DOAJ (DOAJ: Directory of Open Access Journals), Feb 1, 2014
Evaluate the epidemiology of malaria in a cohort of children 6 months to 6 years, randomized livi... more Evaluate the epidemiology of malaria in a cohort of children 6 months to 6 years, randomized living in two villages with different malaria transmission pattern. We conducted a prospective cohort study with a longitudinal follow-up coupled transverse monthly passes on the anti malaria chemoprophylaxis in two different villages. It is an epidemiological study of choice of a potential site for the anti malaria vaccine phase I. Randomization was made on the SPSS software to reset the subjects included in two groups by site. Chemo prophylaxis has been made with the chloroquine + Proguanil (CQ + PG). Were included all subjects aged 6 months to 6 years who reside in the two study sites. The oral consent of parents or guardians is obtained prior to its participation in the study. Are not included all subjects that do not meet the criteria for inclusion in the study, and also volunteers who decide to withdraw from the study. Sex ratio is 1.20 and 1.03 respectively at Doneguebougou and Sotuba for the male in our study population. Plasmodique index does not change significantly (p = 0.50) between the two sites. Splenic index inclusion in December indicates a significant variation between the two sites (p = 0. 0005). This variation is cancels with the introduction of the chemo prophylaxis in the months of August and September. The shielding moved progressively during the other months of follow-up. The incidence of malaria is high Doneguebougou (41.4%) to Sotuba (18.3%). Which is related with the hyper Malaria endemicity of Doneguebougou and meso Sotuba endemic in our study we did had not registered in our cohort of children to the third access to the group under chemo prophylaxis. No child of this group to Sotuba is saved in the Access 2. In the control group two children went to the second access to Doneguebougou against four Sotuba. Children under chemo prophylaxis are fewer Marsh episodes than the control group. The average rate of anthropophilie year .gambiae. Sl to Doneguebougou (92.7%, n = 2390) was comparable to that observed at Sotuba (87.6%, n = 873) for the same vector (p = 0. 000005). Chemoprophylaxis had a significant effect on indices, paludometriques at the level of the two sites. The plasmodique index is significantly different, whereas the average rate of anthropophilie remains similar in the two sites. Doneguebougou might be a good site for vaccine testing of phase I. The year species. gambiae sl, and year. funestus were the main vectors of transmission.
Intermittent preventive treatment in pregnancy (IPTp) with 3 or more doses of sulfadoxine-pyrimet... more Intermittent preventive treatment in pregnancy (IPTp) with 3 or more doses of sulfadoxine-pyrimethamine (SP) is recommended by the World Health Organization to prevent malaria in pregnant women living in high-risk areas. According to the 2015 malaria indicator survey in Mali, malaria prevalence is 34.6%. The high risk of malaria among pregnant women and children led the Malian government to provide free SP during antenatal clinics visits. The Malian National Program of Malaria Control recommends at least 3 doses during pregnancy. The proportion of pregnant women taking 3 or more doses of IPTp-SP (IPTp 3+) still remains low. In Mali, only 36.7% of pregnant women with a live birth in the past 2 yr received IPTp 3+. To investigate the factors associated with this low coverage, we carried out a secondary data analysis using the database of the Mali 2015 Malaria Indicator Survey. Multiple logistic regression was used to analyze these factors among 2,382 interviewed women. Taking less than 3 doses was higher among women below 20 yr (adjusted odds ratio [AOR] = 1.43, 95% confidence interval [CI, 1.03; 1.98]); however, media accessibility (listening to radio) (AOR = 0.71, 95% CI [0.53–0.95]) and residing in Segou (AOR = 0.56, 95% CI [0.35–0.90]) seem to favor the opposite after adjusting the potential confusion. Residence, educational level, and wealth index were not statistically associated with taking 3 doses of IPTp-SP. This study identifies that women less than 20 yr of age were significantly associated with taking lower than 3 doses of IPTp-SP.
The American Journal of Tropical Medicine and Hygiene
In Mali, malaria vector control relies mostly on long-lasting insecticidal nets and indoor residu... more In Mali, malaria vector control relies mostly on long-lasting insecticidal nets and indoor residual spraying (IRS). From 2008 to 2016, an IRS program was implemented in the district of Koulikoro. After a significant reduction in malaria indicators, IRS was stopped in 2016. This study evaluated the effect of IRS withdrawal on entomological parameters of malaria transmission and incidence in children aged 6 months to 10 years in the district of Koulikoro. Entomological parameters of malaria transmission during the last year of IRS implementation in 2016 were compared with those obtained 2 years after IRS withdrawal in 2018 in two villages of Koulikoro. Mosquito vectors were collected by mouth aspiration and pyrethrum spray catches in the villages to monitor these transmission parameters. A sharp increase (10.8 times higher) in vector abundance after IRS withdrawal was observed. The infection rate of Anopheles gambiae sensu lato to Plasmodium falciparum increased from zero during IRS i...
Introduction Although an essential frontline service in the prevention of child morbidity and mor... more Introduction Although an essential frontline service in the prevention of child morbidity and mortality, there are indications that routine vaccinations have been disrupted during the COVID-19 pandemic. The present study aimed to compare vaccination coverage before COVID-19 in Mali in 2019 and one year after COVID-19 in 2020. Objective To compare vaccination coverages before COVID-19 in Mali in 2019 and one year after COVID-19 in 2020. Design Cross-sectional study. Setting and participants We collected routine immunization data from 2019 and 2020 of children under one year in the health district of Commune V in Bamako which includes twelve community health centers (CSCom). Results Overall, vaccination coverage of the nine vaccines was higher in 2019 (89.4%) compared to 2020 (79%; p < 10− 3). In 2020, low proportions of children vaccinated were observed in May (54.8%) two months after the first COVID-19 case in Mali on March 25, 2020. For all vaccines, the mean number of children ...
Symptoms due to their diversity and variability are the most common reasons for consultation. The... more Symptoms due to their diversity and variability are the most common reasons for consultation. The grouping of these symptoms into entities could guide explorations and facilitate clinicians' diagnosis: leucorrhoea, pelvic pain, disorders of the cycle and genital hemorrhages, sexual disorders, urinary and rectal disorders, symptoms of breast fertility. To better target the diagnosis of common pathology, we have undertaken a study to determine the reasons for consultation in gynecology at CHU GABRIEL TOURE in Bamako. It consisted of a systematic collection of information on patients who had consulted the gynecology department from 1 January 2008 to 31 December 2009. It was found that women in periods of genital activity (15 to 49 years) constituted 86.3% 'sample. They were housewives in 58.5% of the cases and the average age of the consultants was 32.29 years with extremes of 1 to 96 years. Pregnancy desire was 16.3%; Pelvic pain 11.6% and vulvovaginal pruritus 8.9%. Vaginitis...
Background : Seasonal malaria chemoprevention (SMC) is the administration of complete therapeutic... more Background : Seasonal malaria chemoprevention (SMC) is the administration of complete therapeutic courses of antimalarial to all children 3–59 months old during the malaria transmission season. This study measured coverage, impact and cost of adding SMC in children aged 5-10 years. Methods : A non-randomized, pre-post design, with an intervention (Kita) and control (Bafoulabe) district implemented SMC for children 5-10 years old through the health system in 2017 and 2018. SMC implementation consisted of the administration of SP + AQ at monthly intervals in children 5-10 years in July, August, September and October annually. Baseline and endline household surveys were conducted in both districts. Separate surveys to measure adherence and tolerance to treatment occurred annually in the intervention district (200 households) following each of the four treatment rounds. Routine data on malaria cases tested and treated and information on SMC campaign and treatment costs were collected. R...
AIM The purpose of this study is to help prevent the consequences associated with early sexual ac... more AIM The purpose of this study is to help prevent the consequences associated with early sexual activity and fertility in young people. It is intended to analyze the logical use of emergency contraception among health students. MATERIALS AND METHODS Cross-sectional, the study involved students enrolled for the 2012-2013 academic year. It took place in Bamako and Cotonou over two stages. It had two components, a qualitative preparatory and qualitative decisional one. RESULTS All students surveyed had heard of contraception. The proportion of students who have had sexual intercourse is 91.2%. During their first sexual intercourse, only 20.3% of sexually active students used a contraceptive method. With regards to the use of emergency contraception by sexually active students, 9 out of 10 have used emergency contraception. CONCLUSION The analysis of data from this study helps to know that emergency contraception is well known by students in medical academia. And although they are aware ...
DOAJ (DOAJ: Directory of Open Access Journals), Feb 1, 2014
Evaluate the epidemiology of malaria in a cohort of children 6 months to 6 years, randomized livi... more Evaluate the epidemiology of malaria in a cohort of children 6 months to 6 years, randomized living in two villages with different malaria transmission pattern. We conducted a prospective cohort study with a longitudinal follow-up coupled transverse monthly passes on the anti malaria chemoprophylaxis in two different villages. It is an epidemiological study of choice of a potential site for the anti malaria vaccine phase I. Randomization was made on the SPSS software to reset the subjects included in two groups by site. Chemo prophylaxis has been made with the chloroquine + Proguanil (CQ + PG). Were included all subjects aged 6 months to 6 years who reside in the two study sites. The oral consent of parents or guardians is obtained prior to its participation in the study. Are not included all subjects that do not meet the criteria for inclusion in the study, and also volunteers who decide to withdraw from the study. Sex ratio is 1.20 and 1.03 respectively at Doneguebougou and Sotuba for the male in our study population. Plasmodique index does not change significantly (p = 0.50) between the two sites. Splenic index inclusion in December indicates a significant variation between the two sites (p = 0. 0005). This variation is cancels with the introduction of the chemo prophylaxis in the months of August and September. The shielding moved progressively during the other months of follow-up. The incidence of malaria is high Doneguebougou (41.4%) to Sotuba (18.3%). Which is related with the hyper Malaria endemicity of Doneguebougou and meso Sotuba endemic in our study we did had not registered in our cohort of children to the third access to the group under chemo prophylaxis. No child of this group to Sotuba is saved in the Access 2. In the control group two children went to the second access to Doneguebougou against four Sotuba. Children under chemo prophylaxis are fewer Marsh episodes than the control group. The average rate of anthropophilie year .gambiae. Sl to Doneguebougou (92.7%, n = 2390) was comparable to that observed at Sotuba (87.6%, n = 873) for the same vector (p = 0. 000005). Chemoprophylaxis had a significant effect on indices, paludometriques at the level of the two sites. The plasmodique index is significantly different, whereas the average rate of anthropophilie remains similar in the two sites. Doneguebougou might be a good site for vaccine testing of phase I. The year species. gambiae sl, and year. funestus were the main vectors of transmission.
Intermittent preventive treatment in pregnancy (IPTp) with 3 or more doses of sulfadoxine-pyrimet... more Intermittent preventive treatment in pregnancy (IPTp) with 3 or more doses of sulfadoxine-pyrimethamine (SP) is recommended by the World Health Organization to prevent malaria in pregnant women living in high-risk areas. According to the 2015 malaria indicator survey in Mali, malaria prevalence is 34.6%. The high risk of malaria among pregnant women and children led the Malian government to provide free SP during antenatal clinics visits. The Malian National Program of Malaria Control recommends at least 3 doses during pregnancy. The proportion of pregnant women taking 3 or more doses of IPTp-SP (IPTp 3+) still remains low. In Mali, only 36.7% of pregnant women with a live birth in the past 2 yr received IPTp 3+. To investigate the factors associated with this low coverage, we carried out a secondary data analysis using the database of the Mali 2015 Malaria Indicator Survey. Multiple logistic regression was used to analyze these factors among 2,382 interviewed women. Taking less than 3 doses was higher among women below 20 yr (adjusted odds ratio [AOR] = 1.43, 95% confidence interval [CI, 1.03; 1.98]); however, media accessibility (listening to radio) (AOR = 0.71, 95% CI [0.53–0.95]) and residing in Segou (AOR = 0.56, 95% CI [0.35–0.90]) seem to favor the opposite after adjusting the potential confusion. Residence, educational level, and wealth index were not statistically associated with taking 3 doses of IPTp-SP. This study identifies that women less than 20 yr of age were significantly associated with taking lower than 3 doses of IPTp-SP.
The American Journal of Tropical Medicine and Hygiene
In Mali, malaria vector control relies mostly on long-lasting insecticidal nets and indoor residu... more In Mali, malaria vector control relies mostly on long-lasting insecticidal nets and indoor residual spraying (IRS). From 2008 to 2016, an IRS program was implemented in the district of Koulikoro. After a significant reduction in malaria indicators, IRS was stopped in 2016. This study evaluated the effect of IRS withdrawal on entomological parameters of malaria transmission and incidence in children aged 6 months to 10 years in the district of Koulikoro. Entomological parameters of malaria transmission during the last year of IRS implementation in 2016 were compared with those obtained 2 years after IRS withdrawal in 2018 in two villages of Koulikoro. Mosquito vectors were collected by mouth aspiration and pyrethrum spray catches in the villages to monitor these transmission parameters. A sharp increase (10.8 times higher) in vector abundance after IRS withdrawal was observed. The infection rate of Anopheles gambiae sensu lato to Plasmodium falciparum increased from zero during IRS i...
Introduction Although an essential frontline service in the prevention of child morbidity and mor... more Introduction Although an essential frontline service in the prevention of child morbidity and mortality, there are indications that routine vaccinations have been disrupted during the COVID-19 pandemic. The present study aimed to compare vaccination coverage before COVID-19 in Mali in 2019 and one year after COVID-19 in 2020. Objective To compare vaccination coverages before COVID-19 in Mali in 2019 and one year after COVID-19 in 2020. Design Cross-sectional study. Setting and participants We collected routine immunization data from 2019 and 2020 of children under one year in the health district of Commune V in Bamako which includes twelve community health centers (CSCom). Results Overall, vaccination coverage of the nine vaccines was higher in 2019 (89.4%) compared to 2020 (79%; p < 10− 3). In 2020, low proportions of children vaccinated were observed in May (54.8%) two months after the first COVID-19 case in Mali on March 25, 2020. For all vaccines, the mean number of children ...
Symptoms due to their diversity and variability are the most common reasons for consultation. The... more Symptoms due to their diversity and variability are the most common reasons for consultation. The grouping of these symptoms into entities could guide explorations and facilitate clinicians' diagnosis: leucorrhoea, pelvic pain, disorders of the cycle and genital hemorrhages, sexual disorders, urinary and rectal disorders, symptoms of breast fertility. To better target the diagnosis of common pathology, we have undertaken a study to determine the reasons for consultation in gynecology at CHU GABRIEL TOURE in Bamako. It consisted of a systematic collection of information on patients who had consulted the gynecology department from 1 January 2008 to 31 December 2009. It was found that women in periods of genital activity (15 to 49 years) constituted 86.3% 'sample. They were housewives in 58.5% of the cases and the average age of the consultants was 32.29 years with extremes of 1 to 96 years. Pregnancy desire was 16.3%; Pelvic pain 11.6% and vulvovaginal pruritus 8.9%. Vaginitis...
Background : Seasonal malaria chemoprevention (SMC) is the administration of complete therapeutic... more Background : Seasonal malaria chemoprevention (SMC) is the administration of complete therapeutic courses of antimalarial to all children 3–59 months old during the malaria transmission season. This study measured coverage, impact and cost of adding SMC in children aged 5-10 years. Methods : A non-randomized, pre-post design, with an intervention (Kita) and control (Bafoulabe) district implemented SMC for children 5-10 years old through the health system in 2017 and 2018. SMC implementation consisted of the administration of SP + AQ at monthly intervals in children 5-10 years in July, August, September and October annually. Baseline and endline household surveys were conducted in both districts. Separate surveys to measure adherence and tolerance to treatment occurred annually in the intervention district (200 households) following each of the four treatment rounds. Routine data on malaria cases tested and treated and information on SMC campaign and treatment costs were collected. R...
AIM The purpose of this study is to help prevent the consequences associated with early sexual ac... more AIM The purpose of this study is to help prevent the consequences associated with early sexual activity and fertility in young people. It is intended to analyze the logical use of emergency contraception among health students. MATERIALS AND METHODS Cross-sectional, the study involved students enrolled for the 2012-2013 academic year. It took place in Bamako and Cotonou over two stages. It had two components, a qualitative preparatory and qualitative decisional one. RESULTS All students surveyed had heard of contraception. The proportion of students who have had sexual intercourse is 91.2%. During their first sexual intercourse, only 20.3% of sexually active students used a contraceptive method. With regards to the use of emergency contraception by sexually active students, 9 out of 10 have used emergency contraception. CONCLUSION The analysis of data from this study helps to know that emergency contraception is well known by students in medical academia. And although they are aware ...
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