... Erdal Polat1, Serhat Sirekbasan1, Zehra Yıldırım1, Yaşar Bağdatlı1, İsmail Çepni2, Tayfur Çif... more ... Erdal Polat1, Serhat Sirekbasan1, Zehra Yıldırım1, Yaşar Bağdatlı1, İsmail Çepni2, Tayfur Çift2, Nezihe D. Baltalı3 ... USA 1999; 252. 2. Karaman Ü, Atambay M, Aycan ÖM, Daldal N. Trichomonas vaginalis'in çeşitli ortamlarda ve farklı ısılarda yaşam süresi. ...
European Journal of Obstetrics & Gynecology and Reproductive Biology, Sep 1, 2005
The aim of the study is to compare the efficacy and safety of oral (100 microg) and vaginal (50 m... more The aim of the study is to compare the efficacy and safety of oral (100 microg) and vaginal (50 microg) misoprostol for labor induction. Ninety-nine patients with indications for labor induction randomly received 100 microg oral misoprostol every 4 h or 50 microg vaginal misoprostol every 4 h, using maximum six doses. Mean induction to delivery interval, mode of delivery, rates of tachysystole, hypertonus and hyperstimulation syndrome, oxytocin use, number of doses used, failed induction rate and neonatal outcomes were compared for the two groups. Mean dose of misoprostol used for oral and vaginal misoprostol groups were 2.17+/-1.35 and 1.91+/-0.94, respectively (p=0.65). There were two failed inductions in the oral (4%) and one failed induction (2.5%) in the vaginal group after a total of six doses of misoprostol (p=0.58). There was no significant difference for the mean induction to delivery interval, to the beginning of active phase interval, active phase duration, second stage duration and the number of women who received oxytocin for induction or augmentation between the two groups (p>0.05). There were also no significant differences for intrapartum complications and neonatal outcomes between the oral and vaginal misoprostol groups (p>0.05). Our findings indicate that, in a closely supervised hospital setting with adequate monitoring, 100 microg oral misoprostol has the potential to induce labor as safely and effectively as its 50 microg vaginal analogue. As oral use of the drug is easier for both the patient and the doctor, oral misoprostol will probably be more preferable than the vaginal route.
This study was designed to determine the incidence of group B Streptococcus (GBS) colonization in... more This study was designed to determine the incidence of group B Streptococcus (GBS) colonization in pregnant women and newborns, and to evaluate the antimicrobial resistance during delivery. A total of 300 pregnant women and their newborns were enrolled in this prospective study performed in the maternity ward of Cerrahpasa Medical Faculty and Bakirkoy SSK Hospital, Istanbul, Turkey. Samples were collected from pregnant women and their newborns in the delivery room. GBS was isolated from 24 women and the colonization rate was found to be 8%. Two newborns were colonized with GBS. None of the isolates were resistant to penicillin, whereas 20% showed resistance to erythromycin and clindamycin. Screening and antimicrobial susceptibility testing of GBS during pregnancy show similar results with other studies performed in different regions of our country.
International Journal of Gynecological Cancer, Mar 1, 2003
primary infertility of four years duration with a BMI of 38kg/m2. A 8-mm bilayer thick endometriu... more primary infertility of four years duration with a BMI of 38kg/m2. A 8-mm bilayer thick endometrium was noted at transvaginal ultrasonography. Due to menometrorrhagia a diagnostic endometrial biopsy was performed and a well differentiated adenocarcinoma was reported. The patient wished to preserve her fertility after undertaking an extensive discussion of risks and alternatives. After imaging the absence of myometrial invasion by Magnetic Resonance (MRI) preoperatively, the patient was subjected to the surgical staging procedure consisting peritoneal cytology, complete pelvic-paraaortic lymphadenectomy, omentectomy and bilateral wedge biopsies. No extrauterine pathology was noted at the pathology report. The patient underwent 160mg/day megestrol acetate for 6 months but the following curettage showed residual adenocarcinoma. After checking myometrial invasion by MRI, treatment switched to continuous medroxyprogesterone acetate 10mg/day. Following 6-month treatment with medroxyprogesterone acetate, a repeat endometrial biopsy revealed complex atypical hyperplasia with no persistent cancer. The patient conceived by ICSI was and a 1740 gr. breech presented infant was delivered by C/S at 30th week of gestation due to preterm delivery. No tumour could be identified in the placenta. Conclusion: Fertility-saving management with hormonal therapy followed by endometrial sampling may be reasonable in such patients who wish to bear children.
... Erdal Polat1, Serhat Sirekbasan1, Zehra Yıldırım1, Yaşar Bağdatlı1, İsmail Çepni2, Tayfur Çif... more ... Erdal Polat1, Serhat Sirekbasan1, Zehra Yıldırım1, Yaşar Bağdatlı1, İsmail Çepni2, Tayfur Çift2, Nezihe D. Baltalı3 ... USA 1999; 252. 2. Karaman Ü, Atambay M, Aycan ÖM, Daldal N. Trichomonas vaginalis'in çeşitli ortamlarda ve farklı ısılarda yaşam süresi. ...
European Journal of Obstetrics & Gynecology and Reproductive Biology, Sep 1, 2005
The aim of the study is to compare the efficacy and safety of oral (100 microg) and vaginal (50 m... more The aim of the study is to compare the efficacy and safety of oral (100 microg) and vaginal (50 microg) misoprostol for labor induction. Ninety-nine patients with indications for labor induction randomly received 100 microg oral misoprostol every 4 h or 50 microg vaginal misoprostol every 4 h, using maximum six doses. Mean induction to delivery interval, mode of delivery, rates of tachysystole, hypertonus and hyperstimulation syndrome, oxytocin use, number of doses used, failed induction rate and neonatal outcomes were compared for the two groups. Mean dose of misoprostol used for oral and vaginal misoprostol groups were 2.17+/-1.35 and 1.91+/-0.94, respectively (p=0.65). There were two failed inductions in the oral (4%) and one failed induction (2.5%) in the vaginal group after a total of six doses of misoprostol (p=0.58). There was no significant difference for the mean induction to delivery interval, to the beginning of active phase interval, active phase duration, second stage duration and the number of women who received oxytocin for induction or augmentation between the two groups (p>0.05). There were also no significant differences for intrapartum complications and neonatal outcomes between the oral and vaginal misoprostol groups (p>0.05). Our findings indicate that, in a closely supervised hospital setting with adequate monitoring, 100 microg oral misoprostol has the potential to induce labor as safely and effectively as its 50 microg vaginal analogue. As oral use of the drug is easier for both the patient and the doctor, oral misoprostol will probably be more preferable than the vaginal route.
This study was designed to determine the incidence of group B Streptococcus (GBS) colonization in... more This study was designed to determine the incidence of group B Streptococcus (GBS) colonization in pregnant women and newborns, and to evaluate the antimicrobial resistance during delivery. A total of 300 pregnant women and their newborns were enrolled in this prospective study performed in the maternity ward of Cerrahpasa Medical Faculty and Bakirkoy SSK Hospital, Istanbul, Turkey. Samples were collected from pregnant women and their newborns in the delivery room. GBS was isolated from 24 women and the colonization rate was found to be 8%. Two newborns were colonized with GBS. None of the isolates were resistant to penicillin, whereas 20% showed resistance to erythromycin and clindamycin. Screening and antimicrobial susceptibility testing of GBS during pregnancy show similar results with other studies performed in different regions of our country.
International Journal of Gynecological Cancer, Mar 1, 2003
primary infertility of four years duration with a BMI of 38kg/m2. A 8-mm bilayer thick endometriu... more primary infertility of four years duration with a BMI of 38kg/m2. A 8-mm bilayer thick endometrium was noted at transvaginal ultrasonography. Due to menometrorrhagia a diagnostic endometrial biopsy was performed and a well differentiated adenocarcinoma was reported. The patient wished to preserve her fertility after undertaking an extensive discussion of risks and alternatives. After imaging the absence of myometrial invasion by Magnetic Resonance (MRI) preoperatively, the patient was subjected to the surgical staging procedure consisting peritoneal cytology, complete pelvic-paraaortic lymphadenectomy, omentectomy and bilateral wedge biopsies. No extrauterine pathology was noted at the pathology report. The patient underwent 160mg/day megestrol acetate for 6 months but the following curettage showed residual adenocarcinoma. After checking myometrial invasion by MRI, treatment switched to continuous medroxyprogesterone acetate 10mg/day. Following 6-month treatment with medroxyprogesterone acetate, a repeat endometrial biopsy revealed complex atypical hyperplasia with no persistent cancer. The patient conceived by ICSI was and a 1740 gr. breech presented infant was delivered by C/S at 30th week of gestation due to preterm delivery. No tumour could be identified in the placenta. Conclusion: Fertility-saving management with hormonal therapy followed by endometrial sampling may be reasonable in such patients who wish to bear children.
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