Purpose We assessed the associations between population-based polygenic risk scores (PRS) for bre... more Purpose We assessed the associations between population-based polygenic risk scores (PRS) for breast (BC) or epithelial ovarian cancer (EOC) with cancer risks for BRCA1 and BRCA2 pathogenic variant carriers. Methods Retrospective cohort data on 18,935 BRCA1 and 12,339 BRCA2 female pathogenic variant carriers of European ancestry were available. Three versions of a 313 single-nucleotide polymorphism (SNP) BC PRS were evaluated based on whether they predict overall, estrogen receptor (ER)–negative, or ER-positive BC, and two PRS for overall or high-grade serous EOC. Associations were validated in a prospective cohort. Results The ER-negative PRS showed the strongest association with BC risk for BRCA1 carriers (hazard ratio [HR] per standard deviation = 1.29 [95% CI 1.25–1.33], P = 3×10−72). For BRCA2, the strongest association was with overall BC PRS (HR = 1.31 [95% CI 1.27–1.36], P = 7×10−50). HR estimates decreased significantly with age and there was evidence for differences in ass...
ABSTRACT Background Histology is a prognostic and predictor of the response factor in advanced no... more ABSTRACT Background Histology is a prognostic and predictor of the response factor in advanced non-small cell lung cancer (NSCLC). Adenocarcinoma (ADC) has a better prognosis in advanced NSCLC whereas it is considered that resected patients (pts) with squamous-cell-carcinoma (SqCC) have a better outcome. We have analyzed our experience of resected stage I-II NSCLC pts to determine the impact of ADC vs SqCC histology in this setting. Methods From 1996 to 2010, 289 stage I pts and 220 stage II pts were treated by surgery. Chemotherapy (CT) was administered in 19 (6.6%) pts with stage I disease and 94 (42.7%) pts with stage II disease. Overall survival (OS) and cause-specific survival (CSS) curves were estimated by Kaplan-Meier analysis and differences were assessed with the log-rank test or the Peto and Peto modification of the Gehan-Wilcoxon test. Results Most pts (92.9%) were men. Median age was 68 years and mean follow-up was 37.4 months. Median OS for pts with stage I NSCLC was 68 mo (IC 95: 55-123) for ADC and 55 mo (IC 95: 47-67) for SqCC (p = 0.0604) with an estimated OS at 5 years of 54.1% vs 48%. Median CSS were not achieved in the two histology groups, with an estimated CSS at 5 years of 78.3% for ADC versus 71.5% for SqCC (p = 0. 626). For pts in stage II disease, the median OS was 31 mo (IC 95: 21-45) for ADC and 24 mo (IC 95: 18-34) for SqCC (p = 0.515) with an estimated OS at 5 years of 20.5% vs 29.6%. Median CSS were 45 mo (IC 95: 31-NA) for ADC and 93 mo (IC 95: 39-NA) for SqCC (p = 0.462), with an estimated CSS at 5 years of 44.8% vs 54.3%. Conclusions A trend for better OS of ADC was observed in stage I compared to SqCC but it disappeared for CSS. Thus, no statistically significant differences in OS nor CSS were observed in resected stage I-II NSCLC patients between ADC vs SqCC histology. Disclosure All authors have declared no conflicts of interest.
Background: To analyze the perception of causes and prevention of cancer among women, from Girona... more Background: To analyze the perception of causes and prevention of cancer among women, from Girona, Spain, as well as to assess the knowledge of initial symptoms and participation in cancer screening activities. Subjects and methods: Crossectional survey with the following items: cancer risk factors, initial symptoms, perceived susceptibility, knowledge and practice of screening, beliefs regarding prevention and treatment of cancer, intention to attend screening tests and socio-demographic variables. A stratified random sample of 408 women aged 40 to 70 from two counties in Girona, Spain was selected. Results: More than 80% of women identified tobacco, radioactivity and other environmental factors as causes of cancer, being the alcohol identified by 70% of women. It was clearly observed that a high level of these women (97.5%) considered a lump in the breast as an initial symptom of cancer, whereas only a 6.6% thought it was always due to cancer. With regard to cancer screening, 21.9% of women have ever practiced a mammography, 28.5% a cervical citology with Papanicolaou staining and 53.2% self-breast examinations. All these screening activities were inversely associated to age (p < 0.05) and directly to educational level (p < 0.05). Conclusion: A high knowledge regarding the causes of cancer with the exception of diet was observed in women from Girona, Spain. Knowledge and participation in screening activities is still low in practice of population cancer screening programmes.
We aimed to assess the population-based incidence and survival of primary Merkel cell carcinoma. ... more We aimed to assess the population-based incidence and survival of primary Merkel cell carcinoma. From January 1995 to December 2005, 19 patients diagnosed with primary Merkel cell carcinoma were recruited in the population-based Cancer Registry of Girona. The age-adjusted incidence was 1,3 per 10(6) person-year; higher in males (1,5) than in females (1,1). Cases occurred mostly in people older than 65 years (94,7%), especially involving the head (79%). To our knowledge, this study is the first to define the incidence and survival of Merkel cell carcinoma in Europe. The age-adjusted incidence of primary Merkel cell carcinoma in our area is similar than the age-adjusted incidence of the 2000 US standard population.
Purpose We assessed the associations between population-based polygenic risk scores (PRS) for bre... more Purpose We assessed the associations between population-based polygenic risk scores (PRS) for breast (BC) or epithelial ovarian cancer (EOC) with cancer risks for BRCA1 and BRCA2 pathogenic variant carriers. Methods Retrospective cohort data on 18,935 BRCA1 and 12,339 BRCA2 female pathogenic variant carriers of European ancestry were available. Three versions of a 313 single-nucleotide polymorphism (SNP) BC PRS were evaluated based on whether they predict overall, estrogen receptor (ER)–negative, or ER-positive BC, and two PRS for overall or high-grade serous EOC. Associations were validated in a prospective cohort. Results The ER-negative PRS showed the strongest association with BC risk for BRCA1 carriers (hazard ratio [HR] per standard deviation = 1.29 [95% CI 1.25–1.33], P = 3×10−72). For BRCA2, the strongest association was with overall BC PRS (HR = 1.31 [95% CI 1.27–1.36], P = 7×10−50). HR estimates decreased significantly with age and there was evidence for differences in ass...
ABSTRACT Background Histology is a prognostic and predictor of the response factor in advanced no... more ABSTRACT Background Histology is a prognostic and predictor of the response factor in advanced non-small cell lung cancer (NSCLC). Adenocarcinoma (ADC) has a better prognosis in advanced NSCLC whereas it is considered that resected patients (pts) with squamous-cell-carcinoma (SqCC) have a better outcome. We have analyzed our experience of resected stage I-II NSCLC pts to determine the impact of ADC vs SqCC histology in this setting. Methods From 1996 to 2010, 289 stage I pts and 220 stage II pts were treated by surgery. Chemotherapy (CT) was administered in 19 (6.6%) pts with stage I disease and 94 (42.7%) pts with stage II disease. Overall survival (OS) and cause-specific survival (CSS) curves were estimated by Kaplan-Meier analysis and differences were assessed with the log-rank test or the Peto and Peto modification of the Gehan-Wilcoxon test. Results Most pts (92.9%) were men. Median age was 68 years and mean follow-up was 37.4 months. Median OS for pts with stage I NSCLC was 68 mo (IC 95: 55-123) for ADC and 55 mo (IC 95: 47-67) for SqCC (p = 0.0604) with an estimated OS at 5 years of 54.1% vs 48%. Median CSS were not achieved in the two histology groups, with an estimated CSS at 5 years of 78.3% for ADC versus 71.5% for SqCC (p = 0. 626). For pts in stage II disease, the median OS was 31 mo (IC 95: 21-45) for ADC and 24 mo (IC 95: 18-34) for SqCC (p = 0.515) with an estimated OS at 5 years of 20.5% vs 29.6%. Median CSS were 45 mo (IC 95: 31-NA) for ADC and 93 mo (IC 95: 39-NA) for SqCC (p = 0.462), with an estimated CSS at 5 years of 44.8% vs 54.3%. Conclusions A trend for better OS of ADC was observed in stage I compared to SqCC but it disappeared for CSS. Thus, no statistically significant differences in OS nor CSS were observed in resected stage I-II NSCLC patients between ADC vs SqCC histology. Disclosure All authors have declared no conflicts of interest.
Background: To analyze the perception of causes and prevention of cancer among women, from Girona... more Background: To analyze the perception of causes and prevention of cancer among women, from Girona, Spain, as well as to assess the knowledge of initial symptoms and participation in cancer screening activities. Subjects and methods: Crossectional survey with the following items: cancer risk factors, initial symptoms, perceived susceptibility, knowledge and practice of screening, beliefs regarding prevention and treatment of cancer, intention to attend screening tests and socio-demographic variables. A stratified random sample of 408 women aged 40 to 70 from two counties in Girona, Spain was selected. Results: More than 80% of women identified tobacco, radioactivity and other environmental factors as causes of cancer, being the alcohol identified by 70% of women. It was clearly observed that a high level of these women (97.5%) considered a lump in the breast as an initial symptom of cancer, whereas only a 6.6% thought it was always due to cancer. With regard to cancer screening, 21.9% of women have ever practiced a mammography, 28.5% a cervical citology with Papanicolaou staining and 53.2% self-breast examinations. All these screening activities were inversely associated to age (p < 0.05) and directly to educational level (p < 0.05). Conclusion: A high knowledge regarding the causes of cancer with the exception of diet was observed in women from Girona, Spain. Knowledge and participation in screening activities is still low in practice of population cancer screening programmes.
We aimed to assess the population-based incidence and survival of primary Merkel cell carcinoma. ... more We aimed to assess the population-based incidence and survival of primary Merkel cell carcinoma. From January 1995 to December 2005, 19 patients diagnosed with primary Merkel cell carcinoma were recruited in the population-based Cancer Registry of Girona. The age-adjusted incidence was 1,3 per 10(6) person-year; higher in males (1,5) than in females (1,1). Cases occurred mostly in people older than 65 years (94,7%), especially involving the head (79%). To our knowledge, this study is the first to define the incidence and survival of Merkel cell carcinoma in Europe. The age-adjusted incidence of primary Merkel cell carcinoma in our area is similar than the age-adjusted incidence of the 2000 US standard population.
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Papers by Àngel Izquierdo