International Journal of Pharmaceutical Sciences and Nanotechnology(IJPSN)
Herbal cosmetics contain phytochemicals derived from various botanical sources to address nutrien... more Herbal cosmetics contain phytochemicals derived from various botanical sources to address nutrient deficiencies and improve human appearance. Natural beauty is God's gift; cosmetics help sustain and enhance human beauty and personality. Recently, herbal cosmetics have gained popularity due to their inherent suitability and usefulness and fewer adverse effects than synthetic products. In this article, we highlighted the advantages, types of herbal cosmetics, toxic effects, chemicals and adverse effects of synthetic cosmetics and herbs used for dermal care. Then, we surveyed to investigate the pattern of cosmetic usage in the daily lives of people, their awareness and practices regarding caution with cosmetic use, and common side effects associated with people during cosmetic usage.
Parkinson’s Disease (PD) is the second most common neurodegenerative disease affecting 1-2% of th... more Parkinson’s Disease (PD) is the second most common neurodegenerative disease affecting 1-2% of the global population with no cure to date. PD is characterized by accumulation of Lewy Bodies (LBs), which are caused due to aggregation of incorrectly folded α-Synuclein, (SNCA). Another form of PD manifestation is characterized by loss of function ofparkin, which encodes an E3 ubiquitin ligase. Despite extensive research, the cause for onset and progression of PD remains unknown and current therapeutics mainly help manage the disease. An alternative line of treatment can be useful.In this study, we have employed two different genetic models ofDrosophilato screen forAyurvediccompounds and found anAyurvedicmercury based organo-metallic drug Ras-Sindoor has neuroprotective function. Our data indicate that characteristic locomotory dysfunction phenotype of PD is restored upon administration of the compound. Interestingly, RS fed flies also exhibit reduced transcript levels of initiator casp...
: Nanotechnology suggests different innovative solutions to augment the worth of cosmetic product... more : Nanotechnology suggests different innovative solutions to augment the worth of cosmetic products through the targeted delivery of content that manifests scientific innovation in research and development. Different nanosystems, like liposomes, niosomes, microemulsions, solid lipid nanoparticles, nanoform lipid carriers, nanoemulsions, and nanospheres, are employed in cosmetics. These nanosystems exhibit various innovative cosmetic functions, including site-specific targeting, controlled content release, more stability, improved skin penetration and enhanced entrapment efficiency of loaded compounds. Thus, cosmeceuticals are assumed as the highest-progressing fragment of the personal care industries that have progressed drastically over the years. In recent decades, cosmetic science has widened the origin of its application in different fields. Nanosystems in cosmetics are beneficial in treating different conditions like hyperpigmentation, wrinkles, dandruff, photoaging and hair damage. This review highlights the different nanosystems used in cosmetics for the targeted delivery of loaded content and commercially available formulations. Moreover, this review article has delineated different patented nanocosmetic formulation nanosystems and future aspects of nanocarriers in cosmetics.
Evidence-Based Complementary and Alternative Medicine
For various ailments, natural remedies have been traditionally used. To defend against common dis... more For various ailments, natural remedies have been traditionally used. To defend against common disorders, medicinal plants are progressively used as nutritional supplements. Gingivitis and periodontitis are widespread and can affect most of the world’s population. Gingivitis is a very common, nondestructive inflammatory disease of gums that causes redness and irritation of the gingiva (gums), but periodontitis causes permanent damage to teeth’ subsidiary structures. Herbal medicines are getting popular for the treatment of such types of disorders due to being economical with their medicinal effectiveness, compatibility, and nontoxicity. Traditional chemical therapies can cause cell toxicity along with their disease-curing effects. In this article, we discussed the medicinal plants that can be used as an alternative for the treatment of gingivitis (early-stage gum disease) and periodontitis (chronic-stage gum disease).
G6PD is rate limiting enzyme in pentose phosphate pathway (PPP), have effective physiological rol... more G6PD is rate limiting enzyme in pentose phosphate pathway (PPP), have effective physiological role in supply of NADPH by converting it into Glucose-6-phosphate to phospogluconate which acts as a major cell reductant and useful to cell survival. Brain is highly sophisticated organ of our body which requires continuous supply of energy in form of glucose. Daily requirement of brain glucose is 120gm. G6PD plays a key role in it. According to WHO 75% of world population have more than one gene for G6PD and around 2.9% of population is G6PD deficient. It is most common enzymatic disorder of cell effecting 200-400 million people. G6PD exist in all cell to oxidative damage and it is responsible for various neurodegenerative disorder like Parkinson’s disease, Alzheimer’s, Schizophrenia catatonia, Neuronal toxicity etc. The research work was aimed to check the neuroprotective potential of Melatonin with Primaquine and Melatonin with Aspirin (contraindicated to G6PD deficient individuals) i...
Brazilian Journal of Pharmaceutical Sciences, 2016
Recent advances in drug delivery systems have aimed to achieve better patient compliance. One of ... more Recent advances in drug delivery systems have aimed to achieve better patient compliance. One of these advances is the formulation of orally disintegrating tablets (ODTs) that dissolve instantaneously, releasing drugs within a few seconds without the need of water. The main objective of this paper was to prepare and develop ODTs of clopidogrel. The ODTs were prepared by direct compression. The effect of three superdisintegrants, namely crospovidone, croscarmellose sodium, and sodium starch glycolate, using three different disintegration times on the dissolution rate was investigated. The prepared tablets were evaluated for hardness, friability, disintegration time and in vitro drug release. Furthermore, the interaction of clopidogrel with the formulation excipients was studied using differential scanning calorimetry (DSC). DSC studies revealed that there were no interactions between the drug and the excipients used. All tablets had hardness values in the range 4.0-5.2 kp and friabil...
Orally fast dissolving films have been introduced in the market recently as they provide convenie... more Orally fast dissolving films have been introduced in the market recently as they provide convenience and ease of use over other dosage forms such as orally disintegrating tablets. Fast-dissolving oral delivery systems are solid dosage forms, which can disintegrate or dissolve within 1 min when placed on the tongue without drinking water or chewing. Oral route is the most preferred convenient route for drug administration due to the highest component of patient compliance mainly the pediatrics and geriatrics. These are the formulation having thin film and larger surface area which is easily dissolves in the mouth saliva. Recently oral films containing breath freshener, vitamins supplement and API. These are formulated by incorporating the drug with selected oral cavity absorption enhancers in a specially designed oral dissolving film carriers. This facilitates the rapid absorption in the oral cavity for drugs with low GIT-bioavailability and intensive first-pass effects. The unique p...
Alzheimer's disease and Parkinson's disease are two of the most prevalent and disabling n... more Alzheimer's disease and Parkinson's disease are two of the most prevalent and disabling neurodegenerative diseases globally. Both are proteinopathic conditions and while occasionally inherited, are largely sporadic in nature. Although the advances in our understanding of the two have been significant, they are far from complete and neither diagnosis nor the current practices in treatment and rehabilitation is adequately helpful. Animal models have historically found application as testing beds for novel therapeutics and continue to be valuable aids in pharmacological research. This review chronicles the development of those models in the context of Alzheimer's and Parkinson's disease, and highlights the shifting paradigms in studying two human‐specific conditions in non‐human organisms.
Background: Eutectics are basically multi-component crystalline solids closely related to solid s... more Background: Eutectics are basically multi-component crystalline solids closely related to solid solutions. However, the structural organization of eutectics has not been studied in as much detail as solid solutions, which are defined based on the arrangement of a major (solvent) and a minor (solute) component in the crystal lattice. Purpose: The goal of this study is basically improvement in aqueous solubility of poorly water soluble drug i.e curcumin via its eutectic formation by using salicylic acid as coformer. Material and Method: Here the eutectic mixture of curcumin and salicylic acid was prepared by solvent evaporation technique for improving the dissolution behaviour of curcumin. DSC and FT-IR spectroscopy were used as analytical techniques for characterization of eutectic mixture. Result: The DSC and FT-IR spectroscopy conformed the formation of eutectic mixture and In-Vitro dissolution studies revealed an improved dissolution behaviour for eutectic mixture (69.38 %) as com...
During organogenesis, cell proliferation is followed by the differentiation of specific cell type... more During organogenesis, cell proliferation is followed by the differentiation of specific cell types to form an organ. Any aberration in differentiation can result in developmental defects, which can result in a partial to a near‐complete loss of an organ. We employ the Drosophila eye model to understand the genetic and molecular mechanisms involved in the process of differentiation. In a forward genetic screen, we identified, cullin‐4 (cul‐4), which encodes an E3 ubiquitin ligase, to play an important role in retinal differentiation. During development, cul‐4 is known to be involved in protein degradation, regulation of genomic stability, and regulation of cell cycle. Previously, we have reported that cul‐4 regulates cell death during eye development by downregulating Wingless (Wg)/Wnt signaling pathway. We found that loss‐of‐function of cul‐4 results in a reduced eye phenotype, which can be due to onset of cell death. However, we found that loss‐of‐function of cul‐4 also affects ret...
A simple, selective, rapid, precise and economical reverse phase high-pressure liquid chromatogra... more A simple, selective, rapid, precise and economical reverse phase high-pressure liquid chromatographic method has been developed as per ICH nomination for Development and Validation of Telmisartan in Tablet Dosage form By RP-HPLC Assay Method. The assay method was carried out by using a mobile phase consisting of Buffer Solution and Solution A ((Methanol and Acetonitrile (1:1)) in the gradient ratio. The detection was carried out by using HPLC Shimadzu LC with UV-Visible PDA at 298nm.The column was Hypersil BDS C-8 (12.5 cm X 4.0 mm, 5 μ). The flow rate was selected as 1.2ml/min. The retention time of Telmisartan was found to be 8.3 min respectively. The developed method was validated in terms of specificity, accuracy, precision, linearity and system suitability. The optimized proposed method easy to handle and commercially used for the routine quality control checking of Telmisartan pharmaceutical combine tablets dosage form. RASĀYAN J. Chem., Vol. 14, No.1, 202
The aim of present investigation was formulation and evaluation of orally disintegrating tablets ... more The aim of present investigation was formulation and evaluation of orally disintegrating tablets of Niacinamide. Orally disintegrating tablets offers a solution for Pediatrics, geriatrics; psychiatrics or mentally ill peoples and those who have difficulty in swallowing tablets/capsules resulting in improved patient compliance. Orally disintegrating tablets of Niacinamide were prepared with the addition of different superdisintegrants namely crospovidone,Croscamellose sodium and sodium starch glycolate.Each of these superdisintegrants were used in the conc. of 3-7%w/w,3-5%w/w and 3-5%w/w.Mannitol is used as a filler. Nine formulations having different superdisintegrants at different concentration levels were prepared to assess their efficiency and critical concentration level. The tablets were evaluated for hardness, friability, weight variation, disintegration time, diameter, thickness and wetting time, in vitro dissolution studies and friability. The hardness of the tablets was in ...
: Cancer is a fatal disease, with a collection of related diseases in various body parts. The con... more : Cancer is a fatal disease, with a collection of related diseases in various body parts. The conventional therapies cannot show the desired results of treatment due to their imprecise targeting, deprived drug delivery, and side effects. Therefore, it is required to make the drug engineered in such a way that it can target only cancerous cells and can inhibit its growth and proliferation. Nanotechnology is a technology that can target and differentiate between cancerous cells and the normal cells of the body. Silver itself is a good anticancer and antibacterial agent and employing it with phytochemicals having anticancer properties, and nanotechnology can give the best approach for the treatment. The synthesis of silver nanoparticles using plant extracts is an economical, energy-efficient, low-cost approach and it doesn’t need any hazardous chemicals. In the present review, we discussed different methods of synthesis of silver nanoparticles using herbal extracts and their role against cancer therapy along with the synergistic role of silver and plant extracts against cancer in the formulation.
International Journal of Pharmaceutical Sciences and Nanotechnology(IJPSN)
Herbal cosmetics contain phytochemicals derived from various botanical sources to address nutrien... more Herbal cosmetics contain phytochemicals derived from various botanical sources to address nutrient deficiencies and improve human appearance. Natural beauty is God's gift; cosmetics help sustain and enhance human beauty and personality. Recently, herbal cosmetics have gained popularity due to their inherent suitability and usefulness and fewer adverse effects than synthetic products. In this article, we highlighted the advantages, types of herbal cosmetics, toxic effects, chemicals and adverse effects of synthetic cosmetics and herbs used for dermal care. Then, we surveyed to investigate the pattern of cosmetic usage in the daily lives of people, their awareness and practices regarding caution with cosmetic use, and common side effects associated with people during cosmetic usage.
Parkinson’s Disease (PD) is the second most common neurodegenerative disease affecting 1-2% of th... more Parkinson’s Disease (PD) is the second most common neurodegenerative disease affecting 1-2% of the global population with no cure to date. PD is characterized by accumulation of Lewy Bodies (LBs), which are caused due to aggregation of incorrectly folded α-Synuclein, (SNCA). Another form of PD manifestation is characterized by loss of function ofparkin, which encodes an E3 ubiquitin ligase. Despite extensive research, the cause for onset and progression of PD remains unknown and current therapeutics mainly help manage the disease. An alternative line of treatment can be useful.In this study, we have employed two different genetic models ofDrosophilato screen forAyurvediccompounds and found anAyurvedicmercury based organo-metallic drug Ras-Sindoor has neuroprotective function. Our data indicate that characteristic locomotory dysfunction phenotype of PD is restored upon administration of the compound. Interestingly, RS fed flies also exhibit reduced transcript levels of initiator casp...
: Nanotechnology suggests different innovative solutions to augment the worth of cosmetic product... more : Nanotechnology suggests different innovative solutions to augment the worth of cosmetic products through the targeted delivery of content that manifests scientific innovation in research and development. Different nanosystems, like liposomes, niosomes, microemulsions, solid lipid nanoparticles, nanoform lipid carriers, nanoemulsions, and nanospheres, are employed in cosmetics. These nanosystems exhibit various innovative cosmetic functions, including site-specific targeting, controlled content release, more stability, improved skin penetration and enhanced entrapment efficiency of loaded compounds. Thus, cosmeceuticals are assumed as the highest-progressing fragment of the personal care industries that have progressed drastically over the years. In recent decades, cosmetic science has widened the origin of its application in different fields. Nanosystems in cosmetics are beneficial in treating different conditions like hyperpigmentation, wrinkles, dandruff, photoaging and hair damage. This review highlights the different nanosystems used in cosmetics for the targeted delivery of loaded content and commercially available formulations. Moreover, this review article has delineated different patented nanocosmetic formulation nanosystems and future aspects of nanocarriers in cosmetics.
Evidence-Based Complementary and Alternative Medicine
For various ailments, natural remedies have been traditionally used. To defend against common dis... more For various ailments, natural remedies have been traditionally used. To defend against common disorders, medicinal plants are progressively used as nutritional supplements. Gingivitis and periodontitis are widespread and can affect most of the world’s population. Gingivitis is a very common, nondestructive inflammatory disease of gums that causes redness and irritation of the gingiva (gums), but periodontitis causes permanent damage to teeth’ subsidiary structures. Herbal medicines are getting popular for the treatment of such types of disorders due to being economical with their medicinal effectiveness, compatibility, and nontoxicity. Traditional chemical therapies can cause cell toxicity along with their disease-curing effects. In this article, we discussed the medicinal plants that can be used as an alternative for the treatment of gingivitis (early-stage gum disease) and periodontitis (chronic-stage gum disease).
G6PD is rate limiting enzyme in pentose phosphate pathway (PPP), have effective physiological rol... more G6PD is rate limiting enzyme in pentose phosphate pathway (PPP), have effective physiological role in supply of NADPH by converting it into Glucose-6-phosphate to phospogluconate which acts as a major cell reductant and useful to cell survival. Brain is highly sophisticated organ of our body which requires continuous supply of energy in form of glucose. Daily requirement of brain glucose is 120gm. G6PD plays a key role in it. According to WHO 75% of world population have more than one gene for G6PD and around 2.9% of population is G6PD deficient. It is most common enzymatic disorder of cell effecting 200-400 million people. G6PD exist in all cell to oxidative damage and it is responsible for various neurodegenerative disorder like Parkinson’s disease, Alzheimer’s, Schizophrenia catatonia, Neuronal toxicity etc. The research work was aimed to check the neuroprotective potential of Melatonin with Primaquine and Melatonin with Aspirin (contraindicated to G6PD deficient individuals) i...
Brazilian Journal of Pharmaceutical Sciences, 2016
Recent advances in drug delivery systems have aimed to achieve better patient compliance. One of ... more Recent advances in drug delivery systems have aimed to achieve better patient compliance. One of these advances is the formulation of orally disintegrating tablets (ODTs) that dissolve instantaneously, releasing drugs within a few seconds without the need of water. The main objective of this paper was to prepare and develop ODTs of clopidogrel. The ODTs were prepared by direct compression. The effect of three superdisintegrants, namely crospovidone, croscarmellose sodium, and sodium starch glycolate, using three different disintegration times on the dissolution rate was investigated. The prepared tablets were evaluated for hardness, friability, disintegration time and in vitro drug release. Furthermore, the interaction of clopidogrel with the formulation excipients was studied using differential scanning calorimetry (DSC). DSC studies revealed that there were no interactions between the drug and the excipients used. All tablets had hardness values in the range 4.0-5.2 kp and friabil...
Orally fast dissolving films have been introduced in the market recently as they provide convenie... more Orally fast dissolving films have been introduced in the market recently as they provide convenience and ease of use over other dosage forms such as orally disintegrating tablets. Fast-dissolving oral delivery systems are solid dosage forms, which can disintegrate or dissolve within 1 min when placed on the tongue without drinking water or chewing. Oral route is the most preferred convenient route for drug administration due to the highest component of patient compliance mainly the pediatrics and geriatrics. These are the formulation having thin film and larger surface area which is easily dissolves in the mouth saliva. Recently oral films containing breath freshener, vitamins supplement and API. These are formulated by incorporating the drug with selected oral cavity absorption enhancers in a specially designed oral dissolving film carriers. This facilitates the rapid absorption in the oral cavity for drugs with low GIT-bioavailability and intensive first-pass effects. The unique p...
Alzheimer's disease and Parkinson's disease are two of the most prevalent and disabling n... more Alzheimer's disease and Parkinson's disease are two of the most prevalent and disabling neurodegenerative diseases globally. Both are proteinopathic conditions and while occasionally inherited, are largely sporadic in nature. Although the advances in our understanding of the two have been significant, they are far from complete and neither diagnosis nor the current practices in treatment and rehabilitation is adequately helpful. Animal models have historically found application as testing beds for novel therapeutics and continue to be valuable aids in pharmacological research. This review chronicles the development of those models in the context of Alzheimer's and Parkinson's disease, and highlights the shifting paradigms in studying two human‐specific conditions in non‐human organisms.
Background: Eutectics are basically multi-component crystalline solids closely related to solid s... more Background: Eutectics are basically multi-component crystalline solids closely related to solid solutions. However, the structural organization of eutectics has not been studied in as much detail as solid solutions, which are defined based on the arrangement of a major (solvent) and a minor (solute) component in the crystal lattice. Purpose: The goal of this study is basically improvement in aqueous solubility of poorly water soluble drug i.e curcumin via its eutectic formation by using salicylic acid as coformer. Material and Method: Here the eutectic mixture of curcumin and salicylic acid was prepared by solvent evaporation technique for improving the dissolution behaviour of curcumin. DSC and FT-IR spectroscopy were used as analytical techniques for characterization of eutectic mixture. Result: The DSC and FT-IR spectroscopy conformed the formation of eutectic mixture and In-Vitro dissolution studies revealed an improved dissolution behaviour for eutectic mixture (69.38 %) as com...
During organogenesis, cell proliferation is followed by the differentiation of specific cell type... more During organogenesis, cell proliferation is followed by the differentiation of specific cell types to form an organ. Any aberration in differentiation can result in developmental defects, which can result in a partial to a near‐complete loss of an organ. We employ the Drosophila eye model to understand the genetic and molecular mechanisms involved in the process of differentiation. In a forward genetic screen, we identified, cullin‐4 (cul‐4), which encodes an E3 ubiquitin ligase, to play an important role in retinal differentiation. During development, cul‐4 is known to be involved in protein degradation, regulation of genomic stability, and regulation of cell cycle. Previously, we have reported that cul‐4 regulates cell death during eye development by downregulating Wingless (Wg)/Wnt signaling pathway. We found that loss‐of‐function of cul‐4 results in a reduced eye phenotype, which can be due to onset of cell death. However, we found that loss‐of‐function of cul‐4 also affects ret...
A simple, selective, rapid, precise and economical reverse phase high-pressure liquid chromatogra... more A simple, selective, rapid, precise and economical reverse phase high-pressure liquid chromatographic method has been developed as per ICH nomination for Development and Validation of Telmisartan in Tablet Dosage form By RP-HPLC Assay Method. The assay method was carried out by using a mobile phase consisting of Buffer Solution and Solution A ((Methanol and Acetonitrile (1:1)) in the gradient ratio. The detection was carried out by using HPLC Shimadzu LC with UV-Visible PDA at 298nm.The column was Hypersil BDS C-8 (12.5 cm X 4.0 mm, 5 μ). The flow rate was selected as 1.2ml/min. The retention time of Telmisartan was found to be 8.3 min respectively. The developed method was validated in terms of specificity, accuracy, precision, linearity and system suitability. The optimized proposed method easy to handle and commercially used for the routine quality control checking of Telmisartan pharmaceutical combine tablets dosage form. RASĀYAN J. Chem., Vol. 14, No.1, 202
The aim of present investigation was formulation and evaluation of orally disintegrating tablets ... more The aim of present investigation was formulation and evaluation of orally disintegrating tablets of Niacinamide. Orally disintegrating tablets offers a solution for Pediatrics, geriatrics; psychiatrics or mentally ill peoples and those who have difficulty in swallowing tablets/capsules resulting in improved patient compliance. Orally disintegrating tablets of Niacinamide were prepared with the addition of different superdisintegrants namely crospovidone,Croscamellose sodium and sodium starch glycolate.Each of these superdisintegrants were used in the conc. of 3-7%w/w,3-5%w/w and 3-5%w/w.Mannitol is used as a filler. Nine formulations having different superdisintegrants at different concentration levels were prepared to assess their efficiency and critical concentration level. The tablets were evaluated for hardness, friability, weight variation, disintegration time, diameter, thickness and wetting time, in vitro dissolution studies and friability. The hardness of the tablets was in ...
: Cancer is a fatal disease, with a collection of related diseases in various body parts. The con... more : Cancer is a fatal disease, with a collection of related diseases in various body parts. The conventional therapies cannot show the desired results of treatment due to their imprecise targeting, deprived drug delivery, and side effects. Therefore, it is required to make the drug engineered in such a way that it can target only cancerous cells and can inhibit its growth and proliferation. Nanotechnology is a technology that can target and differentiate between cancerous cells and the normal cells of the body. Silver itself is a good anticancer and antibacterial agent and employing it with phytochemicals having anticancer properties, and nanotechnology can give the best approach for the treatment. The synthesis of silver nanoparticles using plant extracts is an economical, energy-efficient, low-cost approach and it doesn’t need any hazardous chemicals. In the present review, we discussed different methods of synthesis of silver nanoparticles using herbal extracts and their role against cancer therapy along with the synergistic role of silver and plant extracts against cancer in the formulation.
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