Breast cancer is the most common cancer and a major cause of morbidity and mortality in women wor... more Breast cancer is the most common cancer and a major cause of morbidity and mortality in women worldwide annually. The proto-oncogene Human Epidermal growth factor Receptor-2(HER-2/neu) (C-erbB-2) has been localized to chromosome 17q and encodes a transmembrane tyrosine kinase growth factor receptor. The activation of the Her-2/neu oncogene triggers a cascade of growth signals that results in gene activation, which contributes the uncontrolled growth and survival of cancer cells. Molecular biomarker of cerb-B2 (HER-2/neu) is the prognostic indicator to predict the outcome for women with breast cancer. The cross sectional descriptive study was carried out on 31 breast cancer patients admitted to Surgical Department, Hospital Tengku Ampuan Afzan, Kuantan for breast cancer operation, between January, 2012 and July, 2013. This study was approved by Medical research and Ethics Committee, Ministry of Health Malaysia and all the participants gave their written informed consent. The pre- and post-operative serum Her2/neu protein level in all types of breast cancer was measured by ELISA method. Histological grading was done according to Modified Bloom and Richardson Grading2. The data was analysed by using SPSS version 11.5. In 31 patients, the ages ranged from 38 to 77 years with a mean of 54 years. The mean serum concentrations of Her2/neu protein before and after operation were 1.88+1.527 ng/ml and 1.31+0.994) ng/ml, respectively. Paired Sample T test showed there is a significant correlation between pre- and post-operative serum level of Her2/neu (p=0.004). Mann Whitney U test analysis showed the pre-operative serum level of Her2/neu protein was associated with vascular invasion (p=0.009). However, there was no significant relation between prognostic biomarker Her2/neu and the clinical prognostic parameters of tumor size, lymph node involvement, lymphatic invasion, histological type and grade in all types of breast cancer. High HER-2/neu protein expression is associated with more ductal carcinoma in situ, invasive cancer, high cell proliferation rate, lack of response to hormone therapy, aggressive clinical behavior, development of metastasis, treatment resistance, cancer progression, decreased chance of survival and poor prognosis. However, Her2/neu overexpression tumours response to herceptin. Although the duration of study is short and the small size is small, serum Her2/neu protein level in breast cancer may predict the prognosis, response to therapy, and will be able to assist in breast cancer management.
With increasing number of dengue cases in Malaysia, it's of utmost importance that immediate ... more With increasing number of dengue cases in Malaysia, it's of utmost importance that immediate action be taken to limit the epidemic. Since dengue control is a behavioral problem, the knowledge, attitude and practice in population needs to be studied in order to control the disease. Hence, the aim of this study is to assess knowledge, attitude and practice regarding dengue and its associated factors among adult residents of Felda Sungai Panching Selatan (SPT), Kuantan, Pahang, 2014
INTRODUCTION: Most smokers become dependent both physically and psychologically within a few year... more INTRODUCTION: Most smokers become dependent both physically and psychologically within a few years of daily smoking because of its major chemical component of nicotine in tobacco. Nicotine dependence is occurred at any time which affects on successful smoking cessation. The aim of the study was to measure the prevalence of nicotine dependence (ND) among adult male smokers and influences of socio-economic characteristics on it. METHODS: A cross-sectional study was conducted among 297 adult males participants with aged ≥18 years and who were recruited purposively from the house-holds which were selected using simple random sampling at FELDA Bukit Goh, Kuantan, Pahang in February 2015. Smoking and nicotine dependence status of the participants were assessed using a self-administered questionnaire in which consisted of modified smoking and tobacco use questions used in National Health Interview Survey and validated Malay version of Fagerstrom Test for Nicotine Dependence (FTND-M) assess...
Breast cancer is the most common cancer and a major cause of morbidity and mortality in women wor... more Breast cancer is the most common cancer and a major cause of morbidity and mortality in women worldwide annually. The proto-oncogene Human Epidermal growth factor Receptor-2(HER-2/neu) (C-erbB-2) has been localized to chromosome 17q and encodes a transmembrane tyrosine kinase growth factor receptor. The activation of the Her-2/neu oncogene triggers a cascade of growth signals that results in gene activation, which contributes the uncontrolled growth and survival of cancer cells. Molecular biomarker of cerb-B2 (HER-2/neu) is the prognostic indicator to predict the outcome for women with breast cancer. The cross sectional descriptive study was carried out on 31 breast cancer patients admitted to Surgical Department, Hospital Tengku Ampuan Afzan, Kuantan for breast cancer operation, between January, 2012 and July, 2013. This study was approved by Medical research and Ethics Committee, Ministry of Health Malaysia and all the participants gave their written informed consent. The pre- and...
Background: With increasing number of dengue cases in Malaysia, it's of utmost importance tha... more Background: With increasing number of dengue cases in Malaysia, it's of utmost importance that immediate action be taken to limit the epidemic. Since dengue control is a behavioral problem, the knowledge, attitude and practice in population needs to be studied in order to control the disease. Hence, the aim of this study is to assess knowledge, attitude and practice regarding dengue and its associated factors among adult residents of Felda Sungai Panching Timur (SPT), Kuantan, Pahang, 2014. Method: A cross sectional study was carried out involving 265 adult respondents. A face to face interview questionnaire which was divided into 2 parts (Part A: Sociodemoghraphic; Part B: Knowledge, Attitude and Practice) was used. Data was analyzed using descriptive statistics, simple and multiple logistic regression. Results: 53.2% of the respondents had good knowledge about dengue and it was found that the main source of information from mass media (76.6%). However, only 43.4% were found to...
Background: With increasing number of dengue cases in Malaysia, it’s of utmost importance that im... more Background: With increasing number of dengue cases in Malaysia, it’s of utmost importance that immediate action be taken to limit the epidemic. Since dengue control is a behavioral problem, the knowledge, attitude and practice in population needs to be studied in order to control the disease. Hence, the aim of this study is to assess knowledge, attitude and practice regarding dengue and its associated factors among adult residents of Felda Sungai Panching Timur (SPT), Kuantan, Pahang, 2014. Method: A cross sectional study was carried out involving 265 adult respondents. A face to face interview questionnaire which was divided into 2 parts (Part A: Sociodemoghraphic; Part B: Knowledge, Attitude and Practice) was used. Data was analyzed using descriptive statistics, simple and multiple logistic regression. Results: 53.2% of the respondents had good knowledge about dengue and it was found that the main source of information from mass media (76.6%). However, only 43.4% were found to ha...
Breast cancer is the most common cancer and a major cause of morbidity and mortality in women wor... more Breast cancer is the most common cancer and a major cause of morbidity and mortality in women worldwide annually. The proto-oncogene Human Epidermal growth factor Receptor-2(HER-2/neu) (C-erbB-2) has been localized to chromosome 17q and encodes a transmembrane tyrosine kinase growth factor receptor. The activation of the Her-2/neu oncogene triggers a cascade of growth signals that results in gene activation, which contributes the uncontrolled growth and survival of cancer cells. Molecular biomarker of cerb-B2 (HER-2/neu) is the prognostic indicator to predict the outcome for women with breast cancer. The cross sectional descriptive study was carried out on 31 breast cancer patients admitted to Surgical Department, Hospital Tengku Ampuan Afzan, Kuantan for breast cancer operation, between January, 2012 and July, 2013. This study was approved by Medical research and Ethics Committee, Ministry of Health Malaysia and all the participants gave their written informed consent. The pre- and post-operative serum Her2/neu protein level in all types of breast cancer was measured by ELISA method. Histological grading was done according to Modified Bloom and Richardson Grading2. The data was analysed by using SPSS version 11.5. In 31 patients, the ages ranged from 38 to 77 years with a mean of 54 years. The mean serum concentrations of Her2/neu protein before and after operation were 1.88+1.527 ng/ml and 1.31+0.994) ng/ml, respectively. Paired Sample T test showed there is a significant correlation between pre- and post-operative serum level of Her2/neu (p=0.004). Mann Whitney U test analysis showed the pre-operative serum level of Her2/neu protein was associated with vascular invasion (p=0.009). However, there was no significant relation between prognostic biomarker Her2/neu and the clinical prognostic parameters of tumor size, lymph node involvement, lymphatic invasion, histological type and grade in all types of breast cancer. High HER-2/neu protein expression is associated with more ductal carcinoma in situ, invasive cancer, high cell proliferation rate, lack of response to hormone therapy, aggressive clinical behavior, development of metastasis, treatment resistance, cancer progression, decreased chance of survival and poor prognosis. However, Her2/neu overexpression tumours response to herceptin. Although the duration of study is short and the small size is small, serum Her2/neu protein level in breast cancer may predict the prognosis, response to therapy, and will be able to assist in breast cancer management.
With increasing number of dengue cases in Malaysia, it's of utmost importance that immediate ... more With increasing number of dengue cases in Malaysia, it's of utmost importance that immediate action be taken to limit the epidemic. Since dengue control is a behavioral problem, the knowledge, attitude and practice in population needs to be studied in order to control the disease. Hence, the aim of this study is to assess knowledge, attitude and practice regarding dengue and its associated factors among adult residents of Felda Sungai Panching Selatan (SPT), Kuantan, Pahang, 2014
INTRODUCTION: Most smokers become dependent both physically and psychologically within a few year... more INTRODUCTION: Most smokers become dependent both physically and psychologically within a few years of daily smoking because of its major chemical component of nicotine in tobacco. Nicotine dependence is occurred at any time which affects on successful smoking cessation. The aim of the study was to measure the prevalence of nicotine dependence (ND) among adult male smokers and influences of socio-economic characteristics on it. METHODS: A cross-sectional study was conducted among 297 adult males participants with aged ≥18 years and who were recruited purposively from the house-holds which were selected using simple random sampling at FELDA Bukit Goh, Kuantan, Pahang in February 2015. Smoking and nicotine dependence status of the participants were assessed using a self-administered questionnaire in which consisted of modified smoking and tobacco use questions used in National Health Interview Survey and validated Malay version of Fagerstrom Test for Nicotine Dependence (FTND-M) assess...
Breast cancer is the most common cancer and a major cause of morbidity and mortality in women wor... more Breast cancer is the most common cancer and a major cause of morbidity and mortality in women worldwide annually. The proto-oncogene Human Epidermal growth factor Receptor-2(HER-2/neu) (C-erbB-2) has been localized to chromosome 17q and encodes a transmembrane tyrosine kinase growth factor receptor. The activation of the Her-2/neu oncogene triggers a cascade of growth signals that results in gene activation, which contributes the uncontrolled growth and survival of cancer cells. Molecular biomarker of cerb-B2 (HER-2/neu) is the prognostic indicator to predict the outcome for women with breast cancer. The cross sectional descriptive study was carried out on 31 breast cancer patients admitted to Surgical Department, Hospital Tengku Ampuan Afzan, Kuantan for breast cancer operation, between January, 2012 and July, 2013. This study was approved by Medical research and Ethics Committee, Ministry of Health Malaysia and all the participants gave their written informed consent. The pre- and...
Background: With increasing number of dengue cases in Malaysia, it's of utmost importance tha... more Background: With increasing number of dengue cases in Malaysia, it's of utmost importance that immediate action be taken to limit the epidemic. Since dengue control is a behavioral problem, the knowledge, attitude and practice in population needs to be studied in order to control the disease. Hence, the aim of this study is to assess knowledge, attitude and practice regarding dengue and its associated factors among adult residents of Felda Sungai Panching Timur (SPT), Kuantan, Pahang, 2014. Method: A cross sectional study was carried out involving 265 adult respondents. A face to face interview questionnaire which was divided into 2 parts (Part A: Sociodemoghraphic; Part B: Knowledge, Attitude and Practice) was used. Data was analyzed using descriptive statistics, simple and multiple logistic regression. Results: 53.2% of the respondents had good knowledge about dengue and it was found that the main source of information from mass media (76.6%). However, only 43.4% were found to...
Background: With increasing number of dengue cases in Malaysia, it’s of utmost importance that im... more Background: With increasing number of dengue cases in Malaysia, it’s of utmost importance that immediate action be taken to limit the epidemic. Since dengue control is a behavioral problem, the knowledge, attitude and practice in population needs to be studied in order to control the disease. Hence, the aim of this study is to assess knowledge, attitude and practice regarding dengue and its associated factors among adult residents of Felda Sungai Panching Timur (SPT), Kuantan, Pahang, 2014. Method: A cross sectional study was carried out involving 265 adult respondents. A face to face interview questionnaire which was divided into 2 parts (Part A: Sociodemoghraphic; Part B: Knowledge, Attitude and Practice) was used. Data was analyzed using descriptive statistics, simple and multiple logistic regression. Results: 53.2% of the respondents had good knowledge about dengue and it was found that the main source of information from mass media (76.6%). However, only 43.4% were found to ha...
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