Papers by Dr Satyender Kumar
In the current wave of antimicrobial resistance against chemotherapeutic drugs, there is need to ... more In the current wave of antimicrobial resistance against chemotherapeutic drugs, there is need to search for plants that could be resistance-free and affordable. The objective of this study was to investigate the antimicrobial effects of Petroleum ether, chloroform & hydroalcoholic extracts of Pandanus odoratissimus leaf against Bacillus subtilis, Escherichia coli, Staphlococcus aureus and Candida albicans. In terms of antimicrobial effects, all the three extracts exhibited effective inhibition zones against Gram-positive bacteria. However, they were ineffective against Gram-negative bacteria and yeast (Candida albicans). The minimum inhibitory concentration (MIC) of hydro-alcoholic, chloroform and petroleum ether extracts were found to be 25, 50 and 50 mg/ml respectively against Gram-positive bacteria. Out of three extracts, hydro-alcoholic extract showed good antimicrobial activity. The phytochemical study showed the presence of alkaloids and flavonoids in hydro-alcoholic extract, ...
The Journal of medical research, 2019
Phenolic and Polyphenolic are important compounds from the class of phytomedicine and are widely ... more Phenolic and Polyphenolic are important compounds from the class of phytomedicine and are widely distributed in the plant kingdom. Over the years, an increasing amount of interest has been vastly drawn into the plant polyphenolic mainly because these compounds have shown tremendous efficacy in the treatment of oxidative stress-related diseases such as cancer. Currently, much medical investigations are conducted on plant phenolic for improving their identification and development for better therapeutic efficacy in the fight against different types of cancers. We aim to update and provide an extensive overview of the mechanism of action and the role of phenolic compounds in the treatment of tumor. The various databases used to conduct the literature survey are (Pub Med Central, Scopus, Research Gate, EMBASE, Google Scholar, Science Direct, Sci ELO, PLoS (Public Library of Science). In the first stage it includes different types of cancers and their biomarkers. In second stage, differe...
Summary In the current wave of antimicrobial resistance against chemotherapeutic drugs, there is ... more Summary In the current wave of antimicrobial resistance against chemotherapeutic drugs, there is need to search for plants that could be resistance$free and affordable. The objective of this study was to investigate the antimicrobial effects of Petroleum ether, chloroform & hydroalcoholic extracts of Pandanus odoratissimus leaf against Bacillus subtilis, Escherichia coli , Staphlococcus aureus and Candida albicans . In terms of antimicrobial effects, all the three extracts exhibited effective inhibition zones against Gram$positive bacteria. However, they were ineffective against Gram$negative bacteria and yeast ( Candida albicans ). The minimum inhibitory concentration (MIC) of hydro$alcoholic, chloroform and petroleum ether extracts were found to be 25, 50 and 50 mg/ml respectively against Gram$positive bacteria. Out of three extrac ts, hydro$ alcoholic extract showed good antimicrobial activity. The phytochemical study showed the presence of alkaloids and flavonoids in hydro$alcoh...
International Journal of Biochemistry Research & Review, 2019
Cancer a leading cause of human mortality worldwide is characterised by the unseemly growth of ce... more Cancer a leading cause of human mortality worldwide is characterised by the unseemly growth of cellular mass and signalled through the enlargement of stress. Management of cancer treatment is still buried and has been recently alerting the need to discover a drug molecule with lesser side effects. The objective of the present study is to explore the anticancer activity and docking studies of 1-(5-substituted phenyl) isoxazol-3-yl)-5-phenyl-1H-tetrazole derivatives. The compounds were evaluated for in-vitro anticancer activity under the drug discovery program of National Cancer Institute (NCI), USA. Only seven compounds were selected and screened for anticancer activity at a single high dose (10-5 M) using NCI 60 cancer cell lines. Among all the selected compounds, 4b and 4i exhibited significant anticancer activity against Leukemia cell lines. Molecular docking studies for the 5-phenyl-1-(5-substituted phenylisoxazol-3-yl)-1H-tetrazole analogues was done by Schrodinger software. Do...
Indo Global Journal of Pharmaceutical Sciences, 2018
Indo Global Journal of Pharmaceutical Sciences, 2018
Indo Global Journal of Pharmaceutical Sciences, 2018
World Journal of Pharmacy and Pharmaceutical Sciences, 2017
World Journal of Pharmacy and Pharmaceutical Sciences, 2017
Diabetes Mellitus (DM) is a collection of metabolic diseases characterized by hyperglycemia resul... more Diabetes Mellitus (DM) is a collection of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. DM has been divided into four types: Insulin-dependent DM; Non-insulin-dependent DM; Gestational diabetes and monogenic diabetes. According to International Diabetes Federation, in 2015, about, 415 million people have diabetes; by 2040 this will increase to 642 million. The number of diabetic patients in India by 2040 will be 87 million. Therefore, there is a need to develop safe and effective treatment modalities for diabetes. Medicinal plants play an important role in the management of diabetes mellitus, especially in developing countries where resources are meager. This article presents a review on types of diabetes and its management and list of medicinal plants with antidiabetic effects used in the treatment of diabetes is compiled.
Journal of Applied Pharmaceutical Science, 2012
Asian Journal of Pharmaceutical and Clinical Research, 2018
Genetic modifications or mutations has been a bottleneck for the treatment of cancer; it is widel... more Genetic modifications or mutations has been a bottleneck for the treatment of cancer; it is widely known to play a vital role in the progression of metastatic level/stage within the nonsmall cell lung cancer (NSCLC). The NSCLC of cancer is responsible for lung cancer lawsuits. In the various genetic mutations related study has been concluded with the various genes findings, which are named as the epidermal growth factor receptor, anaplastic lymphoma kinase, Kristen rat sarcoma virus, ROS proto-oncogene 1, human epidermal growth factor, B-RAF proto-oncogene, rearranged during Transfection, MET, Phosphatidyl 3-kinases CA, IGF-1R, NTRK1, FGFR1, and DDR2. The various research data supported this study. The involvement of the gene in the NSCLC patients made a paradigm shift in the drug discovery. The presence of one mutation in connection with some other could have an impact on NSCLC remedy.Utilizing this genotype-directed therapy for an advanced NSCLC has to turn out to be an appealing ...
Diabetes Mellitus (DM) is a collection of metabolic diseases characterized by hyperglycemia resul... more Diabetes Mellitus (DM) is a collection of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. DM has been divided into four types: Insulin-dependent DM; Non-insulin-dependent DM; Gestational diabetes and monogenic diabetes. According to International Diabetes Federation, in 2015, about, 415 million people have diabetes; by 2040 this will increase to 642 million. The number of diabetic patients in India by 2040 will be 87 million. Therefore, there is a need to develop safe and effective treatment modalities for diabetes. Medicinal plants play an important role in the management of diabetes mellitus, especially in developing countries where resources are meager. This article presents a review on types of diabetes and its management and list of medicinal plants with antidiabetic effects used in the treatment of diabetes is compiled.
Various drug discovery programs have employed molecular modeling methods in pharmaceutical resear... more Various drug discovery programs have employed molecular modeling methods in pharmaceutical research for studying the complex chemical and biological systems. Experimental and computational strategies when used in combination, plays a very important role in the development and identification of novel compounds. The method of molecular docking is being broadly utilized in modern drug design, for exploring the confirmation of ligand within the target's binding sites. With molecular docking the binding energy of the ligand with receptor can also be estimated. For this purpose, various docking algorithms are available nowadays and it is very important to understand the limitations and advantages of each of these methods for developing efficient strategies and for generating appropriate results. In this review the basics of computational drug designing process has been discussed along with introduction molecular docking method and its application in drug discovery and medicinal chemistry.
This study was undertaken to assess the antifertility effect of hydroalcoholic leaves extract of ... more This study was undertaken to assess the antifertility effect of hydroalcoholic leaves extract of Pandanus odoratissimus Linn. which is traditionally used by the woman in Rajasthan state of India to regulate the fertility. The antifertility activity of the extract at dose levels (200 and 400 mg/kg, orally) was evaluated in two experimental animal models. The extract was found to be safe up to a dose of 4000 mg/kg of the extract when administered orally. A good antiimplantation (37.13%) activity in female rats was observed at the tested dose level (400 mg/kg). The extract, when administered alone at 200 mg/kg dose to immature female albino rats, enhanced the estrogen level in the serum whereas significantly decreased the estrogen level at 400 mg/kg dose. The extract along with estradiol at dose level of 400 mg/kg significantly (p < 0.01) decreased the level of estrogen, in comparison to standard group rats indicating the antiestro-genic nature of the extract. The antiestrogenic effect of the extract at higher dose (400 mg/kg) might be due to negative feedback inhibition on anterior pituitary. Preliminary phytochemical screening has revealed the presence of alkaloids, carbohydrates, flavonoids and saponins in the hydroalcoholic leaf extract of the plant. The antifertility effect of the plant might be due to antiimplantation as well as antie-strogenic effect of the extract which in turn might be due to some of the chemical constituents present in the extract. The results shows that hydroalcoholic extract of P. odoratissimus L. leaves possess significant antifertility activity at 400 mg/kg, thus, justifying the traditional use of this plant in fertility regulation in females.
In the current wave of antimicrobial resistance against
chemotherapeutic drugs, there is need to ... more In the current wave of antimicrobial resistance against
chemotherapeutic drugs, there is need to search for plants that could
be resistance-free and affordable. The objective of this study was to
investigate the antimicrobial effects of Petroleum ether, chloroform
& hydroalcoholic extracts of Pandanus odoratissimus leaf against
Bacillus subtilis, Escherichia coli, Staphlococcus aureus and
Candida albicans. In terms of antimicrobial effects, all the three
extracts exhibited effective inhibition zones against Gram-positive
bacteria. However, they were ineffective against Gram-negative
bacteria and yeast (Candida albicans). The minimum inhibitory
concentration (MIC) of hydro-alcoholic, chloroform and petroleum
ether extracts were found to be 25, 50 and 50 mg/ml respectively
against Gram-positive bacteria. Out of three extracts, hydroalcoholic extract showed good antimicrobial activity. The
phytochemical study showed the presence of alkaloids and
flavonoids in hydro-alcoholic extract, which might be responsible
for its good antimicrobial activity.
Patent by Dr Satyender Kumar
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Papers by Dr Satyender Kumar
chemotherapeutic drugs, there is need to search for plants that could
be resistance-free and affordable. The objective of this study was to
investigate the antimicrobial effects of Petroleum ether, chloroform
& hydroalcoholic extracts of Pandanus odoratissimus leaf against
Bacillus subtilis, Escherichia coli, Staphlococcus aureus and
Candida albicans. In terms of antimicrobial effects, all the three
extracts exhibited effective inhibition zones against Gram-positive
bacteria. However, they were ineffective against Gram-negative
bacteria and yeast (Candida albicans). The minimum inhibitory
concentration (MIC) of hydro-alcoholic, chloroform and petroleum
ether extracts were found to be 25, 50 and 50 mg/ml respectively
against Gram-positive bacteria. Out of three extracts, hydroalcoholic extract showed good antimicrobial activity. The
phytochemical study showed the presence of alkaloids and
flavonoids in hydro-alcoholic extract, which might be responsible
for its good antimicrobial activity.
Patent by Dr Satyender Kumar
chemotherapeutic drugs, there is need to search for plants that could
be resistance-free and affordable. The objective of this study was to
investigate the antimicrobial effects of Petroleum ether, chloroform
& hydroalcoholic extracts of Pandanus odoratissimus leaf against
Bacillus subtilis, Escherichia coli, Staphlococcus aureus and
Candida albicans. In terms of antimicrobial effects, all the three
extracts exhibited effective inhibition zones against Gram-positive
bacteria. However, they were ineffective against Gram-negative
bacteria and yeast (Candida albicans). The minimum inhibitory
concentration (MIC) of hydro-alcoholic, chloroform and petroleum
ether extracts were found to be 25, 50 and 50 mg/ml respectively
against Gram-positive bacteria. Out of three extracts, hydroalcoholic extract showed good antimicrobial activity. The
phytochemical study showed the presence of alkaloids and
flavonoids in hydro-alcoholic extract, which might be responsible
for its good antimicrobial activity.