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Bappaditya Chatterjee

International Islamic University Malaysia, Pharmaceutical technology, Faculty Member

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• Working in the International Islamic University Malaysia (IIUM), Malaysia as an Assistant Professor since March’2013.
• Two years of industry experience on analytical method development and validation by HPLC and LC MS/MS in the Fresenius Kabi Oncology Ltd, Kalyani, India under the regulatory guidance of US FDA.
• Engaged in five (5) major research projects funded by Ministry of Education (MOE), Malaysia (3) and IIUM (2) as Principal investigator (2) and co-investigator (3). Total value of projects is above MYR 300K.
• More than 20 international publications in different indexed journal and 6 conference proceedings in international conferences on analytical/bio analytical study and solid dosage forms.

Citation indices
All Since 2011
h-index
7 7
i10-index
7 6
(https://scholar.google.com.my/citations?hl=en&authorid=7003587403908281627&user=TWFcxTkAAAAJ&cstart=0&pagesize=20)

• Consultant in the Department of R&D (Analytical) under iKOP Sdn Bhd, Malaysia, a GMP certified HALAL pharmaceutical company.
• Teaching experience of 4 years (including the ongoing) on solid dosage form, biopharmaceutics and pharmaceutical engineering at both bachelor and master degree level.
• Research experience of three years as a senior research fellow (SRF) in the Department of Pharmaceutical Technology, Jadavpur University, Kolkata, India. Area of research was solid dosage form.
• Enlisted reviewer of the journals entitled Analytical and Bioanalytical Chemistry (Springer, IF 3.435) and PLOS One (IF: 3.234).

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Papers by Bappaditya Chatterjee

Development and Validation of UV Spectrophotometric Method for Determination of Paracetamol in Chitosan Coated Alginate Beads and Dissolution Studies

Pharmaceutical Chemistry Journal

Formulation development and evaluation of rotigotine mucoadhesive nanoemulsion for intranasal delivery

Journal of Drug Delivery Science and Technology, 2019

Role of angiotensin receptor blockers in the context of Alzheimer's disease

Fundamental & Clinical Pharmacology

As the world's population ages, the prevalence of age‐related neurological disorders such as ... more As the world's population ages, the prevalence of age‐related neurological disorders such as Alzheimer's disease (AD) is increasing. There is currently no treatment for Alzheimer's disease, and the few approved medications have a low success rate in lowering symptoms. As a result, several attempts are underway worldwide to identify new targets for the therapy of Alzheimer's disease. In preclinical studies of Alzheimer's disease, it was recently found that inhibition of angiotensin‐converting enzyme (ACE) and blocking of the angiotensin II receptors reduce symptoms of neurodegeneration, Aβ plaque development, and tau hyperphosphorylation. Angiotensin II type I (AT1) blockers, such as telmisartan, candesartan, valsartan, and others, have a wide safety margin and are commonly used to treat hypertension. Renal and cardiovascular failures are reduced due to their vascular protective actions. Inhibition of AT1 receptors in the brain has a neuroprotective impact in huma...

Dendrimers in the context of targeting central nervous system disorders

Journal of Drug Delivery Science and Technology

Direct compressed tablet with melt dispersed drug particle without binder

Objective: To prepare ibuprofen tablet without binder by direct compression method. Methodology: ... more Objective: To prepare ibuprofen tablet without binder by direct compression method. Methodology: Differential scanning calorimetry (DSC), attenuated total reflectance (ATR) and high performance liquid chromatography (HPLC)analysis were done to investigate ibuprofen stability during melting and solidification process as well as compatibility with microcrystalline cellulose (MCC). Ibuprofen was melted at 85 oC and MCC was dispersed (Ibuprofen: MCC, 1.7: 1 w/w) in molten drug with constant stirring. The dispersion was solidified in an ice bath immediately and then pulverized followed by sieving through 600-micron sieve. The derived powder was tested for flow property and compressibility and compressed into tablet without adding any binder. The prepared tablets were evaluated for hardness, friability, disintegration and in vitro dissolution. Results: No differences in melting peak, enthalpy, functional groups, and chromatographic retention time were observed between ibuprofen and solidi...

Self-emulsifying Drug Delivery System for Oral Anticancer Therapy: Constraints and Recent Development

Current Pharmaceutical Design

: Oral anticancer therapy faces several drawbacks of low aqueous solubility, poor and irregular a... more : Oral anticancer therapy faces several drawbacks of low aqueous solubility, poor and irregular absorption from gastro-intestinal sites, high first-pass metabolism, food-influenced absorption, non-targeted delivery, severe systemic and local adverse effects, etc. Enhancement of oral bioavailability could reduce the drug load and associated adverse effects. Self-emulsifying drug delivery systems (SEDDS) can enhance in-vivo solubility and drug absorption from the gastrointestinal tract, bypass liver metabolism by lymphatic absorption and inhibit efflux transport. All these phenomena ultimately result in improved oral bioavailability. Anticancer drug delivery using the SEDDS has shown promising results for bioavailability and pharmacodynamic response. A handful number of researches have produced evidence of the successful loading of anticancer agents in SEDDS-based formulations. Various potent and established chemotherapeutic agents such as docetaxel, paclitaxel, etoposide, 5 Fluorouracil, doxorubicin etc. have been successfully formulated and evaluated. Improved bioavailability and reduction of dose might be possible by SEDDS. It could be effective for low-dose drugs. But, excessive surfactant-cosurfactant concentration, lacking predictive in-vitro models and adequate IVIVC, unavailability of toxicity data are certain challenges for future researchers. To date, no clinical trials have been recorded with anticancer drug loaded SEDDS. To avail the benefits of anticancer SEDDS, overcoming the challenges and further progression to clinical studies are required. Methods: Hospital based retrospective, observational study in which all the confirmed cases of CSC (272) seen between 2010 and 2019 were included. Supplementary data was collected on follow up visits or through telephonic calls. Results: The male: female ratio was 17:1; low socio-economic status was (155; 73.45%), and occupations such as drivers (61; 28.9%) and outdoor laborers (59; 27.96%) were the most commonly affected. The majority (78.05%; 185) were single expatriates. Financial worries (105; 50.72%) constituted the leading cause of stress. The usage of corticosteroids (83; 30.51%), nasal decongestants (14.70%) or both (17; 6.25%) within one year was common; mostly (82; 30.14%) for rhinitis/respiratory states, though grossly under-recognized. Muscle relaxants and psychotropic medications were the other major medications used by 24 (8.82%) and 25 (9.19%) cases prior to CSC. Seven of 15 women had at least one condition that alters the endocrinal milieu: Pregnancy (3), recent child birth (1), erratic oral contraceptive intake (1), menopause with liver dysfunction (1), hormone replacement therapy for menopause and endometriosis (1), ovarian cyst and infertility (1) hypothyroidism (3), and Cushing syndrome (1). Chronic/ recurrent forms were seen in 31.08%. There were too few glaucoma patients despite both CSC and glaucoma being common among our patients.

3D-printed Drugs: A Fabrication of Pharmaceuticals towards Personalized Medicine

Indian Journal of Pharmaceutical Education and Research, 2020

Exploring blend uniformity of a binary mixture containing metformin Hcl and hydroxypropyl methyl cellulose by DSC

Pharmacokinetic characterization of drugs and new product development

Biopharmaceutics and Pharmacokinetics Considerations, 2021

Advancement in combinatorial chemistry in recent decades has synthesized a large number of potent... more Advancement in combinatorial chemistry in recent decades has synthesized a large number of potential candidates for therapeutic use. High-throughput screening technology helps select the most suitable candidate to proceed from preclinical to clinical stage. However, attrition of drug candidates at the late stage of the clinical trial is not rare. Such attrition increases drug development costs and adversely affects the demand and expectation for new therapeutic agents. Therefore decision-making step for “go or no-go” in every stage of preclinical and clinical development is of utmost importance. Pharmacokinetic (PK) characterization of the drug candidate under development is one of the essential steps that help the decision-making process. In general, PK characterization in a preclinical study assesses the drug’s absorption, distribution, metabolism and elimination (ADME) to predict its bioavailability and determine human dose. Apart from ADME assessment, drug–drug interaction, food...

Incorporation of carbopol to palm olein based analgesic cream: effect on formulation characteristics

The purpose of the investigation was to incorporate carbopol gel with palm olein based emulsion a... more The purpose of the investigation was to incorporate carbopol gel with palm olein based emulsion and to investigate the effect of such incorporation on formulation characteristics. A palm olein based emulsion was formulated followed by addition of carbopol 940 to it. The critical parameters of incorporating carbopol in bench scale level were checked. The developed palm olein-carbopol based analgesic cream was analyzed for pH, zeta potential, viscosity, rheological property and forced centrifugation.Incorporation of 0.3% of carbopol gel (1% w/w) helps to maintain the viscosity and stability. pH and zeta potential of palm olein-carbopol combined cream was within range of 6.90 to 7.20 and -23.1 to -74.9, respectively. Combination of palm olein based emulsion and carbopol would be a suitable option for topical cream formulation. The pH of carbopol gel and method of mixing with the palm olein based emulsion had crucial effects on phase separation of the product.

Electro-hydrodynamic assisted synthesis of lecithin-stabilized peppermint oil-loaded alginate microbeads for intestinal drug delivery

International Journal of Biological Macromolecules, 2021

Encapsulation of Black Seed Oil in Alginate Beads as a pH-Sensitive Carrier for Intestine-Targeted Drug Delivery: In Vitro, In Vivo and Ex Vivo Study

Pharmaceutics, 2020

Black seed oil (BSO) has been used for various therapeutic purposes around the world since ancien... more Black seed oil (BSO) has been used for various therapeutic purposes around the world since ancient eras. It is one of the most prominent oils used in nutraceutical formulations and daily consumption for its significant therapeutic value is common phenomena. The main aim of this study was to develop alginate-BSO beads as a controlled release system designed to control drug release in the gastrointestinal tract (GIT). Electrospray technology facilitates formulation of small and uniform beads with higher diffusion and swelling rates resulting in process performance improvement. The effect of different formulation and process variables was evaluated on the internal and external bead morphology, size, shape, encapsulation efficiency, swelling rate, in vitro drug release, release mechanism, ex vivo mucoadhesive strength and gastrointestinal tract qualitative and quantitative distribution. All the formulated beads showed small sizes of 0.58 ± 0.01 mm (F8) and spherical shape of 0.03 ± 0.00...

Effects of Different Formulation Methods on Drug Crystallinity, Drug-Carrier Interaction, and Ex Vivo Permeation of a Ternary Solid Dispersion Containing Nisoldipine

Journal of Pharmaceutical Innovation, 2019

Quantitation of Pregabalin by HPLC-UV Method using Ninhydrin Derivatization: Development and Validation

Current Pharmaceutical Analysis, 2020

Introduction: A simple and reliable high performance liquid chromatographic method has been devel... more Introduction: A simple and reliable high performance liquid chromatographic method has been developed for the quantitative determination of pregabalin in bulk and dosage form. Pregabalin, a γ amino butyric acid analogue, has negligible sensitivity to UV or fluorescence detection. Hence, it has been derivatized by ninhydrin to form a chromophoric complex that could be quantified by UV detection. Materials and Methods: The concentration of ninhydrin was set to 5 mg/ml and a phosphate buffer solution (pH 7.4) was used as a solvent for the reaction. The resultant complex was separated by HPLC and detected by a UV detector at 569nm wavelength. Results: The developed method showed a linear response within 50 to 600 μg/mL of pregabalin. The method was accurate with mean recovery values within 100 ± 2%. The repeatability of the method was established by intra-day and inter-day precision study. Finally, a commercial pregabalin capsule was assayed by the developed HPLC method including ninhyd...

Optimization of Aceclofenac Proniosomes by Using Different Carriers, Part 1: Development and Characterization

Pharmaceutics, 2019

In the contemporary medical model world, the proniosomal system has been serving as a new drug de... more In the contemporary medical model world, the proniosomal system has been serving as a new drug delivery system that is considered to significantly enhance the bioavailability of drugs with low water solubility. The application of this system can improve the bioavailability of aceclofenac that is used for the relief of pain and inflammation in osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. The present study is intended to develop an optimized proniosomal aceclofenac formula by the use of different carriers. Aceclofenac proniosomes have been prepared by slurry method, and different carriers such as maltodextrin, mannitol, and glucose were tried. Prepared proniosomes characterized by differential scanning calorimetry (DSC) analysis and Fourier transform infrared (FTIR) analysis revealed the compatibility of the drug chosen with the ingredient added, powder X-ray diffractometry (XRD) confirmed the amorphous phase of the prepared proniosomes, and finally, the surfactan...

Mucoadhesive Polymers and Their Mode of Action: A Recent Update

Journal of Applied Pharmaceutical Science, 2017

Potential and future scope of nanoemulgel formulation for topical delivery of lipophilic drugs

International Journal of Pharmaceutics, 2017

Glidant effect of hydrophobic and hydrophilic nanosilica on a cohesive powder: Comparison of different flow characterization techniques

Particuology, 2017

Abstract The methods used for flow characterization of a powder mass include the angle of repose ... more Abstract The methods used for flow characterization of a powder mass include the angle of repose (AOR), Carr index (CI), and powder flow tester (PFT). The use of nanosilica as a flow modifier (glidant) is very common in industry. This study aims to compare the glidant effect of hydrophobic and hydrophilic silica on a poorly flowable active pharmaceutical ingredient (ibuprofen) by different flow characterization techniques. Different percentages (0.5, 1.0, and 2.0 wt%) of both types of mixed silica–ibuprofen powders were evaluated by the AOR, CI, bulk density, and PFT. The flow factor, effective angle of friction, and cohesion were determined to explain the bulk powder properties. The results show that different types of silica show different levels of flow property improvement, but the techniques do not equally discriminate the differences. Hydrophobic silica results in better improvement of the flow property than hydrophilic silica, probably because of its better surface coverage of silica on the host particles. Change of the bulk density with applied pressure was significant for the different powders. This study demonstrates that combining several characterization methods provides a better understanding of bulk powder flow properties with respect to powder–process relationships than a single flow indicator.

A Bioanalytical Method for Quantification of Telmisartan in rat Plasma; Development, Validation and Application to Pharmacokinetic Study

Research Journal of Pharmacy and Technology, 2021

The telmisartan was determined in a rat plasma using developed and validated a reversed-phase hig... more The telmisartan was determined in a rat plasma using developed and validated a reversed-phase high performance liquid chromatographic (HPLC). The pre-treatment of the plasma sample involving liquid-liquid extraction using ethanol as the extracting solvent. The HPLC method validation has been shown a linear calibration curve over a plasma concentrations range of 0.7 to 10µg/mL with a correlation coefficient of 0.9979, the limit of detection and the limit of quantification were determined to be 0.025µg/ml and 0.07µg/ml, respectively. The precision and accuracy were in an acceptable limit. The pharmacokinetic parameters of telmisartan were adequately evaluated following a single oral dose (4mg/kg) in Sprague-Dawley rats. The results observed conclude that the developed bioanalytical HPLC method is appropriate and applicable as an analytical tool in the pharmacokinetic study of telmisartan.

Development and validation of a LC- MS/MS Method for simultaneous quantitation of telmisartan and pioglitazone in rat plasma

In majority of complex diseases like diabetes, multiple medications are essential to achieve the ... more In majority of complex diseases like diabetes, multiple medications are essential to achieve the better therapeutic control, as several mediators are involved in their pathogenesis. Likewise, although the primary component of diabetes care is to control blood glucose level, management of cardiovascular risk factors should also be considered as vital one. Literature review reveals that the major and common health problems associated with pathophysiological mechanism for arterial damage in diabetes is hypertension. It is well established that angiotensin receptor blocker (ARB) class of antihypertensives are better tolerated antihypertensive. Amongst ARBs, telmisartan has fewer drug-related adverse events and provides superior blood pressure control. On the other hand, pioglitazone is a useful therapeutic drug for type 2 diabetes having beneficial pleiotropic effects on cardiovascular diseases. Thus, the combination therapy of telmisartan and pioglitazone can be beneficial to treat a p...

Development and Validation of UV Spectrophotometric Method for Determination of Paracetamol in Chitosan Coated Alginate Beads and Dissolution Studies

Pharmaceutical Chemistry Journal

Formulation development and evaluation of rotigotine mucoadhesive nanoemulsion for intranasal delivery

Journal of Drug Delivery Science and Technology, 2019

Role of angiotensin receptor blockers in the context of Alzheimer's disease

Fundamental & Clinical Pharmacology

As the world's population ages, the prevalence of age‐related neurological disorders such as ... more As the world's population ages, the prevalence of age‐related neurological disorders such as Alzheimer's disease (AD) is increasing. There is currently no treatment for Alzheimer's disease, and the few approved medications have a low success rate in lowering symptoms. As a result, several attempts are underway worldwide to identify new targets for the therapy of Alzheimer's disease. In preclinical studies of Alzheimer's disease, it was recently found that inhibition of angiotensin‐converting enzyme (ACE) and blocking of the angiotensin II receptors reduce symptoms of neurodegeneration, Aβ plaque development, and tau hyperphosphorylation. Angiotensin II type I (AT1) blockers, such as telmisartan, candesartan, valsartan, and others, have a wide safety margin and are commonly used to treat hypertension. Renal and cardiovascular failures are reduced due to their vascular protective actions. Inhibition of AT1 receptors in the brain has a neuroprotective impact in huma...

Dendrimers in the context of targeting central nervous system disorders

Journal of Drug Delivery Science and Technology

Direct compressed tablet with melt dispersed drug particle without binder

Objective: To prepare ibuprofen tablet without binder by direct compression method. Methodology: ... more Objective: To prepare ibuprofen tablet without binder by direct compression method. Methodology: Differential scanning calorimetry (DSC), attenuated total reflectance (ATR) and high performance liquid chromatography (HPLC)analysis were done to investigate ibuprofen stability during melting and solidification process as well as compatibility with microcrystalline cellulose (MCC). Ibuprofen was melted at 85 oC and MCC was dispersed (Ibuprofen: MCC, 1.7: 1 w/w) in molten drug with constant stirring. The dispersion was solidified in an ice bath immediately and then pulverized followed by sieving through 600-micron sieve. The derived powder was tested for flow property and compressibility and compressed into tablet without adding any binder. The prepared tablets were evaluated for hardness, friability, disintegration and in vitro dissolution. Results: No differences in melting peak, enthalpy, functional groups, and chromatographic retention time were observed between ibuprofen and solidi...

Self-emulsifying Drug Delivery System for Oral Anticancer Therapy: Constraints and Recent Development

Current Pharmaceutical Design

: Oral anticancer therapy faces several drawbacks of low aqueous solubility, poor and irregular a... more : Oral anticancer therapy faces several drawbacks of low aqueous solubility, poor and irregular absorption from gastro-intestinal sites, high first-pass metabolism, food-influenced absorption, non-targeted delivery, severe systemic and local adverse effects, etc. Enhancement of oral bioavailability could reduce the drug load and associated adverse effects. Self-emulsifying drug delivery systems (SEDDS) can enhance in-vivo solubility and drug absorption from the gastrointestinal tract, bypass liver metabolism by lymphatic absorption and inhibit efflux transport. All these phenomena ultimately result in improved oral bioavailability. Anticancer drug delivery using the SEDDS has shown promising results for bioavailability and pharmacodynamic response. A handful number of researches have produced evidence of the successful loading of anticancer agents in SEDDS-based formulations. Various potent and established chemotherapeutic agents such as docetaxel, paclitaxel, etoposide, 5 Fluorouracil, doxorubicin etc. have been successfully formulated and evaluated. Improved bioavailability and reduction of dose might be possible by SEDDS. It could be effective for low-dose drugs. But, excessive surfactant-cosurfactant concentration, lacking predictive in-vitro models and adequate IVIVC, unavailability of toxicity data are certain challenges for future researchers. To date, no clinical trials have been recorded with anticancer drug loaded SEDDS. To avail the benefits of anticancer SEDDS, overcoming the challenges and further progression to clinical studies are required. Methods: Hospital based retrospective, observational study in which all the confirmed cases of CSC (272) seen between 2010 and 2019 were included. Supplementary data was collected on follow up visits or through telephonic calls. Results: The male: female ratio was 17:1; low socio-economic status was (155; 73.45%), and occupations such as drivers (61; 28.9%) and outdoor laborers (59; 27.96%) were the most commonly affected. The majority (78.05%; 185) were single expatriates. Financial worries (105; 50.72%) constituted the leading cause of stress. The usage of corticosteroids (83; 30.51%), nasal decongestants (14.70%) or both (17; 6.25%) within one year was common; mostly (82; 30.14%) for rhinitis/respiratory states, though grossly under-recognized. Muscle relaxants and psychotropic medications were the other major medications used by 24 (8.82%) and 25 (9.19%) cases prior to CSC. Seven of 15 women had at least one condition that alters the endocrinal milieu: Pregnancy (3), recent child birth (1), erratic oral contraceptive intake (1), menopause with liver dysfunction (1), hormone replacement therapy for menopause and endometriosis (1), ovarian cyst and infertility (1) hypothyroidism (3), and Cushing syndrome (1). Chronic/ recurrent forms were seen in 31.08%. There were too few glaucoma patients despite both CSC and glaucoma being common among our patients.

3D-printed Drugs: A Fabrication of Pharmaceuticals towards Personalized Medicine

Indian Journal of Pharmaceutical Education and Research, 2020

Exploring blend uniformity of a binary mixture containing metformin Hcl and hydroxypropyl methyl cellulose by DSC

Pharmacokinetic characterization of drugs and new product development

Biopharmaceutics and Pharmacokinetics Considerations, 2021

Advancement in combinatorial chemistry in recent decades has synthesized a large number of potent... more Advancement in combinatorial chemistry in recent decades has synthesized a large number of potential candidates for therapeutic use. High-throughput screening technology helps select the most suitable candidate to proceed from preclinical to clinical stage. However, attrition of drug candidates at the late stage of the clinical trial is not rare. Such attrition increases drug development costs and adversely affects the demand and expectation for new therapeutic agents. Therefore decision-making step for “go or no-go” in every stage of preclinical and clinical development is of utmost importance. Pharmacokinetic (PK) characterization of the drug candidate under development is one of the essential steps that help the decision-making process. In general, PK characterization in a preclinical study assesses the drug’s absorption, distribution, metabolism and elimination (ADME) to predict its bioavailability and determine human dose. Apart from ADME assessment, drug–drug interaction, food...

Incorporation of carbopol to palm olein based analgesic cream: effect on formulation characteristics

The purpose of the investigation was to incorporate carbopol gel with palm olein based emulsion a... more The purpose of the investigation was to incorporate carbopol gel with palm olein based emulsion and to investigate the effect of such incorporation on formulation characteristics. A palm olein based emulsion was formulated followed by addition of carbopol 940 to it. The critical parameters of incorporating carbopol in bench scale level were checked. The developed palm olein-carbopol based analgesic cream was analyzed for pH, zeta potential, viscosity, rheological property and forced centrifugation.Incorporation of 0.3% of carbopol gel (1% w/w) helps to maintain the viscosity and stability. pH and zeta potential of palm olein-carbopol combined cream was within range of 6.90 to 7.20 and -23.1 to -74.9, respectively. Combination of palm olein based emulsion and carbopol would be a suitable option for topical cream formulation. The pH of carbopol gel and method of mixing with the palm olein based emulsion had crucial effects on phase separation of the product.

Electro-hydrodynamic assisted synthesis of lecithin-stabilized peppermint oil-loaded alginate microbeads for intestinal drug delivery

International Journal of Biological Macromolecules, 2021

Encapsulation of Black Seed Oil in Alginate Beads as a pH-Sensitive Carrier for Intestine-Targeted Drug Delivery: In Vitro, In Vivo and Ex Vivo Study

Pharmaceutics, 2020

Black seed oil (BSO) has been used for various therapeutic purposes around the world since ancien... more Black seed oil (BSO) has been used for various therapeutic purposes around the world since ancient eras. It is one of the most prominent oils used in nutraceutical formulations and daily consumption for its significant therapeutic value is common phenomena. The main aim of this study was to develop alginate-BSO beads as a controlled release system designed to control drug release in the gastrointestinal tract (GIT). Electrospray technology facilitates formulation of small and uniform beads with higher diffusion and swelling rates resulting in process performance improvement. The effect of different formulation and process variables was evaluated on the internal and external bead morphology, size, shape, encapsulation efficiency, swelling rate, in vitro drug release, release mechanism, ex vivo mucoadhesive strength and gastrointestinal tract qualitative and quantitative distribution. All the formulated beads showed small sizes of 0.58 ± 0.01 mm (F8) and spherical shape of 0.03 ± 0.00...

Effects of Different Formulation Methods on Drug Crystallinity, Drug-Carrier Interaction, and Ex Vivo Permeation of a Ternary Solid Dispersion Containing Nisoldipine

Journal of Pharmaceutical Innovation, 2019

Quantitation of Pregabalin by HPLC-UV Method using Ninhydrin Derivatization: Development and Validation

Current Pharmaceutical Analysis, 2020

Introduction: A simple and reliable high performance liquid chromatographic method has been devel... more Introduction: A simple and reliable high performance liquid chromatographic method has been developed for the quantitative determination of pregabalin in bulk and dosage form. Pregabalin, a γ amino butyric acid analogue, has negligible sensitivity to UV or fluorescence detection. Hence, it has been derivatized by ninhydrin to form a chromophoric complex that could be quantified by UV detection. Materials and Methods: The concentration of ninhydrin was set to 5 mg/ml and a phosphate buffer solution (pH 7.4) was used as a solvent for the reaction. The resultant complex was separated by HPLC and detected by a UV detector at 569nm wavelength. Results: The developed method showed a linear response within 50 to 600 μg/mL of pregabalin. The method was accurate with mean recovery values within 100 ± 2%. The repeatability of the method was established by intra-day and inter-day precision study. Finally, a commercial pregabalin capsule was assayed by the developed HPLC method including ninhyd...

Optimization of Aceclofenac Proniosomes by Using Different Carriers, Part 1: Development and Characterization

Pharmaceutics, 2019

In the contemporary medical model world, the proniosomal system has been serving as a new drug de... more In the contemporary medical model world, the proniosomal system has been serving as a new drug delivery system that is considered to significantly enhance the bioavailability of drugs with low water solubility. The application of this system can improve the bioavailability of aceclofenac that is used for the relief of pain and inflammation in osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. The present study is intended to develop an optimized proniosomal aceclofenac formula by the use of different carriers. Aceclofenac proniosomes have been prepared by slurry method, and different carriers such as maltodextrin, mannitol, and glucose were tried. Prepared proniosomes characterized by differential scanning calorimetry (DSC) analysis and Fourier transform infrared (FTIR) analysis revealed the compatibility of the drug chosen with the ingredient added, powder X-ray diffractometry (XRD) confirmed the amorphous phase of the prepared proniosomes, and finally, the surfactan...

Mucoadhesive Polymers and Their Mode of Action: A Recent Update

Journal of Applied Pharmaceutical Science, 2017

Potential and future scope of nanoemulgel formulation for topical delivery of lipophilic drugs

International Journal of Pharmaceutics, 2017

Glidant effect of hydrophobic and hydrophilic nanosilica on a cohesive powder: Comparison of different flow characterization techniques

Particuology, 2017

Abstract The methods used for flow characterization of a powder mass include the angle of repose ... more Abstract The methods used for flow characterization of a powder mass include the angle of repose (AOR), Carr index (CI), and powder flow tester (PFT). The use of nanosilica as a flow modifier (glidant) is very common in industry. This study aims to compare the glidant effect of hydrophobic and hydrophilic silica on a poorly flowable active pharmaceutical ingredient (ibuprofen) by different flow characterization techniques. Different percentages (0.5, 1.0, and 2.0 wt%) of both types of mixed silica–ibuprofen powders were evaluated by the AOR, CI, bulk density, and PFT. The flow factor, effective angle of friction, and cohesion were determined to explain the bulk powder properties. The results show that different types of silica show different levels of flow property improvement, but the techniques do not equally discriminate the differences. Hydrophobic silica results in better improvement of the flow property than hydrophilic silica, probably because of its better surface coverage of silica on the host particles. Change of the bulk density with applied pressure was significant for the different powders. This study demonstrates that combining several characterization methods provides a better understanding of bulk powder flow properties with respect to powder–process relationships than a single flow indicator.

A Bioanalytical Method for Quantification of Telmisartan in rat Plasma; Development, Validation and Application to Pharmacokinetic Study

Research Journal of Pharmacy and Technology, 2021

The telmisartan was determined in a rat plasma using developed and validated a reversed-phase hig... more The telmisartan was determined in a rat plasma using developed and validated a reversed-phase high performance liquid chromatographic (HPLC). The pre-treatment of the plasma sample involving liquid-liquid extraction using ethanol as the extracting solvent. The HPLC method validation has been shown a linear calibration curve over a plasma concentrations range of 0.7 to 10µg/mL with a correlation coefficient of 0.9979, the limit of detection and the limit of quantification were determined to be 0.025µg/ml and 0.07µg/ml, respectively. The precision and accuracy were in an acceptable limit. The pharmacokinetic parameters of telmisartan were adequately evaluated following a single oral dose (4mg/kg) in Sprague-Dawley rats. The results observed conclude that the developed bioanalytical HPLC method is appropriate and applicable as an analytical tool in the pharmacokinetic study of telmisartan.

Development and validation of a LC- MS/MS Method for simultaneous quantitation of telmisartan and pioglitazone in rat plasma

In majority of complex diseases like diabetes, multiple medications are essential to achieve the ... more In majority of complex diseases like diabetes, multiple medications are essential to achieve the better therapeutic control, as several mediators are involved in their pathogenesis. Likewise, although the primary component of diabetes care is to control blood glucose level, management of cardiovascular risk factors should also be considered as vital one. Literature review reveals that the major and common health problems associated with pathophysiological mechanism for arterial damage in diabetes is hypertension. It is well established that angiotensin receptor blocker (ARB) class of antihypertensives are better tolerated antihypertensive. Amongst ARBs, telmisartan has fewer drug-related adverse events and provides superior blood pressure control. On the other hand, pioglitazone is a useful therapeutic drug for type 2 diabetes having beneficial pleiotropic effects on cardiovascular diseases. Thus, the combination therapy of telmisartan and pioglitazone can be beneficial to treat a p...