilic leukocyte largely as a result of recent findings (Forsham, Thorn, Prunty and Hills, 1948; Speirs and Meyer, 1949; McDermott, Fry, Bro-beck and Long, 1950) that the numbers of these elements in the peripheral blood are affected sensitively by hormonal factors, particularly those of the adrenal, and by a variety of stressful states. Explanations have been proposed for the drop in peripheral blood eosinophiles following cortisone or epinephrine administration primarily on the basis of redistribution and destruction of these cells; the evidence favoring these views has been inferential for the most part and the question must still be considered as open.Peripheral blood of normal animals contains relatively low concentrations of eosinophiles. Ringoen (1938) reported that eosinophiles in values as great as 25% of the total cellular count could be found in peritoneal fluid.

Some studies on the fluorescence of mast cells after paraformaldehyde treatment

Zeitschrift f�r Zellforschung und Mikroskopische Anatomie, 1966